公开(公告)号：US06592612B1

公开(公告)日：2003-07-15

申请号：US09564958

申请日：2000-05-04

申请人： Wilfred Samson ,  Hoa Nguyen ,  Mike Lee ,  Brady Esch ,  Eric Olsen ,  Jeff Valko

发明人： Wilfred Samson ,  Hoa Nguyen ,  Mike Lee ,  Brady Esch ,  Eric Olsen ,  Jeff Valko

IPC分类号： A61F700

CPC分类号： A61F7/12 ,  A61F2007/126

摘要： The present invention relates to catheters for selectively cooling or warming tissue within a patient's vasculature. The present invention utilizes novel heat exchanging devices, which reside inside the catheter body for selectively altering the temperature of fluid that flows through the catheter shaft. In addition, the present invention utilizes novel pumping devices, which reside within a patient's vasculature for withdrawing oxygenated blood into the catheter body where heat exchange occurs across a heat transfer interface for selective cooling or warming of the blood occurs. The present invention can be used in a multiplicity of medical disciplines where it is advantageous to selectively alter the temperature of tissue, including beating heart applications, as well as stopped heart medical interventions.

摘要翻译： 本发明涉及用于选择性地冷却或加热病人脉管系统内的组织的导管。 本发明利用新的热交换装置，它们位于导管主体内部，用于选择性地改变流过导管轴的流体的温度。 此外，本发明利用新的泵送装置，其驻留在患者的脉管系统内，用于将含氧血液抽出到导管体中，导管主体的热交换发生在热传递界面上，用于血液的选择性冷却或升温。 本发明可以用于多种医学学科，其中有选择地改变组织的温度，包括心脏跳动的应用以及停止的心脏医学干预。

公开(公告)号：US06210363B1

公开(公告)日：2001-04-03

申请号：US09256263

申请日：1999-02-23

申请人： Brady Esch ,  Janine Robinson ,  John Macoviak ,  Wilfred Samson ,  Eric Olsen

发明人： Brady Esch ,  Janine Robinson ,  John Macoviak ,  Wilfred Samson ,  Eric Olsen

IPC分类号： A61M2900

CPC分类号： A61B17/12136 ,  A61B17/12109 ,  A61B2017/00252 ,  A61M25/0052 ,  A61M25/10 ,  A61M2025/1052 ,  A61M2025/1097

摘要： The present invention includes an apparatus and methods for differentially perfusing a patient undergoing cardiopulmonary bypass. A cardiopulmonary bypass machine is configured to provide hypothermic oxygenated blood and normothermic oxygenated blood to an aortic balloon catheter. The catheter has arch perfusion ports and corporeal perfusion ports and is introduced into a patient's aorta and navigated transluminally until the occlusion balloon is located in the descending aorta. The occlusion balloon is inflated and hypothermic oxygenated blood is perfused to the arch vessels while normothermic oxygenated blood is perfused to the corporeal circulation. This procedure offers the benefit of cerebral protection from embolic events during cardiopulmonary bypass surgery.

公开(公告)号：US20050004503A1

公开(公告)日：2005-01-06

申请号：US10897491

申请日：2004-07-23

申请人： Wilfred Samson ,  Janine Robinson ,  Brady Esch

发明人： Wilfred Samson ,  Janine Robinson ,  Brady Esch

IPC分类号： A61B17/00 ,  A61B17/12 ,  A61F2/958 ,  A61F7/12 ,  A61M1/36 ,  A61M5/44 ,  A61M25/00 ,  A61M29/02 ,  A61M37/00

CPC分类号： A61M25/1011 ,  A61B17/12022 ,  A61B17/12045 ,  A61B17/12109 ,  A61B17/12136 ,  A61B2017/00243 ,  A61B2017/12127 ,  A61F7/12 ,  A61F2007/126 ,  A61M1/3613 ,  A61M1/369 ,  A61M5/44 ,  A61M25/00 ,  A61M2025/1015 ,  A61M2025/1095 ,  A61M2205/366 ,  A61M2210/125 ,  A61M2210/127

摘要： An apparatus and method are described for quickly inducing therapeutic hypothermia of the heart by perfusing the myocardium with hypothermic fluid in alternatingly antegrade and retrograde directions. The apparatus and method provide rapid cooling of the affected myocardium to achieve optimal myocardial salvage in a patient experiencing acute myocardial infarction. The therapeutic hypothermia system includes one or more coronary artery perfusion catheters, a coronary sinus perfusion catheter and a fluid source for delivering a hypothermically-cooled physiologically-acceptable fluid, such as saline solution, oxygenated venous blood, autologously-oxygenated arterial blood and/or an oxygenated blood substitute. The system may also include one or more guidewires, subselective catheters and/or interventional catheters introduced through a lumen in one or more of the perfusion catheters.

摘要翻译： 描述了一种装置和方法，用于通过在交替顺行和逆行方向上用低温流体灌注心肌来快速诱导心脏的治疗低温。 该装置和方法提供受影响的心肌的快速冷却，以在经历急性心肌梗塞的患者中实现最佳的心肌救助。 治疗低温系统包括一个或多个冠状动脉灌注导管，冠状窦灌注导管和用于递送低温生理学上可接受的流体的流体源，例如盐水溶液，含氧静脉血，自体氧合的动脉血和/或 氧合血液替代品。 该系统还可以包括通过一个或多个灌注导管中的内腔引入的一个或多个导线，子选择性导管和/或介入导管。

公开(公告)号：US4424833A

公开(公告)日：1984-01-10

申请号：US307888

申请日：1981-10-02

申请人： Kenneth A. Spector ,  Wilfred Samson ,  Richard M. DeMello

发明人： Kenneth A. Spector ,  Wilfred Samson ,  Richard M. DeMello

IPC分类号： A61M39/06 ,  A61M5/00 ,  A61M25/00

CPC分类号： A61M39/0606 ,  A61M2039/062 ,  A61M2039/0633 ,  A61M2039/064 ,  A61M2039/0653 ,  A61M2039/0666 ,  A61M2039/0686 ,  Y10T137/7885

摘要： A molded one-piece, self-sealing gasket maintains its seal at all times including during insertion of a tube, such as a catheter, as well as after the tube is withdrawn.

摘要翻译： 模制的一体式自密封垫片始终保持其密封，包括在插入诸如导管的管之前以及在管被拉出之后。

公开(公告)号：US20100256483A1

公开(公告)日：2010-10-07

申请号：US12753492

申请日：2010-04-02

申请人： James Wall ,  Kenneth Wu ,  Eric Willis ,  Zachary J. Malchano ,  Wenkang Qi ,  Wilfred Samson ,  Michael H. Rosenthal

发明人： James Wall ,  Kenneth Wu ,  Eric Willis ,  Zachary J. Malchano ,  Wenkang Qi ,  Wilfred Samson ,  Michael H. Rosenthal

IPC分类号： A61B5/05 ,  A61B8/00 ,  A61B6/00 ,  G08B3/00

CPC分类号： A61B1/3135 ,  A61B1/06 ,  A61B5/05 ,  A61B5/0536 ,  A61B5/4896 ,  A61B8/00

摘要： A device for use in a process that involves accessing an epidural space includes an elongated member having a distal end and a proximal end, a sensor located at the distal end of the elongated member, a handle coupled to the proximal end of the elongated member, and an indicator coupled to the sensor, wherein the indicator is configured to provide a sensory indication for assisting a user to identify a desired entry path to access an epidural space, wherein the indicator is configured to provide the sensory indication based at least in part on a signal received from the sensor.

摘要翻译： 一种在涉及进入硬膜外腔的过程中使用的装置包括具有远端和近端的细长构件，位于细长构件的远端处的传感器，连接到细长构件的近端的手柄， 以及耦合到所述传感器的指示器，其中所述指示器被配置为提供用于帮助用户识别用于访问硬膜外腔的期望进入路径的感觉指示，其中所述指示器被配置为至少部分地基于 从传感器接收的信号。

公开(公告)号：US06669680B1

公开(公告)日：2003-12-30

申请号：US09564281

申请日：2000-05-04

申请人： John Macoviak ,  Wilfred Samson

发明人： John Macoviak ,  Wilfred Samson

IPC分类号： A61M3100

CPC分类号： A61M25/0067 ,  A61B17/12036 ,  A61B17/12045 ,  A61B17/12109 ,  A61B17/12131 ,  A61B17/12136 ,  A61B2017/1205 ,  A61M25/007 ,  A61M25/1002 ,  A61M2025/0037 ,  A61M2025/0073 ,  A61M2025/1072 ,  A61M2025/1095

摘要： The invention is a catheter with a fluid flow divider positioned near the distal end of the catheter for dividing a first lumen into two channels at a point where a second lumen branches from the first lumen, and for selectively perfusing the branch lumen. The invention is particularly suited for use in the aortic arch. The fluid flow divider may comprise one or more inflatable chambers or one or more deployable shrouds comprising a plurality of arms with a webbing extending between adjacent arms. The inflatable chambers may be relatively noncompliant or they may be compliant, exhibiting elastic behavior after initial inflation, to closely fit the aortic lumen size and curvature. The catheter may further include one or more additional or auxiliary flow control members located upstream or downstream from the fluid flow divider to further segment the patient's circulatory system for selective perfusion to different organ systems within the body or to assist in anchoring the catheter in a desired position.

摘要翻译： 本发明是一种导管，其具有定位在导管远端附近的流体分流器，用于在第二腔从第一腔分支的点处将第一腔分成两个通道，并用于选择性地灌注分支腔。 本发明特别适用于主动脉弓。 流体分流器可以包括一个或多个可充气室或一个或多个可展开的护罩，其包括具有在相邻臂之间延伸的织带的多个臂。 充气室可以是相对不符合的，或者它们可以是柔顺的，在初始充气之后表现出弹性，以紧密地适应主动脉腔的尺寸和曲率。 导管还可以包括位于流体分流器的上游或下游的一个或多个附加或辅助流动控制构件，以进一步分割患者的循环系统，以选择性灌注到体内的不同器官系统，或帮助将导管锚定在期望的 位置。