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    Methods of modulating apoptosis using inhibitors of brain-localized protein kinases homologous to homeodomain-interacting protein kinases
    1.
    发明授权
    Methods of modulating apoptosis using inhibitors of brain-localized protein kinases homologous to homeodomain-interacting protein kinases 失效
    使用与同源结构域相互作用蛋白激酶同源的脑定位蛋白激酶抑制剂调节凋亡的方法

    公开(公告)号：US07745164B2

    公开(公告)日：2010-06-29

    申请号：US11645056

    申请日：2006-12-26

    申请人： Wei Liu ,  Bradley A. Ozenberger ,  Leeying Wu ,  Ching-Hsiung Frederick Lo ,  Steven A. Haney ,  Hemchand Sookdeo ,  Jee Hyung Lee

    发明人： Wei Liu ,  Bradley A. Ozenberger ,  Leeying Wu ,  Ching-Hsiung Frederick Lo ,  Steven A. Haney ,  Hemchand Sookdeo ,  Jee Hyung Lee

    IPC分类号： C12Q1/48

    CPC分类号： C12N9/1205

    摘要： The invention provides isolated protein kinase polypeptides related to novel brain-localized protein kinases homologous to known homeodomain-interacting protein kinases (HIPKs), isolated nucleic acid molecules that encode these polypeptides, inhibitors, and methods related thereto. The novel polypeptides and nucleic acid molecules of the invention are termed HIPK4. The invention also provides genetically engineered expression vectors, host cells, and transgenic animals comprising the novel nucleic acid molecules of the invention. The invention additionally provides antisense and RNAi molecules to the nucleic acid molecules of the invention, as well as inhibitors, activators, and antibodies capable of binding to the protein kinase polypeptides of the invention. The invention further provides uses of HIPK4 and its inhibitors, e.g., mutants of HIPK4 lacking protein kinase activity, for modulation of apoptosis, as well as the prevention and treatment of neurological disorders and cancers.

    摘要翻译： 本发明提供与与已知同源结构域相互作用蛋白激酶（HIPK）同源的新型脑定位蛋白激酶相关的分离的蛋白激酶多肽，编码这些多肽的分离的核酸分子，抑制剂及其相关方法。 本发明的新型多肽和核酸分子称为HIPK4。 本发明还提供了遗传工程改造的表达载体，宿主细胞和包含本发明的新型核酸分子的转基因动物。 本发明还向本发明的核酸分子以及能够结合本发明的蛋白激酶多肽的抑制剂，激活剂和抗体提供反义和RNAi分子。 本发明还提供了HIPK4及其抑制剂（例如缺乏蛋白激酶活性的HIPK4的突变体）用于调节凋亡以及预防和治疗神经障碍和癌症的用途。