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26 条记录 (耗时 0.024 秒)

    R-NSAID esters and their use
    2.
    发明授权
    R-NSAID esters and their use 失效
    R-NSAID酯及其用途

    公开(公告)号：US07074826B2

    公开(公告)日：2006-07-11

    申请号：US10678430

    申请日：2003-10-03

    申请人： William J. Wechter ,  Elaine Benaksas Schwartz

    发明人： William J. Wechter ,  Elaine Benaksas Schwartz

    IPC分类号： A61K31/341 ,  A61K31/216 ,  C07D307/62 ,  C07C69/612

    CPC分类号： C07D405/04 ,  C07D307/62 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D487/04 ,  C07D491/04

    摘要： The present invention concerns esters of R-enantiomers of a non-steroidal anti-inflammatory drug, which is substantially free from the S-enantiomer. The compounds of the invention may be used in treating a disease or illness in a mammal. To this end, a composition comprising a compound mentioned above, or a pharmaceutically acceptable salt thereof where salt formation occurs, is administered to the mammal in an amount sufficient to elicit a chemopreventative effect or a chemoprotective effect or a therapeutic effect or a prophylactic effect.

    摘要翻译： 本发明涉及基本上不含S-对映异构体的非甾族抗炎药的R-对映体的酯。 本发明的化合物可用于治疗哺乳动物的疾病或疾病。 为此，将含有上述化合物或其药学上可接受的盐形成的组合物以足以引发化学预防作用或化学保护作用或治疗效果或预防效果的量施用给哺乳动物。

    3-Cyano thiophen-2-yl oxamic acid and derivatives
    4.
    发明授权
    3-Cyano thiophen-2-yl oxamic acid and derivatives 失效
    3-氰基噻吩-2-基氨基甲酸及其衍生物

    公开(公告)号：US3953468A

    公开(公告)日：1976-04-27

    申请号：US451509

    申请日：1974-03-15

    申请人： William J. Wechter ,  John B. Wright

    发明人： William J. Wechter ,  John B. Wright

    IPC分类号： C07D333/38 ,  C07D333/24

    CPC分类号： C07D333/38

    摘要： Compounds represented below ##SPC1##And pharmaceutical compositions thereof are useful in the prophylactic treatment of mammals for allergy and all anaphylactic reactions of a reagin or non-reagin mediated nature.

    摘要翻译： 其代表的化合物及其药物组合物可用于哺乳动物用于过敏反应和非依赖性介导的自然反应的所有神经酰胺反应的主动物的预处理。

    Method for treatment of inflammation with R-NSAIDS
    5.
    发明授权
    Method for treatment of inflammation with R-NSAIDS 失效
    药物组合物和治疗炎症的方法

    公开(公告)号：US06472433B2

    公开(公告)日：2002-10-29

    申请号：US09797022

    申请日：2001-03-01

    申请人： William J. Wechter

    发明人： William J. Wechter

    IPC分类号： A61K3119

    CPC分类号： A61K31/192 ,  A61K31/381 ,  A61K31/402 ,  A61K31/403 ,  A61K31/407 ,  A61K31/423

    摘要： This invention relates to the use of enantiomerically pure R-NSAIDs for the treatment of inflammation. Preferably, the R-NSAID used is R-flurbiprofen and is administered in a dose of at least 5 milligrams per kilogram of body weight per day. The anti-inflammatory action of R-NSAIDs is due to their ability to interfere with the biosynthesis of COX-2 by inhibiting COX-2 mRNA synthesis, rather than by just blocking the action of the enzyme itself. In order to effect the inhibition of COX-2 mRNA synthesis, the R-NSAID must be present at relatively high doses. Because the R-NSAID is selective in its action, that is, it does not inhibit either COX-1 mRNA synthesis or the COX-1 enzyme itself, it can be administered in the required high doses because the tissue protective effects of prostaglandins made through the COX-1 pathway are not interfered with.

    摘要翻译： 本发明涉及对映异构体纯的R-NSAIDs用于治疗炎症的用途。 优选地，所用的R-NSAID是R-氟比洛芬，并且以每千克体重每天至少5毫克的剂量施用。 R-NSAIDs的抗炎作用是由于其通过抑制COX-2 mRNA合成而干扰COX-2的生物合成的能力，而不是仅仅阻断酶本身的作用。 为了实现COX-2 mRNA合成的抑制，R-NSAID必须以相当高的剂量存在。 因为R-NSAID在其作用中是选择性的，即它不抑制COX-1 mRNA合成或COX-1酶本身，因此可以以所需的高剂量施用，因为前列腺素的组织保护作用通过 COX-1途径不受干扰。

    Use of &ggr;-tocopherol and its oxidative metabolite LLU-&agr; in the treatment of disease
    6.
    发明授权
    Use of &ggr;-tocopherol and its oxidative metabolite LLU-&agr; in the treatment of disease 有权

    公开(公告)号：US06410589B1

    公开(公告)日：2002-06-25

    申请号：US09814330

    申请日：2001-03-21

    申请人： William J. Wechter

    发明人： William J. Wechter

    IPC分类号： A61K3135

    摘要： The present invention is generally related to the discovery of the therapeutic benefit of administering &ggr;-tocopherol and &ggr;-tocopherol derivatives. More specifically, the use of &ggr;-tocopherol and racemic LLU-&agr;, (S)-LLU-&agr;, or &ggr;-tocopherol derivatives as antioxidants and nitrogen oxide scavengers which treat and prevent high blood pressure, thromboembolic disease, cardiovascular disease, cancer, natriuretic disease, the formation of neuropathological lesions, and a reduced immune system response are disclosed.

    Method of treating rheumatoid arthritis
    8.
    发明授权
    Method of treating rheumatoid arthritis 失效

    公开(公告)号：US4172889A

    公开(公告)日：1979-10-30

    申请号：US895674

    申请日：1978-04-12

    申请人： William J. Wechter ,  Carter D. Brooks

    发明人： William J. Wechter ,  Carter D. Brooks

    IPC分类号： C07H19/06 ,  A61K31/70 ,  C07H19/08

    CPC分类号： C07H19/06 ,  Y10S514/825

    摘要： A process of treatment for the management of the condition known as rheumatoid arthritis. The process manages rheumatoid arthritis by controlling the inflammatory process in a rheumatoid joint by the intra-articular administration to said joint of an effective amount for controlling the inflammatory process of certain N.sup.4 -acyl-ara-cytidines, 5'-O-acyl-ara-cytidines and pharmaceutically acceptable acid addition salts thereof, and pharmaceutically acceptable acid addition salts of 5'-O-acyl-2,2'-anhydro-ara-cytidines.

    Antipyretic and analgesic methods using optically pure R-ketorolac
    10.
    发明授权
    Antipyretic and analgesic methods using optically pure R-ketorolac 失效
    使用光学纯的R-酮咯酸的解热镇痛方法

    公开(公告)号：US5382591A

    公开(公告)日：1995-01-17

    申请号：US118160

    申请日：1993-09-08

    申请人： Timothy J. Barberich ,  Stephen L. Matson ,  William J. Wechter

    发明人： Timothy J. Barberich ,  Stephen L. Matson ,  William J. Wechter

    IPC分类号： C07D487/04 ,  A61K31/00 ,  A61K31/40 ,  A61P25/00 ,  A61P25/04 ,  A61P29/00

    CPC分类号： A61K31/40

    摘要： Methods are disclosed utilizing optically pure R-ketorolac for the treatment of pain, including but not limited to pain associated with toothaches, headaches, sprains, joint pain and surgical pain, for example dental pain (e.g., after periodontal surgery) and ophthalmic pain (e.g., after cataract surgery) while avoiding adverse effects which are associated with the administration of the racemic mixture of ketorolac. The optically pure R-ketorolac is also useful in treating pyrexia while avoiding the adverse effects associated with the administration of the racemic mixture of ketorolac.

    摘要翻译： 公开利用光学纯的R-酮咯酸用于治疗疼痛的方法，包括但不限于与牙痛，头痛，扭伤，关节疼痛和手术疼痛相关的疼痛，例如牙痛（例如牙周手术后）和眼痛（ 例如在白内障手术之后），同时避免与给予酮咯酸的外消旋混合物相关的不良反应。 光学纯的R-酮咯酸也可用于治疗发热，同时避免与给予酮咯酸的外消旋混合物相关的不利影响。