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    Conductive polymer contrast agent compositions and uses therefor
    2.
    发明授权
    Conductive polymer contrast agent compositions and uses therefor 失效
    导电聚合物造影剂组合物及其用途

    公开(公告)号：US06355224B1

    公开(公告)日：2002-03-12

    申请号：US09156549

    申请日：1998-09-17

    申请人： Venkatram R. Shastri ,  Robert S. Langer, Jr.

    发明人： Venkatram R. Shastri ,  Robert S. Langer, Jr.

    IPC分类号： A61B5055

    CPC分类号： A61K49/1857 ,  Y10S977/929 ,  Y10S977/93

    摘要： The use of electroactive materials having regions of high electron density as contrast agents in magnetic resonance imaging is described. The electroactive materials may be electroactive polymers, inorganic clusters, carbon clusters, molecules that inherently exhibit electron donor-acceptor behavior having regions or moieties of high electron density, or any combination of the abovementioned contrast agents. The contrast agents of the invention decrease relaxation times of water when introduced into a subject for magnetic resonance imaging. It is particularly preferred that the contrast agents be introduced in the form of a colloidal suspension.

    摘要翻译： 描述了在磁共振成像中使用具有高电子密度区域的电活性材料作为造影剂。 电活性材料可以是电活性聚合物，无机簇，碳簇，固有地表现出具有高电子密度的区域或部分的电子给体 - 受体行为的分子，或上述造影剂的任何组合。 本发明的造影剂在引入受试者的磁共振成像时减少水的松弛时间。 特别优选的是造影剂以胶态悬浮液的形式引入。

    Electroactive materials for stimulation of biological activity of bone marrow stromal cells
    3.
    发明授权
    Electroactive materials for stimulation of biological activity of bone marrow stromal cells 失效
    用于刺激骨髓基质细胞生物活性的电活性材料

    公开(公告)号：US06190893B1

    公开(公告)日：2001-02-20

    申请号：US09156317

    申请日：1998-09-18

    申请人： Venkatram R. Shastri ,  Nahid Rahman ,  Ivan Martin ,  Robert S. Langer, Jr.

    发明人： Venkatram R. Shastri ,  Nahid Rahman ,  Ivan Martin ,  Robert S. Langer, Jr.

    IPC分类号： C12N1300

    CPC分类号： C12N13/00 ,  C12M35/02 ,  C12N5/0068 ,  C12N2533/30

    摘要： Compositions, methods and systems are provided for the stimulation of biological activities within bone marrow stromal cells by applying electromagnetic stimulation to an electroactive material, wherein the electromagnetic stimulation is coupled to the electromagnetic material. In general the present invention involves attaching or associating the desired bone marrow stromal cells to or with a surface comprising an electroactive material, and applying electromagnetic radiation directly to the desired area. In preferred embodiments, the stimulation of biological activities within bone marrow stromal cells results from inducing one or more activities including, but not limited to, gene expression, cell growth, cell differentiation, signal transduction, membrane permeability, cell division and cell signalling. In particularly preferred embodiments, the present invention stimulates bone cell regeneration. In exemplary embodiments, the electroactive materials used in the present invention are either two-dimensional substrates such as thin films having at least one surface of an electroactive material, or in alternative embodiments, the electroactive materials are three-dimensional substrates comprising a matrix having at least one surface of an electroactive material.

    摘要翻译： 提供了组合物，方法和系统，用于通过对电活性材料施加电磁刺激来刺激骨髓基质细胞内的生物活性，其中电磁刺激与电磁材料耦合。 通常，本发明涉及将期望的骨髓基质细胞附着或连接到包含电活性物质的表面或与包含电活性材料的表面相连，并将电磁辐射直接施加到所需区域。 在优选的实施方案中，刺激骨髓基质细胞内的生物活性是由于诱导一种或多种活性，包括但不限于基因表达，细胞生长，细胞分化，信号转导，膜通透性，细胞分裂和细胞信号传导。 在特别优选的实施方案中，本发明刺激骨细胞再生。 在示例性实施方案中，本发明中使用的电活性材料是二维底物，例如具有至少一种电活性材料表面的薄膜，或者在替代实施方案中，电活性材料是三维基质，其包含基质， 电活性材料的至少一个表面。

    Tissue regrafting
    4.
    发明授权
    Tissue regrafting 失效
    组织再植

    公开(公告)号：US07108721B2

    公开(公告)日：2006-09-19

    申请号：US10275618

    申请日：2001-05-10

    申请人： James William Huckle ,  Melissa Anderson ,  Allen E. Goodship ,  Venkatram R. Shastri

    发明人： James William Huckle ,  Melissa Anderson ,  Allen E. Goodship ,  Venkatram R. Shastri

    IPC分类号： A61F2/36 ,  A61F2/08 ,  A61F2/28

    CPC分类号： A61L27/3645 ,  A61L27/38

    摘要： The present invention is based on the discovery of new methods for obtaining a tissue graft. The method can be carried out, for example, by implanting a biocompatible scaffold into a mammal and then removing the scaffold from the mammal. The scaffold is implanted in direct contact with (i.e. physically touching over at least a portion of its external surface), or adjacent to (i.e. physically separated from) mature or immature target tissue, for a period of time that is sufficient to allow cells of the target tissue to associate with the scaffold. The invention also features grafts generated by the methods described herein and methods for using those grafts to treat patients who have a defect in a target.

    摘要翻译： 本发明基于获得组织移植物的新方法的发现。 该方法可以例如通过将生物相容性支架植入哺乳动物中，然后从哺乳动物中除去支架来进行。 将支架植入与成熟或未成熟靶组织直接接触（即物理接触其外表面的至少一部分）或邻近（即物理分离）成熟或未成熟靶组织，持续一段时间，足以使细胞 目标组织与支架相关联。 本发明还涉及通过本文所述的方法产生的移植物以及使用这些移植物治疗患有目标缺陷的患者的方法。

    Drug delivery composition and device
    5.
    发明授权
    Drug delivery composition and device 失效
    药物输送成分及装置

    公开(公告)号：US06582717B1

    公开(公告)日：2003-06-24

    申请号：US09543964

    申请日：2000-04-07

    申请人： Venkatram R. Shastri ,  Isaac Yue ,  Robert S. Langer

    发明人： Venkatram R. Shastri ,  Isaac Yue ,  Robert S. Langer

    IPC分类号： A61F200

    CPC分类号： A61K9/0063 ,  B33Y80/00

    摘要： Drug delivery composition. The composition includes a polymeric material, a complexing agent, and a bioactive agent complexed with the complexing agent. The polymeric material, the complexing agent and the bioactive agent are formed into a delivery matrix. The delivery matrix is particularly adapted for placement below the gum line in a periodontal cavity.

    摘要翻译： 药物输送成分。 该组合物包括聚合物材料，络合剂和与络合剂络合的生物活性剂。 将聚合物材料，络合剂和生物活性剂形成为递送基质。 递送基质特别适于放置在牙周腔中的牙龈线下方。

    Biodegradable polymer networks for use in orthopedic and dental applications
    7.
    发明授权
    Biodegradable polymer networks for use in orthopedic and dental applications 失效
    用于矫形和牙科应用的可生物降解聚合物网络

    公开(公告)号：US5902599A

    公开(公告)日：1999-05-11

    申请号：US603171

    申请日：1996-02-20

    申请人： Kristi S. Anseth ,  Robert Langer ,  Venkatram R. Shastri

    发明人： Kristi S. Anseth ,  Robert Langer ,  Venkatram R. Shastri

    IPC分类号： A61F2/28 ,  A61F2/30 ,  A61K47/32 ,  C08F2/46

    CPC分类号： C08F2/48 ,  A61C8/0012 ,  A61L27/16 ,  A61L27/58

    摘要： Biodegradable polymer networks are provided which are useful in a variety of dental and orthopedic applications. The biodegradable polymer networks can be formed in one embodiment by polymerizing anhydride prepolymers including crosslinkable groups, such as unsaturated moieties. The anhydride prepolymers can be crosslinked, for example in a photopolymerization reaction by irradiation of the prepolymer with light in the presence of a free radical initiator. Suitable anhydride prepolymers include dianhydrides of a dicarboxylic acid and a carboxylic acid molecule comprising a crosslinkable group. For example, methacrylic acid dianhydrides of monomers or oligomers of a diacid such as sebacic acid or 1,3-bis(p-carboxyphenoxy)-hexane can be used. The anhydride prepolymers can be applied in vivo to a site where an orthopedic implant is needed, and then may be crosslinked, for example, by irradiation with U.V. light, to form a biodegradable implant such as a rods, pin or plate. The implants advantageously provide mechanical support and also are capable of slow surface degradation to permit bone ingrowth.

    摘要翻译： 提供可生物降解的聚合物网络，其可用于各种牙科和矫形应用。 可生物降解的聚合物网络可以在一个实施方案中通过聚合包括可交联基团如不饱和部分的酸酐预聚物来形成。 酸酐预聚物可以交联，例如通过在自由基引发剂的存在下用光照射预聚物进行光聚合反应。 合适的酸酐预聚物包括二羧酸的二酸酐和包含可交联基团的羧酸分子。 例如，可以使用二酸的单体或低聚物如癸二酸或1,3-双（对羧基苯氧基） - 己烷的甲基丙烯酸二酐。 酸酐预聚物可以在体内应用于需要整形外科植入物的部位，然后可以例如通过用紫外线照射来交联。 光，以形成可生物降解的植入物，例如杆，针或板。 植入物有利地提供机械支撑并且还能够缓慢的表面退化以允许骨向内生长。