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17 条记录 (耗时 0.087 秒)

    Nucleic acids and polypeptides of C1 bacteriophage and uses thereof
    1.
    发明授权
    Nucleic acids and polypeptides of C1 bacteriophage and uses thereof 有权
    C1噬菌体的核酸和多肽及其用途

    公开(公告)号：US07582729B2

    公开(公告)日：2009-09-01

    申请号：US10556359

    申请日：2004-05-14

    申请人： Vincent Fischetti ,  Daniel Nelson ,  Raymond Schuch

    发明人： Vincent Fischetti ,  Daniel Nelson ,  Raymond Schuch

    IPC分类号： C07K14/00

    CPC分类号： C12N9/503

    摘要： The full-length nucleic acid sequence of the C1 bacteriophage is disclosed in the present application. The specific regions of the C1 genome encoding the PlyC lysin have also been identified and sequenced. The invention relates to the pharmaceutical and diagnostic utility of these sequences and provides for development of pharmaceutical compositions for treating or preventing streptococcal infections in mammals, for compositions for decontamination of inanimate surfaces and for diagnosis of streptococcal infections.

    摘要翻译： C1噬菌体的全长核酸序列在本申请中公开。 编码PlyC溶素的C1基因组的特定区域也已被鉴定并测序。 本发明涉及这些序列的药物和诊断实用性，并且提供用于治疗或预防哺乳动物中链球菌感染的药物组合物的开发，用于无生物表面净化的组合物和用于诊断链球菌感染的组合物。

    Nucleic Acids and Polypeptides of C1 Bacteriophage and Uses Thereof
    2.
    发明申请
    Nucleic Acids and Polypeptides of C1 Bacteriophage and Uses Thereof 有权
    C1噬菌体的核酸和多肽及其用途

    公开(公告)号：US20070265198A1

    公开(公告)日：2007-11-15

    申请号：US10556359

    申请日：2004-05-14

    申请人： Vincent Fischetti ,  Daniel Nelson ,  Raymond Schuch

    发明人： Vincent Fischetti ,  Daniel Nelson ,  Raymond Schuch

    IPC分类号： A61K38/16 ,  A61P31/04 ,  C07H21/00 ,  C07K14/00 ,  C07K16/00 ,  C12N5/06 ,  C12Q1/66 ,  C12Q1/68 ,  G01N33/53

    CPC分类号： C12N9/503

    摘要： The full-length nucleic acid sequence of the C1 bacteriophage is disclosed in the present application. The specific regions of the C1 genome encoding the PlyC lysin have also been identified and sequenced. The invention relates to the pharmaceutical and diagnostic utility of these sequences and provides for development of pharmaceutical compositions for treating or preventing streptococcal infections in mammals, for compositions for decontamination of inanimate surfaces and for diagnosis of streptococcal infections.

    摘要翻译： 本申请中公开了C 1 噬菌体的全长核酸序列。 还鉴定并测序了编码PlyC溶素的C 1 H 2基因组的特定区域。 本发明涉及这些序列的药物和诊断实用性，并且提供用于治疗或预防哺乳动物中链球菌感染的药物组合物的开发，用于无生物表面净化的组合物和用于诊断链球菌感染的组合物。

    Nucleic acids and polypeptides of C1 bacteriophage and uses thereof
    3.
    发明授权
    Nucleic acids and polypeptides of C1 bacteriophage and uses thereof 有权
    C1噬菌体的核酸和多肽及其用途

    公开(公告)号：US07838255B2

    公开(公告)日：2010-11-23

    申请号：US12460746

    申请日：2009-07-23

    申请人： Vincent Fischetti ,  Daniel Nelson ,  Raymond Schuch

    发明人： Vincent Fischetti ,  Daniel Nelson ,  Raymond Schuch

    IPC分类号： G01N33/53 ,  A61L2/00

    CPC分类号： C12N9/503

    摘要： The full-length nucleic acid sequence of the C1 bacteriophage is disclosed in the present application. The specific regions of the C1 genome encoding the PlyC lysin have also been identified and sequenced. The invention relates to the pharmaceutical and diagnostic utility of these sequences and provides for development of pharmaceutical compositions for treating or preventing streptococcal infections in mammals, for compositions for decontamination of inanimate surfaces and for diagnosis of streptococcal infections.

    摘要翻译： C1噬菌体的全长核酸序列在本申请中公开。 编码PlyC溶素的C1基因组的特定区域也已被鉴定并测序。 本发明涉及这些序列的药物和诊断实用性，并且提供用于治疗或预防哺乳动物中链球菌感染的药物组合物的开发，用于无生物表面净化的组合物和用于诊断链球菌感染的组合物。

    Nucleic acids and polypeptides of C1 bacteriophage and uses thereof
    5.
    发明申请
    Nucleic acids and polypeptides of C1 bacteriophage and uses thereof 有权
    C1噬菌体的核酸和多肽及其用途

    公开(公告)号：US20100047222A1

    公开(公告)日：2010-02-25

    申请号：US12460746

    申请日：2009-07-23

    申请人： Vincent Fischetti ,  Daniel Nelson ,  Raymond Schuch

    发明人： Vincent Fischetti ,  Daniel Nelson ,  Raymond Schuch

    IPC分类号： A61K38/43 ,  G01N33/569 ,  C12Q1/66 ,  C12Q1/68

    CPC分类号： C12N9/503

    摘要： The full-length nucleic acid sequence of the C1 bacteriophage is disclosed in the present application The specific regions of the C1 genome encoding the PlyC lysin have also been identified and sequenced. The invention relates to the pharmaceutical and diagnostic utility of these sequences and provides for development of pharmaceutical compositions for treating or preventing streptococcal infections in mammals, for compositions for decontamination of inanimate surfaces and for diagnosis of streptococcal infections.

    摘要翻译： C1噬菌体的全长核酸序列在本申请中公开。编码PlyC溶素的C1基因组的特定区域也已经被鉴定和测序。 本发明涉及这些序列的药物和诊断实用性，并且提供用于治疗或预防哺乳动物中链球菌感染的药物组合物的开发，用于无生物表面净化的组合物和用于诊断链球菌感染的组合物。

    Bactiophage lysins for Enterococcus faecalis, Enterococcus faecium and other bacteria
    6.
    发明申请
    Bactiophage lysins for Enterococcus faecalis, Enterococcus faecium and other bacteria 有权
    肠球菌噬菌体溶菌酶，粪肠球菌和其他细菌

    公开(公告)号：US20070025978A1

    公开(公告)日：2007-02-01

    申请号：US11439846

    申请日：2006-05-24

    申请人： Pauline Yoong ,  Raymond Schuch ,  Daniel Nelson ,  Vincent Fischetti

    发明人： Pauline Yoong ,  Raymond Schuch ,  Daniel Nelson ,  Vincent Fischetti

    IPC分类号： A61K38/48

    CPC分类号： C12Y302/01017 ,  A61K38/47

    摘要： The present disclosure relates to bacteriophage lysins useful for the reduction of certain bacterial populations, including methods and compositions for the treatment of various bacterial infections. For example, bacteriophage lysins were isolated and shown to effectively kill various bacteria, including both E. faecalis and E. faecium (including vancomycin resistant strains), as well as other human pathogens.

    摘要翻译： 本公开涉及可用于减少某些细菌群体的噬菌体溶素，包括用于治疗各种细菌感染的方法和组合物。 例如，噬菌体溶素被分离并显示有效地杀死各种细菌，包括粪肠球菌和屎肠球菌（包括万古霉素抗性菌株）以及其他人类病原体。

    Bacteriophage lysins for Bacillus anthracis
    9.
    发明授权
    Bacteriophage lysins for Bacillus anthracis 有权
    炭疽杆菌的噬菌体溶素

    公开(公告)号：US08389469B2

    公开(公告)日：2013-03-05

    申请号：US11916208

    申请日：2006-05-31

    申请人： Pauline Yoong ,  Raymond Schuch ,  Daniel Nelson ,  Vincent A. Fischetti

    发明人： Pauline Yoong ,  Raymond Schuch ,  Daniel Nelson ,  Vincent A. Fischetti

    IPC分类号： A61K38/16 ,  A61P31/04 ,  C07K14/195

    CPC分类号： C12N9/503 ,  A61K38/00

    摘要： The present disclosure relates to methods, compositions and articles of manufacture useful for the treatment of Bacillus anthracis and B. cereus bacteria and spores, and related conditions. The disclosure further relates to compositions comprising various phage associated lytic enzyme that rapidly and specifically detect and kill Bacillus anthracis and other bacteria. Related articles of manufacture, methods of degrading spores and methods of treatment of infections or bacteria populations of, or subjects exposed to or at risk for exposure to Bacillus anthracis are also provided.

    摘要翻译： 本公开涉及可用于治疗炭疽芽孢杆菌和蜡状芽孢杆菌和孢子的方法，组合物和制品以及相关条件。 本公开还涉及包含各种噬菌体相关裂解酶的组合物，其快速且特异性地检测和杀死炭疽杆菌和其他细菌。 还提供了相关的制造方法，降低孢子的方法和处理暴露于或有暴露于炭疽芽孢杆菌的风险的感染或细菌群体或受试者的方法。