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公开(公告)号：US4802591A
公开(公告)日：1989-02-07
申请号：US167690
申请日：1988-03-14
申请人： William E. Lower , W. Nash McCauley , Stephen C. Mitchell , Roger C. Robins , Steven A. Schmidt
发明人： William E. Lower , W. Nash McCauley , Stephen C. Mitchell , Roger C. Robins , Steven A. Schmidt
CPC分类号： B07B1/54 , B07B1/12 , B07B1/46 , D21B1/023 , B07B2201/04
摘要： A machine and method for separating chip-like particles according to thickness which provides low blinding and high efficiency at high throughput in sustained operation. The machine has a sloping deck mounting a series of spaced flexible louvers or slats which extend parallel to the direction of chip flow down the deck. The slats are canted transversely to the direction of flow, and present unobstructed full length slot-like chip openings between them. The deck is driven with a horizontal gyratory motion such that during the upstream half of each cycle of movement, each slot moves toward chips on the adjacent slat which slopes toward it, and moves away from such chips during the downstream half of the cycle. The path of screening movement is uniform over the entire deck, that is, the motion of the lower or discharge end of the deck matches that of the upper or feed end. Adjacent slats are supported at alternate or staggered positions along their length so that they can deflect slightly relative to one other along their entire length. Ball cleaners are directed to impact on the slats in the transverse direction to deflect them and thereby dislodge chips stuck between the slats.
摘要翻译： 根据厚度分离芯片状颗粒的机器和方法，其在持续操作中以高产量提供低盲目性和高效率。 该机器具有倾斜的甲板，其安装了一系列间隔开的柔性百叶窗或板条，其平行于芯片沿着甲板流动的方向延伸。 板条横向于流动方向倾斜，并且在它们之间呈现无阻碍的全长槽状切屑开口。 甲板由水平回转运动驱动，使得在每个运动循环的上游一半期间，每个槽向靠近其倾斜的相邻板条上的切屑移动，并在该循环的下半部分期间离开这种切屑。 整个甲板上的筛选运动的路径是均匀的，也就是说，甲板的下部或排放端的运动与上部或进料端的运动相匹配。 相邻的板条沿着它们的长度被支撑在交替或交错的位置处，使得它们可以沿其整个长度相对于彼此稍微偏转。 球形清洁剂被引导以在横向上对板条的冲击以使其偏转，从而移除卡在板条之间的碎屑。
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公开(公告)号：US5301814A
公开(公告)日：1994-04-12
申请号：US961430
申请日：1992-10-15
CPC分类号： B07B1/42 , B07B1/38 , Y10T74/18344
摘要： The screening efficiency of a gyratory screening machine, of the type having a moving base, is significantly increased by mounting to the base a spring/mass system which is tuned so that operation of the machine drive produces amplified movement of the mass along at least one of two perpendicular axes on which the base moves. Movement of the mass reduces the net force on the base along the axis on which the mass oscillates. The reaction force of the machine drive on the base along the other of the two perpendicular axes may be offset by a rotary counterbalance operated by the drive. Movement of the base relative to the ground is thereby reduced, and movement of the screen deck relative to ground is increased. This both increases the effectiveness of the screening motion and decreases the total reaction force transmitted through the base.
摘要翻译： 具有移动底座的旋转筛选机的筛选效率通过将弹簧/质量系统安装到基座而显着增加，该弹簧/质量系统被调整为使得机器驱动器的操作产生沿着至少一个 两个垂直轴在基座上移动。 质量的运动减少了基体上沿着质量振荡轴线的净力。 沿着两个垂直轴中的另一个的机器驱动器在基座上的反作用力可能被由驱动器操作的旋转平衡平衡构成。 因此，底座相对于地面的移动减少，并且屏幕甲板相对于地面的运动增加。 这两者都增加了筛选运动的有效性，并降低了通过基底传递的总反作用力。
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公开(公告)号：US5069778A
公开(公告)日：1991-12-03
申请号：US611835
申请日：1990-11-13
CPC分类号： B07B1/4609 , B07B1/12 , B07B1/54
摘要： A screen deck having spaced, canted parallel slats which present screening slots between them, wherein the slats are mounted on pedestals that are positioned and aligned by parallel rods which extend transversely through the pedestals. The pedestals are spaced apart by spacers between them, the spacers being held in place by the rods. Slat mounting is facilitated and slot width uniformity is improved by use of the pedestals.
摘要翻译： 具有间隔开的倾斜平行板条的筛板，其在它们之间形成筛分槽，其中板条安装在基座上，所述基座通过横向延伸穿过基座的平行杆定位和对齐。 基座之间由间隔件间隔开，间隔件通过杆保持就位。 通过使用底座来促进板条安装并提高槽宽均匀性。
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公开(公告)号：US5730297A
公开(公告)日：1998-03-24
申请号：US565628
申请日：1995-11-27
摘要： A screening machine of the moving base type has an oscillating force reducer and a single counterbalance drive, with the weight of the drive counterbalance sized to underbalance the longitudinal reaction force exerted by the deck on the drive shaft, but to substantially overbalance the lateral reaction force exerted by the deck on the drive shaft. The weight of the force reducer, the spring constant of the spring which oscillates the force reducer, and overall cost are surprisingly reduced.
摘要翻译： 移动式底座的筛分机具有摆动力减速器和单个平衡驱动装置，其中驱动平衡重的重量大小使得甲板在驱动轴上施加的纵向反作用力不平衡，但是基本上使横向反作用力过度平衡 由甲板在驱动轴上施加。 力减速器的重量，使减速器振动的弹簧的弹簧常数和总成本惊人地减少。
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公开(公告)号：US4234416A
公开(公告)日：1980-11-18
申请号：US68908
申请日：1979-08-23
CPC分类号： B07B13/16
摘要： In a multiple deck screening machine, the feed material is divided into separate equal fractions as it falls into parallel vertical channels. Each channel serves a particular screen deck via a chute which diverts the respective fraction from the channel onto the screen. The lower chutes include widened portions that extend laterally from their respective channels into areas which are masked or closed above by overlying upper chutes, in order to provide flow areas onto the respective screens which are wider than the channels that feed them, and thereby provide better flow distribution onto the screens.
摘要翻译： 在多层筛选机中，饲料在分离成平行的垂直通道时被分成相等的分数。 每个通道通过滑槽将特定的屏幕卡片服务，该滑槽将相应的分数从通道转移到屏幕上。 下斜槽包括从其各自的通道横向延伸到上面通过覆盖上部斜槽而被掩蔽或闭合的区域的加宽部分，以便在相应的屏幕上提供比供给它们的通道更宽的流动区域，从而提供更好的 流量分布到屏幕上。
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公开(公告)号：US3977728A
公开(公告)日：1976-08-31
申请号：US537359
申请日：1974-12-30
CPC分类号： F01D5/028 , F01D5/282 , Y02T50/672 , Y02T50/673
摘要： A wheel comprising a plurality of wheel plies, each wheel ply including concentric inner and outer hoops and a plurality of circumferentially spaced spoke loops therebetween, wherein each of the spoke loops is entrapped within the hoops. In one embodiment the wheel comprises a laminate of alternating wheel plies and intermediate plies bonded together. A spoked frame comprising one or more of the wheels is provided, the frame including fairing means to substantially envelope the spokes and retain the individual wheels in their proper spacial relationship.
摘要翻译： 包括多个轮子层的车轮，每个车轮帘布层包括同心的内圈和外圈以及在其间的多个周向间隔的轮辐环，其中每个轮辐环被夹在箍中。 在一个实施例中，车轮包括交替的轮子层和粘结在一起的中间帘布层的叠层。 提供了包括一个或多个轮的发射框架，框架包括整流装置，以基本上包围辐条并将各个车轮保持在适当的空间关系。
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公开(公告)号：US20090226921A1
公开(公告)日：2009-09-10
申请号：US12389293
申请日：2009-02-19
申请人： Daniel E. H. AFAR , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas Saffran , Stephen C. Mitchell , Aya Jakobovits , Mary Faris , Igor Vivanco
发明人： Daniel E. H. AFAR , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas Saffran , Stephen C. Mitchell , Aya Jakobovits , Mary Faris , Igor Vivanco
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , G01N33/57419 , G01N33/57434 , G01N33/57488 , G01N2333/95
摘要： Compositions for the diagnosis and therapy of prostate and colon cancer, derived from or based on a novel prostate-specific, androgen-regulated, cell membrane associated and secreted serine protease termed 20P1F12/TMPRSS2 are described. A full length cDNA comprising the entire coding sequence of the 20P1F12/TMPRSS2 gene (also designated 20P1F12-GTC1 herein) is provided (FIG. 1). Among the compositions provided are antibodies that bind to 20P1F12/TMPRSS2 proteins and polypeptide fragments thereof, including antibodies labeled with a detectable marker or toxin or therapeutic composition. The invention also provides prognostic and diagnostic methods of examining a biological sample for evidence of disregulated cellular growth by comparing the status of 20P1F12/TMPRSS2 in the biological sample to the status of 20P1F12/TMPRSS2 in a corresponding normal sample, wherein alterations in the status of 20P1F12/TMPRSS2 in the biological sample are associated with disregulated cellular growth. The invention further provides various therapeutic compositions and strategies for treating prostate cancer, including particularly, 20P1F12/TMPRSS2 polypeptide and anti-20P1F12/TMPRSS2 antibody therapy methods and compositions, cancer vaccines, and small molecule therapy.
摘要翻译： 描述了衍生自或基于称为20P1F12 / TMPRSS2的新型前列腺特异性，雄激素调节的细胞膜相关和分泌的丝氨酸蛋白酶的前列腺和结肠癌的诊断和治疗的组合物。 提供了包含20P1F12 / TMPRSS2基因（本文中也称为20P1F12-GTC1）的整个编码序列的全长cDNA（图1）。 所提供的组合物是结合20P1F12 / TMPRSS2蛋白和其多肽片段的抗体，包括用可检测标记或毒素或治疗组合物标记的抗体。 本发明还提供了通过将生物样品中20P1F12 / TMPRSS2的状态与对应的正常样品中的20P1F12 / TMPRSS2的状态进行比较来检查生物样品以检测细胞生长失调的证据的预后和诊断方法，其中， 生物样品中的20P1F12 / TMPRSS2与细胞生长失调有关。 本发明还提供了治疗前列腺癌的各种治疗组合物和策略，特别包括20P1F12 / TMPRSS2多肽和抗-20P1F12 / TMPRSS2抗体治疗方法和组合物，癌症疫苗和小分子治疗。
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公开(公告)号：US5511604A
公开(公告)日：1996-04-30
申请号：US355128
申请日：1994-12-13
申请人： Richard Ravenhall , Charles R. Wojciechowski , Stephen C. Mitchell , Gary D. Mercer , Thomas J. Kelly , Melvin A. Schobert , Harvey M. Maclin
发明人： Richard Ravenhall , Charles R. Wojciechowski , Stephen C. Mitchell , Gary D. Mercer , Thomas J. Kelly , Melvin A. Schobert , Harvey M. Maclin
CPC分类号： F01D5/282 , C22C1/1036 , Y02T50/672 , Y10S60/909 , Y10T428/12486
摘要： A cast article having a reinforced structural composite core is disclosed. The cast article includes a structural element which is embedded in the otherwise cast metal article. The structural element is comprised of a metal matrix composite structural core. It includes a plurality of reinforcing fibers within a metal matrix. The fibers are generally a non-metallic material such as a ceramic which degrade at a temperature below the melting temperature of the cast metal comprising the article. The metal matrix composite structural core is encased with a sheath. The sheath, attached to and completely surrounding the core, is made of the same metal as the cast metal article. In a preferred embodiment, the article is a titanium alloy strut for a gas turbine engine.
摘要翻译： 公开了一种具有增强结构复合芯的铸造制品。 铸造制品包括嵌入另外的铸造金属制品中的结构元件。 结构元件由金属基复合结构芯构成。 它在金属基体内包括多个增强纤维。 纤维通常是非金属材料，例如陶瓷，其在低于包含制品的铸造金属的熔融温度的温度下降解。 金属基复合结构芯被护套包裹。 附着在并完全围绕芯的护套由与铸造金属制品相同的金属制成。 在优选实施例中，制品是用于燃气涡轮发动机的钛合金支柱。
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公开(公告)号：US5074012A
公开(公告)日：1991-12-24
申请号：US701788
申请日：1991-05-17
申请人： Stephen C. Mitchell
发明人： Stephen C. Mitchell
IPC分类号： B07B1/46 , B07B1/48 , F16B39/282
CPC分类号： F16B39/282 , B07B1/46 , B07B1/48 , Y10T24/44504 , Y10T24/44598 , Y10T24/44974 , Y10T403/32393 , Y10T403/583
摘要： A self-locking clamp has a handle which locks to a non-rotating member if the handle starts to turn while in clamping use. The clamp has a retractable collar which is splined to the handle and is biased toward locking engagement with a sleeve that in turn seats against the member to be clamped. The collar can be held retracted from the sleeve for tightening and loosening the clamp.
摘要翻译： 如果手柄在夹紧使用时开始转动，则自锁夹具具有锁定到非旋转构件的手柄。 夹具具有可伸缩的套环，其可以花键连接到手柄并被偏压以与套筒锁定接合，该套筒又抵靠待夹紧的构件。 套环可以从套筒中缩回以收紧和松开夹具。
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公开(公告)号：US07981624B2
公开(公告)日：2011-07-19
申请号：US12389293
申请日：2009-02-19
申请人： Daniel E. H. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas Saffran , Stephen C. Mitchell , Aya Jakobovits , Mary Faris , Igor Vivanco
发明人： Daniel E. H. Afar , Rene S. Hubert , Kahan Leong , Arthur B. Raitano , Douglas Saffran , Stephen C. Mitchell , Aya Jakobovits , Mary Faris , Igor Vivanco
IPC分类号： G01N33/53
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , G01N33/57419 , G01N33/57434 , G01N33/57488 , G01N2333/95
摘要： Compositions for the diagnosis and therapy of prostate and colon cancer, derived from or based on a novel prostate-specific, androgen-regulated, cell membrane associated and secreted serine protease termed 20P1F12/TMPRSS2 are described. A full length cDNA comprising the entire coding sequence of the 20P1F12/TMPRSS2 gene (also designated 20P1F12-GTC1 herein) is provided (FIG. 1). Among the compositions provided are antibodies that bind to 20P1F12/TMPRSS2 proteins and polypeptide fragments thereof, including antibodies labeled with a detectable marker or toxin or therapeutic composition. The invention also provides prognostic and diagnostic methods of examining a biological sample for evidence of disregulated cellular growth by comparing the status of 20P1F12/TMPRSS2 in the biological sample to the status of 20P1F12/TMPRSS2 in a corresponding normal sample, wherein alterations in the status of 20P1F12/TMPRSS2 in the biological sample are associated with disregulated cellular growth. The invention further provides various therapeutic compositions and strategies for treating prostate cancer, including particularly, 20P1F12/TMPRSS2 polypeptide and anti-20P1F12/TMPRSS2 antibody therapy methods and compositions, cancer vaccines, and small molecule therapy.
摘要翻译： 描述了衍生自或基于称为20P1F12 / TMPRSS2的新型前列腺特异性，雄激素调节的细胞膜相关和分泌的丝氨酸蛋白酶的前列腺和结肠癌的诊断和治疗的组合物。 提供了包含20P1F12 / TMPRSS2基因（本文中也称为20P1F12-GTC1）的整个编码序列的全长cDNA（图1）。 所提供的组合物是结合20P1F12 / TMPRSS2蛋白和其多肽片段的抗体，包括用可检测标记或毒素或治疗组合物标记的抗体。 本发明还提供了通过将生物样品中20P1F12 / TMPRSS2的状态与对应的正常样品中的20P1F12 / TMPRSS2的状态进行比较来检查生物样品以检测细胞生长失调的证据的预后和诊断方法，其中， 生物样品中的20P1F12 / TMPRSS2与细胞生长失调有关。 本发明还提供了治疗前列腺癌的各种治疗组合物和策略，特别包括20P1F12 / TMPRSS2多肽和抗-20P1F12 / TMPRSS2抗体治疗方法和组合物，癌症疫苗和小分子治疗。
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