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36 条记录 (耗时 0.022 秒)

    Microfabricated injectable drug delivery system
    1.
    发明授权
    Microfabricated injectable drug delivery system 失效
    微量注射给药系统

    公开(公告)号：US06454759B2

    公开(公告)日：2002-09-24

    申请号：US09795384

    申请日：2001-02-28

    申请人： Peter A. Krulevitch ,  Amy W. Wang

    发明人： Peter A. Krulevitch ,  Amy W. Wang

    IPC分类号： A61K922

    CPC分类号： A61K9/0024 ,  A61K9/0009 ,  A61K9/0097

    摘要： A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.

    摘要翻译： 一种能够在长时间（多达一年）内分泌多种药物的受控剂量的微制剂，完全一体化的药物输送系统。 该装置包括具有尖锐前缘的长而窄的植入物，用于以类似于条子的方式在人的皮肤下植入。 植入物包括：1）一个或多个微加工，集成的零功率，高和恒压产生渗透引擎; 2）用于打开渗透引擎和用于打开药物出口的低功率可寻址单稳态记忆聚合物（SMP）阀; 3）用于从药物填充的微通道分离压力源的微制造聚合物活塞; 4）多种药物/多剂量容量，以及5）各向异性蚀刻，原子锋利的硅前缘，用于在植入期间穿透皮肤。 该装置包括外部安装的控制器，用于控制板上电子装置，其激活植入物的SMP微型阀等。

    Method for loading shape memory polymer gripper mechanisms
    3.
    发明授权
    Method for loading shape memory polymer gripper mechanisms 有权

    公开(公告)号：US06370757B1

    公开(公告)日：2002-04-16

    申请号：US09568615

    申请日：2000-05-10

    申请人： Abraham P. Lee ,  William J. Benett ,  Daniel L. Schumann ,  Peter A. Krulevitch ,  Joseph P. Fitch

    发明人： Abraham P. Lee ,  William J. Benett ,  Daniel L. Schumann ,  Peter A. Krulevitch ,  Joseph P. Fitch

    IPC分类号： B23P1102

    摘要： A method and apparatus for loading deposit material, such as an embolic coil, into a shape memory polymer (SMP) gripping/release mechanism. The apparatus enables the application of uniform pressure to secure a grip by the SMP mechanism on the deposit material via differential pressure between, for example, vacuum within the SMP mechanism and hydrostatic water pressure on the exterior of the SMP mechanism. The SMP tubing material of the mechanism is heated to above the glass transformation temperature (Tg) while reshaping, and subsequently cooled to below Tg to freeze the shape. The heating and/or cooling may, for example, be provided by the same water applied for pressurization or the heating can be applied by optical fibers packaged to the SMP mechanism for directing a laser beam, for example, thereunto. At a point of use, the deposit material is released from the SMP mechanism by reheating the SMP material to above the temperature Tg whereby it returns to its initial shape. The reheating of the SMP material may be carried out by injecting heated fluid (water) through an associated catheter or by optical fibers and an associated beam of laser light, for example.

    Release mechanism utilizing shape memory polymer material
    4.
    发明授权
    Release mechanism utilizing shape memory polymer material 有权
    使用形状记忆聚合物材料的释放机制

    公开(公告)号：US6102933A

    公开(公告)日：2000-08-15

    申请号：US245832

    申请日：1999-02-05

    申请人： Abraham P. Lee ,  M. Allen Northrup ,  Dino R. Ciarlo ,  Peter A. Krulevitch ,  William J. Benett

    发明人： Abraham P. Lee ,  M. Allen Northrup ,  Dino R. Ciarlo ,  Peter A. Krulevitch ,  William J. Benett

    IPC分类号： A61B17/00 ,  A61B17/12 ,  A61M25/16 ,  A61B17/28

    CPC分类号： A61B17/1214 ,  A61B17/12022 ,  A61B2017/00867 ,  A61B2017/00871 ,  A61B2017/12068 ,  A61B2017/12077

    摘要： Microfabricated therapeutic actuators are fabricated using a shape memory polymer (SMP), a polyurethane-based material that undergoes a phase transformation at a specified temperature (Tg). At a temperature above temperature Tg material is soft and can be easily reshaped into another configuration. As the temperature is lowered below temperature Tg the new shape is fixed and locked in as long as the material stays below temperature Tg. Upon reheating the material to a temperature above Tg, the material will return to its original shape. By the use of such SMP material, SMP microtubing can be used as a release actuator for the delivery of embolic coils through catheters into aneurysms, for example. The microtubing can be manufactured in various sizes and the phase change temperature Tg is determinate for an intended temperature target and intended use.

    摘要翻译： 使用形状记忆聚合物（SMP），在特定温度（Tg）下经历相变的基于聚氨酯的材料制造微制剂治疗致动器。 在高于温度的温度下，Tg材料是柔软的并且可以容易地重塑成另一种构型。 当温度降低到温度Tg以下时，只要材料保持低于温度Tg，新形状就会被固定和锁定。 将材料重新加热至高于Tg的温度时，材料将恢复到原来的形状。 通过使用这种SMP材料，SMP微管可以用作例如通过导管将栓塞线圈输送到动脉瘤中的释放致动器。 微管可以以各种尺寸制造，相变温度Tg对于预期的温度目标和预期用途是确定的。

    Microbiopsy/precision cutting devices
    5.
    发明授权
    Microbiopsy/precision cutting devices 失效
    微生物/精密切割装置

    公开(公告)号：US5928161A

    公开(公告)日：1999-07-27

    申请号：US887780

    申请日：1997-07-03

    申请人： Peter A. Krulevitch ,  Abraham P. Lee ,  M. Allen Northrup ,  William J. Benett

    发明人： Peter A. Krulevitch ,  Abraham P. Lee ,  M. Allen Northrup ,  William J. Benett

    IPC分类号： A61B10/00 ,  A61B10/02 ,  A61B17/00

    CPC分类号： A61B10/0275 ,  A61B2017/00345 ,  A61B2017/00398

    摘要： Devices for performing tissue biopsy on a small scale (microbiopsy). By reducing the size of the biopsy tool and removing only a small amount of tissue or other material in a minimally invasive manner, the risks, costs, injury and patient discomfort associated with traditional biopsy procedures can be reduced. By using micromachining and precision machining capabilities, it is possible to fabricate small biopsy/cutting devices from silicon. These devices can be used in one of four ways 1) intravascularly, 2) extravascularly, 3) by vessel puncture, and 4) externally. Additionally, the devices may be used in precision surgical cutting.

    摘要翻译： 用于小规模进行组织活检的装置（微生物活检）。 通过减小活检工具的尺寸并以微创方式仅去除少量的组织或其它材料，可以减少与传统活检程序相关的风险，成本，损伤和患者的不适。 通过使用微加工和精密加工能力，可以从硅制造小的活检/切割装置。 这些装置可以以四种方式之一使用：1）血管内，2）血管外，3）通过血管穿刺，4）外部使用。 另外，这些装置可用于精密手术切割。

    Microfabricated therapeutic actuator mechanisms
    6.
    发明授权
    Microfabricated therapeutic actuator mechanisms 失效
    微型治疗执行机构

    公开(公告)号：US5645564A

    公开(公告)日：1997-07-08

    申请号：US446146

    申请日：1995-05-22

    申请人： Milton A. Northrup ,  Dino R. Ciarlo ,  Abraham P. Lee ,  Peter A. Krulevitch

    发明人： Milton A. Northrup ,  Dino R. Ciarlo ,  Abraham P. Lee ,  Peter A. Krulevitch

    IPC分类号： A61B17/28 ,  A61B17/00 ,  A61B17/12 ,  B25J7/00 ,  B25J15/02 ,  B81B7/00

    CPC分类号： B81C99/002 ,  A61B17/12022 ,  B25J15/0206 ,  B25J7/00 ,  A61B17/29 ,  A61B2017/00292 ,  A61B2017/00345 ,  A61B2017/00398 ,  A61B2017/1205 ,  A61B2017/12068 ,  A61B2017/12077 ,  A61B2017/12081 ,  A61B2017/2926

    摘要： Electromechanical microstructures (microgrippers), either integrated circuit (IC) silicon-based or precision machined, to extend and improve the application of catheter-based interventional therapies for the repair of aneurysms in the brain or other interventional clinical therapies. These micromechanisms can be specifically applied to release platinum coils or other materials into bulging portions of the blood vessels also known as aneurysms. The "micro" size of the release mechanism is necessary since the brain vessels are the smallest in the body. Through a catheter more than one meter long, the micromechanism located at one end of the catheter can be manipulated from the other end thereof. The microgripper (micromechanism) of the invention will also find applications in non-medical areas where a remotely actuated microgripper or similar actuator would be useful or where micro-assembling is needed.

    摘要翻译： 机电微结构（microgrippers），集成电路（IC）硅基或精密加工，以扩展和改进基于导管的介入治疗在脑或其他介入性临床治疗中的动脉瘤修复的应用。 这些微机制可以专门用于将铂线圈或其他材料释放到也被称为动脉瘤的血管的隆起部分。 释放机制的“微”尺寸是必要的，因为脑血管在体内是最小的。 通过超过一米长的导管，位于导管一端的微机构可以从其另一端被操纵。 本发明的微夹持器（微机构）也将在非医疗领域中得到应用，其中远程致动的微爪或类似的致动器将是有用的或者在需要微组装的地方。

    Microvalve
    10.
    发明授权
    Microvalve 失效
    微型阀门

    公开(公告)号：US5819749A

    公开(公告)日：1998-10-13

    申请号：US898032

    申请日：1997-07-22

    申请人： Abraham P. Lee ,  Peter A. Krulevitch ,  M. Allen Northrup ,  Jimmy C. Trevino

    发明人： Abraham P. Lee ,  Peter A. Krulevitch ,  M. Allen Northrup ,  Jimmy C. Trevino

    IPC分类号： A61B17/00 ,  A61B17/12 ,  A61B17/28 ,  A61B19/00

    CPC分类号： A61B17/12022 ,  G01L1/18 ,  A61B17/29 ,  A61B2017/00292 ,  A61B2017/00318 ,  A61B2017/00345 ,  A61B2017/1205 ,  A61B2017/2926

    摘要： Micromachined thin film cantilever actuators having means for individually controlling the deflection of the cantilevers, valve members, and rudders for steering same through blood vessels, or positioning same within a blood vessel, for example. Such cantilever actuators include tactile sensor arrays mounted on a catheter or guide wire tip for navigation and tissues identification, shape-memory alloy film based catheter/guide wire steering mechanisms, and rudder-based steering devices that allow the selective actuation of rudders that use the flowing blood itself to help direct the catheter direction through the blood vessel. While particularly adapted for medical applications, these cantilever actuators can be used for steering through piping and tubing systems.

    摘要翻译： 微加工薄膜悬臂致动器具有用于单独控制悬臂，阀构件和用于通过血管转向其的方向舵的偏转的装置，或者例如将其定位在血管内。 这种悬臂致动器包括安装在用于导航和组织识别的导管或导丝尖端的触觉传感器阵列，基于形状记忆合金膜的导管/导丝线转向机构和基于方向舵的转向装置，其允许选择性地致动使用 流血本身帮助导管导管通过血管。 虽然这些悬臂式致动器特别适用于医疗应用，但可用于通过管道和管道系统进行转向。