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公开(公告)号：US20100266658A1
公开(公告)日：2010-10-21
申请号：US12684448
申请日：2010-01-08
申请人： William F. McKay , Scott D. Boden , Neil Beals
发明人： William F. McKay , Scott D. Boden , Neil Beals
CPC分类号： A61B17/707 , A61B17/8085 , A61B2017/00004 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2430/02 , C07K14/51 , C07K14/78 , Y10S514/801
摘要： Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.
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2.发明申请公开(公告)号：US20100266660A1
公开(公告)日：2010-10-21
申请号：US12684480
申请日：2010-01-08
申请人： William F. McKay , Scott D. Boden , Neil Beals
发明人： William F. McKay , Scott D. Boden , Neil Beals
CPC分类号： A61B17/707 , A61B17/8085 , A61B2017/00004 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2430/02 , C07K14/51 , C07K14/78 , Y10S514/801
摘要： Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.
摘要翻译： 描述的是成骨植入物，其包括至少部分地由承载成骨蛋白质例如骨形态发生蛋白质的第二种植体材料覆盖的第一种植体材料。 第一植入材料可以包括矿物并且提供用于支撑骨向内生长的内部支架部分，并且第二植入材料可以包括覆盖第一植入材料并且具有吸入其中的液体成骨蛋白质制剂的胶原蛋白或其它海绵载体。 相关植入材料及其制备和使用方法构成本发明的另外方面。
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3.发明授权Osteogenic implants with combined implant materials, and materials and methods for same 有权具有组合种植体材料的成骨植入物，以及用于其的材料和方法公开(公告)号：US07722895B1
公开(公告)日：2010-05-25
申请号：US11361026
申请日：2006-02-23
申请人： William F. McKay , Scott D. Boden , Neil Beals
发明人： William F. McKay , Scott D. Boden , Neil Beals
IPC分类号： A61F2/00 , A61F2/02 , A61F2/28 , A61K38/00 , A61K38/16 , A61K38/17 , A61K38/18 , C07K14/78 , C07K14/51
CPC分类号： A61B17/707 , A61B17/8085 , A61B2017/00004 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2430/02 , C07K14/51 , C07K14/78 , Y10S514/801
摘要： Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.
摘要翻译： 描述的是成骨植入物，其包括至少部分地由承载成骨蛋白质例如骨形态发生蛋白质的第二种植体材料覆盖的第一种植体材料。 第一植入材料可以包括矿物并且提供用于支撑骨向内生长的内部支架部分，并且第二植入材料可以包括覆盖第一植入材料并且具有吸入其中的液体成骨蛋白质制剂的胶原蛋白或其它海绵载体。 相关植入材料及其制备和使用方法构成本发明的另外方面。
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4.发明申请OSTEOGENIC IMPLANTS WITH COMBINED IMPLANT MATERIALS AND METHODS FOR SAME 有权具有组合植入物的OSTEOGENIC植入物及其方法公开(公告)号：US20100266661A1
公开(公告)日：2010-10-21
申请号：US12687518
申请日：2010-01-14
申请人： William F. McKay , Scott D. Boden , Neil B. Beals
发明人： William F. McKay , Scott D. Boden , Neil B. Beals
CPC分类号： A61B17/707 , A61B17/8085 , A61B2017/00004 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2430/02 , C07K14/51 , C07K14/78 , Y10S514/801
摘要： Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.
摘要翻译： 描述的是成骨植入物，其包括至少部分地由承载成骨蛋白质例如骨形态发生蛋白质的第二种植体材料覆盖的第一种植体材料。 第一植入材料可以包括矿物并且提供用于支撑骨向内生长的内部支架部分，并且第二植入材料可以包括覆盖第一植入材料并且具有吸入其中的液体成骨蛋白质制剂的胶原蛋白或其它海绵载体。 相关植入材料及其制备和使用方法构成本发明的另外方面。
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公开(公告)号：US08148329B2
公开(公告)日：2012-04-03
申请号：US12687518
申请日：2010-01-14
申请人： William F. McKay , Scott D. Boden , Neil B. Beals
发明人： William F. McKay , Scott D. Boden , Neil B. Beals
CPC分类号： A61B17/707 , A61B17/8085 , A61B2017/00004 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2430/02 , C07K14/51 , C07K14/78 , Y10S514/801
摘要： Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.
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公开(公告)号：US08916691B2
公开(公告)日：2014-12-23
申请号：US11545349
申请日：2006-10-10
IPC分类号： C07K1/36 , C07K1/22 , C07K14/435 , C07K16/18 , C07K14/78 , A61L27/38 , C07K14/47 , A61K48/00 , A61K35/12 , A61K35/00
CPC分类号： A61L27/3856 , A61K35/12 , A61K35/13 , A61K48/00 , A61K2121/00 , C07K14/47 , C07K14/78 , C07K16/18 , C12N2799/022
摘要： Methods of expressing LIM mineralization protein in mammalian cells are described. Methods of expressing LIM mineralization protein and assessing glycosylation of the LIM mineralization protein in prokaryotic and non-mammalian eukaryotic cells are also described. The methods involve transfecting the cells with an isolated nucleic acid comprising a nucleotide sequence encoding a LIM mineralization protein. Transfection may be accomplished in vitro, ex vivo or in vivo by direct injection of virus or naked DNA, or by a nonviral vector such as a plasmid.
摘要翻译： 描述了在哺乳动物细胞中表达LIM矿化蛋白的方法。 还描述了在原核和非哺乳动物真核细胞中表达LIM矿化蛋白和评估LIM矿化蛋白的糖基化的方法。 所述方法包括用包含编码LIM矿化蛋白的核苷酸序列的分离的核酸转染细胞。 转染可以通过直接注射病毒或裸露DNA或非病毒载体如质粒在体外，离体或体内完成。
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7.发明授权公开(公告)号：US08470354B2
公开(公告)日：2013-06-25
申请号：US12684480
申请日：2010-01-08
申请人： William F. McKay , Scott D. Boden , Neil B. Beals
发明人： William F. McKay , Scott D. Boden , Neil B. Beals
IPC分类号： A61F2/00 , A61F2/02 , A61F2/28 , A61K38/00 , A61K38/16 , A61K38/17 , A61K38/18 , C07K14/78 , C07K14/51
CPC分类号： A61B17/707 , A61B17/8085 , A61B2017/00004 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2430/02 , C07K14/51 , C07K14/78 , Y10S514/801
摘要： Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.
摘要翻译： 描述的是成骨植入物，其包括至少部分地由承载成骨蛋白质例如骨形态发生蛋白质的第二种植体材料覆盖的第一种植体材料。 第一植入材料可以包括矿物并且提供用于支撑骨向内生长的内部支架部分，并且第二植入材料可以包括覆盖第一植入材料并且具有吸入其中的液体成骨蛋白质制剂的胶原蛋白或其它海绵载体。 相关植入材料及其制备和使用方法构成本发明的另外方面。
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8.发明授权公开(公告)号：US08092823B2
公开(公告)日：2012-01-10
申请号：US12684448
申请日：2010-01-08
申请人： William F. McKay , Scott D. Boden , Neil B. Beals
发明人： William F. McKay , Scott D. Boden , Neil B. Beals
IPC分类号： A61F2/00 , A61F2/02 , A61F2/28 , A61K38/00 , A61K38/16 , A61K38/17 , A61K38/18 , C07K14/78 , C07K14/51
CPC分类号： A61B17/707 , A61B17/8085 , A61B2017/00004 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2430/02 , C07K14/51 , C07K14/78 , Y10S514/801
摘要： Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.
摘要翻译： 描述的是成骨植入物，其包括至少部分地由承载成骨蛋白质例如骨形态发生蛋白质的第二种植体材料覆盖的第一种植体材料。 第一植入材料可以包括矿物并且提供用于支撑骨向内生长的内部支架部分，并且第二植入材料可以包括覆盖第一植入材料并且具有吸入其中的液体成骨蛋白质制剂的胶原蛋白或其它海绵载体。 相关植入材料及其制备和使用方法构成本发明的另外方面。
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9.发明授权Method for inducing deposition and maturation of bone comprising a co-therapeutic regimen of LMP-1 and BMP-2 有权诱导骨沉积和成熟的方法，包括LMP-1和BMP-2的共同治疗方案公开(公告)号：US07504374B2
公开(公告)日：2009-03-17
申请号：US11385612
申请日：2006-03-21
CPC分类号： A61K38/1709 , A61K38/1875 , A61K2300/00
摘要： The present invention relates to the methods and compositions for the treatment of subjects having compromised bone conditions. Specifically, the invention relates to combinatorial therapeutic strategies including small molecules and peptide mimics of LIM mineralization proteins, particularly LMP-1, to overcome the dose-related translational barriers for BMP-2 therapeutics.
摘要翻译： 本发明涉及用于治疗受损骨患者的方法和组合物。 具体地，本发明涉及包括LIM矿化蛋白（特别是LMP-1）的小分子和肽模拟物的组合治疗策略，以克服BMP-2治疗剂的剂量相关翻译屏障。
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公开(公告)号：US09616153B2
公开(公告)日：2017-04-11
申请号：US12104564
申请日：2008-04-17
申请人： William F. McKay
发明人： William F. McKay
CPC分类号： A61L27/56 , A61F2/2803 , A61F2002/2817 , A61F2002/30062 , A61F2002/3092 , A61F2002/3096 , A61F2210/0004 , A61F2310/00293 , A61F2310/00365 , A61L27/40 , A61L27/54 , A61L2300/414 , A61L2430/02
摘要： A bone graft substitute includes a porous matrix at least partially covered by a reinforcing outer layer. The porous matrix may be a collagen-ceramic composite, and the reinforcing outer layer may be formed from highly cross-linked collagen. The implant may also include one or more reinforcement ribs, which may be made from calcium phosphate or dense collagen. In addition, the bone graft substitute preferably includes an effective amount of a bioactive agent, such as BMP-2, rhBMP-2, or functional fragments thereof. The bioactive agent is preferably disposed within the porous matrix.
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