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1.发明授权Known and selected novel arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and anti-inflammatory agents 失效已知和选择的可用作抗过敏剂和抗炎剂的噻唑烷酮，咪唑烷酮和恶唑烷酮的新型芳基亚甲基衍生物
公开(公告)号：US5208250A
公开(公告)日：1993-05-04
申请号：US702132
申请日：1991-05-13
申请人： Wiaczeslaw A. Cetenko , David T. Connor , Roderick J. Sorenson , Paul C. Unangst , Stephen S. Stabler
发明人： Wiaczeslaw A. Cetenko , David T. Connor , Roderick J. Sorenson , Paul C. Unangst , Stephen S. Stabler
IPC分类号： A61K31/415 , A61K31/42 , A61K31/425 , C07D233/78 , C07D233/86 , C07D233/96 , C07D263/44 , C07D263/46 , C07D277/20 , C07D277/34 , C07D417/06
CPC分类号： C07D263/44 , A61K31/415 , A61K31/42 , A61K31/425 , C07D233/78 , C07D233/86 , C07D233/96 , C07D263/46 , C07D277/20 , C07D417/06
摘要： The present invention is for selected novel compounds, as well as, pharmaceutical compositions and methods of use for known and the selected novel compounds both of the formula ##STR1## having activity useful for treating allergies and inflammation.
摘要翻译： 本发明涉及选择的新化合物，以及用于已知和所选新型化合物的药物组合物和方法，其具有可用于治疗过敏和炎症的活性。
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公开(公告)号：US4868205A
公开(公告)日：1989-09-19
申请号：US167272
申请日：1988-03-11
申请人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
发明人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
IPC分类号： C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D307/92 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
CPC分类号： C07D307/92 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
摘要： The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
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公开(公告)号：US4868199A
公开(公告)日：1989-09-19
申请号：US167264
申请日：1988-03-09
申请人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
发明人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
IPC分类号： C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D307/92 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04 , C07D491/048
CPC分类号： C07D307/92 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
摘要： The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
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4.发明授权
公开(公告)号：US4761424A
公开(公告)日：1988-08-02
申请号：US782623
申请日：1985-10-01
申请人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
发明人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
IPC分类号： C07D491/048 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/35 , A61K31/352 , A61K31/38 , A61K31/381 , A61K31/382 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/54 , A61P9/00 , A61P11/00 , A61P25/04 , A61P25/06 , A61P29/00 , A61P37/08 , A61P43/00 , C07D209/12 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/68 , C07D307/83 , C07D307/84 , C07D307/92 , C07D311/22 , C07D311/24 , C07D333/60 , C07D333/64 , C07D333/68 , C07D333/70 , C07D335/06 , C07D491/04
CPC分类号： C07D307/92 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
摘要： The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
摘要翻译： 本发明涉及新型烯醇酰胺型化合物，药物组合物及其使用方法，其可用于治疗其中脂肪氧合酶活性产物或白细胞三烯作用有助于病理状况的疾病。
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5.发明授权N-1H-tetrazol-5-yl-2-thiophene carboxamides, N-1H-tetrazol-5-yl-2-pyrrole carboxamides, N-1H-tetrazol-5-yl-2-furan carboxamides, and anti-allergic and anti-inflammatory use thereof 失效N-1H-四唑-5-基-2-噻吩甲酰胺，N-1H-四唑-5-基-2-吡咯甲酰胺，N-1H-四唑-5-基-2-呋喃甲酰胺和抗过敏和 其抗炎用途
公开(公告)号：US4748183A
公开(公告)日：1988-05-31
申请号：US27453
申请日：1987-03-18
IPC分类号： C07D207/34 , C07D403/12 , C07D405/12 , C07D409/12 , A61K31/41
CPC分类号： C07D403/12 , C07D207/34 , C07D405/12 , C07D409/12
摘要： The present invention is for compounds having the formula of N-1H-tetrazol-5-yl-2-thiophenecarboxamides, N-1H-tetrazol-5-yl-2-pyrrolecarboxamides, N-1H-tetrazol-5-yl-2-furancarboxamides or analogs of each of the carboxamides. The compounds are useful for the treatment of allergic or inflammatory conditions or diseases. Thus, pharmaceutical compositions and methods of use are also the invention. Processes of preparation for the compounds are also the invention.
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6.发明授权Oxo-pyrido[1,2-a]thienopyrimidine compounds and methods for their production 失效氧代 - 吡啶并[1,2-a]噻吩并嘧啶化合物及其制备方法
公开(公告)号：US4230707A
公开(公告)日：1980-10-28
申请号：US70227
申请日：1979-08-27
申请人： Francis J. Tinney , David T. Connor , Wiaczeslaw A. Cetenko , Joseph J. Kerbleski , Roderick J. Sorenson
发明人： Francis J. Tinney , David T. Connor , Wiaczeslaw A. Cetenko , Joseph J. Kerbleski , Roderick J. Sorenson
IPC分类号： C07D495/04 , A61K31/505 , A61P37/08 , C07D333/38 , C07D495/14
CPC分类号： C07D495/14 , C07D333/38
摘要： Oxo-pyrido[1,2-a]thienopyrimidine compounds, salts thereof, methods of production, intermediates in their production, pharmaceutical compositions containing said compounds and methods for treating allergies using said compositions are disclosed.
摘要翻译： 公开了氧 - 吡啶并[1,2-a]噻吩并嘧啶化合物，其盐，生产方法，其制备中间体，含有所述化合物的药物组合物和使用所述组合物治疗过敏症的方法。
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公开(公告)号：US20120077806A1
公开(公告)日：2012-03-29
申请号：US13241802
申请日：2011-09-23
申请人： Nicholas J. Donato , Christiane Wobus , Hollis D. Showalter , Moshe Talpaz , Jeffrey W. Perry , Roderick J. Sorenson , Mary X. O'Riordan , Yafei Jin
发明人： Nicholas J. Donato , Christiane Wobus , Hollis D. Showalter , Moshe Talpaz , Jeffrey W. Perry , Roderick J. Sorenson , Mary X. O'Riordan , Yafei Jin
IPC分类号： A61K31/541 , C12N5/02 , A61K31/5377 , A61K31/53 , A61K31/50 , C07D413/12 , A61K31/496 , A61K31/505 , A61K31/454 , A61K31/4439 , A61K31/44 , A61K31/433 , A61K31/4245 , A61K31/426 , A61K31/42 , A61K31/4164 , A61K31/415 , A61K31/165 , C07D417/12 , C07D253/065 , C07D253/04 , C07D237/06 , C07D239/02 , A61K31/4965 , C07D401/12 , C07D213/57 , C07D285/06 , C07D285/12 , C07D271/10 , C07D277/30 , C07D261/06 , C07D233/90 , C07D231/10 , C07C255/32 , A61P25/28 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00 , A61P35/00 , C12N9/99
CPC分类号： C07D495/04 , C07C255/43 , C07D213/30 , C07D213/32 , C07D213/61 , C07D213/68 , C07D213/74 , C07D213/75 , C07D231/12 , C07D233/54 , C07D233/64 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/08 , C07D251/16 , C07D261/08 , C07D271/04 , C07D271/10 , C07D277/30 , C07D285/12 , C07D285/16 , C07D401/12 , C07D417/12 , C12N9/99
摘要： Disclosed herein are methods of inhibiting a deubiquitinase (DUB), methods of treating pathogenic infections (e.g., viral, bacterial, and/or parasitic), methods of inhibiting cell proliferation, methods of treating a neurodegenerative disease, methods of treating one or more symptoms of a neurodegenerative disease or a genetic disorder, and compounds.
摘要翻译： 本文公开了抑制去泛素酶（DUB），治疗病原体感染（例如病毒，细菌和/或寄生虫）的方法，抑制细胞增殖的方法，治疗神经变性疾病的方法，治疗一种或多种症状的方法 的神经变性疾病或遗传性疾病，以及化合物。
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公开(公告)号：US5306822A
公开(公告)日：1994-04-26
申请号：US988562
申请日：1992-12-10
申请人： Wiaczeslaw A. Cetenko , David T. Connor , Roderick J. Sorenson , Paul C. Unangst , Stephen R. Stabler
发明人： Wiaczeslaw A. Cetenko , David T. Connor , Roderick J. Sorenson , Paul C. Unangst , Stephen R. Stabler
IPC分类号： A61K31/415 , A61K31/42 , A61K31/425 , C07D233/78 , C07D233/86 , C07D233/96 , C07D263/44 , C07D263/46 , C07D277/20 , C07D277/34 , C07D417/06
CPC分类号： C07D263/44 , A61K31/415 , A61K31/42 , A61K31/425 , C07D233/78 , C07D233/86 , C07D233/96 , C07D263/46 , C07D277/20 , C07D417/06
摘要： The present invention is for selected novel compounds, as well as, pharmaceutical compositions and methods of use for known and the selected novel compounds both of the formula ##STR1## having activity useful for treating allergies and inflammation.
摘要翻译： 本发明用于选择的新化合物，以及用于已知和所选新型化合物的药物组合物和方法，其具有可用于治疗过敏和炎症的活性的式（*化学结构*）。
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9.发明授权3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents 失效2-取代噻唑烷酮，恶唑烷酮和咪唑啉酮的3,5-二叔丁基-4-羟基苯基亚甲基衍生物作为抗炎剂
公开(公告)号：US5290800A
公开(公告)日：1994-03-01
申请号：US896299
申请日：1992-06-10
申请人： Wiaczeslaw A. Cetenko , David T. Connor , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst
发明人： Wiaczeslaw A. Cetenko , David T. Connor , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst
IPC分类号： A61K31/415 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61P29/00 , C07D233/96 , C07D263/40 , C07D263/46 , C07D263/48 , C07D277/20 , C07D277/34 , C07D277/36 , C07D277/48 , C07D277/50 , C07D277/54 , C07D203/40
CPC分类号： C07D277/20 , C07D233/96 , C07D263/46 , C07D263/48
摘要： The novel 3,5-ditertiarybutyl-4-hydroxy-phenylmethylene derivative of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents having inhibiting activity for 5-lipoxygenase, cyclooxygenase, or both.
摘要翻译： 2-取代的噻唑烷酮，恶唑烷酮和咪唑啉酮的3,5-二叔丁基-4-羟基 - 苯基亚甲基衍生物作为具有5-脂氧合酶抑制活性，环氧合酶或两者的抗炎剂。
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公开(公告)号：US4931459A
公开(公告)日：1990-06-05
申请号：US438928
申请日：1989-11-17
IPC分类号： C07D307/85 , C07D333/70 , C07D405/12 , C07D409/12
CPC分类号： C07D405/12 , C07D307/85 , C07D333/70 , C07D409/12
摘要： Novel benzothiophenes having antiallergic activity and both novel and other selected benzothiophenes having activity for treating acute respiratory distress syndrome. The benzothiophenes of the present invention are particularly 2-tetrazolylcarboxamides of the benzothiophenes.
摘要翻译： 具有抗过敏活性的新型苯并噻吩和具有治疗急性呼吸窘迫综合征的活性的新型和其它选择的苯并噻吩类。 本发明的苯并噻吩特别是苯并噻吩的2-四唑基甲酰胺。
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