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公开(公告)号：US4326033A
公开(公告)日：1982-04-20
申请号：US146823
申请日：1980-05-05
CPC分类号： C12N9/6462 , C12N9/00 , C12Y304/21073 , A61K38/00
摘要： Described is a structurally modified urokinase which is biologically active over an extended time period in comparison to native urokinase. The extended activity permits the administration of lower doses of urokinase when it is used in the treatment of thromboembolic diseases. Methods of appropriately modifying the structure of urokinase are described.
摘要翻译： 描述了与天然尿激酶相比在延长的时间段内具有生物活性的结构修饰的尿激酶。 延长的活性允许在用于治疗血栓栓塞性疾病时施用较低剂量的尿激酶。 描述适当改变尿激酶结构的方法。
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2.发明授权Deoxyribonucleic acid synthesis using binding protein extracted from chick embryo fibroblasts 失效使用从鸡胚成纤维细胞提取的结合蛋白的脱氧核糖核酸合成
公开(公告)号：US4331589A
公开(公告)日：1982-05-25
申请号：US254726
申请日：1981-04-16
申请人： Paul P. Hung , Shaw-Guang Lee
发明人： Paul P. Hung , Shaw-Guang Lee
CPC分类号： C12P19/34 , C12N15/1096 , Y10S530/808 , Y10S530/821 , Y10S530/826
摘要： Described is a method of obtaining complete copying of the entire length of single stranded ribonucleic acid (RNA) into its complementary deoxyribonucleic acid (cDNA) by reverse transcription using binding protein. The method can be used in recombinant DNA research to copy total messenger RNA into DNA.
摘要翻译： 描述了通过使用结合蛋白的逆转录获得将全长的单链核糖核酸（RNA）完全复制到其互补的脱氧核糖核酸（cDNA）中的方法。 该方法可用于重组DNA研究，将总信使RNA复制到DNA中。
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3.发明授权
公开(公告)号：US4370417A
公开(公告)日：1983-01-25
申请号：US137032
申请日：1980-04-03
申请人： Paul P. Hung , Shaw-Guang Lee , Ranajit Roychoudhury , Barry J. Ratzkin , W. Jurgen Schrenk , Michael C. Chen
发明人： Paul P. Hung , Shaw-Guang Lee , Ranajit Roychoudhury , Barry J. Ratzkin , W. Jurgen Schrenk , Michael C. Chen
IPC分类号： A61K38/04 , A61K38/46 , A61P7/02 , C07H21/00 , C07H21/04 , C07K14/745 , C12N1/14 , C12N1/18 , C12N1/20 , C12N1/21 , C12N9/64 , C12N9/72 , C12N15/00 , C12N15/09 , C12P21/00 , C12R1/19 , C12R1/91
CPC分类号： C12N9/6462 , C12Y304/21073 , Y10S530/808
摘要： The present invention provides a deoxyribonucleic acid (DNA) segment related to a human plasminogen activator gene. The segment is inserted into a plasmid vector which in turn can be incorporated into a bacterium or other microorganism. The bacterium can then be cultured to produce a plasminogen activator protein having properties of human urokinase.
摘要翻译： 本发明提供与人纤溶酶原激活物基因相关的脱氧核糖核酸（DNA）片段。 将片段插入质粒载体，其又可以并入细菌或其他微生物中。 然后可以培养细菌以产生具有人尿激酶特性的纤溶酶原激活物蛋白。
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4.发明授权Recombinant deoxyribonucleic acid which codes for plasminogen activator and method of making plasminogen activator protein therefrom 失效编码纤溶酶原激活物的重组脱氧核糖核酸及其制备纤溶酶原激活蛋白的方法
公开(公告)号：US4558010A
公开(公告)日：1985-12-10
申请号：US415491
申请日：1982-09-07
摘要： The present invention provides a deoxyribonucleic acid (DNA) segment related to a human plasminogen activator gene. The segment is inserted into a plasmid vector which in turn can be incorporated into a bacterium or other microorganism. The bacterium can then be cultured to produce a plasminogen activator protein having properties of human urokinase.
摘要翻译： 本发明提供与人纤溶酶原激活物基因相关的脱氧核糖核酸（DNA）片段。 将片段插入质粒载体，其又可以并入细菌或其他微生物中。 然后可以培养细菌以产生具有人尿激酶特性的纤溶酶原激活物蛋白。
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