公开(公告)号：US20150133773A1

公开(公告)日：2015-05-14

申请号：US14501610

申请日：2014-09-30

Applicant: VisEn Medical, Inc.

Inventor： Farouc Jaffer ,  Milind Rajopadhye

IPC: A61B5/00 ,  A61F2/82 ,  A61B1/04 ,  A61B19/00 ,  A61B5/06 ,  A61K49/00

CPC classification number: A61B5/0071 ,  A61B1/043 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0073 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/02007 ,  A61B5/061 ,  A61B5/066 ,  A61B5/4851 ,  A61B5/7275 ,  A61B90/20 ,  A61B2576/02 ,  A61F2/82 ,  A61K49/0034 ,  A61K49/0097

Abstract: The invention provides methods and compositions for determining whether a subject containing a stent immobilized in a blood vessel has asymptomatic stent thrombosis or is at risk of developing clinically symptomatic stent thrombosis. In one approach, the method involves imaging a region of the blood vessel that contains the stent using a probe that contains a fluorochrome, for example, a near-infrared fluorochrome, and a targeting moiety that binds a molecular marker indicative of the presence of asymptomatic stent thrombosis or the development of symptomatic stent thrombosis. To the extent that the subject displays one or more such markers, the probe binds to the markers and increases the local concentration of the probe in the vicinity of the stent. The imaging method identifies those patients that display a higher density of such markers in the vicinity of the stent. As a result, those patients can be monitored for, and/or treated to prevent, symptomatic stent thrombosis.

Abstract translation: 本发明提供了用于确定含有固定在血管中的支架的受试者是否具有无症状的支架内血栓形成或具有发展为临床症状性支架内血栓形成的风险的方法和组合物。 在一种方法中，该方法涉及使用包含荧光染料（例如近红外荧光染料）的探针对含有支架的血管的区域成像，以及结合指示存在无症状的分子标记的靶向部分 支架血栓形成或症状性支架血栓形成的发展。 在受试者显示一种或多种这样的标记物的程度上，探针结合标记并增加探针在支架附近的局部浓度。 成像方法识别那些在支架附近显示较高密度的标记物的患者。 因此，可以监测和/或治疗这些患者以防止症状性支架内血栓形成。

公开(公告)号：US10092188B2

公开(公告)日：2018-10-09

申请号：US14501610

申请日：2014-09-30

Applicant: VisEn Medical, Inc.

Inventor： Farouc Jaffer ,  Milind Rajopadhye

IPC: A61B6/00 ,  A61B5/00 ,  A61B5/02 ,  A61K49/00 ,  A61B1/04 ,  A61B5/06 ,  A61F2/82 ,  A61B90/20

Abstract: The invention provides methods and compositions for determining whether a subject containing a stent immobilized in a blood vessel has asymptomatic stent thrombosis or is at risk of developing clinically symptomatic stent thrombosis. In one approach, the method involves imaging a region of the blood vessel that contains the stent using a probe that contains a fluorochrome, for example, a near-infrared fluorochrome, and a targeting moiety that binds a molecular marker indicative of the presence of asymptomatic stent thrombosis or the development of symptomatic stent thrombosis. To the extent that the subject displays one or more such markers, the probe binds to the markers and increases the local concentration of the probe in the vicinity of the stent. The imaging method identifies those patients that display a higher density of such markers in the vicinity of the stent. As a result, those patients can be monitored for, and/or treated to prevent, symptomatic stent thrombosis.