公开(公告)号：US06190893B1

公开(公告)日：2001-02-20

申请号：US09156317

申请日：1998-09-18

申请人： Venkatram R. Shastri ,  Nahid Rahman ,  Ivan Martin ,  Robert S. Langer, Jr.

发明人： Venkatram R. Shastri ,  Nahid Rahman ,  Ivan Martin ,  Robert S. Langer, Jr.

IPC分类号： C12N1300

CPC分类号： C12N13/00 ,  C12M35/02 ,  C12N5/0068 ,  C12N2533/30

摘要： Compositions, methods and systems are provided for the stimulation of biological activities within bone marrow stromal cells by applying electromagnetic stimulation to an electroactive material, wherein the electromagnetic stimulation is coupled to the electromagnetic material. In general the present invention involves attaching or associating the desired bone marrow stromal cells to or with a surface comprising an electroactive material, and applying electromagnetic radiation directly to the desired area. In preferred embodiments, the stimulation of biological activities within bone marrow stromal cells results from inducing one or more activities including, but not limited to, gene expression, cell growth, cell differentiation, signal transduction, membrane permeability, cell division and cell signalling. In particularly preferred embodiments, the present invention stimulates bone cell regeneration. In exemplary embodiments, the electroactive materials used in the present invention are either two-dimensional substrates such as thin films having at least one surface of an electroactive material, or in alternative embodiments, the electroactive materials are three-dimensional substrates comprising a matrix having at least one surface of an electroactive material.

摘要翻译： 提供了组合物，方法和系统，用于通过对电活性材料施加电磁刺激来刺激骨髓基质细胞内的生物活性，其中电磁刺激与电磁材料耦合。 通常，本发明涉及将期望的骨髓基质细胞附着或连接到包含电活性物质的表面或与包含电活性材料的表面相连，并将电磁辐射直接施加到所需区域。 在优选的实施方案中，刺激骨髓基质细胞内的生物活性是由于诱导一种或多种活性，包括但不限于基因表达，细胞生长，细胞分化，信号转导，膜通透性，细胞分裂和细胞信号传导。 在特别优选的实施方案中，本发明刺激骨细胞再生。 在示例性实施方案中，本发明中使用的电活性材料是二维底物，例如具有至少一种电活性材料表面的薄膜，或者在替代实施方案中，电活性材料是三维基质，其包含基质， 电活性材料的至少一个表面。

公开(公告)号：US06569654B2

公开(公告)日：2003-05-27

申请号：US09753407

申请日：2001-01-02

申请人： Venkatram Shastri ,  Ivan Martin ,  Robert Langer ,  Nahid Rahman

发明人： Venkatram Shastri ,  Ivan Martin ,  Robert Langer ,  Nahid Rahman

IPC分类号： C12N1300

CPC分类号： A61K41/0052 ,  C12M35/02 ,  C12N5/0068 ,  C12N13/00 ,  C12N2533/30 ,  Y10S977/91 ,  Y10S977/925

摘要： Compositions, methods and systems are provided for the stimulation of biological activities within stem cells by applying electromagnetic stimulation to an electroactive material, wherein the electromagnetic stimulation is coupled to the electromagnetic material. In general the present invention involves attaching or associating the desired cells to or with a surface comprising an electroactive material, and applying electromagnetic radiation directly to the desired area. In preferred embodiments, the stimulation of biological activities within cells results from inducing one or more activities including, but not limited to, gene expression, cell growth, cell differentiation, signal transduction, membrane permeability, cell division, contraction, and cell signaling. In exemplary embodiments, the electroactive materials used in the present invention are either two-dimensional substrates such as thin films having at least one surface of an electroactive material, or in alternative embodiments, the electroactive materials are three-dimensional substrates comprising a matrix having at least one surface of an electroactive material.

公开(公告)号：US09608317B2

公开(公告)日：2017-03-28

申请号：US14312360

申请日：2014-06-23

申请人： Nahid Rahman ,  Mohammed N. Afsar

发明人： Nahid Rahman ,  Mohammed N. Afsar

IPC分类号： H01Q1/36 ,  H01Q21/00 ,  H01Q7/00 ,  H01Q9/27

CPC分类号： H01Q1/36 ,  H01Q7/00 ,  H01Q9/27 ,  H01Q21/00

摘要： A spiral antenna device includes a plurality of generally polygonal loops. The polygonal loops have respective side counts that decrease progressively as a function of the loop's radial distance from a center of the antenna device. The side count may vary between loops as a multiple of a power of two.