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公开(公告)号：US20080227956A1
公开(公告)日：2008-09-18
申请号：US11824672
申请日：2007-07-02
申请人： William K. Jones , Ronald F. Tucker , David C. Rueger , Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath
发明人： William K. Jones , Ronald F. Tucker , David C. Rueger , Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath
IPC分类号： C07K14/435
CPC分类号： C07K16/22 , A23C9/20 , A23L33/19 , A61F2310/00365 , A61K6/0017 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61K48/00 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , G01N33/6893 , G01N2500/10 , Y10S435/975 , Y10S436/811 , Y10S436/815 , A61K2300/00 , C08L89/00
摘要： Disclosed are novel compositions of morphogenic proteins constituting soluble forms of these proteins, antibodies that distinguish between soluble and mature forms, and method for producing these morphogenic proteins and antibodies.
摘要翻译： 公开了构成这些蛋白质的可溶形式的形态发生蛋白质的新型组合物，区分可溶性和成熟形式的抗体，以及用于产生这些形态发生蛋白质和抗体的方法。
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公开(公告)号：US06395883B1
公开(公告)日：2002-05-28
申请号：US08402542
申请日：1995-03-13
申请人： William K. Jones , Ronald F. Tucker , David C. Rueger , Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath
发明人： William K. Jones , Ronald F. Tucker , David C. Rueger , Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath
IPC分类号： C07K14475
CPC分类号： C07K16/22 , A23C9/20 , A23L33/19 , A61F2310/00365 , A61K6/0017 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61K48/00 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , G01N33/6893 , G01N2500/10 , Y10S435/975 , Y10S436/811 , Y10S436/815 , A61K2300/00 , C08L89/00
摘要： Disclosed are novel compositions of morphogenic proteins constituting soluble forms of these proteins, antibodies that distinguish between soluble and mature forms, and method for producing these morphogenic proteins and antibodies.
摘要翻译： 公开了构成这些蛋白质的可溶形式的形态发生蛋白质的新型组合物，区分可溶性和成熟形式的抗体，以及用于产生这些形态发生蛋白质和抗体的方法。
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公开(公告)号：US6071708A
公开(公告)日：2000-06-06
申请号：US889419
申请日：1997-07-08
申请人： William K. Jones , Ronald F. Tucker , David C. Rueger , Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath
发明人： William K. Jones , Ronald F. Tucker , David C. Rueger , Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath
IPC分类号： A01N1/02 , A23C9/20 , A23L1/305 , A61F2/00 , A61K6/00 , A61K38/00 , A61K38/17 , A61K38/18 , A61K48/00 , A61L27/22 , A61L27/24 , C07K14/495 , C07K14/51 , C07K16/22 , G01N33/68 , G01N33/53
CPC分类号： C07K16/22 , A23C9/20 , A23L33/19 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61K6/0017 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , G01N33/6893 , A61F2310/00365 , A61K48/00 , G01N2500/10 , Y10S435/975 , Y10S436/811 , Y10S436/815
摘要： Disclosed are novel compositions of morphogenic proteins constituting soluble forms of these proteins, antibodies that distinguish between soluble and mature forms, and method for producing these morphogenic proteins and antibodies.
摘要翻译： 公开了构成这些蛋白质的可溶形式的形态发生蛋白质的新型组合物，区分可溶性和成熟形式的抗体，以及用于产生这些形态发生蛋白质和抗体的方法。
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公开(公告)号：US5834179A
公开(公告)日：1998-11-10
申请号：US459346
申请日：1995-06-02
申请人： William K. Jones , Ronald F. Tucker , David C. Rueger , Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath
发明人： William K. Jones , Ronald F. Tucker , David C. Rueger , Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath
IPC分类号： A01N1/02 , A23C9/20 , A23L1/305 , A61F2/00 , A61K6/00 , A61K38/00 , A61K38/17 , A61K38/18 , A61K48/00 , A61L27/22 , A61L27/24 , C07K14/495 , C07K14/51 , C07K16/22 , G01N33/68 , C12Q1/00 , G01N33/53 , G01N33/537 , G01N33/542
CPC分类号： C07K16/22 , A23C9/20 , A23L33/19 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61K6/0017 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , G01N33/6893 , A61F2310/00365 , A61K48/00 , G01N2500/10 , Y10S435/975 , Y10S436/811 , Y10S436/815
摘要： Disclosed are novel compositions of morphogenic proteins constituting soluble forms of these proteins, antibodies that distinguish between soluble and mature forms, and method for producing these morphogenic proteins and antibodies.
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公开(公告)号：US07268208B2
公开(公告)日：2007-09-11
申请号：US10122026
申请日：2002-04-12
申请人： William K. Jones , Ronald F. Tucker , David C. Rueger , Hermann Oppermann , Engin Ozkaynak , Thangavel Kubersmith
发明人： William K. Jones , Ronald F. Tucker , David C. Rueger , Hermann Oppermann , Engin Ozkaynak , Thangavel Kubersmith
CPC分类号： C07K16/22 , A23C9/20 , A23L33/19 , A61F2310/00365 , A61K6/0017 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61K48/00 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , G01N33/6893 , G01N2500/10 , Y10S435/975 , Y10S436/811 , Y10S436/815 , A61K2300/00 , C08L89/00
摘要： Disclosed are novel compositions of morphogenic proteins constituting soluble forms of these proteins, antibodies that distinguish between soluble and mature forms, and method for producing these morphogenic proteins and antibodies.
摘要翻译： 公开了构成这些蛋白质的可溶形式的形态发生蛋白质的新型组合物，区分可溶性和成熟形式的抗体，以及用于产生这些形态发生蛋白质和抗体的方法。
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6.发明授权Compositions and methods for identification and use of soluble complex forms of osteogenic proteins 失效用于鉴定和使用可溶性复合形式的成骨蛋白的组合物和方法
公开(公告)号：US5610021A
公开(公告)日：1997-03-11
申请号：US206864
申请日：1994-03-04
申请人： David C. Rueger , William K. Jones , Ronald F. Tucker , Hermann Oppermann , Engin Ozkaynak , Kuber T. Sampath
发明人： David C. Rueger , William K. Jones , Ronald F. Tucker , Hermann Oppermann , Engin Ozkaynak , Kuber T. Sampath
IPC分类号： A61K9/00 , A61K38/00 , A61L27/22 , C07K16/22 , G01N33/53 , C07K16/18 , G01N33/541 , G01N33/68
CPC分类号： A61K9/0024 , A61L27/227 , C07K16/22 , A61K38/00 , A61L2430/02
摘要： Disclosed are novel compositions of osteogenic proteins constituting soluble forms of these proteins, and methods and compositions for distinguishing between soluble and mature forms of these proteins.
摘要翻译： 公开了构成这些蛋白质的可溶形式的成骨蛋白质的新型组合物，以及用于区分这些蛋白质的可溶性和成熟形式的方法和组合物。
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公开(公告)号：US07557078B1
公开(公告)日：2009-07-07
申请号：US08937756
申请日：1997-09-25
申请人： David C. Rueger , Thangavel Kuberasampath , Hermann Oppermann , Engin Ozkaynak , Roy H. L. Pang , Charles M. Cohen
发明人： David C. Rueger , Thangavel Kuberasampath , Hermann Oppermann , Engin Ozkaynak , Roy H. L. Pang , Charles M. Cohen
CPC分类号： C07K16/22 , A01N1/0226 , A61F2310/00365 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L2430/32 , C07K14/495 , C07K14/51 , G01N2500/10 , A61K2300/00
摘要： Disclosed are therapeutic treatment methods, compositions and devices for maintaining neural pathways in a mammal, including enhancing survival of neurons at risk of dying, inducing cellular repair of damaged neurons and neural pathways, and stimulating neurons to maintain their differentiated phenotype. In one embodiment, the invention provides means for stimulating CAM expression in neurons. The invention also provides means for evaluating the status of nerve tissue, including means for detecting and monitoring neuropathies in a mammal. The methods, devices and compositions include a morphogen or morphogen-stimulating agent provided to the mammal in a therapeutically effective concentration.
摘要翻译： 公开了用于在哺乳动物中维持神经通路的治疗治疗方法，组合物和装置，包括增加有死亡风险的神经元的存活，诱导受损神经元和神经通路的细胞修复，以及刺激神经元维持其分化表型。 在一个实施方案中，本发明提供用于刺激神经元中的CAM表达的装置。 本发明还提供用于评估神经组织状态的手段，包括用于检测和监测哺乳动物神经病变的手段。 方法，装置和组合物包括以治疗有效浓度提供给哺乳动物的形态发生剂或形态发生剂。
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公开(公告)号：US20080233170A1
公开(公告)日：2008-09-25
申请号：US12038606
申请日：2008-02-27
申请人： Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang
发明人： Hermann Oppermann , Engin Ozkaynak , Thangavel Kuberasampath , David C. Rueger , Roy H. L. Pang
CPC分类号： A61K38/1875
摘要： Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors carrying sequences encoding these novel polypeptide chains and host cells transfected with these vectors; (4) methods of producing these polypeptide chains using recombinant DNA technology; (5) antibodies specific for these novel polypeptide chains; (6) osteogenic devices comprising these recombinantly produced proteins in association with an appropriate carrier matrix; and (7) methods of using the osteogenic devices to mimic the natural course of endochondral bone formation in mammals.
摘要翻译： 公开的是（1）包含含有基本上纯天然来源的哺乳动物成骨蛋白质的基质的成骨装置; （2）可用作二聚成骨蛋白亚基的新型多肽链的DNA和氨基酸序列; （3）携带编码这些新型多肽链的序列的载体和用这些载体转染的宿主细胞; （4）使用重组DNA技术生产这些多肽链的方法; （5）对这些新型多肽链具有特异性的抗体; （6）包含这些重组产生的蛋白质与合适的载体基质相结合的成骨装置; 和（7）使用成骨装置来模拟哺乳动物软骨内骨形成的自然过程的方法。
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公开(公告)号：US06399569B1
公开(公告)日：2002-06-04
申请号：US08461113
申请日：1995-06-05
申请人： Charles M. Cohen , Marc F. Charette , Thangavel Kuberasampath , David C. Rueger , Hermann Oppermann , Roy H. L. Pang , Engin Ozkaynak , John E. Smart
发明人： Charles M. Cohen , Marc F. Charette , Thangavel Kuberasampath , David C. Rueger , Hermann Oppermann , Roy H. L. Pang , Engin Ozkaynak , John E. Smart
IPC分类号： A61K3818
CPC分类号： G01N33/6872 , A61F2310/00365 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , C07K16/22 , G01N2500/10 , G01N2800/06 , A61K2300/00
摘要： Disclosed are methods and compositions for maintaining the integrity of the gastrointestinal tract luminal lining in a mammal, including (1) limiting epithelial cell proliferation, (2) inhibiting ulcerative lesion formation, (3) inhibiting inflammation normally associated with ulcerative diseases, and (4) stimulating the repair of ulcerative lesions and the regeneration of the luminal tissue. The methods and compositions include a therapeutically effective amount of a morphogen as defined herein.
摘要翻译： 公开了用于维持哺乳动物胃肠道腔内衬的完整性的方法和组合物，包括（1）限制上皮细胞增殖，（2）抑制溃疡性病变形成，（3）抑制通常与溃疡性疾病相关的炎症，和（4 ）刺激溃疡性病变的修复和管腔组织的再生。 方法和组合物包括治疗有效量的如本文所定义的形态发生素。
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公开(公告)号：US5750651A
公开(公告)日：1998-05-12
申请号：US145812
申请日：1993-11-01
IPC分类号： A61C8/00 , A61F2/00 , A61K9/00 , A61K38/00 , A61L27/22 , A61L27/24 , A61L27/34 , A61L27/36 , A61L27/56 , C07K14/51 , C12N15/18 , C07K14/435 , C12N15/12
CPC分类号： A61K9/0024 , A61L27/227 , A61L27/24 , A61L27/34 , A61L27/3608 , A61L27/365 , A61L27/3654 , A61L27/56 , C07K14/51 , A61C8/0006 , A61F2310/00365 , A61K38/00 , A61L2430/02 , Y10S530/84
摘要： Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data, amino acid composition, solubility properties, structural features, homologies and various other data characterizing osteogenic proteins, 3) methods of producing osteogenic proteins using recombinant DNA technology, and 4) osteogenically and chondrogenically active synthetic protein constructs.
摘要翻译： 公开的是1）包含含有成骨蛋白的基质的成骨装置和使用该装置在哺乳动物中诱导软骨内骨生长的方法; 2）氨基酸序列数据，氨基酸组成，溶解性，结构特征，同源性和各种其他数据表征成骨蛋白，3）使用重组DNA技术生产成骨蛋白的方法，以及4）成骨和软骨形成活性合成蛋白质构建体。
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