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    Embolic protection devices
    1.
    发明授权
    Embolic protection devices 有权
    栓塞保护装置

    公开(公告)号：US06702834B1

    公开(公告)日：2004-03-09

    申请号：US09727102

    申请日：2000-11-28

    申请人： John F. Boylan ,  William J. Boyle ,  Andy E. Denison ,  Debashis Dutta ,  Benjamin C. Huter ,  Scott J. Huter ,  Paul F. Muller ,  Samir Patel ,  Christopher J. Tarapata ,  Chicheng Wang ,  Francisco Sanchez ,  Kent C. B. Stalker

    发明人： John F. Boylan ,  William J. Boyle ,  Andy E. Denison ,  Debashis Dutta ,  Benjamin C. Huter ,  Scott J. Huter ,  Paul F. Muller ,  Samir Patel ,  Christopher J. Tarapata ,  Chicheng Wang ,  Francisco Sanchez ,  Kent C. B. Stalker

    IPC分类号： A61M2900

    CPC分类号： A61F2/013 ,  A61F2002/015 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/008

    摘要： An embolic protection device for use in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filtering assembly having a self-expanding strut assembly and a filter element attached thereto. In one embodiment, the filtering assembly is attached to the distal end of a guide wire and is deployed within the patient's vasculature as the guide wire is manipulated into the area of treatment. A restraining sheath placed over the filtering assembly in a coaxial arrangement maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Thereafter, the sheath can be retracted to expose the filtering assembly which will then self-expand within the patient's vasculature. Interventional devices can be delivered over the guide wire and any embolic debris created during the interventional procedure and released into the blood stream will enter the filtering assembly and be captured therein. Other embodiments include filtering assemblies attached to an outer tubular member and inner shaft member which apply axial force to the distal ends of the assembly to either expand or contract the struts as needed.

    摘要翻译： 一种用于血管中的栓塞保护装置，当在狭窄或闭塞区域进行介入手术以捕获可能在手术期间产生和释放到血流中的任何栓塞物质。 该装置包括具有自扩张支柱组件和附接到其上的过滤元件的过滤组件。 在一个实施例中，过滤组件附接到导丝的远端，并且当导丝被操纵进入治疗区域时，其被布置在患者的脉管系统内。 以同轴布置放置在过滤组件上方的限制护套将过滤组件保持在其收缩位置，直到其准备好由医师部署。 此后，护套可缩回以露出过滤组件，然后过滤组件将在患者的脉管系统内自我扩张。 介入装置可以在导丝上传送，并且在介入手术期间产生的并释放到血流中的任何栓塞碎片将进入过滤组件并被捕获在其中。 其他实施例包括附接到外部管状构件和内部轴构件的过滤构件，其向组件的远端施加轴向力，以根据需要来扩展或收缩支柱。

    Method of processing open-celled microcellular polymeric foams with controlled porosity for use as vascular grafts and stent covers
    2.
    发明授权
    Method of processing open-celled microcellular polymeric foams with controlled porosity for use as vascular grafts and stent covers 有权
    处理具有受控孔隙率的开孔微孔聚合物泡沫的方法，用作血管移植物和支架盖

    公开(公告)号：US06702849B1

    公开(公告)日：2004-03-09

    申请号：US09460271

    申请日：1999-12-13

    申请人： Debashis Dutta ,  Chicheng Wang ,  Kondapavulur T. V. Rao

    发明人： Debashis Dutta ,  Chicheng Wang ,  Kondapavulur T. V. Rao

    IPC分类号： A61F206

    CPC分类号： A61L31/16 ,  A61F2002/072 ,  A61L27/40 ,  A61L27/54 ,  A61L27/56 ,  A61L31/10 ,  A61L31/146 ,  A61L2300/602 ,  A61L2300/606 ,  C08L67/04

    摘要： Porous vascular grafts and stent covers are formed of open-celled microcellular polymeric foams having a porosity that can be modified to be adapted for carrying and delivering different types of therapeutic drugs. A stent cover is formed of a tubular member including at least one layer of a porous, microcellular foam formed from a polymeric material capable of absorbing and releasing therapeutic drugs at predictable rates for delivery of the therapeutic drugs in localized drug therapy in a blood vessel. A composite metal and polymer vascular graft is formed of an interior structural stent member, and an outer layer or coating of the porous, microcellular foam. The method of making the composite metal and polymer vascular graft involves providing an interior structural stent member with an outer layer or coating of the porous, microcellular foam, and can further comprise the step of loading a therapeutic drug into the outer layer of the porous, microcellular foam for delivery of the therapeutic drugs in localized drug therapy in a blood vessel.

    摘要翻译： 多孔血管移植物和支架覆盖物由具有孔隙率的开孔微孔聚合物泡沫形成，孔隙度可以被修饰以适于携带和递送不同类型的治疗药物。 支架盖由管状构件形成，该管状构件包括由能够以可预测的速率吸收和释放治疗药物的聚合材料形成的多孔微孔泡沫层，用于在血管中的局部药物治疗中递送治疗药物。 复合金属和聚合物血管移植物由内部结构支架构件和多孔微孔泡沫的外层或涂层形成。 制备复合金属和聚合物血管移植物的方法包括提供具有多孔，微孔泡沫体的外层或涂层的内部结构支架构件，并且还可以包括将治疗药物装载到多孔， 用于在血管中局部药物治疗中递送治疗药物的微孔泡沫。

    Expandable stent dimensional retention system and method
    3.
    发明授权
    Expandable stent dimensional retention system and method 有权
    可扩展支架尺寸保持系统和方法

    公开(公告)号：US06506202B1

    公开(公告)日：2003-01-14

    申请号：US09612855

    申请日：2000-07-10

    申请人： Debashis Dutta ,  Chicheng Wang

    发明人： Debashis Dutta ,  Chicheng Wang

    IPC分类号： A61M2900

    CPC分类号： A61F2/958 ,  A61F2002/9583 ,  A61M25/10 ,  A61M2025/1075

    摘要： A system used in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region, which is capable of treating an entire affected area in a blood vessel while preventing adverse effects for healthy tissue. The system includes a catheter which is positionable in a blood vessel at the interventional procedure site. The system further includes an expandable interventional instrument such as an expandable stent which is expandable and which may be deployed in the blood vessel at the interventional procedure site, which includes an unexpanded axial dimension. The system also includes an expandable member such as an expandable balloon, for expanding the expandable stent. The expandable balloon is capable of expanding so as to expand and deploy the expandable stent, and to substantially retain the unexpanded axial dimension of the expandable stent. The expansion of the expandable balloon prevents lengthening or shortening of the expandable stent, so as to enable the entire affected lesion area to be covered precisely without affecting the surrounding healthy tissue upon deployment of the expandable stent.

    摘要翻译： 当在狭窄或闭塞的区域进行介入手术时在血管中使用的系统，其能够治疗血管中的整个受影响区域，同时防止对健康组织的不利影响。 该系统包括可在介入手术部位的血管中定位的导管。 该系统还包括可扩张的介入器械，例如可扩张的支架，其是可扩张的并且可以在包括未膨胀的轴向尺寸的介入手术部位的血管中展开。 该系统还包括可膨胀构件，例如可膨胀气囊，用于扩张可扩张支架。 可膨胀气囊能够膨胀以扩张和展开可扩张支架，并且基本上保持可扩张支架的未膨胀的轴向尺寸。 可膨胀气囊的膨胀防止了可扩张支架的延长或缩短，从而使整个受影响的损伤区域能够精确地覆盖，而不会在展开支架时展开周围的健康组织。

    Methods and compositions for detection of biological materials using microfluidic devices
    4.
    发明授权
    Methods and compositions for detection of biological materials using microfluidic devices 有权
    使用微流体装置检测生物材料的方法和组合物

    公开(公告)号：US08507208B2

    公开(公告)日：2013-08-13

    申请号：US12842526

    申请日：2010-07-23

    申请人： Robert C. Corcoran ,  Debashis Dutta

    发明人： Robert C. Corcoran ,  Debashis Dutta

    IPC分类号： G01N33/53 ,  G01N33/573 ,  G01N33/561

    CPC分类号： G01N33/54366 ,  B01L3/502753 ,  B01L3/502776 ,  G01N33/558

    摘要： Provided herein are microfluidic devices and methods useful for sensitive detection of analytes. The methods and devices described herein are also useful for detecting direct or indirect binding of enzymes or catalysts to a surface, for example a surface having analytes bound thereon. Methods disclosed herein include embodiments utilizing a pre-concentration scheme to improve signal levels of corresponding reporter moieties.

    摘要翻译： 本文提供了用于敏感检测分析物的微流体装置和方法。 本文所述的方法和装置也可用于检测酶或催化剂对表面的直接或间接结合，例如具有结合在其上的分析物的表面。 本文公开的方法包括利用预浓缩方案来改善对应的报道部分的信号水平的实施方案。

    Inflatable member formed of liquid crystal polymeric material blend
    6.
    发明授权
    Inflatable member formed of liquid crystal polymeric material blend 有权
    由液晶聚合材料混合形成的充气构件

    公开(公告)号：US06325780B1

    公开(公告)日：2001-12-04

    申请号：US09394235

    申请日：1999-09-13

    申请人： Stephen G. Schaible ,  Debashis Dutta

    发明人： Stephen G. Schaible ,  Debashis Dutta

    IPC分类号： A61M2900

    CPC分类号： A61L29/126 ,  A61M25/10 ,  Y10T428/1334

    摘要： A catheter having an inflatable member formed of a liquid crystal polymeric material. The inflatable member is formed from a blend of a minor amount, preferably less than 10%, of liquid crystal polymer with a major amount of a non-liquid crystal polymer having LCP fibers that are highly oriented in the machine direction. The aspect ratio of the liquid crystal polymeric material fibers is greater than 10, so that the polymer blend has mechanical characteristics similar to a fiber-reinforced composite with improved strength and optimal compliance.

    摘要翻译： 一种具有由液晶聚合物材料形成的可膨胀构件的导管。 可膨胀构件由少量，优选小于10％的液晶聚合物与主要量的在机器方向上高度取向的LCP纤维的非液晶聚合物的共混物形成。 液晶聚合物材料纤维的纵横比大于10，使得聚合物共混物具有类似于纤维增强复合材料的机械特征，其具有改进的强度和最佳顺应性。

    Methods and Compositions for Detection of Biological Materials Using Microfluidic Devices
    8.
    发明申请
    Methods and Compositions for Detection of Biological Materials Using Microfluidic Devices 有权
    用微流控装置检测生物材料的方法和组合

    公开(公告)号：US20110177530A1

    公开(公告)日：2011-07-21

    申请号：US12842526

    申请日：2010-07-23

    申请人： Robert C. Corcoran ,  Debashis Dutta

    发明人： Robert C. Corcoran ,  Debashis Dutta

    IPC分类号： G01N33/53

    CPC分类号： G01N33/54366 ,  B01L3/502753 ,  B01L3/502776 ,  G01N33/558

    摘要： Provided herein are microfluidic devices and methods useful for sensitive detection of analytes. The methods and devices described herein are also useful for detecting direct or indirect binding of enzymes or catalysts to a surface, for example a surface having analytes bound thereon. Methods disclosed herein include embodiments utilizing a pre-concentration scheme to improve signal levels of corresponding reporter moieties.

    摘要翻译： 本文提供了用于敏感检测分析物的微流体装置和方法。 本文所述的方法和装置也可用于检测酶或催化剂对表面的直接或间接结合，例如具有结合在其上的分析物的表面。 本文公开的方法包括利用预浓缩方案来改善对应的报道部分的信号水平的实施方案。

    Biodegradable polymers for use with implantable medical devices
    9.
    发明申请
    Biodegradable polymers for use with implantable medical devices 有权
    用于可植入医疗器械的可生物降解聚合物

    公开(公告)号：US20050232971A1

    公开(公告)日：2005-10-20

    申请号：US11155036

    申请日：2005-06-16

    申请人： Syed Hossainy ,  Debashis Dutta

    发明人： Syed Hossainy ,  Debashis Dutta

    IPC分类号： A61F2/00 ,  A61F2/02 ,  A61F2/82

    CPC分类号： A61F2/82 ,  A61F2210/0004

    摘要： The present invention relates to a stent fabricated of or coated with a composition comprising a biodegradable hydrophobic polymer containing water-labile bonds such that a device fabricated of the composition or the surface of a device coated with the requisite mechanical characteristics required of a stent and the polymer erodes from its outer surface inward.

    摘要翻译： 本发明涉及一种由含有水不稳定键的可生物降解的疏水性聚合物的组合物制成或涂覆的支架，使得由组合物制造的装置或涂覆有支架所需的必要机械特性的装置的表面和 聚合物从其外表面向内侵蚀。

    System for blocking the passage of emboli through a body vessel
    10.
    发明授权
    System for blocking the passage of emboli through a body vessel 有权
    阻塞栓塞穿过身体血管的系统

    公开(公告)号：US06623450B1

    公开(公告)日：2003-09-23

    申请号：US09466366

    申请日：1999-12-17

    申请人： Debashis Dutta

    发明人： Debashis Dutta

    IPC分类号： A61M2900

    CPC分类号： A61F2/01 ,  A61F2230/0006

    摘要： An expandable filtering material expands within a body vessel (e.g. artery) when fluid flows through the vessel. Expandable pockets in the filtering material trap emboli released in the fluid. The filtering material is inserted into the vessel at a particular position distal to a lesion in the direction of the fluid flow. A protective sleeve covers the filtering material. An interventional device is disposed in the vessel at the lesion position to treat the lesion. The sleeve is removed from the expandable filtering material thereby expanding the filtering material within the vessel. The interventional device treats the lesion and opens up the vessel at the lesion position. The interventional device is thereafter removed. Retaining pockets in the expandable filtering material trap emboli released in the fluid of the body vessel.

    摘要翻译： 当流体流过容器时，可膨胀过滤材料在体内容器（例如动脉）内膨胀。 过滤材料中的可膨胀口袋中的栓塞释放在流体中。 过滤材料在流体流动方向上的病变远侧的特定位置处插入容器中。 保护套罩覆盖过滤材料。 将介入装置设置在病变位置处的血管中以治疗病变。 将套筒从可膨胀的过滤材料中取出，从而使过滤材料膨胀在容器内。 介入装置治疗病变并在病变位置打开血管。 之后移除介入装置。 在可膨胀的过滤材料中的保留凹陷栓塞释放在身体血管的流体中。