公开(公告)号：US07083643B2

公开(公告)日：2006-08-01

申请号：US10388741

申请日：2003-03-17

申请人： Thomas J. Whalen, II ,  Richard J. Greff ,  Kevin P. Gilmartin ,  Douglas Ray Hayman ,  Todd J. Hewitt ,  Ed L. Olson ,  Mark A. Pecor ,  Earl H. Slee ,  George Wallace

发明人： Thomas J. Whalen, II ,  Richard J. Greff ,  Kevin P. Gilmartin ,  Douglas Ray Hayman ,  Todd J. Hewitt ,  Ed L. Olson ,  Mark A. Pecor ,  Earl H. Slee ,  George Wallace

IPC分类号： A61F2/06

CPC分类号： A61F2/958 ,  A61B17/00491 ,  A61B17/12022 ,  A61B17/12118 ,  A61B17/12186 ,  A61B2017/00495 ,  A61F2/86 ,  A61F2/90 ,  A61F2/91 ,  A61F2002/823 ,  A61F2230/0054 ,  A61F2250/0018 ,  A61F2250/0039 ,  A61L24/043 ,  A61M25/1011 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2025/1086 ,  Y10S623/903

摘要： This invention is directed to methods for treating aneurysms wherein the aneurysmal sac is filled with a non-particulate agent or plurality of such agents and/or with a fluid composition which solidifies in situ. Filling of the aneurysmal sac employs sufficient amount of the non-particulate agent or plurality of such agents and/or the fluid composition to inhibit blood flow into the aneurysm sac. In addition, the methods of this invention also provide for non-endogenous isolation of the parent artery proximal and distal to the aneurysmal sac from systemic blood flow of the treated mammal. The combination of these features provides for treatment of the aneurysmal sac while, at the same time, inhibiting aneurysm formation and/or regrowth in the diseased portions of the arterial wall proximal and distal to the treated aneurysm.

公开(公告)号：US06645167B1

公开(公告)日：2003-11-11

申请号：US09574500

申请日：2000-05-19

申请人： Thomas J. Whalen, II ,  Chinh Ngoc Tran ,  Douglas Ray Hayman ,  Noah Michael Roth ,  Jacques Moret ,  Richard J. Greff

发明人： Thomas J. Whalen, II ,  Chinh Ngoc Tran ,  Douglas Ray Hayman ,  Noah Michael Roth ,  Jacques Moret ,  Richard J. Greff

IPC分类号： A61F200

CPC分类号： A61K49/0419 ,  A61K9/0024 ,  A61L24/001 ,  A61L24/046 ,  A61L24/06 ,  A61L24/08 ,  A61L2430/36 ,  A61M5/31586 ,  A61M2025/1052 ,  C08J3/091 ,  C08L29/04

摘要： Disclosed are novel methods for embolizing blood vessels comprising delivering, via a catheter, an embolic composition comprising a biocompatible polymer, a biocompatible water insoluble contrast agent, and a biocompatible solvent. In one embodiment, the method is conducted during a single surgical procedure whereby a flow-arresting device is positioned and activated at the vascular site to be embolized, the embolic composition is injected, and the flow-arresting device is deactivated. In another embodiment, the method is conducted during a single surgical procedure whereby two embolic compositions, situated adjacent to one another, are injected at the vascular site to be embolized.

摘要翻译： 公开了用于栓塞血管的新颖方法，包括通过导管递送包含生物相容性聚合物，生物相容性水不溶性造影剂和生物相容性溶剂的栓塞组合物。 在一个实施方案中，该方法在单次外科手术过程中进行，由此在要栓塞的血管部位定位并激活止血装置，注射栓塞组合物，并且阻流装置停用。 在另一个实施方案中，该方法在单次外科手术过程中进行，由此彼此相邻的两个栓塞组合物被注射到待栓塞的血管部位。

公开(公告)号：US06565601B2

公开(公告)日：2003-05-20

申请号：US09811600

申请日：2001-03-20

申请人： George Wallace ,  Richard J. Greff ,  Earl H. Slee ,  Thomas J. Whalen, II

发明人： George Wallace ,  Richard J. Greff ,  Earl H. Slee ,  Thomas J. Whalen, II

IPC分类号： A61F206

CPC分类号： A61F2/07 ,  A61B17/00491 ,  A61B17/12022 ,  A61B17/12109 ,  A61B17/12118 ,  A61B17/1214 ,  A61B17/12172 ,  A61B17/12186 ,  A61B2017/1205 ,  A61F2/90 ,  A61F2/945 ,  A61F2002/077 ,  A61F2002/30583 ,  A61F2210/0085 ,  Y10S623/903

摘要： Disclosed are methods for vascular reconstruction of diseased, non-aneurysmal arteries.

公开(公告)号：US06569190B2

公开(公告)日：2003-05-27

申请号：US09811423

申请日：2001-03-20

申请人： Thomas J. Whalen, II ,  Richard J. Greff ,  Kevin P. Gilmartin ,  Douglas Ray Hayman ,  Todd J. Hewitt ,  Ed L. Olson ,  Mark A. Pecor ,  Earl H. Slee ,  George Wallace

发明人： Thomas J. Whalen, II ,  Richard J. Greff ,  Kevin P. Gilmartin ,  Douglas Ray Hayman ,  Todd J. Hewitt ,  Ed L. Olson ,  Mark A. Pecor ,  Earl H. Slee ,  George Wallace

IPC分类号： A61F206

CPC分类号： A61F2/958 ,  A61B17/00491 ,  A61B17/12022 ,  A61B17/12118 ,  A61B17/12186 ,  A61B2017/00495 ,  A61F2/86 ,  A61F2/90 ,  A61F2/91 ,  A61F2002/823 ,  A61F2230/0054 ,  A61F2250/0018 ,  A61F2250/0039 ,  A61L24/043 ,  A61M25/1011 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2025/1086 ,  Y10S623/903

摘要： This invention is directed to methods for treating aneurysms wherein the aneurysmal sac is filled with a non-particulate agent or plurality of such agents and/or with a fluid composition which solidifies in situ. Filling of the aneurysmal sac employs sufficient amount of the non-particulate agent or plurality of such agents and/or the fluid composition to inhibit blood flow into the aneurysm sac. In addition, the methods of this invention also provide for non-endogenous isolation of the parent artery proximal and distal to the aneurysmal sac from systemic blood flow of the treated mammal. The combination of these features provides for treatment of the aneurysmal sac while, at the same time, inhibiting aneurysm formation and/or regrowth in the diseased portions of the arterial wall proximal and distal to the treated aneurysm.

公开(公告)号：US06511472B1

公开(公告)日：2003-01-28

申请号：US09574392

申请日：2000-05-19

申请人： Douglas R. Hayman ,  Ed Olsen ,  Noah M. Roth ,  Gary Curri ,  Thomas J. Whalen, II

发明人： Douglas R. Hayman ,  Ed Olsen ,  Noah M. Roth ,  Gary Curri ,  Thomas J. Whalen, II

IPC分类号： A61M3900

CPC分类号： A61M25/0097 ,  A61M5/1407 ,  A61M2005/3201

摘要： An interface needle is used for connecting a syringe to a catheter to create a blunt interface between two or more liquids being delivered through the catheter. The interface needle is particularly useful for creating a blunt interface between a biocompatible solvent and a liquid embolic composition which is delivered to the body for treatment of various conditions including aneurysms. A system for liquid delivery with a blunt liquid interface includes a catheter or other cannula, an interface needle, and a syringe. The interface needle includes a tube extending from a distal end which delivers liquid to a lumen of the catheter bypassing a reservoir in the catheter hub to create the blunt liquid interface. One embodiment of the interface needle controls an injection pressure of high viscosity liquids.

摘要翻译： 接口针用于将注射器连接到导管，以在通过导管输送的两种或多种液体之间形成钝的界面。 界面针对于在生物相容性溶剂和液体栓塞组合物之间形成钝性界面特别有用，该组合物被输送到身体以治疗包括动脉瘤的各种状况。 用于具有钝液界面的液体递送系统包括导管或其它插管，接口针和注射器。 接口针包括从远端延伸的管，其将液体输送到绕过导管座中的储存器的导管的内腔，以产生钝的液体界面。 接口针的一个实施例控制高粘度液体的注射压力。

公开(公告)号：US07374568B2

公开(公告)日：2008-05-20

申请号：US10345127

申请日：2003-01-14

申请人： Thomas J. Whalen, II ,  Earl Slee ,  Amanda Conner

发明人： Thomas J. Whalen, II ,  Earl Slee ,  Amanda Conner

IPC分类号： A61M29/00

CPC分类号： A61L24/001 ,  A61L31/14 ,  A61L31/18 ,  A61L2430/36

摘要： Novel methods for embolizing blood vessels which are particularly suited for treating aneurysms are provided. The presently disclosed methods provide for the embolization of aneurysms wherein occlusion of the neck of the aneurysm during embolization by a flow arresting device such as balloon is not required. In one embodiment, the compositions employed in the methods of this invention comprise a biocompatible polymer, a biocompatible solvent and a biocompatible contrast agent wherein the viscosity of this composition is at least about 1000 centistokes at 40° C. and, preferably, at least about 2500 centistokes at 40° C.

摘要翻译： 提供了特别适用于治疗动脉瘤的新型栓塞栓塞方法。 目前公开的方法提供动脉瘤的栓塞，其中不需要通过诸如气囊的止血装置在栓塞期间闭塞动脉瘤颈部。 在一个实施方案中，用于本发明方法的组合物包含生物相容性聚合物，生物相容性溶剂和生物相容性造影剂，其中该组合物的粘度在40℃至少为约1000厘沲，优选为至少约 在40℃下2500厘沲

公开(公告)号：US06531111B1

公开(公告)日：2003-03-11

申请号：US09574379

申请日：2000-05-19

申请人： Thomas J. Whalen, II ,  Chinh N. Tran ,  Noah M. Roth ,  Richard J. Greff

发明人： Thomas J. Whalen, II ,  Chinh N. Tran ,  Noah M. Roth ,  Richard J. Greff

IPC分类号： A61K4900

CPC分类号： A61L24/08 ,  A61K49/0002 ,  A61K49/0409 ,  A61L24/001 ,  A61L24/02 ,  A61L24/046 ,  A61L24/06 ,  A61L27/56 ,  A61L27/58 ,  A61L2430/36

摘要： Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery.

公开(公告)号：US07011677B2

公开(公告)日：2006-03-14

申请号：US10388657

申请日：2003-03-17

申请人： George Wallace ,  Richard J. Greff ,  Earl H. Slee ,  Thomas J. Whalen, II

发明人： George Wallace ,  Richard J. Greff ,  Earl H. Slee ,  Thomas J. Whalen, II

IPC分类号： A61F2/06

CPC分类号： A61F2/07 ,  A61B17/00491 ,  A61B17/12022 ,  A61B17/12109 ,  A61B17/12118 ,  A61B17/1214 ,  A61B17/12172 ,  A61B17/12186 ,  A61B2017/1205 ,  A61F2/90 ,  A61F2/945 ,  A61F2002/077 ,  A61F2002/30583 ,  A61F2210/0085 ,  Y10S623/903

摘要： Disclosed are methods for vascular reconstruction of diseased, non-aneurysmal arteries.