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    SYNTHETIC STREPTOCOCCUS PNEUMONIAE VACCINE
    3.
    发明申请
    SYNTHETIC STREPTOCOCCUS PNEUMONIAE VACCINE 有权
    合成环孢菌素疫苗

    公开(公告)号：US20100143394A1

    公开(公告)日：2010-06-10

    申请号：US12442044

    申请日：2007-09-26

    申请人： Karim C. El Kasmi ,  Brad Jordan ,  Richard Kriwacki ,  Beth Mann ,  Carlos J. Orihuela ,  Elaine Tuomanen

    发明人： Karim C. El Kasmi ,  Brad Jordan ,  Richard Kriwacki ,  Beth Mann ,  Carlos J. Orihuela ,  Elaine Tuomanen

    IPC分类号： A61K39/02 ,  C07K14/315 ,  A61P31/04 ,  A61P37/04

    CPC分类号： C07K14/3156 ,  A61K39/00

    摘要： Compositions and methods for preventing and treating pneumococcal infections are provided. Compositions include novel polypeptides comprising an amino acid sequence corresponding to the R2i or R22 domain of CbpA or a consensus sequence of one of these domains, and variants and fragments thereof, wherein the polypeptide is stabilized in a desired conformation, particularly a loop conformation. The polypeptides of the invention may be engineered to comprise a first and a second cysteine residue, thereby resulting in the formation of a disulfide bond that stabilizes the polypeptide in the desired conformation. Alternatively, a polypeptide of the invention may be modified to create a synthetic linkage between a first and second amino acid residue present within the polypeptide, wherein the synthetic linkage stabilizes the polypeptide in the desired conformation. The polypeptides of the invention may further comprise an amino acid sequence for a T cell epitope. Compositions further include isolated nucleic acid molecules that encode the polypeptides of the invention, immunogenic compositions and vaccines comprising the disclosed polypeptides, and antibodies specific for these polypeptides.

    摘要翻译： 提供了预防和治疗肺炎球菌感染的组合物和方法。 组合物包括包含对应于CbpA的R2i或R22结构域的氨基酸序列或这些结构域之一的共有序列及其变体和片段的新型多肽，其中所述多肽被稳定为期望的构象，特别是环构象。 本发明的多肽可被工程化以包含第一和第二半胱氨酸残基，由此导致二硫键的形成，从而将多肽稳定在所需构象。 或者，可以修饰本发明的多肽以在多肽内存在的第一和第二氨基酸残基之间产生合成连接，其中所述合成连接使所述多肽以所需构象稳定。 本发明的多肽还可以包含T细胞表位的氨基酸序列。 组合物还包括编码本发明多肽的分离的核酸分子，包含所公开的多肽的免疫原性组合物和疫苗以及对这些多肽特异的抗体。

    Synthetic Streptococcus pneumoniae vaccine
    4.
    发明授权
    Synthetic Streptococcus pneumoniae vaccine 有权
    合成型肺炎链球菌疫苗

    公开(公告)号：US08722055B2

    公开(公告)日：2014-05-13

    申请号：US12442044

    申请日：2007-09-26

    申请人： Karim C. El Kasmi ,  Brad Jordan ,  Richard Kriwacki ,  Beth Mann ,  Carlos J. Orihuela ,  Elaine Tuomanen

    发明人： Karim C. El Kasmi ,  Brad Jordan ,  Richard Kriwacki ,  Beth Mann ,  Carlos J. Orihuela ,  Elaine Tuomanen

    IPC分类号： A61K39/02 ,  A61K39/385 ,  A61K39/085 ,  A61K39/09 ,  A61K45/00 ,  A61K47/00 ,  A61K47/48 ,  C07K16/12 ,  C07K14/005

    CPC分类号： C07K14/3156 ,  A61K39/00

    摘要： Compositions and methods for preventing and treating pneumococcal infections are provided. Compositions include novel polypeptides comprising an amino acid sequence corresponding to the R2i or R22 domain of CbpA or a consensus sequence of one of these domains, and variants and fragments thereof, wherein the polypeptide is stabilized in a desired conformation, particularly a loop conformation. The polypeptides of the invention may be engineered to comprise a first and a second cysteine residue, thereby resulting in the formation of a disulfide bond that stabilizes the polypeptide in the desired conformation. Alternatively, a polypeptide of the invention may be modified to create a synthetic linkage between a first and second amino acid residue present within the polypeptide, wherein the synthetic linkage stabilizes the polypeptide in the desired conformation. The polypeptides of the invention may further comprise an amino acid sequence for a T cell epitope. Compositions further include isolated nucleic acid molecules that encode the polypeptides of the invention, immunogenic compositions and vaccines comprising the disclosed polypeptides, and antibodies specific for these polypeptides.

    摘要翻译： 提供了预防和治疗肺炎球菌感染的组合物和方法。 组合物包括包含对应于CbpA的R2i或R22结构域的氨基酸序列或这些结构域之一的共有序列及其变体和片段的新型多肽，其中所述多肽被稳定为期望的构象，特别是环构象。 本发明的多肽可被工程化以包含第一和第二半胱氨酸残基，由此导致二硫键的形成，从而将多肽稳定在所需构象。 或者，可以修饰本发明的多肽以在多肽内存在的第一和第二氨基酸残基之间产生合成连接，其中所述合成连接使所述多肽以所需构象稳定。 本发明的多肽还可以包含T细胞表位的氨基酸序列。 组合物还包括编码本发明多肽的分离的核酸分子，包含所公开的多肽的免疫原性组合物和疫苗以及对这些多肽特异的抗体。

    System and method for advertisement delivery within a video time shifting architecture
    10.
    发明申请
    System and method for advertisement delivery within a video time shifting architecture 有权
    视频时移结构中广告传送的系统和方法

    公开(公告)号：US20050060229A1

    公开(公告)日：2005-03-17

    申请号：US10899289

    申请日：2004-07-26

    申请人： Steve Riedl ,  Erik Urdang ,  Tom Gonder ,  Bryan Santangelo ,  Brad Jordan

    发明人： Steve Riedl ,  Erik Urdang ,  Tom Gonder ,  Bryan Santangelo ,  Brad Jordan

    IPC分类号： H04N7/173 ,  G06F17/60

    CPC分类号： H04N21/4532 ,  G06Q30/02 ,  G06Q30/0255 ,  G06Q30/0258 ,  G06Q30/0264 ,  G06Q30/0272 ,  G06Q30/0276 ,  G06Q30/0277 ,  H04N7/17318 ,  H04N21/2407 ,  H04N21/25883 ,  H04N21/26258 ,  H04N21/2668 ,  H04N21/2747 ,  H04N21/44222 ,  H04N21/6582 ,  H04N21/6587 ,  H04N21/812 ,  H04N21/84 ,  H04N21/854 ,  H04N21/8543

    摘要： The present invention is directed to systems and methods for employing canonical metadata to describe advertisements comprising an advertiser storing an advertisement and arbitrarily complex metadata that is descriptive of the advertisement, which is received at a control center. At the control center, the advertisement is mapped to canonical metadata. The advertisement and canonical metadata are stored at the control center for use in discriminating between advertisements from a plurality of advertisers. An application program interface is provided for facilitating communication between a first computer and a second computer comprising means for the first computer requesting registration with the second computer, means for the second computer responding to the registration request of the first computer, means for the second computer requesting an advertisement identifier from the first computer in response to the occurrence of an event and means for transmitting the advertisement identifier from the second computer to the first computer.

    摘要翻译： 本发明涉及用于使用规范元数据来描述广告的系统和方法，所述广告包括存储广告的广告和描述在控制中心处接收的广告的任意复杂的元数据。 在控制中心，广告被映射到规范元数据。 广告和规范元数据被存储在控制中心，以用于区分来自多个广告商的广告。 提供了一种用于促进第一计算机和第二计算机之间的通信的应用程序接口，包括用于第一计算机请求与第二计算机注册的装置，第二计算机响应第一计算机的注册请求的装置，用于第二计算机的装置 响应于事件的发生，从第一计算机请求广告标识符以及用于将广告标识符从第二计算机发送到第一计算机的装置。