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1.发明授权Certain dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency 有权某些二核苷酸及其作为粘膜纤毛清除和睫状肌拍频的调节剂公开(公告)号：US06977246B2
公开(公告)日：2005-12-20
申请号：US10007451
申请日：2001-11-06
IPC分类号： C07H19/207 , A61K9/00 , A61K31/7084 , A61P11/00 , A61P27/02 , A61P27/16 , A61P43/00 , C07H19/10 , C07H19/20 , C07H21/00 , A61K31/70
CPC分类号： C07H19/10 , A61K9/0048 , C07H19/20 , C07H21/00
摘要： The present invention relates to certain novel dinucleotides and formulations thereof which are highly selective agonists of the P2Y2 and/or P2Y4 purinergic receptor. They are useful in the treatment of chronic obstructive pulmonary diseases such as chronic bronchitis, PCD, cystic fibrosis, as well as prevention of pneumonia due to immobility. Furthermore, because of their general ability to clear retained mucus secretions and stimulate ciliary beat frequency, the compounds of the present invention are also useful in the treatment of sinusitis, otitis media and nasolacrimal duct obstruction. They are also useful for treatment of dry eye disease and retinal detachment as well as facilitating sputum induction and expectoration.
摘要翻译： 本发明涉及某些新的二核苷酸及其制剂，它们是P2Y 2和/或P2Y 4H-嘌呤能受体的高度选择性激动剂。 它们可用于治疗慢性阻塞性肺疾病如慢性支气管炎，PCD，囊性纤维化，以及由于不动而预防肺炎。 此外，由于它们具有清除保留的粘液分泌物并刺激睫状肌搏动频率的一般能力，本发明的化合物也可用于治疗鼻窦炎，中耳炎和鼻泪管阻塞。 它们也可用于治疗干眼症和视网膜脱离以及促进痰诱导和咳痰。
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2.发明授权Certain dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency 失效某些二核苷酸及其作为粘膜纤毛清除和睫状肌拍频的调节剂公开(公告)号：US06348589B1
公开(公告)日：2002-02-19
申请号：US09101395
申请日：1998-07-10
IPC分类号： C07H2100
CPC分类号： C07H19/10 , A61K9/0048 , C07H19/20 , C07H21/00
摘要： The present invention relates to certain novel dinucleotides and formulations thereof which are highly selective agonists of the P2Y2 and/or P2Y4 purinergic receptor. They are useful in the treatment of chronic obstructive pulmonary diseases such as chronic bronchitis, PCD, cystic fibrosis, as well as prevention of pneumonia due to immobility. Furthermore, because of their general ability to clear retained mucus secretions and stimulate ciliary beat frequency, the compounds of the present invention are also useful in the treatment of sinusitis, otitis media and nasolacrimal duct obstruction. They are also useful for treatment of dry eye disease and retinal detachment.
摘要翻译： 本发明涉及作为P2Y2和/或P2Y4嘌呤能受体的高选择性激动剂的某些新型二核苷酸及其制剂。 它们可用于治疗慢性阻塞性肺疾病如慢性支气管炎，PCD，囊性纤维化，以及由于不动而预防肺炎。 此外，由于它们具有清除保留的粘液分泌物并刺激睫状肌搏动频率的一般能力，本发明的化合物也可用于治疗鼻窦炎，中耳炎和鼻泪管阻塞。 它们也可用于治疗干眼病和视网膜脱离。
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3.发明授权Dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency 失效二核苷酸及其作为粘膜纤毛清除和睫状肌拍频的调节剂
公开(公告)号：US5837861A
公开(公告)日：1998-11-17
申请号：US798508
申请日：1997-02-10
IPC分类号： A61K31/7084 , C07H19/04 , C07H19/20 , C07H21/00 , C07H21/02
CPC分类号： C07H19/20 , A61K31/7084 , C07H19/04 , C07H21/00
摘要： The present invention encompasses structures of the formula ##STR1## wherein: X is oxygen, methylene, or difluoromethylene; n=0 or 1; m=0 or 1; n+m=0, 1 or 2; and B and B' are each independently a purine residue or a pyrimidine residue linked through the 9- or 1-position, respectively, provided that compounds disclosed in Table I are excluded. In the instance where B and B' are uracil, attached at the N-1 position to the ribosyl moiety, then the total of m+n may equal 3 or 4 when X is oxygen. The compounds of the present invention are highly selective agonists of the P2Y.sub.2 purinergic receptor, thus, they are useful in the treatment of chronic obstructive pulmonary diseases such as chronic bronchitis, PCD, cystic fibrosis, as well as prevention of pneumonia due to immobility. Furthermore, because of their general ability to clear retained mucus secretions and stimulate ciliary beat frequency, the compounds of the present invention are also useful in the treatment of sinusitis and otitis media.
摘要翻译： 本发明包括下式的结构：其中：X是氧，亚甲基或二氟亚甲基; n = 0或1; m = 0或1; n + m = 0,1或2; 并且B和B'各自独立地是嘌呤残基或连接在9-位或1-位上的嘧啶残基，条件是排除表I中公开的化合物。 在B和B'是尿嘧啶的情况下，在N-1位置连接到核糖基部分，则当X是氧时，m + n的总和可以等于3或4。 本发明的化合物是P2Y2嘌呤能受体的高选择性激动剂，因此它们可用于治疗慢性阻塞性肺疾病如慢性支气管炎，PCD，囊性纤维化，以及由于不动而预防肺炎。 此外，由于它们具有清除保留的粘液分泌物和刺激睫状肌搏动频率的一般能力，本发明的化合物也可用于治疗鼻窦炎和中耳炎。
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公开(公告)号：US20100330164A1
公开(公告)日：2010-12-30
申请号：US12825051
申请日：2010-06-28
IPC分类号： A61K31/7076 , A61K31/7072 , A61K9/127 , A61P27/04
CPC分类号： C07H19/10 , A61K9/0048 , A61K31/7084 , A61K45/06 , C07H19/20 , C07H21/00 , Y10S514/912 , Y10S514/915
摘要： A method and preparation for the stimulation of tear secretion in a subject in need of such treatment is disclosed. The method comprises administering to the ocular surfaces of the subject a purinergic receptor agonist such as uridine 5′-triphosphate (UTP), dinucleotides, cytidine 5′-triphosphate (CTP), adenosine 5′-triphosphate (ATP), or their therapeutically useful analogs and derivatives, in an amount effective to stimulate tear fluid secretion and enhance drainage of the lacrimal system. Pharmaceutical formulations and methods of making the same are also disclosed. Methods of administering the same would include: topical administration via a liquid, gel, cream, or as part of a contact lens or selective release membrane; or systemic administration via nasal drops or spray, inhalation by nebulizer or other device, oral form (liquid or pill), injectable, intra-operative instillation or suppository form.
摘要翻译： 公开了用于刺激需要这种治疗的受试者的泪液分泌的方法和制剂。 该方法包括向受试者的眼表面施用嘌呤能受体激动剂如尿苷5'-三磷酸（UTP），二核苷酸，胞苷5'-三磷酸（CTP），腺苷5'-三磷酸（ATP）或其治疗上有用的 类似物和衍生物，其量有效地刺激泪液分泌并增强泪液系统的引流。 还公开了药物制剂及其制备方法。 施用该方法的方法将包括：通过液体，凝胶，霜剂或作为隐形眼镜或选择性释放膜的一部分局部给药; 或通过鼻滴或喷雾进行全身给药，通过喷雾器或其它装置吸入，口服形式（液体或丸剂），可注射的，术中滴注或栓剂形式。
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公开(公告)号：US07759322B2
公开(公告)日：2010-07-20
申请号：US11821091
申请日：2007-06-20
CPC分类号： C07H19/10 , A61K9/0048 , A61K31/7084 , A61K45/06 , C07H19/20 , C07H21/00 , Y10S514/912 , Y10S514/915
摘要： A method and preparation for the stimulation of tear secretion in a subject in need of such treatment is disclosed. The method comprises administering to the ocular surfaces of the subject a purinergic receptor agonist such as uridine 5′-triphosphate (UTP), dinucleotides, cytidine 5′-triphosphate (CTP), adenosine 5′-triphosphate (ATP), or their therapeutically useful analogs and derivatives, in an amount effective to stimulate tear fluid secretion and enhance drainage of the lacrimal system. Pharmaceutical formulations and methods of making the same are also disclosed. Methods of administering the same would include: topical administration via a liquid, gel, cream, or as part of a contact lens or selective release membrane; or systemic administration via nasal drops or spray, inhalation by nebulizer or other device, oral form (liquid or pill), injectable, intra-operative instillation or suppository form.
摘要翻译： 公开了用于刺激需要这种治疗的受试者的泪液分泌的方法和制剂。 该方法包括向受试者的眼表面施用嘌呤能受体激动剂如尿苷5'-三磷酸（UTP），二核苷酸，胞苷5'-三磷酸（CTP），腺苷5'-三磷酸（ATP）或其治疗上有用的 类似物和衍生物，其量有效地刺激泪液分泌并增强泪液系统的引流。 还公开了药物制剂及其制备方法。 施用该方法的方法将包括：通过液体，凝胶，霜剂或作为隐形眼镜或选择性释放膜的一部分局部给药; 或通过鼻滴或喷雾进行全身给药，通过喷雾器或其它装置吸入，口服形式（液体或丸剂），可注射的，术中滴注或栓剂形式。
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公开(公告)号：US06323187B1
公开(公告)日：2001-11-27
申请号：US09316571
申请日：1999-05-21
申请人： Benjamin R. Yerxa , William Pendergast , Janet L. Rideout , Maryse Picher , Richard C. Boucher, Jr. , M. Jackson Stutts
发明人： Benjamin R. Yerxa , William Pendergast , Janet L. Rideout , Maryse Picher , Richard C. Boucher, Jr. , M. Jackson Stutts
IPC分类号： A01N4304
CPC分类号： A61K31/7048 , A61K31/70 , C07H19/207 , C07H21/00
摘要： The present invention relates to P1-(cytidine 5′-)-P-(uridine 5′-)tetraphosphates and its salts, esters and amides, and formulations thereof which are highly stable and selective agonists of the P2Y2 and/or P2Y4 purinergic receptor. The compounds of the invention are useful in the treatment of chronic obstructive pulmonary diseases such as chronic bronchitis, primary ciliary dyskinesia, cystic fibrosis, as well as prevention of pneumonia due to immobility, and the induction of sputum and its expectoration. Furthermore, because of their general ability to clear retained mucus secretions and stimulate ciliary beat frequency, the compounds of the present invention are also useful in the treatment of sinusitis and otitis media.
摘要翻译： 本发明涉及P2Y2和/或P2Y4嘌呤能受体的高度稳定和选择性激动剂的P1-（胞苷5' - ） - （ - 尿苷5' - ）四磷酸及其盐，酯和酰胺及其制剂 。 本发明的化合物可用于治疗慢性阻塞性肺疾病如慢性支气管炎，原发性纤毛运动障碍，囊性纤维化，以及预防由于不动的肺炎，以及诱导痰及其咳痰。 此外，由于它们具有清除保留的粘液分泌物和刺激睫状肌搏动频率的一般能力，本发明的化合物也可用于治疗鼻窦炎和中耳炎。
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公开(公告)号：US20080214490A1
公开(公告)日：2008-09-04
申请号：US12043845
申请日：2008-03-06
IPC分类号： A61K31/7076 , A61P15/02
摘要： The present invention provides a method of stimulating cervical and vaginal secretions in a mammal by treatment with P2Y2 and/or P2Y4 purinergic receptor agonists. Treatment of vaginal dryness associated with menopause, chemotherapy, and various disease states as well as the treatment of vulvar pain is discussed. Suitable agonists such as UTP, CTP, ATP, dinucleotides and analogs thereof are disclosed.
摘要翻译： 本发明提供了通过用P2Y2和/或P2Y4N4嘌呤能受体激动剂治疗来刺激哺乳动物的宫颈和阴道分泌物的方法。 讨论了与绝经，化疗和各种疾病状态相关的阴道干燥的治疗以及外阴疼痛的治疗。 公开了合适的激动剂，例如UTP，CTP，ATP，二核苷酸及其类似物。
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公开(公告)号：US06921755B2
公开(公告)日：2005-07-26
申请号：US10010055
申请日：2001-11-09
CPC分类号： A61K45/06 , Y10S514/912
摘要： A method and preparation for the stimulation of tear secretion in a subject in need of such treatment is disclosed. The method comprises administering to the ocular surfaces of the subject a purinergic receptor agonist such as uridine 5′-triphosphate (UTP), dinucleotides, cytidine 5′-triphosphate (CTP), adenosine 5′-triphosphate (ATP), or their therapeutically useful analogs and derivatives, in an amount effective to stimulate tear fluid secretion and enhance drainage of the lacrimal system. Pharmaceutical formulations and methods of making the same are also disclosed. Methods of administering the same would include: topical administration via a liquid, gel, cream, or as part of a contact lens or selective release membrane; or systemic administration via nasal drops or spray, inhalation by nebulizer or other device, oral form (liquid or pill), injectable, intra-operative instillation or suppository form.
摘要翻译： 公开了用于刺激需要这种治疗的受试者的泪液分泌的方法和制剂。 该方法包括向受试者的眼表面施用嘌呤能受体激动剂如尿苷5'-三磷酸（UTP），二核苷酸，胞苷5'-三磷酸（CTP），腺苷5'-三磷酸（ATP）或其治疗上有用的 类似物和衍生物，其量有效地刺激泪液分泌并增强泪液系统的引流。 还公开了药物制剂及其制备方法。 施用该方法的方法将包括：通过液体，凝胶，霜剂或作为隐形眼镜或选择性释放膜的一部分局部给药; 或通过鼻滴或喷雾进行全身给药，通过喷雾器或其它装置吸入，口服形式（液体或丸剂），可注射的，术中滴注或栓剂形式。
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9.发明授权Method of treating ciliary dyskinesia with uridine triphosphates and related compounds 失效用尿苷三磷酸和相关化合物治疗睫状肌运动障碍的方法公开(公告)号：US06420347B1
公开(公告)日：2002-07-16
申请号：US09101840
申请日：1998-07-17
申请人： Karla M. Jacobus , Benjamin R. Yerxa , William Pendergast , Richard C. Boucher, Jr. , Janet L. Rideout , David J. Drutz , Michael K. James , Monroe Jackson Stutts , Cary Geary , Edwardo R. Lazarowski
发明人： Karla M. Jacobus , Benjamin R. Yerxa , William Pendergast , Richard C. Boucher, Jr. , Janet L. Rideout , David J. Drutz , Michael K. James , Monroe Jackson Stutts , Cary Geary , Edwardo R. Lazarowski
IPC分类号： A61K3170
CPC分类号： A61K31/70
摘要： A method of stimulating ciliary beat frequency in a subject in need of such treatment is disclosed. The method comprises administering to the airways, ears, eyes, or genito-urinary tract of the subject a triphosphate nucleotide such as uridine 5′-triphosphate (UTP), an analog of UTP, or any other analog, in an amount effective to stimulate ciliary beat frequency. This method is useful for treating patients afflicted with ciliary dyskinesia, Kartagener's syndrome, or any other disease involving dysfunction of ciliary movement, such as male infertility caused by impairment of propulsion of the spermatozoa or immune deficiency caused by impairment of ciliary movement in neutrophils or macrophages. Pharmaceutical formulations and methods of making the same are also disclosed. Methods of administering the same would include any liquid suspension (including nasal spray or nasal or eye drops), oral, inhaled by nebulization, topical, injected, suppository, intra-operative by instillation or application, or ex vivo direct application to spermatozoa.
摘要翻译： 公开了一种在需要这种治疗的受试者中刺激睫状肌搏动频率的方法。 该方法包括向受试者的气道，耳朵，眼睛或生殖泌尿道施用有效刺激的量的三磷酸核苷酸，例如尿苷5'-三磷酸（UTP），UTP类似物或任何其它类似物 睫毛拍频。 该方法可用于治疗患有睫状肌运动障碍，Kartagener综合征或涉及睫状肌运动功能障碍的任何其他疾病，例如由嗜中性粒细胞或巨噬细胞的睫状肌运动损伤引起的精子推进或免疫缺陷引起的男性不育症 。 还公开了药物制剂及其制备方法。 给药方法包括任何液体悬浮液（包括鼻喷雾或鼻腔或滴眼液），口服，通过雾化吸入，局部注射，注射，栓剂，通过滴注或施用手术，或离体直接施用于精子。
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公开(公告)号：US07432252B1
公开(公告)日：2008-10-07
申请号：US09531851
申请日：2000-03-20
IPC分类号： A61K31/70
CPC分类号： C07H21/00
摘要： The present invention provides a method of stimulating cervical and vaginal secretions in a mammal by treatment with P2Y2 and/or P2Y4 purinergic receptor agonists. Treatment of vaginal dryness associated with menopause, chemotherapy, and various disease states as well as the treatment of vulvar pain is discussed. Suitable agonists such as UTP, CTP, ATP, dinucleotides and analogs thereof are disclosed.
摘要翻译： 本发明提供了通过用P2Y2和/或P2Y4N4嘌呤能受体激动剂治疗来刺激哺乳动物的宫颈和阴道分泌物的方法。 讨论了与绝经，化疗和各种疾病状态相关的阴道干燥的治疗以及外阴疼痛的治疗。 公开了合适的激动剂，例如UTP，CTP，ATP，二核苷酸及其类似物。
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