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公开(公告)号：US20170007603A1
公开(公告)日：2017-01-12
申请号：US15204422
申请日：2016-07-07
发明人： Chengguo Dong , Yi Fan , Katerina Leftheris , Stephen D. Lotesta , Suresh B. Singh , Colin M. Tice , Wei Zhao , Yajun Zheng , Linghang Zhuang
IPC分类号： A61K31/506
CPC分类号： A61K31/506 , A61K31/4985 , C07D487/04 , C07F7/1804
摘要： Provided herein are novel compounds and pharmaceutically acceptable salts thereof that are liver X receptor modulators. Also provided are compositions comprising compounds of the invention and a carrier. Additionally, use of the compounds herein and methods for treating a disease or disorder associated with the liver X receptor are further described.
摘要翻译： 本文提供的是肝X受体调节剂的新化合物及其药学上可接受的盐。 还提供了包含本发明化合物和载体的组合物。 此外，进一步描述了本文的化合物的使用和与肝X受体相关的疾病或病症的治疗方法。
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公开(公告)号：US20180117041A1
公开(公告)日：2018-05-03
申请号：US15618297
申请日：2017-06-09
发明人： Chengguo Dong , Yi Fan , Katerina Leftheris , Stephen D. Lotesta , Suresh B. Singh , Colin M. Tice , Wei Zhao , Yajun Zheng , Linghang Zhuang
IPC分类号： A61K31/506 , C07F7/18 , C07D487/04 , A61K31/4985
CPC分类号： A61K31/506 , A61K31/4985 , C07D487/04 , C07F7/1804
摘要： Provided herein are novel compounds and pharmaceutically acceptable salts thereof that are liver X receptor modulators. Also provided are compositions comprising compounds of the invention and a carrier. Additionally, use of the compounds herein and methods for treating a disease or disorder associated with the liver X receptor are further described.
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公开(公告)号：US09814715B2
公开(公告)日：2017-11-14
申请号：US15182749
申请日：2016-06-15
发明人： Chengguo Dong , Yi Fan , Katerina Leftheris , Stephen D. Lotesta , Suresh B. Singh , Colin M. Tice , Wei Zhao , Yajun Zheng , Linghang Zhuang
IPC分类号： A61K31/506 , A61K31/4985 , C07D487/04
CPC分类号： A61K31/506 , A61K31/4985 , C07D487/04
摘要： Provided herein are novel compounds and pharmaceutically acceptable salts thereof that are liver X receptor modulators. Also provided are compositions comprising compounds of the invention and a carrier. Additionally, use of the compounds herein and methods for treating a disease or disorder associated with the liver X receptor are further described.
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公开(公告)号：US09006244B2
公开(公告)日：2015-04-14
申请号：US14385688
申请日：2013-03-14
发明人： Chengguo Dong , Yi Fan , Katerina Leftheris , Stephen D. Lotesta , Suresh B. Singh , Colin M. Tice , Wei Zhao , Yajun Zheng , Linghang Zhuang
IPC分类号： C07D487/04 , A61K31/4985
CPC分类号： A61K31/506 , A61K31/4985 , C07D487/04
摘要： Provided herein are novel compounds and pharmaceutically acceptable salts thereof that are liver X receptor modulators. Also provided are compositions comprising compounds of the invention and a carrier. Additionally, use of the compounds herein and methods for treating a disease or disorder associated with the liver X receptor are further described.
摘要翻译： 本文提供的是肝X受体调节剂的新化合物及其药学上可接受的盐。 还提供了包含本发明化合物和载体的组合物。 此外，进一步描述了本文的化合物的使用和与肝X受体相关的疾病或病症的治疗方法。
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公开(公告)号：US20150080406A1
公开(公告)日：2015-03-19
申请号：US14547804
申请日：2014-11-19
IPC分类号： C07D487/04
CPC分类号： A61K31/506 , A61K31/4985 , C07D487/04
摘要： Provided herein are novel compounds and pharmaceutically acceptable salts thereof that are liver X receptor modulators. Also provided are compositions comprising compounds of the invention and a carrier. Additionally, use of the compounds herein and methods for treating a disease or disorder associated with the liver X receptor are further described.
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公开(公告)号：US10336717B2
公开(公告)日：2019-07-02
申请号：US14883720
申请日：2015-10-15
发明人： Salvacion Cacatian , David A. Claremon , Lawrence Wayne Dillard , Klaus Fuchs , Niklas Heine , Lanqi Jia , Katerina Leftheris , Brian McKeever , Angel Morales-Ramos , Suresh B. Singh , Shankar Venkatraman , Guosheng Wu , Zhongren Wu , Zhenrong Xu , Jing Yuan , Yajun Zheng
IPC分类号： C07D233/46 , C07D235/02 , C07D239/70 , C07D271/12 , C07D277/60 , C07D279/08 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/10 , C07D487/10 , C07D491/10 , C07D493/20 , C07D495/10 , C07D498/10 , C07D513/10
摘要： The present invention is directed to a compound represented by the following structural formula or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions and method of use of the compounds are also described.
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公开(公告)号：US10144715B2
公开(公告)日：2018-12-04
申请号：US15502356
申请日：2015-08-04
发明人： David A. Claremon , Chengguo Dong , Yi Fan , Katerina Leftheris , Stephen D. Lotesta , Suresh B. Singh , Colin M. Tice , Wei Zhao , Yajun Zheng , Linghang Zhuang
IPC分类号： C07D241/04 , C07D403/04 , C07D413/14 , C07D401/04 , C07D401/06 , C07D403/14 , C07D405/06 , C07D413/04 , C07D417/04 , C07D417/14 , C07D497/04 , C07D513/04
摘要： Provided are novel compounds of Formula (I): pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are liver X receptor modulators, and which are useful in the treatment of diseases and disorders associated with the liver X receptor. Also provided are the compounds of Formula (I) and pharmaceutical compositions thereof for treating atherosclerosis, cardiovascular disease, Alzheimer's disease, dermatitis, dyslipidemia, cancer and other diseases or disorders.
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公开(公告)号：US20170226067A1
公开(公告)日：2017-08-10
申请号：US15502356
申请日：2015-08-04
发明人： David A. Claremon , Chengguo Dong , Yi Fan , Katerina Leftheris , Stephen D. Lotesta , Suresh B. Singh , Colin M. Tice , Wei Zhao , Yajun Zheng , Linghang Zhuang
IPC分类号： C07D241/04 , C07D401/04 , C07D413/04 , C07D403/14 , C07D513/04 , C07D417/14 , C07D413/14 , C07D403/04 , C07D417/04
CPC分类号： C07D241/04 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/14 , C07D405/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D497/04 , C07D513/04
摘要： Provided are novel compounds of Formula (I): pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are liver X receptor modulators, and which are useful in the treatment of diseases and disorders associated with the liver X receptor. Also provided are the compounds of Formula (I) and pharmaceutical compositions thereof for treating atherosclerosis, cardiovascular disease, Alzheimer's disease, dermatitis, dyslipidemia, cancer and other diseases or disorders.
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9.发明授权Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use 有权取代的5-，6-和7-元杂环，含有这些化合物的药物及其用途公开(公告)号：US09090605B2
公开(公告)日：2015-07-28
申请号：US14497782
申请日：2014-09-26
发明人： Matthias Eckhardt , Frank Himmelsbach , Katerina Leftheris , Suresh B. Singh , Colin M. Tice , Zhenrong Xu , Yuanjie Ye , Linghang Zhuang
IPC分类号： C07D239/04 , C07D401/10 , C07D239/34 , C07D417/14 , C07D413/10 , C07D413/14
CPC分类号： C07D417/14 , A61K31/5355 , C07D413/10 , C07D413/14
摘要： Disclosed are compounds represented by Formula (I): or pharmaceutically acceptable salts, enantiomers or diastereomers thereof. Also disclosed are pharmaceutical compositions comprising the compounds of Formula (I) or pharmaceutically acceptable salts, enantiomers or diastereomers thereof for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. Values for the variables of Formula (I) are defined herein.
摘要翻译： 公开了由式（I）表示的化合物或其药学上可接受的盐，对映异构体或非对映异构体。 还公开了包含式（I）化合物或其药学上可接受的盐，对映异构体或非对映异构体的药物组合物，用于治疗与哺乳动物中11β-HSD1的调节或抑制相关的疾病的治疗。 式（I）的变量的值在本文中定义。
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公开(公告)号：US09045500B2
公开(公告)日：2015-06-02
申请号：US14509498
申请日：2014-10-08
发明人： Lawrence Wayne Dillard , Jing Yuan , Katerina Leftheris , Shankar Venkatraman , Guosheng Wu , Lanqi Jia , Zhenrong Xu , Salvacion Cacatian , Angel Morales-Ramos , Suresh B. Singh , Yajun Zheng
IPC分类号： C07D471/04 , C07D491/107 , C07D209/54 , C07D487/04 , A61K31/5395 , A61K31/519 , C07D513/04 , C07D498/04
CPC分类号： C07D513/04 , C07D209/54 , C07D209/96 , C07D401/04 , C07D471/04 , C07D487/04 , C07D491/10 , C07D491/107 , C07D498/04
摘要： The present invention relates to compounds represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. Definitions for the variables are provided herein.
摘要翻译： 本发明涉及由结构式（I）表示的化合物或其药学上可接受的盐。 变量的定义在这里提供。
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