公开(公告)号：US07601286B2

公开(公告)日：2009-10-13

申请号：US10107933

申请日：2002-03-26

申请人： William Benett ,  Peter Krulevitch ,  Mariam Maghribi ,  Julie Hamilton ,  Klint Rose ,  Amy W. Wang

发明人： William Benett ,  Peter Krulevitch ,  Mariam Maghribi ,  Julie Hamilton ,  Klint Rose ,  Amy W. Wang

IPC分类号： B29C33/76

CPC分类号： B29C39/10 ,  B29C33/3842 ,  B29C39/34 ,  B29K2083/00 ,  B29K2083/005 ,  B29L2031/24 ,  B29L2031/756

摘要： A method of forming a polymer-based microfluidic system platform using network building blocks selected from a set of interconnectable network building blocks, such as wire, pins, blocks, and interconnects. The selected building blocks are interconnectably assembled and fixedly positioned in precise positions in a mold cavity of a mold frame to construct a three-dimensional model construction of a microfluidic flow path network preferably having meso-scale dimensions. A hardenable liquid, such as poly (dimethylsiloxane) is then introduced into the mold cavity and hardened to form a platform structure as well as to mold the microfluidic flow path network having channels, reservoirs and ports. Pre-fabricated elbows, T's and other joints are used to interconnect various building block elements together. After hardening the liquid the building blocks are removed from the platform structure to make available the channels, cavities and ports within the platform structure. Microdevices may be embedded within the cast polymer-based platform, or bonded to the platform structure subsequent to molding, to create an integrated microfluidic system. In this manner, the new microfluidic platform is versatile and capable of quickly generating prototype systems, and could easily be adapted to a manufacturing setting.

公开(公告)号：US06201980B1

公开(公告)日：2001-03-13

申请号：US09166236

申请日：1998-10-05

申请人： Christopher B. Darrow ,  Joe H. Satcher, Jr. ,  Stephen M. Lane ,  Abraham P. Lee ,  Amy W. Wang

发明人： Christopher B. Darrow ,  Joe H. Satcher, Jr. ,  Stephen M. Lane ,  Abraham P. Lee ,  Amy W. Wang

IPC分类号： A61B505

CPC分类号： A61B5/0031 ,  A61B5/14532 ,  A61B2562/028

摘要： An implantable chemical sensor system for medical applications is described which permits selective recognition of an analyte using an expandable biocompatible sensor, such as a polymer, that undergoes a dimensional change in the presence of the analyte. The expandable polymer is incorporated into an electronic circuit component that changes its properties (e.g., frequency) when the polymer changes dimension. As the circuit changes its characteristics, an external interrogator transmits a signal transdermally to the transducer, and the concentration of the analyte is determined from the measured changes in the circuit. This invention may be used for minimally invasive monitoring of blood glucose levels in diabetic patients.

摘要翻译： 描述了用于医疗应用的可植入化学传感器系统，其允许使用在分析物存在下经历尺寸变化的可扩展生物相容性传感器（例如聚合物）来选择性识别分析物。 当聚合物改变尺寸时，可膨胀聚合物结合到电子电路组件中，其改变其性质（例如，频率）。 随着电路改变其特性，外部询问器将信号经皮传递至换能器，并根据测量的电路变化确定分析物的浓度。 本发明可用于糖尿病患者血糖水平的微创监测。

公开(公告)号：US06576459B2

公开(公告)日：2003-06-10

申请号：US09815624

申请日：2001-03-23

申请人： Robin R. Miles ,  Amy W. Wang ,  Christopher K. Fuller ,  Asuncion V. Lemoff ,  Kerry A. Bettencourt ,  June Yu

发明人： Robin R. Miles ,  Amy W. Wang ,  Christopher K. Fuller ,  Asuncion V. Lemoff ,  Kerry A. Bettencourt ,  June Yu

IPC分类号： C12M136

CPC分类号： B01L3/5027 ,  B01F13/0059 ,  B01F13/0076 ,  B01L7/52 ,  B01L2200/10 ,  B01L2400/0424 ,  B01L2400/043 ,  G01N1/4077 ,  G01N15/0656 ,  G01N2015/0088 ,  Y10S435/81 ,  Y10S435/962

摘要： A sample preparation and analysis device which incorporates both immunoassays and PCR assays in one compact, field-portable microchip. The device provides new capabilities in fluid and particle control which allows the building of a fluidic chip with no moving parts, thus decreasing fabrication cost and increasing the robustness of the device. The device can operate in a true continuous (not batch) mode. The device incorporates magnetohydrodynamic (MHD) pumps to move the fluid through the system, acoustic mixing and fractionation, dielectropheretic (DEP) sample concentration and purification, and on-chip optical detection capabilities.

公开(公告)号：US06480730B2

公开(公告)日：2002-11-12

申请号：US09742775

申请日：2000-12-20

申请人： Christopher B. Darrow ,  Joe H. Satcher, Jr. ,  Stephen M. Lane ,  Abraham P. Lee ,  Amy W. Wang

发明人： Christopher B. Darrow ,  Joe H. Satcher, Jr. ,  Stephen M. Lane ,  Abraham P. Lee ,  Amy W. Wang

IPC分类号： A61B505

CPC分类号： A61B5/0031 ,  A61B5/14532 ,  A61B2562/028

摘要： An implantable chemical sensor system for medical applications is described which permits selective recognition of an analyte using an expandable biocompatible sensor, such as a polymer, that undergoes a dimensional change in the presence of the analyte. The expandable polymer is incorporated into an electronic circuit component that changes its properties (e.g., frequency) when the polymer changes dimension. As the circuit changes its characteristics, an external interrogator transmits a signal transdermally to the transducer, and the concentration of the analyte is determined from the measured changes in the circuit. This invention may be used for minimally invasive monitoring of blood glucose levels in diabetic patients.

摘要翻译： 描述了用于医疗应用的可植入化学传感器系统，其允许使用在分析物存在下经历尺寸变化的可扩展生物相容性传感器（例如聚合物）来选择性识别分析物。 当聚合物改变尺寸时，可膨胀聚合物结合到电子电路组件中，其改变其性质（例如，频率）。 随着电路改变其特性，外部询问器将信号经皮传递至换能器，并根据测量的电路变化确定分析物的浓度。 本发明可用于糖尿病患者血糖水平的微创监测。

公开(公告)号：US06454759B2

公开(公告)日：2002-09-24

申请号：US09795384

申请日：2001-02-28

申请人： Peter A. Krulevitch ,  Amy W. Wang

发明人： Peter A. Krulevitch ,  Amy W. Wang

IPC分类号： A61K922

CPC分类号： A61K9/0024 ,  A61K9/0009 ,  A61K9/0097

摘要： A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.

摘要翻译： 一种能够在长时间（多达一年）内分泌多种药物的受控剂量的微制剂，完全一体化的药物输送系统。 该装置包括具有尖锐前缘的长而窄的植入物，用于以类似于条子的方式在人的皮肤下植入。 植入物包括：1）一个或多个微加工，集成的零功率，高和恒压产生渗透引擎; 2）用于打开渗透引擎和用于打开药物出口的低功率可寻址单稳态记忆聚合物（SMP）阀; 3）用于从药物填充的微通道分离压力源的微制造聚合物活塞; 4）多种药物/多剂量容量，以及5）各向异性蚀刻，原子锋利的硅前缘，用于在植入期间穿透皮肤。 该装置包括外部安装的控制器，用于控制板上电子装置，其激活植入物的SMP微型阀等。