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公开(公告)号：US20230149732A1
公开(公告)日：2023-05-18
申请号：US17989669
申请日：2022-11-17
Applicant: Wake Forest University Health Sciences
Inventor： Daniel B. Kim-Shapiro , James Eric Jordan , Elmira Alipour , Nadeem Wajih
IPC: A61N5/06
CPC classification number: A61N5/062 , A61N2005/0663 , A61N2005/0651
Abstract: A method for inhibiting device thrombosis for a patient may include circulating blood through an extracorporeal circuit coupled to the patient, infusing nitrite into the flow of blood such that the nitrite is bioactivated by red blood cells to form nitric oxide, and illuminating the flow of blood with far-red light to increase bioactivation of the nitrite by the red blood cells. A system for inhibiting device thrombosis for a patient may include an extracorporeal circuit configured to circulate a flow of blood, a nitrite infusion device coupled to the extracorporeal circuit and configured to infuse nitrite into the flow of blood, and one or more light sources disposed along the extracorporeal circuit and configured to illuminate the flow of blood with far-red light.
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2.发明申请公开(公告)号：US20190000433A1
公开(公告)日：2019-01-03
申请号：US16109073
申请日：2018-08-22
Applicant: Wake Forest University Health Sciences
Inventor： Louis C. Argenta , David L. Carroll , Nicole H. Levi , Michael J. Morykwas , James Eric Jordan , William D. Wagner , Jie Liu
Abstract: A method and apparatus are provided for treating cardiac tissue to modulate ischemic heart tissue with topical sub-atmospheric pressure to minimize cell death and damage.
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公开(公告)号：US10076318B2
公开(公告)日：2018-09-18
申请号：US14626313
申请日：2015-02-19
Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventor： Louis C Argenta , David L Carroll , Nicole H Levi , Michael J Morykwas , James Eric Jordan , William D Wagner , Jie Liu
CPC classification number: A61B17/00234 , A61B90/06 , A61B2017/00243 , A61B2017/306 , A61B2090/064 , A61F13/00068 , A61F2013/0028 , A61M1/0031 , A61M1/0037 , A61M1/0088 , A61M2210/1082 , A61M2210/125
Abstract: A method and apparatus are provided for treating cardiac tissue to modulate ischemic heart tissue with topical sub-atmospheric pressure to minimize cell death and damage.
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4.发明申请Apparatus and Method for Cardiac Tissue Modulation by Topical Application of Vacuum to Minimize Cell Death and Damage 审中-公开通过真空局部应用来减少细胞死亡和损伤的心脏组织调节的装置和方法公开(公告)号：US20150164492A1
公开(公告)日：2015-06-18
申请号：US14626313
申请日：2015-02-19
Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventor： Louis C. Argenta , David L. Carroll , Nicole H. Levi-Polyachenko , Michael J. Morykwas , James Eric Jordan , William D. Wagner , Jie Liu
IPC: A61B17/00
CPC classification number: A61B17/00234 , A61B90/06 , A61B2017/00243 , A61B2017/306 , A61B2090/064 , A61F13/00068 , A61F2013/0028 , A61M1/0031 , A61M1/0037 , A61M1/0088 , A61M2210/1082 , A61M2210/125
Abstract: A method and apparatus are provided for treating cardiac tissue to modulate ischemic heart tissue with topical sub-atmospheric pressure to minimize cell death and damage.
Abstract translation: 提供了一种方法和装置，用于治疗心脏组织以局部亚大气压力调节缺血性心脏组织以最小化细胞死亡和损伤。
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