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公开(公告)号：US20070219363A1
公开(公告)日：2007-09-20
申请号：US11738146
申请日：2007-04-20
申请人： Vladimir Budker , Jon Wolff , Sean Monahan , Paul Slattum , James Hagstrom , Vladimir Trubetskoy , Tatyana Budker
发明人： Vladimir Budker , Jon Wolff , Sean Monahan , Paul Slattum , James Hagstrom , Vladimir Trubetskoy , Tatyana Budker
IPC分类号： C07D323/00 , C07C211/00 , C07H21/00
CPC分类号： C07D207/16
摘要： Chelator containing compounds are utilized in the delivery of molecules and polymers to animal cells. At least one chelator such as crown ether is attached to a polymer and then associated with another polymer. An ion is then added to the mixture thereby forming condensed polymer. In condensed form and in complex with the chelator, polymer can be delivered to a cell.
摘要翻译： 含螯合剂的化合物用于向动物细胞递送分子和聚合物。 至少一种螯合剂如冠醚连接到聚合物上，然后与另一种聚合物缔合。 然后将离子加入到混合物中，从而形成冷凝聚合物。 在浓缩形式和与螯合剂复合的情况下，聚合物可被递送至电池。
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公开(公告)号：US20070036865A1
公开(公告)日：2007-02-15
申请号：US11533115
申请日：2006-09-19
申请人： David Rozema , Darren Wakefield , Jon Wolff , Vladimir Budker , Tatyana Budker , Sean Monahan , Vladimir Trubetskoy , James Hagstrom , Aaton Loomis , Paul Slattum
发明人： David Rozema , Darren Wakefield , Jon Wolff , Vladimir Budker , Tatyana Budker , Sean Monahan , Vladimir Trubetskoy , James Hagstrom , Aaton Loomis , Paul Slattum
摘要： We describe pH-sensitive endosomolytic polymers, delivery particles containing pH-sensitive endosomolytic polymers. The described particles are capable of delivering polynucleotides to cells from the peripheral circulation with subsequent release from endosomes. The endosomolytic polymers are inactive outside the cell but disrupt membranes upon exposure to an acidified endosomal compartment.
摘要翻译： 我们描述了pH敏感的内分泌溶解聚合物，包含pH敏感的内分解溶解聚合物的递送颗粒。 所述的颗粒能够将多核苷酸递送至来自外周循环的细胞，随后从内体释放。 内细胞分解的聚合物在细胞外是无活性的，但在暴露于酸化的内体室时破坏膜。
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公开(公告)号：US20070010004A1
公开(公告)日：2007-01-11
申请号：US11479587
申请日：2006-06-30
申请人： Sean Monahan , Vladimir Budker , Tatyana Budker , Jon Wolff , Paul Slattum , James Hagstrom
发明人： Sean Monahan , Vladimir Budker , Tatyana Budker , Jon Wolff , Paul Slattum , James Hagstrom
CPC分类号： C07H21/00
摘要： Methods are described for modifying nucleic acids to facilitate delivery of the nucleic acids to cells. Compounds which interact with of modify nucleic acids are interacted with the nucleic acids within reverse micelles.
摘要翻译： 描述了用于修饰核酸以便于将核酸递送至细胞的方法。 与修饰核酸相互作用的化合物与反胶束内的核酸相互作用。
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公开(公告)号：US20050037496A1
公开(公告)日：2005-02-17
申请号：US10899509
申请日：2004-07-26
申请人： David Rozema , Vladimir Budker , James Hagstrom , Vladimir Trubetskoy , Jon Wolff , Sean Monahan , Paul Slattum
发明人： David Rozema , Vladimir Budker , James Hagstrom , Vladimir Trubetskoy , Jon Wolff , Sean Monahan , Paul Slattum
CPC分类号： C12N15/88 , A61K47/58 , A61K47/59 , A61K47/645
摘要： An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
摘要翻译： 为了向细胞递送核酸，将聚二聚物用于缩合的多核苷酸复合物中。 络合物可以用适量的正电荷和/或负电荷形成，使得所得复合物可以递送到血管外空间并且可以进一步递送至细胞。
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公开(公告)号：US20060159764A1
公开(公告)日：2006-07-20
申请号：US11322419
申请日：2005-12-30
申请人： Sean Monahan , David Rozema , Vladimir Trubetskoy , Paul Slattum , Jon Wolff , Vladimir Budker , James Hagstrom , Lisa Hanson
发明人： Sean Monahan , David Rozema , Vladimir Trubetskoy , Paul Slattum , Jon Wolff , Vladimir Budker , James Hagstrom , Lisa Hanson
CPC分类号： C12N15/87 , A61K47/59 , A61K47/60 , A61K47/645 , A61K48/00 , A61K48/0008 , A61K48/0025 , A61K48/0041
摘要： A method of forming polymers in the presence of nucleic acid using template polymerization. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes containing nucleic acid and polymer, and for forming an interpolyelectrolyte complex.
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公开(公告)号：US20060024828A1
公开(公告)日：2006-02-02
申请号：US11235000
申请日：2005-09-26
申请人： Vladimir Trubetskoy , Jon Wolff , Paul Slattum , Lisa Hanson , Vladimir Budker , James Hagstrom
发明人： Vladimir Trubetskoy , Jon Wolff , Paul Slattum , Lisa Hanson , Vladimir Budker , James Hagstrom
CPC分类号： C12N15/87 , A61K47/59 , A61K47/60 , A61K47/645 , A61K48/00 , A61K48/0008 , A61K48/0025 , A61K48/0041
摘要： A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes containing nucleic acid and polymer, and for forming an interpolyelectrolyte complex.
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公开(公告)号：US20050123600A1
公开(公告)日：2005-06-09
申请号：US11046590
申请日：2005-01-28
申请人： Vladimir Trubetskoy , James Hagstrom , Vladimir Budker , Jon Wolff , David Rozema , Sean Monahan
发明人： Vladimir Trubetskoy , James Hagstrom , Vladimir Budker , Jon Wolff , David Rozema , Sean Monahan
CPC分类号： C12N15/88 , A61K47/60 , A61K47/645
摘要： An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
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8.发明申请Expression of zeta negative and zeta positive nucleic acids using a dystrophin gene 审中-公开使用肌营养不良蛋白基因表达ζ阴性和ζ阳性核酸公开(公告)号：US20070173465A9
公开(公告)日：2007-07-26
申请号：US10339934
申请日：2003-01-10
申请人： Sean Monahan , Jon Wolff , Paul Slattum , James Hagstrom , Vladimir Budker , David Rozema
发明人： Sean Monahan , Jon Wolff , Paul Slattum , James Hagstrom , Vladimir Budker , David Rozema
CPC分类号： A61K48/0016 , A61K48/0041 , A61K48/0075 , A61K48/0083
摘要： Disclosed is expression of zeta negative and zeta positive nucleic acids or nucleic acid complexes using a dystrophin gene in a process for providing nucleic acid expression in a striated (skeletal or cardiac) muscle cell for the purpose of providing a change to the endogenous properties of the cell for cells affected by muscular dystrophy.
摘要翻译： 公开了在用于在条纹（骨骼或心脏）肌细胞中提供核酸表达的过程中使用肌营养不良蛋白基因的ζ阴性和ζ阳性核酸或核酸复合物的表达，以提供对 细胞受肌营养不良影响的细胞。
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公开(公告)号：US20050265957A1
公开(公告)日：2005-12-01
申请号：US11102432
申请日：2005-04-08
申请人： Sean Monahan , Lisa Nader , Vladimir Budker , James Hagstrom , Paul Slattum , Jon Wolff
发明人： Sean Monahan , Lisa Nader , Vladimir Budker , James Hagstrom , Paul Slattum , Jon Wolff
摘要： The invention provides for polycations for condensation and delivery of polynucleotides to cells. Processes for forming the polycations by the polymerization of formamide monomers is also described.
摘要翻译： 本发明提供了用于将多核苷酸缩合和递送至细胞的聚阳离子。 还描述了通过甲酰胺单体的聚合形成聚阳离子的方法。
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公开(公告)号：US20050153451A1
公开(公告)日：2005-07-14
申请号：US10977025
申请日：2004-10-28
申请人： Jon Wolff , Vladimir Budker , James Hagstrom , Hans Herweijer , Julia Hegge , Paul Slattum , Sean Monahan , David Rozema
发明人： Jon Wolff , Vladimir Budker , James Hagstrom , Hans Herweijer , Julia Hegge , Paul Slattum , Sean Monahan , David Rozema
CPC分类号： A61K48/0083 , A61K38/00 , A61K48/00 , A61K48/0008 , A61K48/0016 , A61K48/0041 , A61K48/0075 , C12N15/87
摘要： Disclosed is a process for providing for expression of an exogenous nucleic acid in an extravascular parenchymal cell of a mammal. The nucleic acid is inserted into a vessel of a mammal and the permeability of the vessel is increased. Increasing permeability of the vessel allows delivery of the nucleic acid to an extravascular parenchymal cell.
摘要翻译： 公开了一种提供外源核酸在哺乳动物血管外实质细胞中表达的方法。 将核酸插入哺乳动物的容器中并增加血管的渗透性。 增加容器的渗透性允许将核酸递送至血管外实质细胞。
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