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公开(公告)号：US09828391B2
公开(公告)日：2017-11-28
申请号：US15212959
申请日：2016-07-18
发明人： Christopher J. Burns , Denis Daigle , Bin Liu , Daniel McGarry , Daniel C. Pevear , Robert E. Lee Trout
CPC分类号： C07F5/025 , A61K9/0019 , A61K9/0053 , A61K31/69 , A61K45/06 , C07F5/027 , C07F5/04
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US12102648B2
公开(公告)日：2024-10-01
申请号：US18159327
申请日：2023-01-25
发明人： Christopher J. Burns , Glen Coburn , Guo-Hua Chu , Stephen M. Condon , Steven A. Boyd , Daniel C. Pevear
IPC分类号： A61K31/7076 , A61K9/00 , A61K9/20 , A61K9/48 , A61K31/53 , A61K31/675 , A61K31/685 , A61K31/7072 , C07D487/04 , C07F9/6561 , C07H19/06 , C07H19/10 , C07H19/16
CPC分类号： A61K31/7076 , A61K9/0053 , A61K9/2018 , A61K9/2054 , A61K9/2059 , A61K9/4858 , A61K31/53 , A61K31/675 , A61K31/685 , A61K31/7072 , C07D487/04 , C07F9/6561 , C07H19/06 , C07H19/10 , C07H19/16
摘要： Described herein are orally-bioavailable nucleoside analogs and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of coronavirus infections, including SARS-CoV-2 infection.
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公开(公告)号：US11638715B2
公开(公告)日：2023-05-02
申请号：US17842402
申请日：2022-06-16
发明人： Christopher J. Burns , Glen Coburn , Guo-Hua Chu , Stephen M. Condon , Steven A. Boyd , Daniel C. Pevear
IPC分类号： A61K31/7076 , A61K9/48 , C07H19/16 , C07H19/06 , C07F9/6561 , C07H19/10 , A61K31/53 , A61K31/7072 , A61K31/685 , A61K31/675 , A61K9/00 , A61K9/20 , C07D487/04
摘要： Described herein are orally-bioavailable nucleoside analogs and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of coronavirus infections, including SARS-CoV-2 infection.
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4.发明授权公开(公告)号：US11091505B2
公开(公告)日：2021-08-17
申请号：US16491116
申请日：2018-03-05
发明人： Christopher J. Burns , Daniel C. Pevear , Luigi Xerri , Timothy Henkel , Daniel McGarry , Lawrence Rosen , Gerald Brenner , Jean-Baptiste Arlin , Ana Fernandez Casares
IPC分类号： C07F5/02 , A61P31/04 , A61K47/18 , A61K47/12 , A61K47/02 , A61K47/26 , A61K9/00 , A61K31/546
摘要： Described herein are crystalline forms of (R)-3-(2-(trans-4-(2-aminoethylamino)cyclohexyl)acetamido)-2-hydroxy-3,4-dihydro-2H-benzo[e][1,2]oxaborinine-8-carboxylic acid. In some embodiments, the crystalline forms are formulated for treating a subject in need thereof with a bacterial infection.
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公开(公告)号：US10669290B2
公开(公告)日：2020-06-02
申请号：US16238363
申请日：2019-01-02
发明人： Christopher J. Burns , Denis Daigle , Bin Liu , Daniel McGarry , Daniel C. Pevear , Robert E. Lee Trout
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US10294248B2
公开(公告)日：2019-05-21
申请号：US15922376
申请日：2018-03-15
发明人： Christopher J. Burns , Denis Daigle , Bin Liu , Daniel McGarry , Daniel C. Pevear , Robert E. Lee Trout
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US09802966B2
公开(公告)日：2017-10-31
申请号：US15333049
申请日：2016-10-24
发明人： Christopher J. Burns , Denis Daigle , Bin Liu , Daniel McGarry , Daniel C. Pevear , Robert E. Lee Trout
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US09783555B2
公开(公告)日：2017-10-10
申请号：US15435097
申请日：2017-02-16
发明人： Christopher J. Burns , Denis Daigle , Bin Liu , Randy W. Jackson , Jodie Hamrick , Daniel McGarry , Daniel C. Pevear , Robert E. Lee Trout
IPC分类号： A61K31/69 , A61K31/198 , A61K45/06 , C07F5/02
CPC分类号： C07F5/025 , A61K31/198 , A61K31/69 , A61K45/06 , A61K2300/00
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US09376454B2
公开(公告)日：2016-06-28
申请号：US14693318
申请日：2015-04-22
发明人： Christopher J. Burns , Denis Daigle , Bin Liu , Daniel McGarry , Daniel C. Pevear , Robert E. Lee Trout , Randy W. Jackson
IPC分类号： A61K31/69 , C07F5/02 , A61K45/06 , A61K31/407 , A61K31/496 , A61K31/546
CPC分类号： C07F5/025 , A61K31/407 , A61K31/496 , A61K31/546 , A61K31/69 , A61K45/06 , Y02A50/47 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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公开(公告)号：US11332485B2
公开(公告)日：2022-05-17
申请号：US16616294
申请日：2018-05-25
发明人： Christopher J. Burns , Denis Daigle , Guo-Hua Chu , Jodie Hamrick , Matthew Lucas , Steven A. Boyd , Allison L. Zulli , Eugen F. Mesaros , Stephen M. Condon , Robert E. Lee Trout , Cullen L. Myers
摘要： Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
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