-
公开(公告)号：US20120010164A1
公开(公告)日：2012-01-12
申请号：US13145456
申请日：2010-01-19
IPC分类号： A61K31/7064 , A61P31/14 , A61K31/7076 , C07H19/14 , C07H19/19
CPC分类号： C07H19/173 , C07H19/14
摘要： Compounds of structural formula (I): and pharmaceutically acceptable salts thereof; as defined herein, are described for use in the prevention and/or treatment of HCV infections. Novel compounds of the formula (I) and pharmaceutical formulations containing them are also described.
摘要翻译： 结构式（I）的化合物及其药学上可接受的盐; 描述用于预防和/或治疗HCV感染。 还描述了新的式（I）化合物和含有它们的药物制剂。
-
公开(公告)号：US20110306573A1
公开(公告)日：2011-12-15
申请号：US13061746
申请日：2009-09-02
IPC分类号： A61K31/7064 , A61P31/14 , C07H19/23 , C12N9/99 , C07H19/14
CPC分类号： A61K31/7064 , C07H19/14 , C07H19/23
摘要： Compounds of structural formula (I): and pharmaceutically acceptable salts thereof; wherein R1; R2; R3; Q1 and Q2 are as defined herein, processes for their preparation; pharmaceutical compositions containing them and their use in medicine, in particular the treatment or prevention of HCV infections, are disclosed.
摘要翻译： 结构式（I）的化合物及其药学上可接受的盐; 其中R1; R2; R3; Q1和Q2如本文所定义，其制备方法; 公开了含有它们的药物组合物及其在药物中的用途，特别是HCV感染的治疗或预防。
-
公开(公告)号：US20100099695A1
公开(公告)日：2010-04-22
申请号：US12447342
申请日：2007-10-23
申请人： Nigel J. Liverton , Vincenzo Summa , Maria Emilia Di Francesco , Marco Ferrara , Kevin F. Gilbert , Steven Harper , John A. McCauley , Charles A. McIntyre , Alessia Petrocchi , Marco Pompei , Joseph J. Romano , Michael T. Rudd , John W. Butcher , M. Katharine Holloway
发明人： Nigel J. Liverton , Vincenzo Summa , Maria Emilia Di Francesco , Marco Ferrara , Kevin F. Gilbert , Steven Harper , John A. McCauley , Charles A. McIntyre , Alessia Petrocchi , Marco Pompei , Joseph J. Romano , Michael T. Rudd , John W. Butcher , M. Katharine Holloway
IPC分类号： A61K31/439 , C07D513/18 , C07D513/08 , A61K31/407 , A61K31/4748 , A61P31/12
CPC分类号： C07D498/22 , A61K31/407 , A61K31/4192 , A61K31/437 , A61K31/439 , A61K38/00 , A61K45/06 , C07D498/08 , C07D498/18 , C07K5/0804 , C07K5/0806 , C07K5/0808 , C07K5/0812
摘要： The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS3蛋白酶抑制剂及其合成及其用于治疗或预防HCV感染的用途的式（I）的大环化合物。
-
公开(公告)号：US08377873B2
公开(公告)日：2013-02-19
申请号：US12446296
申请日：2007-10-19
申请人： Nigel J. Liverton , Vincenzo Summa , Joseph P. Vacca , Maria Emilia Di Francesco , Marco Pompei
发明人： Nigel J. Liverton , Vincenzo Summa , Joseph P. Vacca , Maria Emilia Di Francesco , Marco Pompei
CPC分类号： C07K5/0812 , A61K38/00 , C07K5/0808
摘要： The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use treating or preventing HCV infections.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS3蛋白酶抑制剂及其合成及其用于治疗或预防HCV感染的用途的式（I）的大环化合物。
-
公开(公告)号：US20100298210A1
公开(公告)日：2010-11-25
申请号：US12446296
申请日：2007-10-19
申请人： Nigel J. Liverton , Vincenzo Summa , Joseph P. Vacca , Maria Emilia Di Francesco , Marco Pompei
发明人： Nigel J. Liverton , Vincenzo Summa , Joseph P. Vacca , Maria Emilia Di Francesco , Marco Pompei
CPC分类号： C07K5/0812 , A61K38/00 , C07K5/0808
摘要： The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use treating or preventing HCV infections.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS3蛋白酶抑制剂及其合成及其用于治疗或预防HCV感染的用途的式（I）的大环化合物。
-
公开(公告)号：US08927569B2
公开(公告)日：2015-01-06
申请号：US12668987
申请日：2008-07-17
申请人： Steven Harper , Vincenzo Summa , Nigel J. Liverton , John A. McCauley , John W. Butcher , Marcello Di Filippo , Maria Emilia Di Francesco , Marco Ferrara , Joseph J. Romano , Michael T. Rudd
发明人： Steven Harper , Vincenzo Summa , Nigel J. Liverton , John A. McCauley , John W. Butcher , Marcello Di Filippo , Maria Emilia Di Francesco , Marco Ferrara , Joseph J. Romano , Michael T. Rudd
IPC分类号： A61K31/44 , A61K31/33 , C07D245/00 , C07D225/04 , C07D295/00 , C07K5/087 , C07K5/083
CPC分类号： C07K5/0812 , C07K5/0808
摘要： A class of macrocyclic compounds of formula (I), wherein R1, R3, R4, Ra, Rb, A, Z, Y, X, M, W, n and m are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes 5 for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection. Formula (I):
摘要翻译： 一类式（I）的大环化合物，其中R1，R3，R4，Ra，Rb，A，Z，Y，X，M，W，n和m如本文所定义，其可用作病毒蛋白酶的抑制剂， 特别是丙型肝炎病毒（HCV）NS3蛋白酶。 还提供了用于合成和使用这种用于治疗或预防HCV感染的大环化合物的方法5。 式（I）：
-
公开(公告)号：US20100183551A1
公开(公告)日：2010-07-22
申请号：US12668987
申请日：2008-07-17
申请人： Steven Harper , Vincenzo Summa , Nigel J. Liverton , John A. McCauley , John W. Butcher , Marcello Di Filippo , Maria Emilia Di Francesco , Marco Ferrara , Joseph J. Romano , Michael T. Rudd
发明人： Steven Harper , Vincenzo Summa , Nigel J. Liverton , John A. McCauley , John W. Butcher , Marcello Di Filippo , Maria Emilia Di Francesco , Marco Ferrara , Joseph J. Romano , Michael T. Rudd
CPC分类号： C07K5/0812 , C07K5/0808
摘要： A class of macrocyclic compounds of formula (I), wherein R1, R3, R4, Ra, Rb, A, Z, Y, X, M, W, n and m are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes 5 for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection. Formula (I):
摘要翻译： 一类式（I）的大环化合物，其中R1，R3，R4，Ra，Rb，A，Z，Y，X，M，W，n和m如本文所定义，其可用作病毒蛋白酶的抑制剂， 特别是丙型肝炎病毒（HCV）NS3蛋白酶。 还提供了用于合成和使用这种用于治疗或预防HCV感染的大环化合物的方法5。 式（I）：
-
公开(公告)号：US09145391B2
公开(公告)日：2015-09-29
申请号：US14116199
申请日：2012-05-04
申请人： Denis Deschenes , Michael D. Altman , John Michael Ellis , Christian Fischer , Andrew M. Haidle , Solomon D. Kattar , Alan B. Northrup , Adam J. Schell , Graham F. Smith , Brandon M. Taoka , Corey Bienstock , Maria Emilia Di Francesco , Anthony Donofrio , Scott Peterson , Kerrie B. Spencer , James Patrick Jewell , Amjad Ali , David Jonathan Bennett , Qun Dang , John Wai
发明人： Denis Deschenes , Michael D. Altman , John Michael Ellis , Christian Fischer , Andrew M. Haidle , Solomon D. Kattar , Alan B. Northrup , Adam J. Schell , Graham F. Smith , Brandon M. Taoka , Corey Bienstock , Maria Emilia Di Francesco , Anthony Donofrio , Scott Peterson , Kerrie B. Spencer , James Patrick Jewell , Amjad Ali , David Jonathan Bennett , Qun Dang , John Wai
IPC分类号： C07D213/73 , C07D401/14 , C07D401/12 , C07D409/14 , C07D417/14 , C07D471/04
CPC分类号： C07D401/14 , C07D401/12 , C07D409/14 , C07D417/14 , C07D471/04
摘要： The present invention provides novel pyrimidine amines of formula I which are potent inhibitors of spleen tyrosine kinase, or are prodrugs thereof, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis and cancer.
摘要翻译： 本发明提供了式I的新型嘧啶胺，其是脾脏酪氨酸激酶的有效抑制剂，或其前药，并且可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD和类风湿性关节炎和癌症。
-
公开(公告)号：US09120785B2
公开(公告)日：2015-09-01
申请号：US14116205
申请日：2012-05-04
申请人： Michael D. Altman , Maria Emilia Di Francesco , Andrew M. Haidle , Ryan D. Otte , John Michael Ellis , Kaleen Konrad Childers , Alan B. Northrup , Liping Wang
发明人： Michael D. Altman , Maria Emilia Di Francesco , Andrew M. Haidle , Ryan D. Otte , John Michael Ellis , Kaleen Konrad Childers , Alan B. Northrup , Liping Wang
IPC分类号： C07D417/14 , A61P37/00 , A61K31/444
CPC分类号： C07D417/14
摘要： The present invention provides novel pyrimidine amines of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.
摘要翻译： 本发明提供了式I的新型嘧啶胺，其是脾脏酪氨酸激酶的有效抑制剂，并且可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD，类风湿性关节炎和癌症。
-
公开(公告)号：US20090258891A1
公开(公告)日：2009-10-15
申请号：US12300887
申请日：2007-05-11
IPC分类号： A61K31/4748 , A61K31/4245 , C07D498/22
CPC分类号： C07K5/0806 , A61K38/00 , C07K5/0808 , C07K5/0812 , C07K5/0821 , C07K5/0827
摘要： The present invention relates to macrocyclic compounds of formula (I): wherein W, n, R1, Ra, Rb, R3, R4, M, Z, ring A and ring B are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and their use for the treatment or prevention of infection by hepatitis C virus.
摘要翻译： 本发明涉及式（I）的大环化合物：其中W，n，R 1，R a，R b，R 3，R 4，M，Z，环A和环B在本文中定义，及其药学上可接受的盐， 它们及其用于治疗或预防丙型肝炎病毒感染的用途。
-
-
-
-
-
-
-
-
-
搜索结果
23 条记录 (耗时 0.032 秒)
