公开(公告)号：US20100118270A1

公开(公告)日：2010-05-13

申请号：US12606993

申请日：2009-10-27

申请人： William Shea ,  Yeou-Yen Cheng ,  Shelly Reed ,  Willem Crone ,  Barry Linder ,  Phillip Baker ,  Yan Zhou

发明人： William Shea ,  Yeou-Yen Cheng ,  Shelly Reed ,  Willem Crone ,  Barry Linder ,  Phillip Baker ,  Yan Zhou

IPC分类号： A61B3/117

CPC分类号： A61B3/117

摘要： An apparatus and method is disclosed that provides a means for mounting a separate optical element, such as a gonio lens, to a hand-held eye imaging device. In this way, the doctor only needs to use one hand to hold the imaging apparatus while the other hand can be freed to open the patient eye lid and also maintain a safe relative distance of the gonio lens with respect to the patient's eye. The gonio lens and adaptor can each or both be made disposable and also mechanically switchable relative to each other as well as relative to the handheld eye imaging device so that different portions of the patient eye can be imaged sequentially without the need to rotate the hand held eye imaging device.

摘要翻译： 公开了一种设备和方法，其提供用于将单独的光学元件（例如gonio透镜）安装到手持式眼睛成像装置的装置。 以这种方式，医生只需要用一只手来保持成像装置，另一只手可以被释放以打开患者眼罩，并且还保持角膜透镜相对于患者眼睛的安全的相对距离。 角膜透镜和适配器可以各自或两者都被制成一次性的并且也可以相对于彼此以及相对于手持式眼睛成像装置机械地切换，使得患者眼睛的不同部分可以顺序成像，而不需要旋转手持 眼睛成像装置。

公开(公告)号：US08328356B2

公开(公告)日：2012-12-11

申请号：US12606041

申请日：2009-10-26

申请人： Yeou-Yen Cheng ,  Barry Linder ,  Willem Crone ,  Yan Zhou

发明人： Yeou-Yen Cheng ,  Barry Linder ,  Willem Crone ,  Yan Zhou

IPC分类号： A61B3/14 ,  A61B3/10

CPC分类号： A61B5/107 ,  A61B3/10 ,  A61B3/15

摘要： An apparatus and method is disclosed that enables an existing handheld eye imaging device to do direct measurement on images taken from the patient eye. In a preferred embodiment, a reticle is arranged in the handheld eye imaging device so that a reticle image is superimposed on the object image. In addition to allowing the user to make measurements, the reticle superimposed eye image can also be used to align the eye with the handheld eye imaging device, be used for registering images taken at different times, and also be used for finding previously recorded points on the images for comparison purposes.

摘要翻译： 公开了一种使现有的手持式眼睛成像装置能够对从患者眼睛拍摄的图像进行直接测量的装置和方法。 在优选实施例中，在手持式眼睛成像装置中布置了掩模版，使得掩模版图像叠加在物体图像上。 除了允许用户进行测量之外，还可以使用掩模版叠加的眼睛图像来将眼睛与手持式眼睛成像装置对准，用于记录在不同时间拍摄的图像，并且还可以用于查找先前记录的点 图像用于比较。

公开(公告)号：US20100110378A1

公开(公告)日：2010-05-06

申请号：US12606041

申请日：2009-10-26

申请人： Yeou-Yen Cheng ,  Barry Linder ,  Willem Crone ,  Yan Zhou

发明人： Yeou-Yen Cheng ,  Barry Linder ,  Willem Crone ,  Yan Zhou

IPC分类号： A61B3/15

CPC分类号： A61B5/107 ,  A61B3/10 ,  A61B3/15

摘要： An apparatus and method is disclosed that enables an existing handheld eye imaging device to do direct measurement on images taken from the patient eye. In a preferred embodiment, a reticle is arranged in the handheld eye imaging device so that a reticle image is superimposed on the object image. In addition to allowing the user to make measurements, the reticle superimposed eye image can also be used to align the eye with the handheld eye imaging device, be used for registering images taken at different times, and also be used for finding previously recorded points on the images for comparison purposes.

摘要翻译： 公开了一种使现有的手持式眼睛成像装置能够对从患者眼睛拍摄的图像进行直接测量的装置和方法。 在优选实施例中，在手持式眼睛成像装置中布置了掩模版，使得掩模版图像叠加在物体图像上。 除了允许用户进行测量之外，还可以使用掩模版叠加的眼睛图像来将眼睛与手持式眼睛成像装置对准，用于记录在不同时间拍摄的图像，并且还可以用于查找先前记录的点 图像用于比较。

公开(公告)号：US20100121442A1

公开(公告)日：2010-05-13

申请号：US12606017

申请日：2009-10-26

申请人： William Shea ,  Barry Linder ,  Phillip Baker ,  Yan Zhou

发明人： William Shea ,  Barry Linder ,  Phillip Baker ,  Yan Zhou

IPC分类号： A61F2/16

CPC分类号： A61K9/0048 ,  A61B3/00 ,  A61B3/125 ,  A61K49/00

摘要： The invention discloses an optical coupling gel that has a set of desired features for application in eye imaging, including being approved for eye contact, optically transparent, able to maintain normal hydration of the ocular surface, flexible and capable of maintaining a distinct shape, minimal in breakdown/change during use, and easily dispensable/applicable. In one embodiment, the gel is made of Sodium Carboxy Methylcellulose (SCMC), where the amount of the cellulose determines the viscosity of the gel for its particular application. The right amount of gel is contained in an applicator for application to one or two eyes.

摘要翻译： 本发明公开了一种光学耦合凝胶，其具有用于眼睛成像中的一组所需特征，包括被认可用于眼睛接触，光学透明的，能够保持眼表面的正常水合，柔性并能够保持不同形状，最小化 在使用过程中发生故障/更换，并且易于安装/适用。 在一个实施方案中，凝胶由羧甲基纤维素钠（SCMC）制成，其中纤维素的量决定了其特定用途的凝胶的粘度。 适量的凝胶包含在施用于一只或两只眼睛的施用器中。

公开(公告)号：US08518109B2

公开(公告)日：2013-08-27

申请号：US12606017

申请日：2009-10-26

申请人： William Shea ,  Barry Linder ,  Phillip Baker ,  Yan Zhou

发明人： William Shea ,  Barry Linder ,  Phillip Baker ,  Yan Zhou

IPC分类号： A61F2/16 ,  A61F2/14

CPC分类号： A61K9/0048 ,  A61B3/00 ,  A61B3/125 ,  A61K49/00

摘要： The invention discloses an optical coupling gel that has a set of desired features for application in eye imaging, including being approved for eye contact, optically transparent, able to maintain normal hydration of the ocular surface, flexible and capable of maintaining a distinct shape, minimal in breakdown/change during use, and easily dispensable/applicable. In one embodiment, the gel is made of Sodium Carboxy Methylcellulose (SCMC), where the amount of the cellulose determines the viscosity of the gel for its particular application. The right amount of gel is contained in an applicator for application to one or two eyes.

摘要翻译： 本发明公开了一种光学耦合凝胶，其具有用于眼睛成像中的一组所需特征，包括被认可用于眼睛接触，光学透明的，能够保持眼表面的正常水合，柔性并能够保持不同形状，最小化 在使用过程中发生故障/更换，并且易于安装/适用。 在一个实施方案中，凝胶由羧甲基纤维素钠（SCMC）制成，其中纤维素的量决定了其特定用途的凝胶的粘度。 适量的凝胶包含在施用于一只或两只眼睛的施用器中。

公开(公告)号：US08100530B2

公开(公告)日：2012-01-24

申请号：US12605219

申请日：2009-10-23

申请人： Yan Zhou ,  William Shea ,  Barry Linder ,  Phillip Baker

发明人： Yan Zhou ,  William Shea ,  Barry Linder ,  Phillip Baker

IPC分类号： A61B3/10

CPC分类号： A61B3/1015 ,  A61B3/0025 ,  A61B3/0041 ,  A61B3/0091 ,  A61B3/036 ,  A61B3/10 ,  A61B3/103 ,  A61B3/1035 ,  A61B3/13 ,  A61B3/14 ,  A61B5/7415 ,  A61B90/20 ,  G01J9/00 ,  G01J2003/064

摘要： Example embodiments include a dynamic wavefront sensor, a controllable wavefront offsetting element and a controller that controls the controllable wavefront offsetting element to offset selected non-plane wave aberration components in order to allow remaining non-plane wave aberration components to be more efficiently detected and measured.

摘要翻译： 示例实施例包括动态波前传感器，可控波前偏移元件和控制器，其控制可控波前偏移元件以偏移所选择的非平面波像差分量，以便更有效地检测和测量剩余的非平面波像差分量 。

公开(公告)号：US08454162B2

公开(公告)日：2013-06-04

申请号：US13354763

申请日：2012-01-20

申请人： Yan Zhou ,  William Shea ,  Barry Linder ,  Baker Phil

发明人： Yan Zhou ,  William Shea ,  Barry Linder ,  Baker Phil

IPC分类号： A61B3/10

CPC分类号： A61B3/1015 ,  A61B3/0025 ,  A61B3/0041 ,  A61B3/0091 ,  A61B3/036 ,  A61B3/10 ,  A61B3/103 ,  A61B3/1035 ,  A61B3/13 ,  A61B3/14 ,  A61B5/7415 ,  A61B90/20 ,  G01J9/00 ,  G01J2003/064

摘要： In one embodiment a wavefront sensor is configured to measure real time aberration values of a wavefront returned from the eye of a patient while an image of the eye of the patient is being viewed by a surgeon during an on-going vision correction procedure and for providing an output signal indicating real time aberration values and a display, coupled to the wavefront sensor, is configured to show a dynamic display indicating the real time aberration values to the surgeon and configured to be viewed by the surgeon while also viewing the image of the eye of the patient during the on-going vision correction procedure.

摘要翻译： 在一个实施例中，波前传感器被配置为测量从患者的眼睛返回的波前的实时像差值，同时外科医生在正在进行的视力矫正程序期间观察患者的眼睛的图像，并提供 指示实时像差值的输出信号和耦合到波前传感器的显示器被配置为向外科医生显示指示实时像差值的动态显示，并被配置为由外科医生观察，同时还观察眼睛的图像 在持续的视力矫正过程中患者。

公开(公告)号：US07621636B2

公开(公告)日：2009-11-24

申请号：US11621943

申请日：2007-01-10

申请人： Wei Su ,  Yan Zhou ,  Qing Chun Zhao ,  Yeou-Yen Cheng

发明人： Wei Su ,  Yan Zhou ,  Qing Chun Zhao ,  Yeou-Yen Cheng

IPC分类号： A61B3/14 ,  A61B3/10

CPC分类号： A61B3/12 ,  A61B3/102 ,  A61B3/152

摘要： In embodiments of optical arrangements of a working distance sensor in a fundus camera that can improve the determination of a correct working distance as well as the transverse positioning of the camera a number of near infrared light sources are arranged to project a number of near infrared illumination beams into the visible light illumination path of the fundus camera and a live view of the retina under near infrared illumination is captured and displayed on a monitor. These embodiments of optical arrangements and associated methods will enable an operator to directly determine if there is any undesirable flare or other artifact appearing within a designated region on the infrared retina view as a result of a wrong alignment of the fundus camera with respect to the eye in terms of not only the working distance but also the horizontal and vertical positions. Pattern recognition algorithms can be used to further enhance the positioning sensitivity of the working distance sensor. An additional iris alignment sensor can be added to achieve a coarse alignment and also function as a measure to determine if the dilation of the iris size is sufficient for different mode of fundus imaging.

摘要翻译： 在眼底照相机中的工作距离传感器的光学布置的实施例中，其可以改善确定正确的工作距离以及相机的横向定位，并且布置多个近红外光源以投射多个近红外照明 光束进入眼底照相机的可见光照明路径，并且在近红外照明下的视网膜的实时图像被捕获并显示在监视器上。 光学布置和相关方法的这些实施例将使得操作者能够直接确定由于眼底照相机相对于眼睛错误对准的结果，在红外线视网膜视图上的指定区域内是否存在任何不期望的耀斑或其他伪像 不仅在于工作距离，还包括水平和垂直位置。 模式识别算法可用于进一步提高工作距离传感器的定位灵敏度。 可以添加附加的虹膜对准传感器以实现粗略对准，并且还用作确定虹膜尺寸的扩张是否足够用于不同的眼底成像模式的措施。

公开(公告)号：US07621638B2

公开(公告)日：2009-11-24

申请号：US11606597

申请日：2006-11-29

申请人： Wei Su ,  Yan Zhou ,  Yeou-Yen Cheng ,  Qing Chun Zhao

发明人： Wei Su ,  Yan Zhou ,  Yeou-Yen Cheng ,  Qing Chun Zhao

IPC分类号： A61B3/10 ,  F21V7/00

CPC分类号： A61B3/0008 ,  A61B3/12

摘要： A light delivery technique includes optical configurations as well as the associated methods that generate a ring beam from a linear light source. In one embodiment, a remote light source module delivers illumination light to a fundus camera and/or slit lamp. In another embodiment, an arrangement combines the use of a light pipe homogenizer and a ring beam transformer for efficiently collecting light from a substantially axially linear light source, homogenizing the collected light that lacks low angle flux relative to the optical axis, and transforming the light into a ring beam with a substantially improved low angle flux distribution. In still another embodiment, light emitted from a substantially axially linear light source is directly collected by a curved surface mirror and spatially filtered into a ring beam. The ring illumination beam can be co-axially projected on a sample such as the pupil of a human eye and at the same time the light beam also has a large enough relatively uniform angular flux distribution so that a wide area on the retina of the eye can be uniformly illuminated.

摘要翻译： 光输送技术包括光学配置以及从线性光源产生环形光束的相关方法。 在一个实施例中，远程光源模块将照明光传送到眼底照相机和/或裂隙灯。 在另一个实施例中，一种布置结合了光管均质器和环形光束变换器的使用，用于有效地收集来自基本轴向线性光源的光，使收集到的光相互均匀化，所述光相对于光轴缺少低角度通量，以及将光转换 成为具有基本上改进的低角度通量分布的环形梁。 在另一个实施例中，从基本轴向线性光源发射的光直接由弯曲表面镜收集，并在空间上过滤成环形光束。 环形照明光束可以同轴地投射在诸如人眼的瞳孔的样品上，并且同时光束也具有足够大的相对均匀的角度通量分布，使得眼睛的视网膜上的广泛区域 可以均匀照明。

公开(公告)号：US20080165322A1

公开(公告)日：2008-07-10

申请号：US11621943

申请日：2007-01-10

申请人： Wei Su ,  Yan Zhou ,  Qing Chun Zhao ,  Yeou-Yen Cheng

发明人： Wei Su ,  Yan Zhou ,  Qing Chun Zhao ,  Yeou-Yen Cheng

IPC分类号： A61B3/12

CPC分类号： A61B3/12 ,  A61B3/102 ,  A61B3/152

摘要： In embodiments of optical arrangements of a working distance sensor in a fundus camera that can improve the determination of a correct working distance as well as the transverse positioning of the camera a number of near infrared light sources are arranged to project a number of near infrared illumination beams into the visible light illumination path of the fundus camera and a live view of the retina under near infrared illumination is captured and displayed on a monitor. These embodiments of optical arrangements and associated methods will enable an operator to directly determine if there is any undesirable flare or other artifact appearing within a designated region on the infrared retina view as a result of a wrong alignment of the fundus camera with respect to the eye in terms of not only the working distance but also the horizontal and vertical positions. Pattern recognition algorithms can be used to further enhance the positioning sensitivity of the working distance sensor. An additional iris alignment sensor can be added to achieve a coarse alignment and also function as a measure to determine if the dilation of the iris size is sufficient for different mode of fundus imaging.

摘要翻译： 在眼底照相机中的工作距离传感器的光学布置的实施例中，其可以改善确定正确的工作距离以及相机的横向定位，并且布置多个近红外光源以投射多个近红外照明 光束进入眼底照相机的可见光照明路径，并且在近红外照明下的视网膜的实时图像被捕获并显示在监视器上。 光学布置和相关方法的这些实施例将使得操作者能够直接确定由于眼底照相机相对于眼睛错误对准的结果，在红外线视网膜视图上的指定区域内是否存在任何不期望的耀斑或其他伪像 不仅在于工作距离，还包括水平和垂直位置。 模式识别算法可用于进一步提高工作距离传感器的定位灵敏度。 可以添加附加的虹膜对准传感器以实现粗略对准，并且还用作确定虹膜尺寸的扩张是否足够用于不同的眼底成像模式的措施。