公开(公告)号：US11351477B2

公开(公告)日：2022-06-07

申请号：US16595627

申请日：2019-10-08

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Edouard S. P. Bouvier ,  Joseph Kareh

IPC: B01D15/16 ,  B01D15/20 ,  G01N30/54 ,  B01D15/22 ,  G01N30/02 ,  G01N30/30

Abstract: Techniques are described for accelerating thermal equilibrium in a chromatographic column. An apparatus comprises a chromatography column, and a plurality of temperature control units in thermal contact with the chromatography column. A method of performing liquid chromatography comprises setting an inlet of a chromatography column to a first temperature using a first temperature control unit in thermal contact with said inlet, setting an outlet of the chromatography column to a second temperature using a second temperature control unit in thermal contact with the outlet, wherein the first temperature is less than the second temperature; and injecting a sample into a liquid stream that flows through the chromatography column after the inlet is set at the first temperature and the outlet is at the second temperature.

公开(公告)号：US10478750B2

公开(公告)日：2019-11-19

申请号：US14406285

申请日：2013-06-26

Applicant: Waters Technologies Corporation

Inventor： Edouard S. P. Bouvier ,  Joseph Kareh

IPC: B01D15/16 ,  B01D15/20 ,  G01N30/54 ,  B01D15/22 ,  G01N30/02 ,  G01N30/30

Abstract: Techniques are described for accelerating thermal equilibrium in a chromatographic column. An apparatus comprises a chromatography column, and a plurality of temperature control units in thermal contact with the chromatography column. A method of performing liquid chromatography comprises setting an inlet of a chromatography column to a first temperature using a first temperature control unit in thermal contact with said inlet, setting an outlet of the chromatography column to a second temperature using a second temperature control unit in thermal contact with the outlet, wherein the first temperature is less than the second temperature; and injecting a sample into a liquid stream that flows through the chromatography column after the inlet is set at the first temperature and the outlet is at the second temperature.

公开(公告)号：US20150157959A1

公开(公告)日：2015-06-11

申请号：US14406285

申请日：2013-06-26

Applicant: Waters Technologies Corporation

Inventor： Edouard S.P. Bouvier ,  Joseph Kareh

IPC: B01D15/16 ,  G01N30/30 ,  B01D15/22

CPC classification number: B01D15/161 ,  B01D15/20 ,  B01D15/22 ,  G01N30/30 ,  G01N30/54 ,  G01N2030/027 ,  G01N2030/3007 ,  G01N2030/3015 ,  G01N2030/3038 ,  G01N2030/3046 ,  G01N2030/3053 ,  G01N2030/3061 ,  G01N2030/3069 ,  G01N2030/3076

Abstract: Techniques are described for accelerating thermal equilibrium in a chromatographic column. An apparatus comprises a chromatography column, and a plurality of temperature control units in thermal contact with the chromatography column. A method of performing liquid chromatography comprises setting an inlet of a chromatography column to a first temperature using a first temperature control unit in thermal contact with said inlet, setting an outlet of the chromatography column to a second temperature using a second temperature control unit in thermal contact with the outlet, wherein the first temperature is less than the second temperature; and injecting a sample into a liquid stream that flows through the chromatography column after the inlet is set at the first temperature and the outlet is at the second temperature.

Abstract translation: 描述了加速色谱柱热平衡的技术。 一种装置包括色谱柱和与色谱柱热接触的多个温度控制单元。 进行液相色谱的方法包括使用与所述入口热接触的第一温度控制单元将色谱柱的入口设定为第一温度，使用第二温度控制单元将色谱柱的出口设定为第二温度 与所述出口接触，其中所述第一温度小于所述第二温度; 并且在入口被设定在第一温度并且出口处于第二温度之后，将样品注入流过色谱柱的液体流中。