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公开(公告)号：US07030292B2
公开(公告)日：2006-04-18
申请号：US10032495
申请日：2002-01-02
申请人： Wen Liang Yan , Steve Chien-Wen Huang , Minh-Thanh Nguyen , Huan (Helen) Lin , Jingqi Lei , Ruchi Khanna
发明人： Wen Liang Yan , Steve Chien-Wen Huang , Minh-Thanh Nguyen , Huan (Helen) Lin , Jingqi Lei , Ruchi Khanna
CPC分类号： C12N5/0603 , A61K35/12 , A61K48/00 , C12N2501/125 , C12N2502/13 , C12N2506/04 , C12N2506/30
摘要： A method of producing a homogenous population of homozygous stem (HS) cells pre-selected for immunotype and/or genotype from donor cells is described herein. The invention relates to methods of using immunohistocompatible HS cells for diagnosis, therapeutic and cosmetic transplantation, and the treatment of various genetic diseases, neurodegenerative diseases, traumatic injuries and cancer. The invention further relates to methods for using histocompatible HS stem cells pre-selected for a non-disease genotype for prophylactic and therapeutic intervention including, but not limited to, therapeutic and cosmetic transplantation, and the treatment of various genetic diseases, neurodegenerative diseases, and cancer. Furthermore, the invention relates to a catalogued transplant depository of HS cells derived from multiple donors, each of the HS cells being homozygous for a unique HLA haplotype, for the purpose of having a constant, reliable, comprehensive supply of immunohistocompatible cells for diagnosis, treatment and/or transplantation.
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2.发明申请Isolated homozygous stem cells, differentiated cells derived therefrom and materials and methods for making and using same 审中-公开分离的纯合干细胞，从其衍生的分化细胞和用于制备和使用它们的材料和方法公开(公告)号：US20080260707A1
公开(公告)日：2008-10-23
申请号：US12078799
申请日：2008-04-04
申请人： Wen Liang Yan , Steve Chien-Wen Huang , Minh-Thanh Nguyen , Hua Helen Lin , Jingqi Lei , Ruchi Khanna
发明人： Wen Liang Yan , Steve Chien-Wen Huang , Minh-Thanh Nguyen , Hua Helen Lin , Jingqi Lei , Ruchi Khanna
CPC分类号： C12N5/0611 , A61K35/12 , A61K48/00 , C12N5/0606 , C12N2506/04 , C12N2510/00 , C12N2517/10
摘要： The present invention discloses and describes pluripotent homozygous stem (HS) cells, and methods and materials for making same. The present invention also provides methods for differentiation of HS cells into progenitor (multipotent) cells or other desired cells, groups of cells or tissues. Further, the applications of the HS cells disclosed herein, include (but are not limited to) the diagnosis and treatment of various diseases (for example, genetic diseases, neurodegenerative diseases, endocrine-related disorders and cancer), traumatic injuries, cosmetic or therapeutic transplantation, gene therapy and cell replacement therapy.
摘要翻译： 本发明公开并描述了多能纯合茎（HS）细胞及其制备方法和材料。 本发明还提供了将HS细胞分化为祖细胞（多能）细胞或其它所需细胞，细胞或组织组的方法。 此外，本文公开的HS细胞的应用包括（但不限于）各种疾病（例如遗传疾病，神经变性疾病，内分泌相关疾病和癌症），创伤性损伤，美容或治疗的诊断和治疗 移植，基因治疗和细胞替代治疗。
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3.发明申请Method for producing a population of homozygous stem cells having a pre-selected immunotype and/or genotype, cells suitable for transplant derived therefrom, and materials and methods using same 审中-公开用于产生具有预先选择的免疫型和/或基因型的纯合干细胞群的方法，适用于从其衍生的移植的细胞，以及使用其的材料和方法公开(公告)号：US20070031859A1
公开(公告)日：2007-02-08
申请号：US11393820
申请日：2006-03-31
申请人： Wen Yan , Steve Huang , Minh-Thanh Nguyen , Hua (Helen) Lin , Jingqi Lei , Ruchi Khanna
发明人： Wen Yan , Steve Huang , Minh-Thanh Nguyen , Hua (Helen) Lin , Jingqi Lei , Ruchi Khanna
CPC分类号： C12N5/0603 , A61K35/12 , A61K48/00 , C12N2501/125 , C12N2502/13 , C12N2506/04 , C12N2506/30
摘要： A method of producing a homogenous population of homozygous stem (HS) cells pre-selected for immunotype and/or genotype from donor cells is described herein. The invention relates to methods of using immunohistocompatible HS cells for diagnosis, therapeutic and cosmetic transplantation, and the treatment of various genetic diseases, neurodegenerative diseases, traumatic injuries and cancer. The invention further relates to methods for using histocompatible HS stem cells pre-selected for a non-disease genotype for prophylactic and therapeutic intervention including, but not limited to, therapeutic and cosmetic transplantation, and the treatment of various genetic diseases, neurodegenerative diseases, and cancer. Furthermore, the invention relates to a catalogued transplant depository of HS cells derived from multiple donors, each of the HS cells being homozygous for a unique HLA haplotype, for the purpose of having a constant, reliable, comprehensive supply of immunohistocompatible cells for diagnosis, treatment and/or transplantation.
摘要翻译： 本文描述了从供体细胞产生预先选择用于免疫型和/或基因型的均质干细胞（HS）细胞群体的方法。 本发明涉及使用免疫组化相容性HS细胞进行诊断，治疗和美容移植以及治疗各种遗传疾病，神经变性疾病，创伤性损伤和癌症的方法。 本发明还涉及使用预先选择用于非疾病基因型的组织相容性HS干细胞进行预防和治疗干预的方法，包括但不限于治疗和美容移植，以及治疗各种遗传疾病，神经变性疾病和 癌症。 此外，本发明涉及来自多个供体的HS细胞的编目的移植保藏体，每个HS细胞对于独特的HLA单倍型是纯合的，目的是具有用于诊断，治疗的恒定，可靠，全面的免疫组织相容性细胞供应 和/或移植。
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