公开(公告)号：US06893613B2

公开(公告)日：2005-05-17

申请号：US10057451

申请日：2002-01-25

申请人： Walter Ruediger ,  A. Erik Rubin ,  Alexander Bertok ,  Victor W. Rosso ,  Joseph Nolfo ,  Harold N. Weller

发明人： Walter Ruediger ,  A. Erik Rubin ,  Alexander Bertok ,  Victor W. Rosso ,  Joseph Nolfo ,  Harold N. Weller

IPC分类号： B01J19/00 ,  B01L7/00 ,  B01L9/06 ,  C40B60/14 ,  B01L9/00

CPC分类号： B01J19/0046 ,  B01J2219/00283 ,  B01J2219/0031 ,  B01J2219/00335 ,  B01J2219/00376 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01L7/00 ,  B01L9/06 ,  B01L2200/025 ,  B01L2200/147 ,  B01L2300/1805 ,  C40B60/14

摘要： The base of the modular reactor includes a frame which defines an opening into which one of a plurality of interchangeable reaction vessel carrying inserts can be removeably received. Each insert has an array of recesses adapted to receive a different number of reaction vessels of different sizes. The recesses are positioned such that all arrays are suitable for use with a standard automated liquid handier. The frame has fluid flow channels for regulating the temperature of the lower portions of the vessels. A temperature control module can be received over the base to regulate the temperature of the upper portions of the vessels for reflux reactions. The corner radii of the insert and frame opening cooperate to permit the insert to be received in the frame in only one orientation. The walls of the insert are inclined to facilitate removal by a friction fit tool. Each vessel receiving recess has a self-centering conical or semi-circular shaped bottom to maximize heat transfer and distribute the load uniformly. The vessels seat as close to the bottom surface of the base as possible to facilitate use with an air driven magnetic stirrer. A thin, electrically heated plate may be received between the base and the stirrer.

摘要翻译： 模块式反应器的底座包括限定开口的框架，多个可互换的反应容器的插入物中的一个可以被移除到该开口中。 每个插入物具有适于接收不同数量的不同尺寸的反应容器的凹部阵列。 这些凹槽定位成使得所有的阵列都适用于标准的自动化液体洗手液。 框架具有用于调节容器下部的温度的流体流动通道。 温度控制模块可以接收在基座上以调节用于回流反应的容器上部的温度。 插入件和框架开口的拐角半径配合以允许插入件仅在一个方向上被容纳在框架中。 插入件的壁倾斜以便于通过摩擦配合工具移除。 每个容器接收凹槽具有自对中圆锥形或半圆形底部以最大限度地传热并均匀地分布载荷。 船只靠近基座的底面尽可能靠近空气驱动的磁力搅拌器使用。 可以在基座和搅拌器之间容纳薄的电加热板。

公开(公告)号：US06573387B1

公开(公告)日：2003-06-03

申请号：US09381407

申请日：2000-01-31

申请人： K. Barry Sharpless ,  A. Erik Rubin

发明人： K. Barry Sharpless ,  A. Erik Rubin

IPC分类号： C07D20304

CPC分类号： C07D203/22 ,  C07C231/12 ,  C07C231/16 ,  C07C303/40 ,  C40B40/04 ,  C40B50/08 ,  C07C311/19

摘要： &agr;,&bgr;-Unsaturated amides and esters are converted to &agr;,&bgr;-substituted amino amides, esters, and acids. An &agr;,&bgr;unsaturated amide or ester is first converted to an &agr;,&bgr;-hydroxysulfonamide or hydroxycarbamate amide or ester using an osmium-catalyzed aminohydroxylation. The &agr;,&bgr;-hydroxysulfonamide or hydroxycarbamate amides or esters is then cyclodehydrated to produce a &agr;,&bgr;-N-sulfonyl- or the &agr;,&bgr;-N-carbamoylaziridine amide or ester. The ring of aziridine intermediate is then nucleophilically opened in a regioselective manner with a variety of nucleophiles to give the $g(&agr;,&bgr;-substituted amino- amides or esters. Preferred nucleophiles include sulfur, oxygen, carbon, and nitrogen nucleophiles.

摘要翻译： α，β-不饱和酰胺和酯转化为α，β-取代的氨基酰胺，酯和酸。 首先使用锇催化的氨基羟基化将α，β-不饱和酰胺或酯转化为α，β-羟基磺酰胺或羟基氨基甲酸酯酰胺或酯。 然后将α，β-羟基磺酰胺或羟基氨基甲酸酯酰胺或酯环化脱水以产生α，β-N-磺酰基或α，β-N-氨基甲酰基氮丙啶酰胺或酯。 然后将氮丙啶中间体环以区域选择性方式用各种亲核试剂进行亲核打开，得到$ g（α，β-取代的氨基酰胺或酯）。优选的亲核试剂包括硫，氧，碳和氮亲核试剂。