公开(公告)号：US20190086371A1

公开(公告)日：2019-03-21

申请号：US16133089

申请日：2018-09-17

Applicant: Waters Technologies Corporation

Inventor： Matthew A. Lauber ,  Mathew H. DeLano ,  Scott A. McCall ,  Jonathan L. Belanger ,  Theodore A. Dourdeville ,  Kerri M. Smith ,  Paul D. Rainville ,  Dimple D. Shah ,  Stephen J. Shiner ,  Catalin Doneanu ,  Michael Donegan

IPC: G01N30/56 ,  G01N30/60 ,  G01N30/72 ,  C23C14/24 ,  C23C14/12 ,  C23C14/04

Abstract: A device for separating analytes is disclosed. The device has a sample injector, sample injection needle, sample reservoir container in communication with the sample injector, chromatography column downstream of the sample injector, and fluid conduits connecting the sample injector and the column. The interior surfaces of the fluid conduits, sample injector, sample reservoir container, and column form a flow path having wetted surfaces. A portion of the wetted surfaces of the flow path are coated with an alkylsilyl coating that is inert to at least one of the analytes. The alkylsilyl coating has the Formula I: R1, R2, R3, R4, R5, and R6 are each independently selected from (C1-C6)alkoxy, —NH(C1-C6)alkyl, —N((C1-C6)alkyl)2, OH, ORA, and halo. RA represents a point of attachment to the interior surfaces of the fluidic system. At least one of R1, R2, R3, R4, R5, and R6 is ORA. X is (C1-C20)alkyl, —O[(CH2)2O]1-20—, —(C1-C10)[NH(CO)NH(C1-C10)]1-20-, or —(C1-C10)[alkylphenyl(C1-C10)alkyl]1-20-.

公开(公告)号：US20180259494A1

公开(公告)日：2018-09-13

申请号：US15914428

申请日：2018-03-07

Applicant: Waters Technologies Corporation

Inventor： Dimple D. Shah ,  Jacob N. Fairchild ,  Euan Ross ,  Benjamin Wuyts

IPC: B01J20/281 ,  G01N30/74 ,  G01N30/72 ,  G01N30/86

CPC classification number: G01N30/482 ,  G01N30/72 ,  G01N30/74 ,  G01N30/8631 ,  G01N30/88 ,  G01N2030/027 ,  G01N2030/884 ,  G01N2033/184

Abstract: The present disclosure relates to the determination of pesticides, e.g., polar pesticides, in a sample using chromatography. The present disclosure can provide direct analysis of polar pesticides, including anionic polar pesticides, using high performance liquid chromatography. The polar pesticides are sufficiently retained and resolved to allow for multiple polar pesticide determinations in a single analysis.

公开(公告)号：US11092577B2

公开(公告)日：2021-08-17

申请号：US15914428

申请日：2018-03-07

Applicant: Waters Technologies Corporation

Inventor： Dimple D. Shah ,  Jacob N. Fairchild ,  Euan Ross ,  Benjamin Wuyts

IPC: G01N30/88 ,  G01N30/72 ,  G01N30/74 ,  B01J20/281 ,  G01N30/86 ,  G01N33/18 ,  G01N30/02

Abstract: The present disclosure relates to the determination of pesticides, e.g., polar pesticides, in a sample using chromatography. The present disclosure can provide direct analysis of polar pesticides, including anionic polar pesticides, using high performance liquid chromatography. The polar pesticides are sufficiently retained and resolved to allow for multiple polar pesticide determinations in a single analysis.

公开(公告)号：US11709155B2

公开(公告)日：2023-07-25

申请号：US16133089

申请日：2018-09-17

Applicant: Waters Technologies Corporation

Inventor： Matthew A. Lauber ,  Mathew H. DeLano ,  Scott A. McCall ,  Jonathan L. Belanger ,  Theodore A. Dourdeville ,  Kerri M. Smith ,  Paul D. Rainville ,  Dimple D. Shah ,  Stephen J. Shiner ,  Catalin Doneanu ,  Michael Donegan

IPC: G01N30/56 ,  B01J20/32 ,  B05D1/00 ,  B01J20/291 ,  C23C16/04 ,  C23C16/30 ,  C23C14/04 ,  C23C14/12 ,  C23C14/24 ,  G01N30/60 ,  G01N30/72

CPC classification number: G01N30/56 ,  B01J20/291 ,  B01J20/3272 ,  B05D1/60 ,  C23C14/046 ,  C23C14/12 ,  C23C14/24 ,  C23C16/045 ,  C23C16/30 ,  G01N30/6052 ,  B05D2518/10 ,  G01N30/7266 ,  G01N2030/567

Abstract: A device for separating analytes is disclosed. The device has a sample injector, sample injection needle, sample reservoir container in communication with the sample injector, chromatography column downstream of the sample injector, and fluid conduits connecting the sample injector and the column. The interior surfaces of the fluid conduits, sample injector, sample reservoir container, and column form a flow path having wetted surfaces. A portion of the wetted surfaces of the flow path are coated with an alkylsilyl coating that is inert to at least one of the analytes. The alkylsilyl coating has the Formula I:




R1, R2, R3, R4, R5, and R6 are each independently selected from (C1-C6)alkoxy, —NH(C1-C6)alkyl, —N((C1-C6)alkyl)2, OH, ORA, and halo. RA represents a point of attachment to the interior surfaces of the fluidic system. At least one of R1, R2, R3, R4, R5, and R6 is ORA. X is (C1-C20)alkyl, —O[(CH2)2O]1-20—, —(C1-C10)[NH(CO)NH(C1-C10)]1-20—, or —(C1-C10)[alkylphenyl(C1-C10)alkyl]1-20-.