公开(公告)号：US20140213731A1

公开(公告)日：2014-07-31

申请号：US14131617

申请日：2012-04-13

申请人： Wenyan Wang ,  Mingqiang Zhang ,  Jian Wang ,  Dengfei Wang ,  Enguang Zou ,  Liping Qiu ,  Qun Dong ,  Jinxian Jiang ,  Jianying Ma ,  Tengjie Ge ,  Yanjie An ,  Deying Zhang ,  Bo Li ,  Gujyue Guo ,  Shihua Wang ,  He Ren ,  Lirong Jing ,  Haifeng Guo

发明人： Wenyan Wang ,  Mingqiang Zhang ,  Jian Wang ,  Dengfei Wang ,  Enguang Zou ,  Liping Qiu ,  Qun Dong ,  Jinxian Jiang ,  Jianying Ma ,  Tengjie Ge ,  Yanjie An ,  Deying Zhang ,  Bo Li ,  Gujyue Guo ,  Shihua Wang ,  He Ren ,  Lirong Jing ,  Haifeng Guo

IPC分类号： C08F255/02

CPC分类号： C08F255/02 ,  Y02P20/544 ,  C08F220/06 ,  C08F212/08 ,  C08F220/18 ,  C08F222/06 ,  C08F2220/1825

摘要： A supercritical carbon dioxide-assisted solid-phase grafting modification method for polypropylene, comprises swelling polypropylene for 0.5 to 10 hours in supercritical carbon dioxide having dissolved vinyl monomer and an initiator, then slowly relieving the pressure; moving the polypropylene that has undergone the swelling process into a reaction kettle, and adding xylene as an interface agent, the mass of xylene being 1% of the polypropylene; increasing the temperature to between 65° C. and 165° C. under normal pressure, and reacting 1 to 10 hours to obtain modified polypropylene; the swelling permeation temperature during the swelling process is from 31° C. to 60° C., the swelling pressure is from 7.5 to 12 MPa; the initiator is an azo compound or a peroxide. In the present method, the grafting rate reaches 5.4%, the thermal property, polarity, and mechanical property all improve substantially, and hydrophilic property is substantially enhanced.

摘要翻译： 用于聚丙烯的超临界二氧化碳辅助固相接枝改性方法包括在具有溶解的乙烯基单体和引发剂的超临界二氧化碳中将聚丙烯溶胀0.5至10小时，然后缓慢释放压力; 将经过溶胀处理的聚丙烯移入反应釜中，加入二甲苯作为界面剂，二甲苯的质量为聚丙烯的1％; 在常压下将温度升至65℃至165℃，反应1至10小时以获得改性聚丙烯; 膨胀过程中的溶胀渗透温度为31℃至60℃，溶胀压力为7.5至12MPa; 引发剂是偶氮化合物或过氧化物。 在本方法中，接枝率达到5.4％，热性能，极性和机械性能均有显着提高，亲水性能明显提高。

公开(公告)号：US07566778B2

公开(公告)日：2009-07-28

申请号：US12024597

申请日：2008-02-01

申请人： Simon James Anthony Grove ,  Julia Adam-Worrall ,  Mingqiang Zhang ,  Robert Gilfillan

发明人： Simon James Anthony Grove ,  Julia Adam-Worrall ,  Mingqiang Zhang ,  Robert Gilfillan

IPC分类号： C07D498/14

CPC分类号： C07D498/14

摘要： The present invention relates to (pyrido/thieno)-[f]-oxazepine-5-one derivatives having the general Formula I wherein R1, R2 and R3 are independently H or (C1-4)alkyl; Ar represents a fused thiophene or pyridine ring optionally substituted with one or more substituents selected from (C1-4)alkyl, (C1-4)alkyloxy, (C1-4)alkyloxy(C1-4)alkyl, CF3, halogen, nitro, cyano, NR4R5, NR4COR6, and CONR4R5; R4 and R5 are independently H or (C1-4-)alkyl; or R4 and R5 form together with the nitrogen atom to which they are bound a 5- or 6-membered saturated heterocyclic ring, optionally containing a further heteroatom selected from O, S or NR6; R6 is (C1-4)alkyl; A represents the residue of a 4-7 membered saturated heterocyclic ring, optionally containing an oxygen atom, the ring being optionally substituted with 1-3 substituents selected from (C1-4)alkyl, (C1-4)alkyloxy, hydroxy, halogen and oxo; or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising said derivatives, and to the use of these (pyrido/thieno)-[f]-oxazepine-5-one derivatives in the treatment of neurological diseases and psychiatric disorders which are responsive to enhancement of synaptic responses mediated by AMPA receptors in the central nervous system.

摘要翻译： 本发明涉及具有通式I的（吡啶并噻吩并[f] - 氧氮杂-5-酮衍生物，其中R 1，R 2和R 3独立地为H或（C 1-4）烷基; Ar表示任选被一个或多个选自（C 1-4）烷基，（C 1-4）烷氧基，（C 1-4）烷氧基（C 1-4）烷基，CF 3，卤素，硝基， 氰基，NR4R5，NR4COR6和CONR4R5; R 4和R 5独立地为H或（C 1-4 - ）烷基; 或R 4和R 5与它们所连接的氮原子一起形成5-或6-元饱和杂环，任选地含有选自O，S或NR 6的另外的杂原子; R6是（C1-4）烷基; A表示任选含有氧原子的4-7元饱和杂环的残基，该环任选被1-3个选自（C 1-4）烷基，（C 1-4）烷氧基，羟基，卤素和 氧代 或其药学上可接受的盐。 本发明还涉及包含所述衍生物的药物组合物，以及这些（吡啶并噻吩并[f] - 氧氮杂-5-酮衍生物在治疗对增强突触反应有反应的神经疾病和精神疾病的用途中的用途） 由AMPA受体介导的中枢神经系统。

公开(公告)号：US20060205757A1

公开(公告)日：2006-09-14

申请号：US11097605

申请日：2005-04-01

申请人： Mingqiang Zhang ,  Rose Sheridan

发明人： Mingqiang Zhang ,  Rose Sheridan

IPC分类号： A61K31/4745 ,  C07D491/14

CPC分类号： C07D498/14 ,  A61K31/4745 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to medical uses of 39-desmethoxyrapamycin.

摘要翻译： 本发明涉及39-去甲氧西他霉素的医疗用途。

公开(公告)号：US6046212A

公开(公告)日：2000-04-04

申请号：US147270

申请日：1998-11-17

申请人： Maria Elizabeth Zwaagstra ,  Mingqiang Zhang ,  Henk Timmerman ,  Kazuhiro Onogi ,  Masahiro Tamura ,  Tsutomu Toma ,  Yasushi Wada

发明人： Maria Elizabeth Zwaagstra ,  Mingqiang Zhang ,  Henk Timmerman ,  Kazuhiro Onogi ,  Masahiro Tamura ,  Tsutomu Toma ,  Yasushi Wada

IPC分类号： A61K31/19 ,  A61K31/41 ,  A61K31/425 ,  A61K31/428 ,  A61K31/47 ,  A61P37/08 ,  C07C49/84 ,  C07C59/84 ,  C07C59/90 ,  C07C65/38 ,  C07C65/40 ,  C07C69/738 ,  C07C69/76 ,  C07C235/84 ,  C07C255/56 ,  C07D215/14 ,  C07D235/12 ,  C07D257/04 ,  C07D257/10 ,  C07D277/64 ,  C07D401/10 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D215/12 ,  C07D235/04 ,  C07D263/62 ,  C07D277/60

CPC分类号： C07D257/04 ,  C07C59/84 ,  C07C59/90 ,  C07C65/38 ,  C07C69/738 ,  C07D215/14 ,  C07D235/12 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

摘要： This invention relates to chalcone derivatives represented by the following formula (1): wherein A represents a phenyl group, a quinolyl group or the like, W represents a vinylene group or the like, and R.sup.1 to R.sup.5 each independently represent a carboxyl, cyano, alkyloxycarbonyl or like group, or salts of the chalcone derivatives, and also to drugs containing them as effective ingredients. These compounds have excellent cys-LT receptor antagonism, and are useful as antiallergic agents or the like.

摘要翻译： PCT No.PCT / JP97 / 01652 Sec。 371日期：1998年11月17日 102（e）1998年11月17日PCT PCT 1997年5月16日PCT公布。 WO97 / 44306 PCT公开号 日期：1997年11月27日本发明涉及下述式（1）表示的查耳酮衍生物：其中A表示苯基，喹啉基等，W表示亚乙烯基等，R 1〜R 5各自独立地表示 羧基，氰基，烷氧基羰基等基团，或查耳酮衍生物的盐，以及含有它们作为有效成分的药物。 这些化合物具有优异的cys-LT受体拮抗作用，可用作抗过敏药剂等。

公开(公告)号：US5714501A

公开(公告)日：1998-02-03

申请号：US634427

申请日：1996-04-18

申请人： Henk Timmerman ,  Mingqiang Zhang

发明人： Henk Timmerman ,  Mingqiang Zhang

IPC分类号： A61K31/445 ,  A61K31/451 ,  A61P37/08 ,  A61P43/00 ,  C07D211/46 ,  C07D211/70 ,  A61K3/445 ,  C07D211/20

CPC分类号： C07D211/46 ,  C07D211/70

摘要： A piperidine derivative of formula (1) or salts thereof: ##STR1## wherein R.sup.1 and R.sup.2 independently represent H or together represent O, R.sup.3 represents H, --R.sup.5 --COOR.sup.6, or --COOR.sup.6 (wherein R.sup.5 is a lower alkylene group, --CONH--, or --CONHCH.sub.2, and R.sup.6 is H or a lower alkyl group), R.sup.4 represents H, an aralkyloxy carbonyl group, an aminomethyl carbonyl group, or an aralkyloxy carbonyl aminomethyl carbonyl group, A represents O or a double bond, and the broken line has the meaning that a bonding hand may be present; and preventive and therapeutic agents for allergies, antihistaminic agents, and antileucotriene agents comprising the derivative or salts as their effective component. The compound of formula (1) has excellent antihistaminic activities and antileukotriene activities, which are well balanced, and is useful as a drug for the prevention and treatment of allergies such as asthma, allergic rhinitis, allergic dermatosis and urticaria.

摘要翻译： 式（1）的哌啶衍生物或其盐：其中R1和R2独立地表示H或一起代表O，R3表示H，-R5-COOR6或-COOR6（其中R5是低级亚烷基 ，-CONH-或-CONHCH 2，R6为H或低级烷基），R4表示H，芳烷氧基羰基，氨基甲基羰基或芳烷氧基羰基氨基甲基羰基，A表示O或双键， 虚线具有粘合手可能存在的意思; 以及包含所述衍生物或盐作为其有效成分的过敏，抗组胺剂和抗孕妇三烯试剂的预防和治疗剂。 式（1）化合物具有优异的抗组胺活性和抗白细胞三烯活性，其平衡良好，可用作预防和治疗哮喘，过敏性鼻炎，过敏性皮肤病和荨麻疹等过敏症的药物。

公开(公告)号：US20100081682A1

公开(公告)日：2010-04-01

申请号：US12630251

申请日：2009-12-03

申请人： Christoph Hendrik Beckmann ,  Steven James Moss ,  Rose Mary Sheridan ,  Mingqiang Zhang ,  Barrie Wilkinson

发明人： Christoph Hendrik Beckmann ,  Steven James Moss ,  Rose Mary Sheridan ,  Mingqiang Zhang ,  Barrie Wilkinson

IPC分类号： A61K31/436

CPC分类号： C07D498/18

摘要： The present invention relates to 39-desmethoxyrapamycin derivatives and their uses thereof. The present invention provides for the use of these compounds in the treatment of cancer and/or B-cell malignancies, the induction or maintenance of immunosuppression, the treatment of transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation, vascular disease and fibrotic diseases, the stimulation of neuronal regeneration or the treatment of fungal infections.

摘要翻译： 本发明涉及39-去甲氧基嘧啶霉素衍生物及其用途。 本发明提供了这些化合物在治疗癌症和/或B细胞恶性肿瘤中的用途，诱导或维持免疫抑制，移植排斥反应，移植物抗宿主病，自身免疫性疾病，炎症疾病，血管 疾病和纤维化疾病，刺激神经元再生或治疗真菌感染。

公开(公告)号：US07026304B2

公开(公告)日：2006-04-11

申请号：US10468072

申请日：2002-02-14

申请人： Mingqiang Zhang ,  Gary Tarver

发明人： Mingqiang Zhang ,  Gary Tarver

IPC分类号： A61K31/715

CPC分类号： C08B37/0012 ,  A61K31/724

摘要： Disclosed are 2-alkylated-cyclodextrin derivatives and pharmaceutically acceptable salts thereof. The 2-alkylated-cyclodextrin derivatives are suitable for use in the reversal of drug-induced neuromuscular block.

摘要翻译： 公开了2-烷基化 - 环糊精衍生物及其药学上可接受的盐。 2-烷基化环糊精衍生物适用于逆转药物诱导的神经肌肉阻滞。

公开(公告)号：US20180325110A1

公开(公告)日：2018-11-15

申请号：US15774433

申请日：2016-06-17

申请人： Mingqiang Zhang

发明人： Mingqiang Zhang

IPC分类号： A01N43/16 ,  A01G22/05 ,  A01G7/06 ,  A01N25/12 ,  A01N63/02

CPC分类号： A01N43/16 ,  A01C21/00 ,  A01G7/06 ,  A01G22/05 ,  A01N25/12 ,  A01N37/44 ,  A01N63/02 ,  A01N2300/00 ,  C05G3/00

摘要： A micro-carbon plant anthocyanin for facilitating advancement of fruit coloring and fruit plumpness, and a preparation method and application thereof are provided. The formula composition of the micro-carbon plant anthocyanin by mass percentage is 30-50% of plant anthocyanin having a particle size of 80-150 μm, 20-40% of micro carbon (abbreviation for water-soluble small-molecule carbohydrates) having a particle size of 100 μm and 20-50% of amino acids. By spraying a 100-500-fold dilution of the micro-carbon plant anthocyanin onto surfaces of foliage and fruits during the fruit development period of grapes and strawberries with a use amount of 10-50 kg/mu in the whole growth period, the colorization can be advanced by 5-15 days, and the harvested fruits have fragrant and sweet tastes, are completely filled, and have an excellent quality.

公开(公告)号：US20100061994A1

公开(公告)日：2010-03-11

申请号：US11908367

申请日：2006-03-10

申请人： Rose Mary Sheridan ,  Mingqiang Zhang ,  Matthew Alan Gregory

发明人： Rose Mary Sheridan ,  Mingqiang Zhang ,  Matthew Alan Gregory

IPC分类号： A61K39/395 ,  A61K31/4353 ,  A61K31/4985 ,  A61K31/704 ,  A61K38/14 ,  A61K31/66 ,  A61K38/08 ,  A61P25/00 ,  A61P35/00

CPC分类号： A61K31/4745 ,  C07D498/14

摘要： The present invention relates to medical uses of 39-desmethoxyrapamycin analogues.

摘要翻译： 本发明涉及39-去甲氧基阿拉霉素类似物的医学用途。

公开(公告)号：US07655673B2

公开(公告)日：2010-02-02

申请号：US11651669

申请日：2007-01-10

申请人： Mingqiang Zhang ,  Rose Mary Sheridan

发明人： Mingqiang Zhang ,  Rose Mary Sheridan

IPC分类号： A61K31/4745

CPC分类号： C07D498/14 ,  A61K31/4745 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to medical uses of 39-desmethoxyrapamycin.

摘要翻译： 本发明涉及39-去甲氧西他霉素的医疗用途。