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    COMBINATION TREATMENT FOR METABOLIC DISORDERS
    1.
    发明申请
    COMBINATION TREATMENT FOR METABOLIC DISORDERS 审中-公开
    代谢障碍的组合治疗

    公开(公告)号：US20130137629A1

    公开(公告)日：2013-05-30

    申请号：US13749135

    申请日：2013-01-24

    申请人： WELLSTAT THERAPEUTICS CORPORATION

    发明人： Stephen D. Wolpe ,  Ramachandran Arudchandran ,  Reid W. von Borstel

    IPC分类号： A61K38/22 ,  A61K31/192

    CPC分类号： A61K38/22 ,  A61K31/192 ,  A61K31/5377

    摘要： Various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis can be treated with a compound selected from an incretin mimetic and a dipeptidyl peptidase IV inhibitor in combination with a Compound of Formula I or a pharmaceutically acceptable salt thereof Three of R1, R2, R3, R4 and R5 are hydrogen and the remainder are independently selected from the group consisting of hydrogen, halo, hydroxy, methyl, ethyl, perfluoromethyl, methoxy, ethoxy, and perfluoromethoxy; and m is 0, 2 or 4. R6 is hydrogen, O or hydroxy, and X is —OR7, wherein R7 is hydrogen or alkyl having from 1 to 3 carbon atoms; or R6 is hydrogen, and X is —NR8R9, wherein R8 is hydrogen or hydroxy and R9 is hydrogen, methyl or ethyl. When X is —NR8R9, hydroxy none of R1, R2, R3, R4 and R5 is hydroxy.

    摘要翻译： 可以用选自肠降血
    球蛋白模拟物和二肽基肽酶IV抑制剂的化合物与下列药物组合治疗各种代谢紊乱，例如胰岛素抵抗综合征，糖尿病，多囊卵巢综合征，高脂血症，脂肪肝疾病，恶病质，肥胖症，动脉粥样硬化和动脉硬化 式I化合物或其药学上可接受的盐R 1，R 2，R 3，R 4和R 5中的三个是氢，其余的独立地选自氢，卤素，羟基，甲基，乙基，全氟甲基，甲氧基，乙氧基， 和全氟甲氧基; R 6是氢，O或羟基，X是-OR 7，其中R 7是氢或具有1至3个碳原子的烷基; 或R6是氢，X是-NR8R9，其中R8是氢或羟基，R9是氢，甲基或乙基。 当X是-NR 8 R 9时，R 1，R 2，R 3，R 4和R 5不是羟基。

    Stem cell mobilization and tissue repair and regeneration
    3.
    发明授权
    Stem cell mobilization and tissue repair and regeneration 有权
    干细胞移动和组织修复和再生

    公开(公告)号：US09428552B2

    公开(公告)日：2016-08-30

    申请号：US14442737

    申请日：2013-11-18

    申请人： Wellstat Therapeutics Corporation

    发明人： Irena Tsyrlova ,  Fawn Petty ,  Reid W. von Borstel ,  Julian Reading ,  Jiong Pei ,  Joel Saydoff

    IPC分类号： C07K7/08 ,  A61K38/00

    CPC分类号： C07K7/08 ,  A61K38/00

    摘要： Stem cells are mobilized from bone marrow by administering an amount of Phe-Pro-His-Phe-Asp-Leu-Ser-His-Gly-Ser-Ala-Gln-Val-Ser-Asp-Lys-Pro (SEQ ID NO: 2) or Phe-Ala-His-Phe-Asp-Leu-Ser-His-Gly-Ser-Ala-Gln-Val-Ser-Asp-Lys-Pro (SEQ ID NO: 3) effective to mobilize the stem cells. This is useful for promoting bodily tissue regeneration in a patient in need of tissue regeneration treatment. Alternatively, the mobilized stem cells can be collected for transplant.

    摘要翻译： 通过给予一定量的Phe-Pro-His-Phe-Asp-Leu-Ser-His-Gly-Ser-Ala-Gln-Val-Ser-Asp-Lys-Pro（SEQ ID NO： 2）或有效调动干细胞的Phe-Ala-His-Phe-Asp-Leu-Ser-His-Gly-Ser-Ala-Gln-Val-Ser-Asp-Lys-Pro（SEQ ID NO：3）。 这对于促进需要组织再生治疗的患者中的身体组织再生是有用的。 或者，可以收集移动的干细胞用于移植。

    Stem Cell Mobilization and Tissue Repair and Regeneration
    4.
    发明申请
    Stem Cell Mobilization and Tissue Repair and Regeneration 审中-公开
    干细胞动员和组织修复和再生

    公开(公告)号：US20160016997A1

    公开(公告)日：2016-01-21

    申请号：US14442737

    申请日：2013-11-18

    申请人： Wellstat Therapeutics Corporation

    发明人： Irena Tsyrlova ,  Fawn Petty ,  Reid W. von Borstel ,  Julian Reading ,  Jiong Pei ,  Joel Saydoff

    IPC分类号： C07K7/08

    CPC分类号： C07K7/08 ,  A61K38/00

    摘要： Stem cells are mobilized from bone marrow by administering an amount of Phe-Pro-His-Phe-Asp-Leu-Ser-His-Gly-Ser-Ala-Gln-Val-Ser-Asp-Lys-Pro (SEQ ID NO: 2) or Phe-Ala-His-Phe-Asp-Leu-Ser-His-Gly-Ser-Ala-Gln-Val-Ser-Asp-Lys-Pro (SEQ ID NO: 3) effective to mobilize the stem cells. This is useful for promoting bodily tissue regeneration in a patient in need of tissue regeneration treatment. Alternatively, the mobilized stem cells can be collected for transplant.

    摘要翻译： 通过给予一定量的Phe-Pro-His-Phe-Asp-Leu-Ser-His-Gly-Ser-Ala-Gln-Val-Ser-Asp-Lys-Pro（SEQ ID NO： 2）或有效调动干细胞的Phe-Ala-His-Phe-Asp-Leu-Ser-His-Gly-Ser-Ala-Gln-Val-Ser-Asp-Lys-Pro（SEQ ID NO：3）。 这对于促进需要组织再生治疗的患者中的身体组织再生是有用的。 或者，可以收集移动的干细胞用于移植。