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22 条记录 (耗时 0.021 秒)

    Process for the preparation of Telmisartan
    9.
    发明授权
    Process for the preparation of Telmisartan 有权
    制备替米沙坦的方法

    公开(公告)号：US07884214B2

    公开(公告)日：2011-02-08

    申请号：US12064150

    申请日：2006-07-19

    申请人： Satyanarayana Chava ,  Seeta Ramanjaneyulu Gorantla ,  Sai Prasanna Bhagya Lakshmi Ginjupalli

    发明人： Satyanarayana Chava ,  Seeta Ramanjaneyulu Gorantla ,  Sai Prasanna Bhagya Lakshmi Ginjupalli

    IPC分类号： C07D403/02

    CPC分类号： C07D235/20

    摘要： The present invention encompasses a method for the preparation of Telmisartan comprises, through Telmisartan dihydrochloride comprises i) Condensing 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid with N-Methyl-O-phenylenediamine dihydrochloride to yields 4-methyl-6 (1-methyl benzimidazol-2-yl)-2-n-propyl 1H-benzimidazole ii) Treating 4-methyl-6-(1-methylbenzimidazol-2-yl)-2-n-propyl-1H-benzimidazole with 4′-(bromomethyl)-2-biphenyl-2-carboxylate in presence of a base in an organic solvent and isolating the ester as acid addition salt iii) Converting ester acid addition salt to Telmisartan dihydrochloride and iv) Converting Telmisartan dihydrochloride to Telmisartan.

    摘要翻译： 本发明包括用于制备替米沙坦的方法，其包括通过替米沙坦二盐酸盐包括i）使4-甲基-2-正丙基-1H-苯并咪唑-6-羧酸与N-甲基-O-苯二胺二盐酸盐冷凝，得到4 - 甲基-6（1-甲基苯并咪唑-2-基）-2-正丙基1H-苯并咪唑ii）处理4-甲基-6-（1-甲基苯并咪唑-2-基）-2-正丙基-1H- 苯并咪唑与4' - （溴甲基）-2-联苯基-2-羧酸叔丁酯在碱的存在下在有机溶剂中反应，并将酯分离为酸加成盐iii）将酯酸加成盐转化为替米沙坦二盐酸盐，和iv）将替米沙坦二盐酸盐转化为 替米沙坦

    Process for the Preparation of Almotriptan
    10.
    发明申请
    Process for the Preparation of Almotriptan 有权
    阿莫曲坦制备方法

    公开(公告)号：US20080234495A1

    公开(公告)日：2008-09-25

    申请号：US11996787

    申请日：2006-07-21

    申请人： Satyanarayana Chava ,  Seeta Ramanjaneyulu Gorantla ,  Ramdas Chavakula ,  Babu Rao Konudula

    发明人： Satyanarayana Chava ,  Seeta Ramanjaneyulu Gorantla ,  Ramdas Chavakula ,  Babu Rao Konudula

    IPC分类号： C07D403/12

    CPC分类号： C07D209/16

    摘要： The present invention encompasses a method for the preparation of Almotriptan and its pharmaceutically acceptable salts comprises, i) Methylation of 3-[5-(1-Pyrrolidinyl sulfonyl methyl) 1H-indol-yl]ethane amine ii) Treating crude Almotriptan with a hydroxy benzoic acid yields hydroxy benzoic acid addition salt of Almotriptan iii) Converting Almotriptan hydroxy benzoic acid addition salt to Almotriptan and iv) Salification of Almotriptan to its pharmaceutically acceptable salts

    摘要翻译： 本发明包括制备阿莫曲坦及其药学上可接受的盐的方法，包括：i）3- [5-（1-吡咯烷基磺酰基甲基）1H-吲哚基]乙烷胺的甲基化; ii）用羟基 苯甲酸产生阿莫曲坦的羟基苯甲酸加成盐iii）将阿莫曲坦羟基苯甲酸加成盐转化为阿莫曲坦，和iv）将阿莫托他汀盐化至其药学上可接受的盐