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公开(公告)号：US06495560B1
公开(公告)日：2002-12-17
申请号：US09857316
申请日：2001-07-12
申请人： William H. Miller , Peter J. Manley
发明人： William H. Miller , Peter J. Manley
IPC分类号： A61K31435
CPC分类号： C07D471/04 , A61K31/47 , A61K33/24 , A61K31/435 , A61K2300/00
摘要： A compound of the formula (I) is disclosed which is a vitronectin receptor antagonist and is useful in the treatment of osteoporosis: or a pharmaceutically acceptable salt thereof.
摘要翻译： 公开了式（I）化合物，其是玻连蛋白受体拮抗剂，可用于治疗骨质疏松症：或其药学上可接受的盐。
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公开(公告)号：US06881736B1
公开(公告)日：2005-04-19
申请号：US10070057
申请日：2000-09-07
IPC分类号： A61K31/44 , A61K31/4427 , A61K31/444 , C07D213/74 , C07D413/08 , C07D413/12 , C07D417/08 , C07D417/12 , C07D471/04
CPC分类号： C07D213/74 , C07D413/12 , C07D417/12 , C07D471/04
摘要： Compounds of the formula (I) are disclosed which are vitronectin receptor antagonists and are useful in the treatment of osteoporosis: wherein R1 is Het or Ar R2 is or a pharmaceutically acceptable salt thereof.
摘要翻译： 公开了式（I）的化合物，其是玻连蛋白受体拮抗剂，可用于治疗骨质疏松症：其中R 1是Het或Ar R 2或其药学上可接受的盐 其可接受的盐。
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公开(公告)号：US06458814B1
公开(公告)日：2002-10-01
申请号：US09762406
申请日：2001-02-07
申请人： Peter J. Manley , William H. Miller
发明人： Peter J. Manley , William H. Miller
IPC分类号： C07D41312
CPC分类号： C07D413/12
摘要： Compounds of the formula (I) are disclosed which are vitronectin receptor antagonists and are useful in the treatment of osteoporosis: or a pharmaceutically acceptable salt thereof.
摘要翻译： 公开了式（I）的化合物，其是玻连蛋白受体拮抗剂，可用于治疗骨质疏松症：或其药学上可接受的盐。
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公开(公告)号：US07544677B2
公开(公告)日：2009-06-09
申请号：US11659606
申请日：2005-08-19
申请人： Mark T. Bilodeau , Nicholas D. P. Cosford , John C. Hartnett , Yiwei Li , Jun Liang , Peter J. Manley , Lou Anne Neilson , Tony Siu , Zhicai Wu
发明人： Mark T. Bilodeau , Nicholas D. P. Cosford , John C. Hartnett , Yiwei Li , Jun Liang , Peter J. Manley , Lou Anne Neilson , Tony Siu , Zhicai Wu
IPC分类号： A61K31/541 , A61K31/5355 , A61K31/519 , C07D471/04 , C07D519/00 , A61P35/00
CPC分类号： C07D471/04
摘要： The present invention is directed to compounds which contain substituted 5-deazapteridine moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
摘要翻译： 本发明涉及含有抑制Akt（丝氨酸/苏氨酸蛋白激酶）活性的取代的5-取代哌啶部分的化合物。 本发明还涉及含有本发明化合物的治疗组合物和治疗癌症的方法，包括施用本发明化合物。
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公开(公告)号：US06586423B2
公开(公告)日：2003-07-01
申请号：US10061817
申请日：2002-02-01
IPC分类号： C07D41312
CPC分类号： C07D417/12 , C07D417/14
摘要： The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
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公开(公告)号：US20200262826A1
公开(公告)日：2020-08-20
申请号：US16646616
申请日：2018-09-14
申请人： Ian M. BELL , Brendan M. CROWLEY , Peter J. MANLEY , William D. SHIPE , Merck Sharp & Dohme Corp.
IPC分类号： C07D413/08 , C07D413/14 , C07D417/08 , C07D417/14 , A61P25/28 , A61P25/16 , A61P25/18
摘要： The present disclosure relates to compounds of formula I that are useful as modulators of 7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation (I).
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公开(公告)号：US07910561B2
公开(公告)日：2011-03-22
申请号：US11792121
申请日：2005-12-09
申请人： Jeannie M. Arruda , Brian T. Campbell , Nicholas D. P. Cosford , Jacob M. Hoffman , Essa H. Hu , Mark E. Layton , Yiwei Li , Jun Liang , Kevin J. Rodzinak , Tony Siu , Brian A. Stearns , Lida R. Tehrani , Mark T. Bilodeau , Peter J. Manley
发明人： Jeannie M. Arruda , Brian T. Campbell , Nicholas D. P. Cosford , Jacob M. Hoffman , Essa H. Hu , Mark E. Layton , Yiwei Li , Jun Liang , Kevin J. Rodzinak , Tony Siu , Brian A. Stearns , Lida R. Tehrani , Mark T. Bilodeau , Peter J. Manley
IPC分类号： A01N43/04 , A01N43/58 , A01N43/42 , A61K31/541 , A61K31/70 , A61K31/50 , A61K31/495 , A61K31/52 , C09B25/00 , C07D487/00 , C07D491/00 , C07H15/00
CPC分类号： C07D471/04
摘要： The present invention is directed to compounds which contain substituted naphthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention. These substituted naphthyridines have unexpected advantageous properties when compared to other naphthyridines reported in PCT publication WO2003/086394, such unexpected advantageous properties may include increased cellular potency/solubility, greater selectivity, enhanced pharmacokinetic properties, lack of off target activity and so on.
摘要翻译： 本发明涉及含有抑制Akt（丝氨酸/苏氨酸蛋白激酶）活性的取代萘啶的化合物。 本发明还涉及含有本发明化合物的治疗组合物和治疗癌症的方法，包括施用本发明化合物。 与PCT公开WO2003 / 086394中报道的其它萘啶类相比，这些取代的萘啶具有意想不到的有利性质，这种意想不到的有利性质可包括增加的细胞效力/溶解度，更大的选择性，增强的药物动力学性质，缺乏目标活性等。
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公开(公告)号：US07750151B2
公开(公告)日：2010-07-06
申请号：US11547113
申请日：2005-04-05
申请人： Mark T. Bilodeau , Chixu Chen , Nicholas D. P. Cosford , Brian W. Eastman , John C. Hartnett , Essa H. Hu , Peter J. Manley , Lou Anne Neilson , Lida R. Tehrani , Zhicai Wu
发明人： Mark T. Bilodeau , Chixu Chen , Nicholas D. P. Cosford , Brian W. Eastman , John C. Hartnett , Essa H. Hu , Peter J. Manley , Lou Anne Neilson , Lida R. Tehrani , Zhicai Wu
IPC分类号： C07D471/04 , C07D413/12 , C07D521/00 , C07D401/14 , C07D487/08 , A61P35/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The present invention is directed to compounds which contain substituted napthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
摘要翻译： 本发明涉及含有抑制Akt（丝氨酸/苏氨酸蛋白激酶）活性的取代萘啶的化合物。 本发明还涉及含有本发明化合物的治疗组合物和治疗癌症的方法，包括施用本发明化合物。
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9.发明授权Inhibitors of catechol O-methyl transferase and their use in the treatment of psychotic disorders 有权儿茶酚O-甲基转移酶的抑制剂及其在治疗精神病中的应用公开(公告)号：US09024032B2
公开(公告)日：2015-05-05
申请号：US13582601
申请日：2011-02-28
申请人： Scott Wolkenberg , James C. Barrow , Michael S. Poslusney , Scott T. Harrison , B. Wesley Trotter , James Mulhearn , Kausik K. Nanda , Peter J. Manley , Zhijian Zhao , Jeffrey W. Schubert , Nathan Kett , Amy Zartman
发明人： Scott Wolkenberg , James C. Barrow , Michael S. Poslusney , Scott T. Harrison , B. Wesley Trotter , James Mulhearn , Kausik K. Nanda , Peter J. Manley , Zhijian Zhao , Jeffrey W. Schubert , Nathan Kett , Amy Zartman
IPC分类号： A61K31/44 , C07D211/90 , C07D213/69 , A61K31/4412 , A61K31/4418 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/5377 , A61K31/541 , A61K31/69 , A61K45/06 , C07D213/73 , C07D213/74 , C07D401/10 , C07D401/14 , C07D413/10 , C07D413/12 , C07D417/10 , C07D471/04 , C07F5/02 , C07D401/04 , C07D401/06
CPC分类号： C07F5/025 , A61K31/4412 , A61K31/4418 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/5377 , A61K31/541 , A61K31/69 , A61K45/06 , C07D213/69 , C07D213/73 , C07D213/74 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D413/10 , C07D413/12 , C07D417/10 , C07D471/04
摘要： The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. The present invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which COMT is involved.
摘要翻译： 本发明涉及作为儿茶酚O-甲基转移酶（COMT）的抑制剂的4-吡啶酮化合物，可用于治疗和预防涉及COMT酶的神经和精神疾病和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及COMT的疾病中的用途。
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10.发明申请公开(公告)号：US20130084346A1
公开(公告)日：2013-04-04
申请号：US13582601
申请日：2011-02-28
申请人： Scott Wolkenberg , James C. Barrow , Michael S. Poslusney , Scott T. Harrison , B. Wesley Trotter , James Mulhearn , Kausik K. Nanda , Peter J. Manley , Zhijian Zhao , Jeffrey W. Schubert , Nathan Kett , Amy Zartman
发明人： Scott Wolkenberg , James C. Barrow , Michael S. Poslusney , Scott T. Harrison , B. Wesley Trotter , James Mulhearn , Kausik K. Nanda , Peter J. Manley , Zhijian Zhao , Jeffrey W. Schubert , Nathan Kett , Amy Zartman
IPC分类号： C07D213/69 , C07D401/10 , A61K31/4439 , C07D213/73 , C07D213/74 , C07F5/02 , A61K31/69 , A61K31/444 , C07D401/14 , C07D471/04 , A61K31/4725 , A61K31/4709 , A61K45/06 , C07D413/10 , A61K31/5377 , A61K31/4545 , C07D417/10 , A61K31/541 , C07D413/12 , A61K31/4418
CPC分类号： C07F5/025 , A61K31/4412 , A61K31/4418 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/5377 , A61K31/541 , A61K31/69 , A61K45/06 , C07D213/69 , C07D213/73 , C07D213/74 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D413/10 , C07D413/12 , C07D417/10 , C07D471/04
摘要： The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. The present invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which COMT is involved.
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