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    Benzotriazolyl-4,5-dihydro-3(2H)-pyridazinones
    7.
    发明授权
    Benzotriazolyl-4,5-dihydro-3(2H)-pyridazinones 失效
    苯并三唑基-4,5-二氢-3（2H） - 哒嗪酮

    公开(公告)号：US4616018A

    公开(公告)日：1986-10-07

    申请号：US749580

    申请日：1985-06-27

    申请人： Norbert Hauel ,  Volkhard Austel ,  Joachim Heider ,  Manfred Reiffen ,  Willi Diederen ,  Walter Haarman

    发明人： Norbert Hauel ,  Volkhard Austel ,  Joachim Heider ,  Manfred Reiffen ,  Willi Diederen ,  Walter Haarman

    IPC分类号： A61K31/50 ,  A61K31/501 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D249/18 ,  C07D401/14 ,  C07D403/04 ,  C07D403/02

    CPC分类号： C07D401/14 ,  C07D237/04 ,  C07D249/18 ,  C07D403/04 ,  Y10S514/822

    摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen; alkyl of 1 to 7 carbon atoms; cycloalkyl of 3 to 7 carbon atoms; monosubstituted alkyl of 1 to 3 carbon atoms, where the substituent is pyridyl, methylpyridyl, phenyl, mono-, di- or trisubstituted phenyl, where the substituents on the phenyl ring, which may be identical to or different from each other, are selected from the group consisting of one amino, one dimethylamino, one to two hydroxyls, one to three methoxys and one to three halogens; .omega.-monosubstituted alkyl of 2 to 4 carbon atoms, where the substituent is hydroxyl or di(alkyl of 1 to 3 carbon atoms)amino; phenyl; monohalo-phenyl; unsubstituted or monosubstituted straight or branched alkanoyl of 1 to 6 carbon atoms, where the substituent is phenyl, methoxyphenyl or cycloalkyl of 3 to 7 carbon atoms; or unsubstituted or monosubstituted phenylsulfonyl, where the substituent is methyl or methoxy; and,R.sub.2 is hydrogen or alkyl of 1 to 3 carbon atoms; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as cardiotonics, hypotensives and antithrombotics.

    摘要翻译： 其中R 1是氢的式IMAMA的化合物; 1至7个碳原子的烷基; 3至7个碳原子的环烷基; 其中取代基是吡啶基，甲基吡啶基，苯基，单 - ，二 - 或三取代的苯基，其中可以相同或不同的苯环上的取代基选自 由一个氨基，一个二甲基氨基，一至两个羟基，一至三个甲氧基和一至三个卤素组成的组; 2至4个碳原子的ω-单取代的烷基，其中取代基是羟基或二（1至3个碳原子的烷基）氨基; 苯基; 单卤代苯基; 未取代的或单取代的1至6个碳原子的直链或支链烷酰基，其中取代基是苯基，甲氧基苯基或3-7个碳原子的环烷基; 或未取代或单取代的苯基磺酰基，其中取代基是甲基或甲氧基; R2为氢或1〜3个碳原子的烷基; 和无毒的，药学上可接受的酸加成盐。 化合物及其盐可用作强心剂，低血糖剂和抗血栓药物。

    Benzotriazolyl-4,5-dihydro-3(2H)-pyridazinones
    9.
    发明授权
    Benzotriazolyl-4,5-dihydro-3(2H)-pyridazinones 失效
    苯并三唑基-4,5-二氢-3（2H） - 哒嗪酮

    公开(公告)号：US4699909A

    公开(公告)日：1987-10-13

    申请号：US889814

    申请日：1986-07-24

    申请人： Norbert Hauel ,  Volkhard Austel ,  Joachim Heider ,  Manfred Reiffen ,  Willi Diederen ,  Walter Haarman

    发明人： Norbert Hauel ,  Volkhard Austel ,  Joachim Heider ,  Manfred Reiffen ,  Willi Diederen ,  Walter Haarman

    IPC分类号： C07D237/04 ,  C07D249/18 ,  C07D401/14 ,  C07D403/04 ,  C07D403/02 ,  A61K31/50

    CPC分类号： C07D401/14 ,  C07D237/04 ,  C07D249/18 ,  C07D403/04

    摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen; alkyl of 1 to 7 carbon atoms; cycloalkyl of 3 to 7 carbon atoms; monosubstituted alkyl of 1 to 3 carbon atoms, where the substituent is pyridyl, methypyridyl, phenyl, mono-, di- or trisubstituted phenyl, where the substituents on the phenyl ring, which may be identical to or different from each other, are selected from the group consisting of one amino, one dimethylamino, one to two hydroxyls, one to three methoxys and one to three halogens; .omega.-monosubstituted alkyl of 2 to 4 carbon atoms, where the substituent is hydroxyl or di(alkyl of 1 to 3 carbon atoms)amino; phenyl; monohalo-phenyl; unsubstituted or monosubstituted straight or branched alkanoyl of 1 to 6 carbon atoms, where the substituent is phenyl, methoxyphenyl or cycloalkyl of 3 to 7 carbon atoms; or unsubstituted or monosubstituted phenylsulfonyl, where the substituent is methyl or methoxy; andR.sub.2 is hydrogen or alkyl of 1 to 3 carbon atoms;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as cardiotonics, hypotensives and antithrombotics.

    摘要翻译： 其中R 1是氢的式IMAMA的化合物; 1至7个碳原子的烷基; 3至7个碳原子的环烷基; 取代基为吡啶基，甲基吡啶基，苯基，单 - ，二 - 或三取代苯基的单取代烷基，其中苯环上的取代基可以相同或不同，选自 由一个氨基，一个二甲基氨基，一至两个羟基，一至三个甲氧基和一至三个卤素组成的组; 2至4个碳原子的ω-单取代的烷基，其中取代基是羟基或二（1至3个碳原子的烷基）氨基; 苯基; 单卤代苯基; 未取代的或单取代的1至6个碳原子的直链或支链烷酰基，其中取代基是苯基，甲氧基苯基或3-7个碳原子的环烷基; 或未取代或单取代的苯基磺酰基，其中取代基是甲基或甲氧基; 并且R 2是氢或1至3个碳原子的烷基; 和无毒的，药学上可接受的酸加成盐。 化合物及其盐可用作强心剂，低血糖剂和抗血栓药物。