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公开(公告)号：US20170368242A1
公开(公告)日：2017-12-28
申请号：US15700667
申请日：2017-09-11
Applicant: Wake Forest University Health Sciences
Inventor： Louis C. Argenta , David L. Carroll , Nicole H. Levi , Jie Liu , Michael J. Morykwas , Stephen Tatter , William D. Wagner
CPC classification number: A61M1/0088 , A61F13/00021 , A61M1/0023 , A61M2210/1003
Abstract: The present invention provides devices and methods that treat damaged spinal cord tissue, such as spinal tissue damaged by disease, infection, or trauma, which may lead to the presence of swelling, compression, and compromised blood flow secondary to interstitial edema.
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2.发明申请NOVEL NANOFIBER-BASED GRAFT FOR HEART VALVE REPLACEMENT AND METHODS OF USING THE SAME 审中-公开用于心脏瓣膜更换的新型基于NANOFIBER的骨架及其使用方法公开(公告)号：US20150272729A1
公开(公告)日：2015-10-01
申请号：US14438142
申请日：2013-10-25
Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventor： William D. Wagner , Levi-Polyachenko Nicole , Rui Wang , Louis C. Argenta , Michael J. Morykwas
CPC classification number: A61F2/2412 , A61F2/2415 , A61F2/82 , A61K9/70 , A61L27/26 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2400/12 , A61L2430/20 , C08J9/0061 , C08J2389/00 , C08J2389/06 , C08J2467/02 , C08J2489/00 , C08J2489/06 , C08L89/00 , C08L89/06 , C08L2201/06 , C08L2203/02 , C08L2203/12 , C08L2205/02 , C08L2205/03 , Y10T428/298 , C08L31/06
Abstract: Nanofiber-based biomaterials containing fibroin for wound repair and tissue replacement and, more particularly, heart valve replacement.
Abstract translation: 含有丝素蛋白用于伤口修复和组织置换的纳米纤维生物材料，更具体地说，是心脏瓣膜置换。
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公开(公告)号：US20150032137A1
公开(公告)日：2015-01-29
申请号：US14391346
申请日：2013-03-15
Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventor： William D. Wagner , Nicole Levi-Polyachenko , Tabitha Rosenbalm , Louis C. Argenta , Michael J. Morykwas
CPC classification number: A61B17/1128 , A61B2017/00004 , A61B2017/00831 , A61B2017/00991 , A61B2017/1132 , A61F2/0077 , A61L27/18 , A61L27/26 , A61L27/446 , A61L27/50 , A61L27/58 , A61L2400/12 , A61L2430/32 , C08G63/12 , C08G63/47 , H01B1/125 , C08L67/00
Abstract: A biphasic material and devices comprising the same are provided for the development of conductive conduits that may be used for the treatment of peripheral nerve injury. These devices or conduits are designed such that repeated electric field gradients can be initiated to promote neurite and axonal outgrowth. Conducting conduits using doped synthetic and/or natural polymers create specifically patterned high and low conducting segmented materials, which are mechanically used to produce the electrical properties needed for nerve conduits. These electrical properties stimulate neurite outgrowth and axonal repair following a peripheral nerve transection.
Abstract translation: 提供双相材料和包含该双相材料的装置用于开发可用于治疗周围神经损伤的导电导管。 这些装置或管道被设计成使得可以开始重复的电场梯度以促进神经突和轴突向外生长。 使用掺杂的合成和/或天然聚合物的导管产生专门图案化的高和低导电分段材料，其被机械地用于产生神经导管所需的电性能。 这些电气特性刺激周围神经横断后的神经突向外生长和轴突修复。
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公开(公告)号：US20130072827A1
公开(公告)日：2013-03-21
申请号：US13622009
申请日：2012-09-18
Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventor： Louis C. Argenta , David L. Carroll , Nicole H. Levi , Michael J. Morykwas , Stephen Tatter , William D. Wagner , Jie Liu
IPC: A61H7/00
CPC classification number: A61M1/0088 , A61H7/00 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/56 , A61M2207/00 , A61M2210/0693 , B29C47/0076 , B29C64/112 , B29C67/202 , B29K2089/00 , B29K2995/006 , B29L2031/753 , C08L67/04 , C08L5/08
Abstract: The present invention relates generally to a device and method for treating tissues of the central nervous system and more particularly, but not exclusively, to a device and method for treating the brain tissue.
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公开(公告)号：US09675358B2
公开(公告)日：2017-06-13
申请号：US14391346
申请日：2013-03-15
Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventor： William D. Wagner , Nicole Levi , Tabitha Rosenbalm , Louis C. Argenta , Michael J. Morykwas
IPC: A61B17/11 , A61L27/18 , A61L27/44 , A61L27/50 , A61F2/00 , A61L27/26 , A61L27/58 , C08G63/12 , C08G63/47 , H01B1/12 , A61B17/00
CPC classification number: A61B17/1128 , A61B2017/00004 , A61B2017/00831 , A61B2017/00991 , A61B2017/1132 , A61F2/0077 , A61L27/18 , A61L27/26 , A61L27/446 , A61L27/50 , A61L27/58 , A61L2400/12 , A61L2430/32 , C08G63/12 , C08G63/47 , H01B1/125 , C08L67/00
Abstract: A biphasic material and devices comprising the same are provided for the development of conductive conduits that may be used for the treatment of peripheral nerve injury. These devices or conduits are designed such that repeated electric field gradients can be initiated to promote neurite and axonal outgrowth. Conducting conduits using doped synthetic and/or natural polymers create specifically patterned high and low conducting segmented materials, which are mechanically used to produce the electrical properties needed for nerve conduits. These electrical properties stimulate neurite outgrowth and axonal repair following a peripheral nerve transection.
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Patent Agency Ranking
6.发明申请METHODS AND COMPOSITIONS FOR INHIBITING FIBROSIS, SCARRING AND/OR FIBROTIC CONTRACTURES 审中-公开阻止纤维化，松弛和/或纤维合成的方法和组合物公开(公告)号：US20150367031A1
公开(公告)日：2015-12-24
申请号：US14765734
申请日：2014-04-02
Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventor： Louis Argenta , Nicole H. Levi , Michael Morykwas , Elizabeth Walles , Maria McGee , William D. Wagner , Elizabeth Graham
CPC classification number: A61L27/34 , A61L27/303 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/108 , A61L2300/606 , A61L2400/12 , A61L2420/06 , A61L2430/04 , A61L2430/34 , C01B32/158 , C01B2202/06
Abstract: Biomedical implants, regenerative scaffolds, and compositions comprise a substrate with a coating, a scaffold, and/or a carrier composition which include anisotropic nanoparticles in or on the coating, scaffold or carrier, to inhibit fibrosis, scarring, and/or fibrotic contracture, or the formation of adhesions, in a tissue contacting or administered the same. In some embodiments the nanoparticles may be electrically conductive nanoparticles such as multi wall carbon nanotubes.
Abstract translation: 生物医学植入物，再生支架和组合物包含具有包衣，支架和/或载体组合物的底物，其包含涂层，支架或载体中或其上的各向异性纳米颗粒，以抑制纤维化，瘢痕形成和/或纤维化挛缩， 或形成粘连，在与之接触或施用的组织中。 在一些实施方案中，纳米颗粒可以是导电纳米颗粒，例如多壁碳纳米管。
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公开(公告)号：US20140350499A1
公开(公告)日：2014-11-27
申请号：US14458790
申请日：2014-08-13
Applicant: Wake Forest University Health Sciences
Inventor： Louis C. Argenta , David L. Carroll , Nicole H. Levi-Polyachenko , Jie Liu , Michael J. Morykwas , Stephen Tatter , William D. Wagner
CPC classification number: A61M1/0088 , A61F13/00021 , A61M1/0023 , A61M2210/1003
Abstract: The present invention provides devices and methods that treat damaged spinal cord tissue, such as spinal tissue damaged by disease, infection, or trauma, which may lead to the presence of swelling, compression, and compromised blood flow secondary to interstitial edema.
Abstract translation: 本发明提供了治疗损伤的脊髓组织（例如由疾病，感染或创伤损伤的脊髓组织）的装置和方法，其可导致继发于间质性水肿的肿胀，压缩和受损的血流。
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公开(公告)号：US10219895B2
公开(公告)日：2019-03-05
申请号：US14438142
申请日：2013-10-25
Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventor： William D. Wagner , Nicole Levi , Rui Wang , Louis C. Argenta , Michael J. Morykwas
IPC: A61F2/24 , A61K9/70 , A61F2/82 , A61L27/26 , A61L27/54 , A61L27/56 , C08J9/00 , C08L89/00 , C08L89/06
Abstract: Nanofiber-based biomaterials containing fibroin for wound repair and tissue replacement and, more particularly, heart valve replacement.
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9.发明申请公开(公告)号：US20190000433A1
公开(公告)日：2019-01-03
申请号：US16109073
申请日：2018-08-22
Applicant: Wake Forest University Health Sciences
Inventor： Louis C. Argenta , David L. Carroll , Nicole H. Levi , Michael J. Morykwas , James Eric Jordan , William D. Wagner , Jie Liu
Abstract: A method and apparatus are provided for treating cardiac tissue to modulate ischemic heart tissue with topical sub-atmospheric pressure to minimize cell death and damage.
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10.发明申请Apparatus and Method for Cardiac Tissue Modulation by Topical Application of Vacuum to Minimize Cell Death and Damage 审中-公开通过真空局部应用来减少细胞死亡和损伤的心脏组织调节的装置和方法公开(公告)号：US20150164492A1
公开(公告)日：2015-06-18
申请号：US14626313
申请日：2015-02-19
Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventor： Louis C. Argenta , David L. Carroll , Nicole H. Levi-Polyachenko , Michael J. Morykwas , James Eric Jordan , William D. Wagner , Jie Liu
IPC: A61B17/00
CPC classification number: A61B17/00234 , A61B90/06 , A61B2017/00243 , A61B2017/306 , A61B2090/064 , A61F13/00068 , A61F2013/0028 , A61M1/0031 , A61M1/0037 , A61M1/0088 , A61M2210/1082 , A61M2210/125
Abstract: A method and apparatus are provided for treating cardiac tissue to modulate ischemic heart tissue with topical sub-atmospheric pressure to minimize cell death and damage.
Abstract translation: 提供了一种方法和装置，用于治疗心脏组织以局部亚大气压力调节缺血性心脏组织以最小化细胞死亡和损伤。
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