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    Fumed silica embolic compositions
    1.
    发明申请
    Fumed silica embolic compositions 审中-公开
    气相二氧化硅栓塞组合物

    公开(公告)号：US20050025707A1

    公开(公告)日：2005-02-03

    申请号：US10789436

    申请日：2004-02-26

    申请人： William Patterson ,  Richard Greff ,  Meyer Rosen ,  Earl Slee ,  Thomas Whalen

    发明人： William Patterson ,  Richard Greff ,  Meyer Rosen ,  Earl Slee ,  Thomas Whalen

    IPC分类号： A61K9/00 ,  A61K47/02 ,  A61L24/00 ,  A61L31/12 ,  A61L31/14 ,  A61L31/18 ,  A61K49/04 ,  A61F2/00 ,  A61M31/00

    CPC分类号： A61L31/18 ,  A61K9/0019 ,  A61K47/02 ,  A61L24/001 ,  A61L24/0089 ,  A61L31/128 ,  A61L31/14 ,  A61L2430/36

    摘要： This invention is directed to compositions for embolizing vascular sites. The compositions described herein comprise fumed silica as a rheological modifier. The fumed silica imparts high viscosity to the compositions under static conditions but allows the compositions to flow readily under shear conditions. This invention is also directed to methods for treatment of aneurysms, arteriovenous fistulae, arteriovenous malformations, tumors, and other vascular diseases using the compositions described herein. Other uses are disclosed as well. Kits of parts including those compositions and devices which can deliver these composition are also described.

    摘要翻译： 本发明涉及栓塞血管部位的组合物。 本文所述的组合物包含热解法二氧化硅作为流变改性剂。 热解法二氧化硅在静态条件下赋予组合物高粘度，但允许组合物在剪切条件下容易流动。 本发明还涉及使用本文所述的组合物治疗动脉瘤，动静脉瘘，动静脉畸形，肿瘤和其它血管疾病的方法。 也披露了其他用途。 还描述了包括可以递送这些组合物的那些组合物和装置的部件的组件。

    Vascular remodeling device
    3.
    发明授权
    Vascular remodeling device 有权
    血管重建装置

    公开(公告)号：US09179918B2

    公开(公告)日：2015-11-10

    申请号：US12506945

    申请日：2009-07-21

    申请人： Elad Israel Levy ,  Earl Slee ,  Sanjay Shrivastava ,  Victoria Schuman ,  Andy Huynh ,  Wenfeng Lu

    发明人： Elad Israel Levy ,  Earl Slee ,  Sanjay Shrivastava ,  Victoria Schuman ,  Andy Huynh ,  Wenfeng Lu

    IPC分类号： A61F2/06 ,  A61B17/12 ,  A61F2/86 ,  A61F2/954 ,  A61F2/82

    CPC分类号： A61F2/86 ,  A61B17/12022 ,  A61B17/12113 ,  A61B17/12118 ,  A61B17/1214 ,  A61B17/12172 ,  A61B2017/12054 ,  A61B2017/12063 ,  A61F2/954 ,  A61F2002/065 ,  A61F2002/823 ,  A61F2230/005 ,  A61F2230/0071

    摘要： A generally spherical vascular remodeling device is permanently positionable at a junction of afferent and efferent vessels of a bifurcation having an aneurysm. After positioning the device at the junction to substantially conform the device to the shape of the junction, the device acts as a scaffolding to inhibit herniation of objects out of the aneurysm and the device permits perfusion to the efferent vessels. Positioning the device may include deployment and mechanical or electrolytic release from a catheter. Embolic material may be inserted in the aneurysm before or after positioning the device. The device may have a first end, a second end substantially opposite to the first end, and a plurality of filaments extending between and coupled at the first end and the second end. Such devices may be football shaped, pumpkin shaped, or twisted. The device may include a plurality of loops forming a generally spherical shape.

    摘要翻译： 通常为球形的血管重建装置可永久定位在具有动脉瘤的分叉的传入和传出血管的交界处。 在将装置定位在接合处以将装置基本上符合接合部的形状之后，该装置用作支架以抑制物体从动脉瘤中的突出，并且该装置允许灌注到传出血管。 定位装置可以包括从导管部署和机械或电解释放。 栓塞材料可以在设备定位之前或之后插入动脉瘤中。 该装置可以具有第一端，与第一端基本相对的第二端，以及在第一端和第二端处延伸并在其之间耦合的多根细丝。 这种装置可以是足球形，南瓜形或扭曲的。 该装置可以包括形成大致球形的多个环。

    Methods for embolizing aneurysmal sites with a high viscosity embolizing composition
    4.
    发明授权
    Methods for embolizing aneurysmal sites with a high viscosity embolizing composition 失效
    用高粘度栓塞组合物栓塞动脉瘤部位的方法

    公开(公告)号：US07374568B2

    公开(公告)日：2008-05-20

    申请号：US10345127

    申请日：2003-01-14

    申请人： Thomas J. Whalen, II ,  Earl Slee ,  Amanda Conner

    发明人： Thomas J. Whalen, II ,  Earl Slee ,  Amanda Conner

    IPC分类号： A61M29/00

    CPC分类号： A61L24/001 ,  A61L31/14 ,  A61L31/18 ,  A61L2430/36

    摘要： Novel methods for embolizing blood vessels which are particularly suited for treating aneurysms are provided. The presently disclosed methods provide for the embolization of aneurysms wherein occlusion of the neck of the aneurysm during embolization by a flow arresting device such as balloon is not required. In one embodiment, the compositions employed in the methods of this invention comprise a biocompatible polymer, a biocompatible solvent and a biocompatible contrast agent wherein the viscosity of this composition is at least about 1000 centistokes at 40° C. and, preferably, at least about 2500 centistokes at 40° C.

    摘要翻译： 提供了特别适用于治疗动脉瘤的新型栓塞栓塞方法。 目前公开的方法提供动脉瘤的栓塞，其中不需要通过诸如气囊的止血装置在栓塞期间闭塞动脉瘤颈部。 在一个实施方案中，用于本发明方法的组合物包含生物相容性聚合物，生物相容性溶剂和生物相容性造影剂，其中该组合物的粘度在40℃至少为约1000厘沲，优选为至少约 在40℃下2500厘沲

    Vascular remodeling device
    7.
    发明授权
    Vascular remodeling device 有权
    血管重建装置

    公开(公告)号：US09468442B2

    公开(公告)日：2016-10-18

    申请号：US13016855

    申请日：2011-01-28

    申请人： Andy Huynh ,  Masoud Molaei ,  Victoria Schuman ,  Sanjay Shrivastava ,  Earl Slee ,  Quang Tran

    发明人： Andy Huynh ,  Masoud Molaei ,  Victoria Schuman ,  Sanjay Shrivastava ,  Earl Slee ,  Quang Tran

    IPC分类号： A61F2/06 ,  A61B17/12 ,  A61F2/856 ,  A61F2/86 ,  A61F2/82 ,  A61F2/95

    CPC分类号： A61B17/12118 ,  A61B17/1214 ,  A61B17/12172 ,  A61F2/856 ,  A61F2/86 ,  A61F2002/823 ,  A61F2002/9528 ,  A61F2002/9534 ,  A61F2230/0063 ,  A61F2230/0071

    摘要： An intraluminal apparatus including a catheter and device is positionable at a junction of afferent and efferent vessels of a bifurcation having an aneurysm. After positioning the device to substantially conform the device to the shape of the junction, the device acts as a scaffolding to inhibit herniation of objects out of the aneurysm and the device permits perfusion to the efferent vessels. Positioning the device may include deployment and optional release from a catheter. Embolic material may be inserted in the aneurysm before or after positioning the device. The device may have a proximal end, a distal end, and a plurality of filaments extending between and coupled at the proximal end and the distal end. The device may include a central filament configured to reshape the device. The distal end of the device may include a covering. The device may be football shaped, pumpkin shaped, or acorn shaped.

    摘要翻译： 包括导管和装置的管腔内装置可定位在具有动脉瘤的分叉的传入和传出血管的交界处。 在将装置定位成使得装置基本上符合接合部的形状之后，该装置用作支架以抑制物体从动脉瘤的突出，并且该装置允许灌注到输出血管。 定位装置可以包括从导管部署和任选的释放。 栓塞材料可以在设备定位之前或之后插入动脉瘤中。 该装置可以具有近端，远端以及在近端和远端处延伸并且在近端和远端处连接的多根细丝。 该装置可以包括被配置成重塑该装置的中心细丝。 设备的远端可以包括覆盖物。 该装置可以是足球形，南瓜形或橡胶形。

    VASCULAR REMODELING DEVICE
    8.
    发明申请
    VASCULAR REMODELING DEVICE 有权
    血管再造装置

    公开(公告)号：US20110184452A1

    公开(公告)日：2011-07-28

    申请号：US13016855

    申请日：2011-01-28

    申请人： Andy Huynh ,  Masoud Molaei ,  Victoria Schuman ,  Sanjay Shrivastava ,  Earl Slee ,  Quang Tran

    发明人： Andy Huynh ,  Masoud Molaei ,  Victoria Schuman ,  Sanjay Shrivastava ,  Earl Slee ,  Quang Tran

    IPC分类号： A61M29/00

    CPC分类号： A61B17/12118 ,  A61B17/1214 ,  A61B17/12172 ,  A61F2/856 ,  A61F2/86 ,  A61F2002/823 ,  A61F2002/9528 ,  A61F2002/9534 ,  A61F2230/0063 ,  A61F2230/0071

    摘要： An intraluminal apparatus including a catheter and device is positionable at a junction of afferent and efferent vessels of a bifurcation having an aneurysm. After positioning the device to substantially conform the device to the shape of the junction, the device acts as a scaffolding to inhibit herniation of objects out of the aneurysm and the device permits perfusion to the efferent vessels. Positioning the device may include deployment and optional release from a catheter. Embolic material may be inserted in the aneurysm before or after positioning the device. The device may have a proximal end, a distal end, and a plurality of filaments extending between and coupled at the proximal end and the distal end. The device may include a central filament configured to reshape the device. The distal end of the device may include a covering. The device may be football shaped, pumpkin shaped, or acorn shaped.

    摘要翻译： 包括导管和装置的管腔内装置可定位在具有动脉瘤的分叉的传入和传出血管的交界处。 在将装置定位成使得装置基本上符合接合部的形状之后，该装置用作支架以抑制物体从动脉瘤的突出，并且该装置允许灌注到输出血管。 定位装置可以包括从导管部署和任选的释放。 栓塞材料可以在设备定位之前或之后插入动脉瘤中。 该装置可以具有近端，远端以及在近端和远端处延伸并且在近端和远端处连接的多根细丝。 该装置可以包括被配置成重塑该装置的中心细丝。 设备的远端可以包括覆盖物。 该装置可以是足球形，南瓜形或橡胶形。

    Vascular remodeling device
    10.
    发明授权
    Vascular remodeling device 有权
    血管重建装置

    公开(公告)号：US08926681B2

    公开(公告)日：2015-01-06

    申请号：US13016858

    申请日：2011-01-28

    申请人： Elad Israel Levy ,  Victoria Schuman ,  Sanjay Shrivastava ,  Earl Slee

    发明人： Elad Israel Levy ,  Victoria Schuman ,  Sanjay Shrivastava ,  Earl Slee

    IPC分类号： A61F2/06 ,  A61M29/00 ,  A61L31/14 ,  A61L31/06 ,  A61L31/04 ,  A61F2/07 ,  A61B17/12

    CPC分类号： A61B17/12109 ,  A61B17/12022 ,  A61B17/12118 ,  A61B17/1214 ,  A61B17/12145 ,  A61B17/12172 ,  A61B2017/00004 ,  A61B2017/1205 ,  A61B2017/12054 ,  A61B2017/12063 ,  A61F2/07 ,  A61L31/041 ,  A61L31/06 ,  A61L31/148 ,  A61L2430/36 ,  C08L67/04

    摘要： A generally spherical vascular remodeling device is permanently positionable at a junction of afferent and efferent vessels of a bifurcation having an aneurysm. After positioning the device at the junction to substantially conform the device to the shape of the junction, the device acts as a scaffolding to inhibit herniation of objects out of the aneurysm and permits perfusion to the efferent vessels. Positioning the device may include deployment and mechanical or electrolytic release from a catheter. Embolic material may be inserted in the aneurysm before or after positioning the device. The device may have a first end, a second end substantially opposite to the first end, and a plurality of polymer filaments extending between and coupled at the first end and the second end. Such devices may be football shaped, pumpkin shaped, or twisted. The device may include a plurality of polymer loops forming a generally spherical shape.

    摘要翻译： 通常为球形的血管重建装置可永久定位在具有动脉瘤的分叉的传入和传出血管的交界处。 在将装置定位在接合处以将装置基本上符合结点的形状之后，该装置用作支架以抑制物体从动脉瘤的突出并允许灌注到输出血管。 定位装置可以包括从导管部署和机械或电解释放。 栓塞材料可以在设备定位之前或之后插入动脉瘤中。 该装置可以具有第一端，与第一端基本相反的第二端，以及在第一端和第二端处延伸并在其之间耦合的多个聚合物细丝。 这种装置可以是足球形，南瓜形或扭曲的。 该装置可以包括形成大致球形的多个聚合物环。