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公开(公告)号：US08816150B2
公开(公告)日：2014-08-26
申请号：US11904373
申请日：2007-09-27
申请人： William Poueymirou , Thomas M. DeChiara , Wojtek Auerbach , David Frendewey , David M. Valenzuela
发明人： William Poueymirou , Thomas M. DeChiara , Wojtek Auerbach , David Frendewey , David M. Valenzuela
IPC分类号： A01K67/027 , C12N15/00
CPC分类号： A01K67/0271 , A01K67/0275 , A01K67/0276 , A01K2207/12 , A01K2227/105 , C07K14/47 , C12N5/0604 , C12N5/16 , C12N15/8509 , C12N2501/235 , C12N2501/415 , C12N2510/00 , C12N2517/02 , C12N2799/026
摘要： Methods of generating modified embryos and mammals by introduction of donor cells into an early stage embryo are provided, such that the resulting embryo and animal generated therefrom has a significant contribution to all tissues from the donor cells and is capable of transmitting the donor cell DNA.
摘要翻译： 提供了通过将供体细胞引入早期胚胎来产生修饰的胚胎和哺乳动物的方法，使得所产生的胚胎和由其产生的动物对来自供体细胞的所有组织具有显着贡献，并且能够传递供体细胞DNA。
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公开(公告)号：US07659442B2
公开(公告)日：2010-02-09
申请号：US11904558
申请日：2007-09-27
申请人： William Poueymirou , Thomas M. DeChiara , Wojtek Auerbach , David Frendewey , David M. Valenzuela
发明人： William Poueymirou , Thomas M. DeChiara , Wojtek Auerbach , David Frendewey , David M. Valenzuela
IPC分类号： C12N16/00
CPC分类号： A01K67/0271 , A01K67/0275 , A01K67/0276 , A01K2207/12 , A01K2227/105 , C07K14/47 , C12N5/0604 , C12N5/16 , C12N15/8509 , C12N2501/235 , C12N2501/415 , C12N2510/00 , C12N2517/02 , C12N2799/026
摘要： Methods of generating modified embryos and mammals by introduction of donor cells into an early stage embryo are provided, such that the resulting embryo and animal generated therefrom has a significant contribution to all tissues from the donor cells and is capable of transmitting the donor cell DNA.
摘要翻译： 提供通过将供体细胞引入早期胚胎来产生修饰的胚胎和哺乳动物的方法，使得由其产生的胚胎和动物对来自供体细胞的所有组织具有显着贡献，并且能够传递供体细胞DNA。
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公开(公告)号：US07576259B2
公开(公告)日：2009-08-18
申请号：US11904559
申请日：2007-09-27
申请人： William Poueymirou , Thomas M. DeChiara , Wojtek Auerbach , David Frendewey , David M. Valenzuela
发明人： William Poueymirou , Thomas M. DeChiara , Wojtek Auerbach , David Frendewey , David M. Valenzuela
IPC分类号： C12N15/00
CPC分类号： A01K67/0271 , A01K67/0275 , A01K67/0276 , A01K2207/12 , A01K2227/105 , C07K14/47 , C12N5/0604 , C12N5/16 , C12N15/8509 , C12N2501/235 , C12N2501/415 , C12N2510/00 , C12N2517/02 , C12N2799/026
摘要： Methods of generating modified embryos and mammals by introduction of donor cells into an early stage embryo are provided, such that the resulting embryo and animal generated therefrom has a significant contribution to all tissues from the donor cells and is capable of transmitting the donor cell DNA.
摘要翻译： 提供通过将供体细胞引入早期胚胎来产生修饰的胚胎和哺乳动物的方法，使得由其产生的胚胎和动物对来自供体细胞的所有组织具有显着贡献，并且能够传递供体细胞DNA。
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公开(公告)号：US07294754B2
公开(公告)日：2007-11-13
申请号：US11254045
申请日：2005-10-19
申请人： William Poueymirou , Thomas M. Dechiara , Wojtek Auerbach , David Frendewey , David M. Valenzuela
发明人： William Poueymirou , Thomas M. Dechiara , Wojtek Auerbach , David Frendewey , David M. Valenzuela
IPC分类号： C12N15/00
CPC分类号： A01K67/0271 , A01K67/0275 , A01K67/0276 , A01K2207/12 , A01K2227/105 , C07K14/47 , C12N5/0604 , C12N5/16 , C12N15/8509 , C12N2501/235 , C12N2501/415 , C12N2510/00 , C12N2517/02 , C12N2799/026
摘要： Methods of generating modified embryos and mammals by introduction of donor cells into an early stage embryo are provided, such that the resulting embryo and animal generated therefrom has a significant or complete contribution to all tissues from the donor cells and is capable of transmitting the donor cell DNA.
摘要翻译： 提供通过将供体细胞引入早期胚胎来产生修饰的胚胎和哺乳动物的方法，使得由其产生的胚胎和动物对来自供体细胞的所有组织有显着或完整的贡献，并且能够传递供体细胞 脱氧核糖核酸。
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公开(公告)号：US20060085866A1
公开(公告)日：2006-04-20
申请号：US11254045
申请日：2005-10-19
IPC分类号： A01K67/027 , C12N5/06
CPC分类号： A01K67/0271 , A01K67/0275 , A01K67/0276 , A01K2207/12 , A01K2227/105 , C07K14/47 , C12N5/0604 , C12N5/16 , C12N15/8509 , C12N2501/235 , C12N2501/415 , C12N2510/00 , C12N2517/02 , C12N2799/026
摘要： Methods of generating modified embryos and mammals by introduction of donor cells into an early stage embryo are provided, such that the resulting embryo and animal generated therefrom has a significant or complete contribution to all tissues from the donor cells and is capable of transmitting the donor cell DNA.
摘要翻译： 提供通过将供体细胞引入早期胚胎来产生修饰的胚胎和哺乳动物的方法，使得由其产生的胚胎和动物对来自供体细胞的所有组织具有显着或完整的贡献，并且能够传递供体细胞 脱氧核糖核酸。
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公开(公告)号：US09149026B2
公开(公告)日：2015-10-06
申请号：US13157728
申请日：2011-06-10
IPC分类号： A01K67/02 , C12N15/873 , A01K67/027 , C12N5/0735 , C12N9/02
CPC分类号： A01K67/0276 , A01K67/0278 , A01K2207/12 , A01K2217/052 , A01K2217/054 , A01K2217/075 , A01K2227/105 , A01K2267/0331 , C12N5/0603 , C12N5/0606 , C12N9/0091 , C12N15/873 , C12N2500/34 , C12N2500/60 , C12N2517/02 , C12N2517/10
摘要： Methods and compositions are described for making phenotypically female fertile animals from XY donor cells and suitable host embryos. Culture media and methods are provided for maintaining XY donor cells in culture that after introduction into a host embryo and gestation in a suitable host will result in fertile XY female animals. Methods and compositions are described for making fertile female animals in an F0 generation from a donor XY cell and a host embryo, as are methods for making F1 progeny that are homozygous for a modification from a heterozygous F0 fertile male and a heterozygous F0 fertile female sibling.
摘要翻译： 描述了从XY供体细胞和合适的宿主胚胎制备表型雌性可育动物的方法和组合物。 提供培养基和方法用于在培养物中维持XY供体细胞，其在引入宿主胚胎之后，并且在合适的宿主中妊娠将导致可育的XY雌性动物。 描述了用于使来自供体XY细胞和宿主胚胎的F0代中的可育雌性动物的方法和组合物，以及用于从杂合的F0可育雄性和杂合的F0可育雌性同胞中进行修饰的F1后代的方法 。
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公开(公告)号：US20080078001A1
公开(公告)日：2008-03-27
申请号：US11904558
申请日：2007-09-27
IPC分类号： C12N15/00
CPC分类号： A01K67/0271 , A01K67/0275 , A01K67/0276 , A01K2207/12 , A01K2227/105 , C07K14/47 , C12N5/0604 , C12N5/16 , C12N15/8509 , C12N2501/235 , C12N2501/415 , C12N2510/00 , C12N2517/02 , C12N2799/026
摘要： Methods of generating modified embryos and mammals by introduction of donor cells into an early stage embryo are provided, such that the resulting embryo and animal generated therefrom has a significant contribution to all tissues from the donor cells and is capable of transmitting the donor cell DNA.
摘要翻译： 提供通过将供体细胞引入早期胚胎来产生修饰的胚胎和哺乳动物的方法，使得由其产生的胚胎和动物对来自供体细胞的所有组织具有显着贡献，并且能够传递供体细胞DNA。
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公开(公告)号：US20080078000A1
公开(公告)日：2008-03-27
申请号：US11904373
申请日：2007-09-27
CPC分类号： A01K67/0271 , A01K67/0275 , A01K67/0276 , A01K2207/12 , A01K2227/105 , C07K14/47 , C12N5/0604 , C12N5/16 , C12N15/8509 , C12N2501/235 , C12N2501/415 , C12N2510/00 , C12N2517/02 , C12N2799/026
摘要： Methods of generating modified embryos and mammals by introduction of donor cells into an early stage embryo are provided, such that the resulting embryo and animal generated therefrom has a significant contribution to all tissues from the donor cells and is capable of transmitting the donor cell DNA.
摘要翻译： 提供通过将供体细胞引入早期胚胎来产生修饰的胚胎和哺乳动物的方法，使得由其产生的胚胎和动物对来自供体细胞的所有组织具有显着贡献，并且能够传递供体细胞DNA。
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公开(公告)号：US20080028479A1
公开(公告)日：2008-01-31
申请号：US11904559
申请日：2007-09-27
IPC分类号： C12N15/00
CPC分类号： A01K67/0271 , A01K67/0275 , A01K67/0276 , A01K2207/12 , A01K2227/105 , C07K14/47 , C12N5/0604 , C12N5/16 , C12N15/8509 , C12N2501/235 , C12N2501/415 , C12N2510/00 , C12N2517/02 , C12N2799/026
摘要： Methods of generating modified embryos and mammals by introduction of donor cells into an early stage embryo are provided, such that the resulting embryo and animal generated therefrom has a significant contribution to all tissues from the donor cells and is capable of transmitting the donor cell DNA.
摘要翻译： 提供了通过将供体细胞引入早期胚胎来产生修饰的胚胎和哺乳动物的方法，使得所产生的胚胎和由其产生的动物对来自供体细胞的所有组织具有显着贡献，并且能够传递供体细胞DNA。
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10.发明申请公开(公告)号：US20060064770A1
公开(公告)日：2006-03-23
申请号：US11227848
申请日：2005-09-15
IPC分类号： A01K67/027 , C12N5/06 , C12N15/87
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2267/0393 , C12N15/907 , C12N2830/00
摘要： Methods for modifying a mammalian cell target such that the presence of a Y chromosome is detectable. The method includes construction of a targeting vector with a detectable marker that can recombine or insert into a pre-selected site on the Y chromosome, allowing the presence of the Y chromosome to be detectable through the presence of the integrated detectable marker. The method can be used to distinguish male from female embryos.
摘要翻译： 用于修饰哺乳动物细胞靶的方法，使得Y染色体的存在是可检测的。 该方法包括构建具有可重组或插入到Y染色体上的预先选择的位点的可检测标记的靶向载体，允许Y染色体的存在通过存在整合的可检测标记来检测。 该方法可用于区分雄性和雌性胚胎。
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