利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

17 条记录 (耗时 0.026 秒)

    Bone matrix compositions and methods
    2.
    发明授权
    Bone matrix compositions and methods 有权

    公开(公告)号：US10328179B2

    公开(公告)日：2019-06-25

    申请号：US14661712

    申请日：2015-03-18

    申请人： WARSAW ORTHOPEDIC, INC.

    发明人： Keyvan Behnam ,  David Knaack

    IPC分类号： A61L27/36 ,  A61K35/32 ,  A61K38/01 ,  A61K38/18 ,  A61L27/12 ,  A61L27/42 ,  A61L27/48 ,  A61L27/54 ,  C07K14/51 ,  A61F2/28 ,  A61F2/30

    摘要： An osteoinductive composition, corresponding osteoimplants, and methods for making the osteoinductive composition are disclosed. The osteoinductive composition comprises osteoinductive factors, such as may be extracted from demineralized bone, and a carrier. The osteoinductive composition is prepared by providing demineralized bone, extracting osteoinductive factors from the demineralized bone, and adding the extracted osteoinductive factors to a carrier. Further additives such as bioactive agents may be added to the osteoinductive composition. The carrier and osteoinductive factors may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, can induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. Also, in some embodiments, the osteoinductive composition can be used as a delivery device to administer bioactive agents.

    Bone Matrix Compositions and Methods
    6.
    发明申请
    Bone Matrix Compositions and Methods 有权
    骨骼组成和方法

    公开(公告)号：US20130136777A1

    公开(公告)日：2013-05-30

    申请号：US13746516

    申请日：2013-01-22

    申请人： Warsaw Orthopedic, Inc.

    发明人： Keyvan Behnam ,  Guobao Wei ,  Nanette Forsyth

    IPC分类号： A61K35/32

    CPC分类号： A61K35/00 ,  A61F2/28 ,  A61F2002/30059 ,  A61F2310/00359 ,  A61K35/32 ,  A61L27/3604 ,  A61L27/3608 ,  A61L27/3683 ,  A61L27/3695 ,  A61L27/3834 ,  A61L27/54 ,  A61L2430/02 ,  A61L2430/40

    摘要： Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone, and optionally providing a tissue-derived extract and adding the tissue-derived extract to the partially demineralized bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.

    摘要翻译： 提供具有增加的生物活性的骨诱导组合物和植入物及其生产方法。 可能增加的生物活性包括但不限于骨形成; 骨愈合; 骨诱导活性，成骨活性，软骨形成活性，伤口愈合活性，神经源性活性，收缩诱导活性，有丝分裂诱导活性，分化诱导活性，趋化活性，血管生成或血管发生活性，以及​​胞吐作用或内吞诱导活性。 在一个实施方案中，用于产生骨诱导性组合物的方法包括提供部分去矿物质的骨，处理所述部分去矿物质的骨以破坏所述骨的胶原结构，以及任选地提供组织衍生的提取物并将所述组织衍生的提取物加入到部分去矿物质 骨。 在另一个实施方案中，可植入的骨诱导和骨传导性组合物包含部分脱矿质骨，其中所述骨的胶原结构已被破坏，并且任选地包含组织衍生的提取物。

    Osteoinductive demineralized cancellous bone
    9.
    发明授权
    Osteoinductive demineralized cancellous bone 有权
    骨诱导软骨松质骨

    公开(公告)号：US09415136B2

    公开(公告)日：2016-08-16

    申请号：US14286640

    申请日：2014-05-23

    申请人： WARSAW ORTHOPEDIC, INC.

    发明人： Keyvan Behnam ,  Nanette Forsyth ,  James Russell ,  John Winterbottom ,  Todd Boyce

    IPC分类号： A61L27/36 ,  A61F2/28 ,  A61L27/38 ,  A61K35/32 ,  A61F2/30

    CPC分类号： A61K35/32 ,  A61F2/28 ,  A61F2002/2817 ,  A61F2002/30059 ,  A61F2310/00359 ,  A61L27/3608 ,  A61L27/3641 ,  A61L27/3645 ,  A61L27/3683 ,  A61L27/3687 ,  A61L27/3691 ,  A61L27/3695 ,  A61L27/3878 ,  A61L2430/02

    摘要： An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone. The osteoinductive demineralized bone matrix may also be prepared by providing demineralized bone and compacting the bone, for example via mechanical compaction, grinding into a particulate, or treatment with a chemical. Additives such as growth factors or bioactive agents may be added to the osteoinductive demineralized bone matrix. The osteoinductive demineralized bone matrix may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, may induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. The osteoinductive demineralized bone matrix may also be used as a delivery device to administer bioactive agents.

    摘要翻译： 公开了一种骨诱导的软骨骨架，相应的骨关节植入物以及用于制造骨诱导性软骨骨架的方法。 可以通过提供软化骨和改变骨的胶原结构来制备骨诱导的软骨骨架。 还可以通过提供脱矿质骨和压实骨，例如通过机械压实，研磨成颗粒或用化学品处理来制备骨诱导的软化骨基质。 添加剂如生长因子或生物活性剂可以加入到骨诱导的软化骨基质中。 骨诱导的骨质疏松骨质可形成成骨植骨。 当植入植入哺乳动物体内的植骨植入物可能在植入物的位置诱导软骨内骨形成的完全发育级联，包括血管化，矿化和骨髓分化。 骨诱导的软化骨基质也可以用作施用生物活性剂的递送装置。

    BONE MATRIX COMPOSITIONS AND METHODS
    10.
    发明申请
    BONE MATRIX COMPOSITIONS AND METHODS 审中-公开
    骨基质组合物和方法

    公开(公告)号：US20160144075A1

    公开(公告)日：2016-05-26

    申请号：US14885649

    申请日：2015-10-16

    申请人： Warsaw Orthopedic, Inc.

    发明人： Keyvan Behnam ,  Guobao Wei ,  Nanette Forsyth

    IPC分类号： A61L27/36 ,  A61L27/54

    CPC分类号： A61K35/00 ,  A61F2/28 ,  A61F2002/30059 ,  A61F2310/00359 ,  A61K35/32 ,  A61L27/3604 ,  A61L27/3608 ,  A61L27/3683 ,  A61L27/3695 ,  A61L27/3834 ,  A61L27/54 ,  A61L2430/02 ,  A61L2430/40

    摘要： Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.

    摘要翻译： 提供具有增加的生物活性的骨诱导组合物和植入物及其生产方法。 可能增加的生物活性包括但不限于骨形成; 骨愈合; 骨诱导活性，成骨活性，软骨形成活性，伤口愈合活性，神经源性活性，收缩诱导活性，有丝分裂诱导活性，分化诱导活性，趋化活性，血管生成或血管发生活性，以及​​胞吐作用或内吞诱导活性。 在一个实施方案中，用于生产骨诱导性组合物的方法包括提供部分去矿物质的骨，处理所述部分去矿物质的骨以破坏所述骨的胶原结构。 在另一个实施方案中，可植入的骨诱导和骨传导性组合物包含部分脱矿质骨，其中所述骨的胶原结构已被破坏，并且任选地包含组织衍生的提取物。