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    Biomedical devices
    1.
    发明授权
    Biomedical devices 失效
    生物医学装置

    公开(公告)号：US08071661B2

    公开(公告)日：2011-12-06

    申请号：US12329700

    申请日：2008-12-08

    申请人： Yu-Chin Lai ,  Weihong Lang

    发明人： Yu-Chin Lai ,  Weihong Lang

    IPC分类号： G02C7/04 ,  G02B1/04 ,  C08F18/20

    CPC分类号： C08F220/22 ,  C08F220/18 ,  C08F220/26 ,  C08F226/10 ,  C08F230/08 ,  G02B1/043 ,  Y10S524/916

    摘要： Biomedical devices are provided herein which are formed from a polymerization product of a mixture comprising (a) a copolymer which is the reaction product of one or more polymerizable polyhydric alcohols and one or more polymerizable fluorine-containing monomers; and (b) a biomedical device-forming comonomer.

    摘要翻译： 本文提供了由混合物的聚合产物形成的生物医学装置，所述混合物包含（a）作为一种或多种可聚合多元醇与一种或多种可聚合含氟单体的反应产物的共聚物; 和（b）生物医学装置形成共聚单体。

    Polysiloxanes and polysiloxane prepolymers with vinyl or epoxy functionality
    2.
    发明授权
    Polysiloxanes and polysiloxane prepolymers with vinyl or epoxy functionality 有权
    具有乙烯基或环氧官能团的聚硅氧烷和聚硅氧烷预聚物

    公开(公告)号：US07781554B2

    公开(公告)日：2010-08-24

    申请号：US12042378

    申请日：2008-03-05

    申请人： Yu-Chin Lai ,  Edmond T. Quinn ,  Weihong Lang ,  Ivan M. Nunez

    发明人： Yu-Chin Lai ,  Edmond T. Quinn ,  Weihong Lang ,  Ivan M. Nunez

    IPC分类号： C08G77/00

    CPC分类号： C08G77/16 ,  C08G18/10 ,  C08G18/61 ,  C08G18/672 ,  C08G77/14 ,  C08G77/20 ,  C08G77/458

    摘要： Polysiloxanes having vinyl or epoxy functionality. The polysiloxanes are used to form polymer-based materials having properties particularly suited for biomedical device applications. The polysiloxanes are of general formula I: wherein R is a C2-10 alkenyl, a C2-10 alkyl with an epoxy group or a C5-C7cycloalkyl with an epoxy group; R2, R3 and R4 are each independently selected from the group consisting of hydrogen, C1-4 alkyl, C1-4 fluoroalkyl, optionally substituted phenyl and optionally substituted benzyl; A is —OH or —NHR5, wherein R5 is hydrogen or a C1-3 alkyl; and B is —R1-A or —R6, wherein R1 is a linking group having an alkylene group with 2 to 8 carbon atoms wherein the alkylene group optionally includes ether, urethane or ureido linkages; and R6 is selected from the group consisting of C1-4 alkyl, optionally substituted phenyl or optionally substituted benzyl; and m and n are integers with an m:n ratio from 30:1 to 3:1.

    摘要翻译： 具有乙烯基或环氧官能团的聚硅氧烷。 聚硅氧烷用于形成具有特别适用于生物医学装置应用的特性的聚合物基材料。 聚硅氧烷具有通式I：其中R是C2-10烯基，具有环氧基的C2-10烷基或具有环氧基的C5-C7环烷基; R 2，R 3和R 4各自独立地选自氢，C 1-4烷基，C 1-4氟烷基，任选取代的苯基和任选取代的苄基; A是-OH或-NHR 5，其中R 5是氢或C 1-3烷基; 并且B是-R1-A或-R6，其中R1是具有2至8个碳原子的亚烷基的连接基团，其中亚烷基任选地包括醚，氨基甲酸酯或脲基键; 并且R 6选自C 1-4烷基，任选取代的苯基或任选取代的苄基; m和n为30：1〜3：1的m：n比的整数。

    Packaging Solutions
    3.
    发明申请
    Packaging Solutions 审中-公开
    包装解决方案

    公开(公告)号：US20090173045A1

    公开(公告)日：2009-07-09

    申请号：US12248222

    申请日：2008-10-09

    申请人： Yu-Chin Lai ,  Weihong Lang

    发明人： Yu-Chin Lai ,  Weihong Lang

    IPC分类号： A45C11/04 ,  B65B55/22

    CPC分类号： A61L12/086 ,  B65B25/008 ,  B65B55/02

    摘要： Packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear are disclosed. A packaging system includes an ophthalmic device stored in an aqueous packaging solution comprising a hydrophilic polymer having one or more non-ethylenically-unsaturated carboxylic acid terminal groups.

    摘要翻译： 公开了用于存储诸如隐形眼镜的眼科装置的包装系统，以及用于包装这些眼科装置的方法以提供穿戴期间镜片的舒适度的解决方案。 包装系统包括存储在包含具有一个或多个非烯键式不饱和羧酸端基的亲水性聚合物的水性包装溶液中的眼科装置。

    Process for Making Biomedical Devices
    4.
    发明申请
    Process for Making Biomedical Devices 审中-公开
    制造生物医学设备的过程

    公开(公告)号：US20090142485A1

    公开(公告)日：2009-06-04

    申请号：US12273192

    申请日：2008-11-18

    申请人： Yu-Chin Lai ,  Edmond T. Quinn ,  Weihong Lang ,  Daniel M. Ammon, JR. ,  Jay F. Kunzler

    发明人： Yu-Chin Lai ,  Edmond T. Quinn ,  Weihong Lang ,  Daniel M. Ammon, JR. ,  Jay F. Kunzler

    IPC分类号： B05D5/06

    CPC分类号： G02B1/043 ,  A61L27/18 ,  A61L27/34 ,  B29D11/00067 ,  C08L83/04

    摘要： A process for treating a silicone hydrogel biomedical device, especially an ophthalmic lens such as a contact lens, involves: immersing the silicone hydrogel biomedical device with a mixture of an organic solvent and a hydrophilic, polymeric material, for a sufficient time that the device is swollen in volume by at least 30%; and removing the organic solvent from the device while retaining at least a portion of the hydrophilic polymeric material therein.

    摘要翻译： 用于处理硅酮水凝胶生物医学装置，特别是诸如隐形眼镜的眼用透镜的方法包括：将硅酮水凝胶生物医学装置与有机溶剂和亲水性聚合物材料的混合物浸渍足够的时间，使该装置为 体积膨胀至少30％; 并从装置中除去有机溶剂，同时将至少一部分亲水性聚合物材料保持在其中。

    Silicone hydrogels with amino surface groups
    6.
    发明授权
    Silicone hydrogels with amino surface groups 失效
    具有氨基表面基团的硅氧烷水凝胶

    公开(公告)号：US08119753B2

    公开(公告)日：2012-02-21

    申请号：US12242955

    申请日：2008-10-01

    申请人： Yu-Chin Lai ,  Weihong Lang

    发明人： Yu-Chin Lai ,  Weihong Lang

    IPC分类号： C08F30/08

    CPC分类号： C08J7/047 ,  C08J2383/08 ,  C08J2400/104 ,  C08J2400/105 ,  C08J2433/24 ,  C08L83/10 ,  G02B1/043 ,  C08L101/14

    摘要： A silicone hydrogel comprising monomeric units of one or more amino monomers, wherein the amino monomers are of formula IA, IB, IIA or IIB and monomeric units of one or more silicone monomers wherein R1, R2 and R3 are independently selected from hydrogen, C1-C6 alkyl or CH2OH; R4 is a C1-C10 alkyl optionally substituted with hydroxyl or carboxylic acid; E is a polymerizable group; X is an anion suitable for quaternary nitrogen; and n is 0, 1, 2, or 3 and m is an integer from 1 to 8.

    摘要翻译： 一种硅氧烷水凝胶，其包含一种或多种氨基单体的单体单元，其中所述氨基单体具有式IA，IB，IIA或IIB以及一种或多种硅氧烷单体的单体单元，其中R 1，R 2和R 3独立地选自氢，C1- C6烷基或CH2OH; R4是任选被羟基或羧酸取代的C1-C10烷基; E是可聚合基团; X是适合季氮的阴离子; n为0,1,2或3，m为1〜8的整数。

    Surface modified biomedical devices
    7.
    发明授权
    Surface modified biomedical devices 失效
    表面改性生物医学装置

    公开(公告)号：US08071660B2

    公开(公告)日：2011-12-06

    申请号：US12329694

    申请日：2008-12-08

    申请人： Weihong Lang ,  Yu-Chin Lai

    发明人： Weihong Lang ,  Yu-Chin Lai

    IPC分类号： G02C7/02 ,  C08F14/18 ,  A61F2/16

    CPC分类号： C08F220/22 ,  C08F220/26 ,  C08F230/08 ,  C08J7/047 ,  C08J2383/04

    摘要： A method for making a surface modified biomedical device is disclosed, the method comprising contacting a surface of a biomedical device with a copolymer which is the reaction product of one or more polymerizable polyhydric alcohols and one or more polymerizable fluorine-containing monomers.

    摘要翻译： 公开了一种制备表面改性生物医学装置的方法，所述方法包括使生物医学装置的表面与作为一种或多种可聚合多元醇和一种或多种可聚合含氟单体的反应产物的共聚物接触。

    Method for Making Surface Modified Biomedical Devices
    9.
    发明申请
    Method for Making Surface Modified Biomedical Devices 审中-公开
    制备表面改性生物医学装置的方法

    公开(公告)号：US20090111942A1

    公开(公告)日：2009-04-30

    申请号：US11924359

    申请日：2007-10-25

    申请人： Weihong Lang ,  Yu-Chin Lai ,  Daniel J. Hook

    发明人： Weihong Lang ,  Yu-Chin Lai ,  Daniel J. Hook

    IPC分类号： C08G63/48

    CPC分类号： A61L27/34 ,  A61L27/50 ,  A61L2400/18 ,  A61L2430/16 ,  C08J7/16

    摘要： Disclosed are methods for making a surface modified biomedical device involving (a) exposing a biomedical device having a plurality of biomedical device surface functional groups to one or more ethylenically unsaturated-containing organic compounds having a reactive group that is co-reactive to the biomedical device surface functional groups of the biomedical device; and (b) graft polymerizing a hydrophilic reactive monomer having a complementary reactive functionality with the ethylenically unsaturated functionalities of the ethylenically unsaturated-containing organic compounds on or near the surface of the biomedical device thus forming a biocompatible surface on the biomedical device. The methods disclosed are two-step methods and do not include any additional surface treatment steps.

    摘要翻译： 公开了用于制备表面改性生物医学装置的方法，其涉及（a）将具有多个生物医学装置表面官能团的生物医学装置暴露于具有与生物医学装置共反应的反应性基团的一种或多种含烯属不饱和的有机化合物 生物医学装置的表面官能团; 和（b）将具有互补反应性官能团的亲水性反应性单体与含烯属不饱和有机化合物的烯属不饱和官能团接枝聚合到生物医学装置的表面上或附近，从而在生物医学装置上形成生物相容性表面。 所公开的方法是两步法，不包括任何额外的表面处理步骤。