利索-全球专利检索

  1. Login
  2. Sign Up

Search Results

28 records (took 0.017 seconds)

    Plasmonic patch as a universal fluorescence enhancer
    6.
    发明授权
    Plasmonic patch as a universal fluorescence enhancer 有权

    公开(公告)号：US11911999B2

    公开(公告)日：2024-02-27

    申请号：US17662293

    申请日：2022-05-06

    Applicant: Washington University

    Inventor： Srikanth Singamaneni ,  Jingyi Luan ,  Jeremiah Morrissey ,  Evan Kharasch

    IPC: B32B27/06

    CPC classification number: B32B27/06 ,  B32B2307/422

    Abstract: Fluorescence-based techniques are the cornerstone of modern biomedical optics with applications ranging from bioimaging at various scales (organelle to organism) to detection and quantification of a wide variety of biological species of interest. However, feeble fluorescence signal remains a persistent challenge in meeting the ever-increasing demand to image, detect and quantify biological species of low abundance. Disclosed herein are simple and universal methods based on a flexible and conformal elastomeric film adsorbed with plasmonic nanostructures, referred to as “plasmonic skin” or “plasmonic patch”, that provide large and uniform enhancement of fluorescence on a variety of surfaces, through an “add-on-top” process. The novel fluorescence enhancement approach presented here represents a disease-, biomarker-, and application-agnostic ubiquitously-applicable fundamental and enabling technology to improve the sensitivity of existing analytical methodologies in an easy-to-handle and cost-effective manner, without changing and/or minimally altering the original procedures of the existing techniques.

    Plasmonic patch as a universal fluorescence enhancer
    8.
    发明授权
    Plasmonic patch as a universal fluorescence enhancer 有权

    公开(公告)号：US11351760B2

    公开(公告)日：2022-06-07

    申请号：US16765441

    申请日：2018-11-27

    Applicant: Washington University

    Inventor： Srikanth Singamaneni ,  Jingyi Luan ,  Jeremiah Morrissey ,  Evan Kharasch

    IPC: B32B27/06

    Abstract: Fluorescence-based techniques are the cornerstone of modern biomedical optics with applications ranging from bioimaging at various scales (organelle to organism) to detection and quantification of a wide variety of biological species of interest. However, feeble fluorescence signal remains a persistent challenge in meeting the ever-increasing demand to image, detect and quantify biological species of low abundance. Disclosed herein are simple and universal methods based on a flexible and conformal elastomeric film adsorbed with plasmonic nanostructures, referred to as “plasmonic skin” or “plasmonic patch”, that provide large and uniform enhancement of fluorescence on a variety of surfaces, through an “add-on-top” process. The novel fluorescence enhancement approach presented here represents a disease-, biomarker-, and application-agnostic ubiquitously-applicable fundamental and enabling technology to improve the sensitivity of existing analytical methodologies in an easy-to-handle and cost-effective manner, without changing and/or minimally altering the original procedures of the existing techniques.

    PLASMONIC PATCH AS A UNIVERSAL FLUORESCENCE ENHANCER
    9.
    发明申请
    PLASMONIC PATCH AS A UNIVERSAL FLUORESCENCE ENHANCER 审中-公开

    公开(公告)号：US20200326282A1

    公开(公告)日：2020-10-15

    申请号：US16765441

    申请日：2018-11-27

    Applicant: Washington University

    Inventor： Srikanth Singamaneni ,  Jingyi Luan ,  Jeremiah Morrissey ,  Evan Kharasch

    IPC: G01N21/64 ,  C08L83/08 ,  B32B27/06

    Abstract: Fluorescence-based techniques are the cornerstone of modern biomedical optics with applications ranging from bioimaging at various scales (organelle to organism) to detection and quantification of a wide variety of biological species of interest. However, feeble fluorescence signal remains a persistent challenge in meeting the ever-increasing demand to image, detect and quantify biological species of low abundance. Disclosed herein are simple and universal methods based on a flexible and conformal elastomeric film adsorbed with plasmonic nanostructures, referred to as “plasmonic skin” or “plasmonic patch”, that provide large and uniform enhancement of fluorescence on a variety of surfaces, through an “add-on-top” process. The novel fluorescence enhancement approach presented here represents a disease-, biomarker-, and application-agnostic ubiquitously-applicable fundamental and enabling technology to improve the sensitivity of existing analytical methodologies in an easy-to-handle and cost-effective manner, without changing and/or minimally altering the original procedures of the existing techniques.

    LABEL-FREE DETECTION OF RENAL CANCER
    10.
    发明申请
    LABEL-FREE DETECTION OF RENAL CANCER 审中-公开
    无标签检测肾癌

    公开(公告)号：US20150253317A1

    公开(公告)日：2015-09-10

    申请号：US14719972

    申请日：2015-05-22

    Applicant: Washington University

    Inventor： Srikanth Singamaneni ,  Evan Kharasch ,  Jeremiah Morrissey ,  Chang Hee Lee

    IPC: G01N33/543

    Abstract: Natural and/or synthetic antibodies for specific proteins are adhered to nanoparticles. The nanoparticles are adhered to a substrate and the substrate is exposed to a sample that may contain the specific proteins. The substrates are then tested with surface enhanced Raman scattering techniques and/or localized surface plasmon resonance techniques to quantify the amount of the specific protein in the sample.

    Abstract translation: 用于特定蛋白质的天然和/或合成抗体粘附到纳米颗粒上。 将纳米颗粒粘附到底物上，将底物暴露于可含有特定蛋白质的样品。 然后用表面增强拉曼散射技术和/或局部表面等离子体共振技术测试底物以量化样品中特定蛋白质的量。

Patent Agency Ranking