公开(公告)号：US12102648B2

公开(公告)日：2024-10-01

申请号：US18159327

申请日：2023-01-25

申请人： Venatorx Pharmaceuticals, Inc.

发明人： Christopher J. Burns ,  Glen Coburn ,  Guo-Hua Chu ,  Stephen M. Condon ,  Steven A. Boyd ,  Daniel C. Pevear

IPC分类号： A61K31/7076 ,  A61K9/00 ,  A61K9/20 ,  A61K9/48 ,  A61K31/53 ,  A61K31/675 ,  A61K31/685 ,  A61K31/7072 ,  C07D487/04 ,  C07F9/6561 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16

CPC分类号： A61K31/7076 ,  A61K9/0053 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/4858 ,  A61K31/53 ,  A61K31/675 ,  A61K31/685 ,  A61K31/7072 ,  C07D487/04 ,  C07F9/6561 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16

摘要： Described herein are orally-bioavailable nucleoside analogs and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of coronavirus infections, including SARS-CoV-2 infection.

公开(公告)号：US11638715B2

公开(公告)日：2023-05-02

申请号：US17842402

申请日：2022-06-16

申请人： Venatorx Pharmaceuticals, Inc.

发明人： Christopher J. Burns ,  Glen Coburn ,  Guo-Hua Chu ,  Stephen M. Condon ,  Steven A. Boyd ,  Daniel C. Pevear

IPC分类号： A61K31/7076 ,  A61K9/48 ,  C07H19/16 ,  C07H19/06 ,  C07F9/6561 ,  C07H19/10 ,  A61K31/53 ,  A61K31/7072 ,  A61K31/685 ,  A61K31/675 ,  A61K9/00 ,  A61K9/20 ,  C07D487/04

摘要： Described herein are orally-bioavailable nucleoside analogs and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of coronavirus infections, including SARS-CoV-2 infection.

公开(公告)号：US12084445B2

公开(公告)日：2024-09-10

申请号：US17057594

申请日：2019-05-29

申请人： VenatoRx Pharmaceuticals, Inc.

发明人： Christopher J. Burns ,  Guo-Hua Chu ,  Jodie Hamrick ,  Steven A. Boyd ,  Stephen M. Condon

IPC分类号： A61K31/403 ,  A61K45/06 ,  A61P31/04 ,  C07D477/20 ,  A61K31/407

CPC分类号： C07D477/20 ,  A61K31/403 ,  A61K45/06 ,  A61P31/04 ,  A61K31/407

摘要： The present disclosure provides broad-spectrum carbapenem derivatives and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such derivatives and/or compositions.

公开(公告)号：US11566001B2

公开(公告)日：2023-01-31

申请号：US17514578

申请日：2021-10-29

申请人： Venatorx Pharmaceuticals, Inc.

发明人： Christopher J. Burns ,  Glen Coburn ,  Bin Liu ,  Jiangchao Yao ,  Christopher Benetatos ,  Steven A. Boyd ,  Stephen M. Condon ,  Thomas Haimowitz

IPC分类号： C07D487/04 ,  C07D207/34 ,  A61P31/20 ,  C07D401/12 ,  C07D405/12 ,  C07D417/12 ,  C07D403/06 ,  C07D498/04 ,  C07D401/06 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D513/04 ,  C07D207/337 ,  C07D401/14 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07F5/02

摘要： Described herein are hepatitis B capsid assembly modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of hepatitis B.

公开(公告)号：US10590076B2

公开(公告)日：2020-03-17

申请号：US16438361

申请日：2019-06-11

申请人： VenatoRx Pharmaceuticals, Inc.

发明人： Christopher J. Burns ,  Glen Coburn ,  Bin Liu ,  Jiangchao Yao ,  Christopher Benetatos ,  Steven A. Boyd ,  Stephen M. Condon ,  Thomas Haimowitz

IPC分类号： C07D207/337 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D487/04 ,  C07D513/04 ,  C07D207/34 ,  A61P31/20 ,  C07D403/06 ,  C07D498/04 ,  C07D471/04 ,  C07D401/14 ,  C07F5/02

摘要： Described herein are hepatitis B capsid assembly modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of hepatitis B.

公开(公告)号：US11247965B2

公开(公告)日：2022-02-15

申请号：US16771387

申请日：2018-12-10

申请人： VenatoRx Pharmaceuticals, Inc.

发明人： Christopher J. Burns ,  Glen Coburn ,  Bin Liu ,  Jiangchao Yao ,  Christopher Benetatos ,  Steven A. Boyd ,  Stephen M. Condon

IPC分类号： C07C233/64 ,  C07D211/46 ,  C07D307/66 ,  C07D265/30 ,  C07D309/14 ,  A61K45/06

摘要： Described herein are hepatitis B capsid assembly modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of hepatitis B.

公开(公告)号：US11332485B2

公开(公告)日：2022-05-17

申请号：US16616294

申请日：2018-05-25

申请人： VenatoRx Pharmaceuticals, Inc.

发明人： Christopher J. Burns ,  Denis Daigle ,  Guo-Hua Chu ,  Jodie Hamrick ,  Matthew Lucas ,  Steven A. Boyd ,  Allison L. Zulli ,  Eugen F. Mesaros ,  Stephen M. Condon ,  Robert E. Lee Trout ,  Cullen L. Myers

IPC分类号： C07F5/02 ,  A61P31/04 ,  A61K9/20 ,  A61K9/48

摘要： Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

公开(公告)号：US11014881B2

公开(公告)日：2021-05-25

申请号：US16671815

申请日：2019-11-01

申请人： VenatoRx Pharmaceuticals, Inc.

发明人： Christopher J. Burns ,  Glen Coburn ,  Bin Liu ,  Jiangchao Yao ,  Christopher Benetatos ,  Steven A. Boyd ,  Stephen M. Condon ,  Thomas Haimowitz

IPC分类号： C07D207/337 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D487/04 ,  C07D513/04 ,  C07D207/34 ,  A61P31/20 ,  C07D403/06 ,  C07D498/04 ,  C07D471/04 ,  C07F5/02

摘要： Described herein are hepatitis B capsid assembly modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of hepatitis B.