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公开(公告)号：US20190010167A1
公开(公告)日：2019-01-10
申请号：US16064998
申请日：2016-12-21
发明人： David A. Claremon , Chenggou Dong , Yi Fan , Lanqi Jia , Suresh B. Singh , Shankar Venkatraman , Jing Yuan , Yajun Zheng , Linghang Zhuang
IPC分类号： C07D495/04 , C07D513/04 , C07D471/10 , C07D487/10
摘要： The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.
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公开(公告)号：US09212153B2
公开(公告)日：2015-12-15
申请号：US14132877
申请日：2013-12-18
发明人： Salvacion Cacatian , David A. Claremon , Lawrence Wayne Dillard , Klaus Fuchs , Niklas Heine , Lanqi Jia , Katerina Leftheris , Brian McKeever , Angel Morales-Ramos , Suresh B. Singh , Shankar Venkatraman , Guosheng Wu , Zhongren Wu , Zhenrong Xu , Jing Yuan , Yajun Zheng
IPC分类号： C07D271/12 , C07D235/02 , C07D239/70 , C07D277/60 , C07D403/06 , C07D405/12 , C07D487/10 , C07D491/10 , C07D498/10 , C07D233/46 , C07D405/06 , C07D413/04 , C07D417/06
CPC分类号： C07D271/12 , C07D233/46 , C07D235/02 , C07D239/70 , C07D277/60 , C07D279/08 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/10 , C07D487/10 , C07D491/10 , C07D493/20 , C07D495/10 , C07D498/10 , C07D513/10
摘要： The present invention is directed to a compound represented by the following structural formula or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions and method of use of the compounds are also described.
摘要翻译： 本发明涉及由以下结构式表示的化合物或其药学上可接受的盐。 还描述了化合物的药物组合物和使用方法。
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公开(公告)号：US20150259325A1
公开(公告)日：2015-09-17
申请号：US14431588
申请日：2013-09-25
发明人： Shankar Venkatraman , Jing Yuan , Yajun Zheng
IPC分类号： C07D401/12 , C07D401/04 , C07D235/02
CPC分类号： C07D401/12 , C07D235/02 , C07D401/04
摘要： The present invention relates to spirocyclic indane imidazole 4-amines and their use as inhibitors of the β-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates.
摘要翻译： 本发明涉及螺环吲哚咪唑4-胺及其作为分泌酶（BACE1）活性的抑制剂的用途，含有它们的药物组合物和使用其作为治疗剂治疗神经变性疾病的方法， 以认知衰退为特征的疾病，认知障碍，痴呆症和以淀粉样蛋白聚集体生产为特征的疾病。
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公开(公告)号：US10336717B2
公开(公告)日：2019-07-02
申请号：US14883720
申请日：2015-10-15
发明人： Salvacion Cacatian , David A. Claremon , Lawrence Wayne Dillard , Klaus Fuchs , Niklas Heine , Lanqi Jia , Katerina Leftheris , Brian McKeever , Angel Morales-Ramos , Suresh B. Singh , Shankar Venkatraman , Guosheng Wu , Zhongren Wu , Zhenrong Xu , Jing Yuan , Yajun Zheng
IPC分类号： C07D233/46 , C07D235/02 , C07D239/70 , C07D271/12 , C07D277/60 , C07D279/08 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/10 , C07D487/10 , C07D491/10 , C07D493/20 , C07D495/10 , C07D498/10 , C07D513/10
摘要： The present invention is directed to a compound represented by the following structural formula or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions and method of use of the compounds are also described.
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公开(公告)号：US20190144459A1
公开(公告)日：2019-05-16
申请号：US16308739
申请日：2017-06-08
发明人： Salvacion Cacatian , David A. Claremon , Lawrence Wayne Dillard , Chengguo Dong , Yi Fan , Lanqi Jia , Stephen D. Lotesta , Andrew Marcus , Angel Morales-Ramos , Suresh B. Singh , Shankar Venkatraman , Jing Yuan , Yajun Zheng , Linghang Zhuang , Stephan D. Parent , Travis L. Houston
IPC分类号： C07D487/10 , A61P35/02 , C07D471/10 , C07F9/6561 , C07D491/107 , C07D403/04 , C07D403/14
CPC分类号： C07D487/10 , A61P35/02 , C07B2200/13 , C07D403/04 , C07D403/14 , C07D405/14 , C07D471/10 , C07D491/10 , C07D491/107 , C07F9/6561
摘要： The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.
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公开(公告)号：US09526727B2
公开(公告)日：2016-12-27
申请号：US14613550
申请日：2015-02-04
发明人： Yuri Bukhtiyarov , Salvacion Cacatian , Lawrence Wayne Dillard , Cornelia Dorner-Ciossek , Klaus Fuchs , Lanqi Jia , Deepak S. Lala , Angel Morales-Ramos , Jonathan Reeves , Suresh B. Singh , Shankar Venkatraman , Zhenrong Xu , Jing Yuan , Yi Zhao , Yajun Zheng , Georg Rast
IPC分类号： A61K31/4184 , A61K31/506 , C07D235/02 , C07D403/06 , C07D407/06 , C07C49/697 , C07C49/747 , C07C49/755 , C07C229/50 , C07C255/47 , C07C313/06 , C07C331/14 , C07D405/06
CPC分类号： A61K31/506 , A61K31/4184 , C07C49/697 , C07C49/747 , C07C49/755 , C07C229/50 , C07C255/47 , C07C313/06 , C07C331/14 , C07D235/02 , C07D403/06 , C07D405/06 , C07D407/06
摘要： The present invention relates to spirocyclic acylguanidines and their use as inhibitors of theβ-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates.
摘要翻译： 本发明涉及螺环酰基胍及其作为β-分泌酶（BACE1）活性的抑制剂的用途，含有它们的药物组合物及其用作治疗神经变性疾病，特征在于认知衰退的病症的治疗剂的方法， 认知功能障碍，痴呆和以β-淀粉样蛋白聚集体生产为特征的疾病。
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公开(公告)号：US09045500B2
公开(公告)日：2015-06-02
申请号：US14509498
申请日：2014-10-08
发明人： Lawrence Wayne Dillard , Jing Yuan , Katerina Leftheris , Shankar Venkatraman , Guosheng Wu , Lanqi Jia , Zhenrong Xu , Salvacion Cacatian , Angel Morales-Ramos , Suresh B. Singh , Yajun Zheng
IPC分类号： C07D471/04 , C07D491/107 , C07D209/54 , C07D487/04 , A61K31/5395 , A61K31/519 , C07D513/04 , C07D498/04
CPC分类号： C07D513/04 , C07D209/54 , C07D209/96 , C07D401/04 , C07D471/04 , C07D487/04 , C07D491/10 , C07D491/107 , C07D498/04
摘要： The present invention relates to compounds represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. Definitions for the variables are provided herein.
摘要翻译： 本发明涉及由结构式（I）表示的化合物或其药学上可接受的盐。 变量的定义在这里提供。
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公开(公告)号：US20150031691A1
公开(公告)日：2015-01-29
申请号：US14509498
申请日：2014-10-08
发明人： Lawrence Wayne Dillard , Jing Yuan , Katerina Leftheris , Shankar Venkatraman , Guosheng Wu , Lanqi Jia , Zhenrong Xu , Salvacion Cacatian , Angel Morales-Ramos , Suresh B. Singh , Yajun Zheng
IPC分类号： C07D513/04 , C07D209/54 , C07D471/04 , C07D491/107 , C07D498/04 , C07D487/04
CPC分类号： C07D513/04 , C07D209/54 , C07D209/96 , C07D401/04 , C07D471/04 , C07D487/04 , C07D491/10 , C07D491/107 , C07D498/04
摘要： The present invention relates to compounds represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. Definitions for the variables are provided herein.
摘要翻译： 本发明涉及由结构式（I）表示的化合物或其药学上可接受的盐。 变量的定义在这里提供。
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公开(公告)号：US10654884B2
公开(公告)日：2020-05-19
申请号：US15306197
申请日：2015-04-23
发明人： Salvacion Cacatian , David A. Claremon , Lanqi Jia , Angel Morales-Ramos , Suresh B. Singh , Shankar Venkatraman , Zhenrong Xu , Yajun Zheng
IPC分类号： C07H19/16 , C07H19/06 , C07D473/36 , C07D473/40 , C07D405/04 , C07D473/34 , A61K31/517 , A61K31/675 , A61K31/7056 , A61K31/7072 , A61K31/7076 , A61K45/06 , C07D239/72 , C07F9/6512 , C07F9/6561 , C07H19/052
摘要： Provided are novel purine nucleoside/nucleotide analogues compounds, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are inhibitors of CD73 and are useful in the treatment of cancer.
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公开(公告)号：US20150239849A1
公开(公告)日：2015-08-27
申请号：US14662553
申请日：2015-03-19
发明人： Yuri Bukhtiyarov , Salvacion Cacatian , Lawrence Wayne Dillard , Klaus Fuchs , Lanqi Jia , Deepak S. Lala , Angel Morales-Ramos , Suresh B. Singh , Shankar Venkatraman , Zhenrong Xu , Jing Yuan , Yi Zhao , Yajun Zheng , Cornelia Dorner-Ciossek , Ulrike Gross , Niklas Heine , Achim Sauer
IPC分类号： C07D235/02 , C07D403/04 , C07D403/06 , C07C255/59 , C07D401/06 , C07C313/06 , C07C49/747 , C07D405/06 , C07D401/14
CPC分类号： C07D235/02 , A61K31/4184 , A61K31/4439 , A61K31/506 , C07C49/747 , C07C49/755 , C07C229/50 , C07C255/59 , C07C313/06 , C07C331/26 , C07C2603/94 , C07C2603/97 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D405/06
摘要： The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates.
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