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公开(公告)号：US5306822A
公开(公告)日：1994-04-26
申请号：US988562
申请日：1992-12-10
申请人： Wiaczeslaw A. Cetenko , David T. Connor , Roderick J. Sorenson , Paul C. Unangst , Stephen R. Stabler
发明人： Wiaczeslaw A. Cetenko , David T. Connor , Roderick J. Sorenson , Paul C. Unangst , Stephen R. Stabler
IPC分类号： A61K31/415 , A61K31/42 , A61K31/425 , C07D233/78 , C07D233/86 , C07D233/96 , C07D263/44 , C07D263/46 , C07D277/20 , C07D277/34 , C07D417/06
CPC分类号： C07D263/44 , A61K31/415 , A61K31/42 , A61K31/425 , C07D233/78 , C07D233/86 , C07D233/96 , C07D263/46 , C07D277/20 , C07D417/06
摘要： The present invention is for selected novel compounds, as well as, pharmaceutical compositions and methods of use for known and the selected novel compounds both of the formula ##STR1## having activity useful for treating allergies and inflammation.
摘要翻译： 本发明用于选择的新化合物，以及用于已知和所选新型化合物的药物组合物和方法，其具有可用于治疗过敏和炎症的活性的式（*化学结构*）。
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2.发明授权Arylmethylenyl derivatives of imidazolidinones useful as antiinflammatory agents 失效可用作抗炎剂的咪唑啉酮的芳基甲基衍生物
公开(公告)号：US5464856A
公开(公告)日：1995-11-07
申请号：US185748
申请日：1994-01-24
申请人： Wiaczeslaw A. Cetenko , David T. Connor , Roderick J. Sorenson , Paul C. Unangst , Stephen R. Stabler
发明人： Wiaczeslaw A. Cetenko , David T. Connor , Roderick J. Sorenson , Paul C. Unangst , Stephen R. Stabler
IPC分类号： A61K31/415 , A61K31/42 , A61K31/425 , C07D233/78 , C07D233/86 , C07D233/96 , C07D263/44 , C07D263/46 , C07D277/20 , C07D277/34 , C07D417/06
CPC分类号： C07D263/44 , A61K31/415 , A61K31/42 , A61K31/425 , C07D233/78 , C07D233/86 , C07D233/96 , C07D263/46 , C07D277/20 , C07D417/06
摘要： The present invention is for selected novel compounds, as well as, pharmaceutical compositions and methods of use for known and the selected novel compounds both of the formula ##STR1## having activity useful for treating allergies and inflammation.
摘要翻译： 本发明涉及选择的新化合物，以及用于已知和所选新型化合物的药物组合物和方法，其具有可用于治疗过敏和炎症的活性。
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3.发明授权3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents 失效2-取代噻唑烷酮，恶唑烷酮和咪唑啉酮的3,5-二叔丁基-4-羟基苯基亚甲基衍生物作为抗炎剂
公开(公告)号：US5290800A
公开(公告)日：1994-03-01
申请号：US896299
申请日：1992-06-10
申请人： Wiaczeslaw A. Cetenko , David T. Connor , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst
发明人： Wiaczeslaw A. Cetenko , David T. Connor , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst
IPC分类号： A61K31/415 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61P29/00 , C07D233/96 , C07D263/40 , C07D263/46 , C07D263/48 , C07D277/20 , C07D277/34 , C07D277/36 , C07D277/48 , C07D277/50 , C07D277/54 , C07D203/40
CPC分类号： C07D277/20 , C07D233/96 , C07D263/46 , C07D263/48
摘要： The novel 3,5-ditertiarybutyl-4-hydroxy-phenylmethylene derivative of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents having inhibiting activity for 5-lipoxygenase, cyclooxygenase, or both.
摘要翻译： 2-取代的噻唑烷酮，恶唑烷酮和咪唑啉酮的3,5-二叔丁基-4-羟基 - 苯基亚甲基衍生物作为具有5-脂氧合酶抑制活性，环氧合酶或两者的抗炎剂。
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4.发明授权3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents 失效2-取代噻唑烷酮，恶唑烷酮和咪唑啉酮的3,5-二叔丁基-4-羟基苯基亚甲基衍生物作为抗炎剂
公开(公告)号：US5494927A
公开(公告)日：1996-02-27
申请号：US353166
申请日：1994-12-09
申请人： Wiaczeslaw A. Cetenko , David T. Connor , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst
发明人： Wiaczeslaw A. Cetenko , David T. Connor , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst
IPC分类号： A61K31/415 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61P29/00 , C07D233/96 , C07D263/40 , C07D263/46 , C07D263/48 , C07D277/20 , C07D277/34 , C07D277/36 , C07D277/48 , C07D277/50 , C07D277/54 , C07D233/86
CPC分类号： C07D277/20 , C07D233/96 , C07D263/46 , C07D263/48
摘要： The novel 3,5-ditertiarybutyl-4-hydroxy-phenylmethylene derivative of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents having inhibiting activity for 5-lipoxygenase, cyclooxygenase, or both.
摘要翻译： 2-取代的噻唑烷酮，恶唑烷酮和咪唑啉酮的3,5-二叔丁基-4-羟基 - 苯基亚甲基衍生物作为具有5-脂氧合酶抑制活性，环加氧酶或两者的抗炎剂。
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5.发明授权3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents 失效作为抗炎药的2-取代的噻唑烷酮，奥昔洛芬和咪唑啉二酮的3,5-二叔丁基-4-羟基苯基乙烯衍生物
公开(公告)号：US5143928A
公开(公告)日：1992-09-01
申请号：US640711
申请日：1991-01-18
申请人： Wiaczeslaw A. Cetenko , David T. Connor , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst
发明人： Wiaczeslaw A. Cetenko , David T. Connor , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst
IPC分类号： A61K31/415 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61P29/00 , C07D233/96 , C07D263/40 , C07D263/46 , C07D263/48 , C07D277/20 , C07D277/34 , C07D277/36 , C07D277/48 , C07D277/50 , C07D277/54
CPC分类号： C07D277/20 , C07D233/96 , C07D263/46 , C07D263/48
摘要： The novel 3,5-ditertiarybutyl-4-hydroxy-phenylmethylene derivative of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents having inhibiting activity for 5-lipoxygenase, cyclooxygenase, or both.
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公开(公告)号：US4868200A
公开(公告)日：1989-09-19
申请号：US166146
申请日：1988-03-09
申请人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
发明人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
IPC分类号： C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D307/92 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
CPC分类号： C07D307/92 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
摘要： The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
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7.发明授权Known and selected novel arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and anti-inflammatory agents 失效已知和选择的可用作抗过敏剂和抗炎剂的噻唑烷酮，咪唑烷酮和恶唑烷酮的新型芳基亚甲基衍生物
公开(公告)号：US5208250A
公开(公告)日：1993-05-04
申请号：US702132
申请日：1991-05-13
申请人： Wiaczeslaw A. Cetenko , David T. Connor , Roderick J. Sorenson , Paul C. Unangst , Stephen S. Stabler
发明人： Wiaczeslaw A. Cetenko , David T. Connor , Roderick J. Sorenson , Paul C. Unangst , Stephen S. Stabler
IPC分类号： A61K31/415 , A61K31/42 , A61K31/425 , C07D233/78 , C07D233/86 , C07D233/96 , C07D263/44 , C07D263/46 , C07D277/20 , C07D277/34 , C07D417/06
CPC分类号： C07D263/44 , A61K31/415 , A61K31/42 , A61K31/425 , C07D233/78 , C07D233/86 , C07D233/96 , C07D263/46 , C07D277/20 , C07D417/06
摘要： The present invention is for selected novel compounds, as well as, pharmaceutical compositions and methods of use for known and the selected novel compounds both of the formula ##STR1## having activity useful for treating allergies and inflammation.
摘要翻译： 本发明涉及选择的新化合物，以及用于已知和所选新型化合物的药物组合物和方法，其具有可用于治疗过敏和炎症的活性。
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公开(公告)号：US4868205A
公开(公告)日：1989-09-19
申请号：US167272
申请日：1988-03-11
申请人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
发明人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
IPC分类号： C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D307/92 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
CPC分类号： C07D307/92 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
摘要： The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
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公开(公告)号：US4868199A
公开(公告)日：1989-09-19
申请号：US167264
申请日：1988-03-09
申请人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
发明人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
IPC分类号： C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D307/92 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04 , C07D491/048
CPC分类号： C07D307/92 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
摘要： The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
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10.发明授权
公开(公告)号：US4761424A
公开(公告)日：1988-08-02
申请号：US782623
申请日：1985-10-01
申请人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
发明人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
IPC分类号： C07D491/048 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/35 , A61K31/352 , A61K31/38 , A61K31/381 , A61K31/382 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/54 , A61P9/00 , A61P11/00 , A61P25/04 , A61P25/06 , A61P29/00 , A61P37/08 , A61P43/00 , C07D209/12 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/68 , C07D307/83 , C07D307/84 , C07D307/92 , C07D311/22 , C07D311/24 , C07D333/60 , C07D333/64 , C07D333/68 , C07D333/70 , C07D335/06 , C07D491/04
CPC分类号： C07D307/92 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
摘要： The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
摘要翻译： 本发明涉及新型烯醇酰胺型化合物，药物组合物及其使用方法，其可用于治疗其中脂肪氧合酶活性产物或白细胞三烯作用有助于病理状况的疾病。
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