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    Composition and method to augment and sustain neurotransmitter production
    2.
    发明授权
    Composition and method to augment and sustain neurotransmitter production 有权
    增加和维持神经递质生成的组成和方法

    公开(公告)号：US07595067B2

    公开(公告)日：2009-09-29

    申请号：US11714052

    申请日：2007-03-05

    Applicant: William Shell ,  Elizabeth Charuvastra

    Inventor： William Shell ,  Elizabeth Charuvastra

    IPC: A61K36/25 ,  A61K36/734 ,  A61K36/00 ,  A61K36/16 ,  A61K36/254 ,  A61K36/54 ,  A61K36/28

    CPC classification number: A61K31/522 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/16 ,  A61K36/185 ,  A61K36/258 ,  A61K36/28 ,  A61K36/38 ,  A61K36/54 ,  A61K36/734 ,  A61K45/06 ,  A61K2300/00 ,  A23V2250/2108 ,  A23V2250/0624 ,  A23V2250/0652 ,  A23V2250/2122 ,  A23V2250/304 ,  A23V2250/0618 ,  A23V2250/2106

    Abstract: This invention describes a method and composition to enhance the synthesis and release of the neurotransmitters by the oral administration of neurotransmitter precursors, along with natural plant substances that stimulate uptake of the neurotransmitters precursors, while adding natural plant substances that activate adenylate cyclase in order to avoid attenuation and prevent pharmacologic tolerance. The invention describes compositions for a medical foods that are designed to improve cognitive function, induced sleep, a improve Parasympathetic function, improve autonomic balance, increase nitric oxide production, reduce blood pressure, increase blood flow, and treat virus infections. The compositions include amino acids such as choline, herbs such ginkgo biloba, and other foods such as coca. The invention also describes the use of physiologic tests such as 24 hour ECG monitoring to create the appropriate combinations and assess the useful proportions.

    Abstract translation: 本发明描述了通过口服神经递质前体以及刺激神经递质前体摄取的天然植物物质来增强神经递质的合成和释放的方法和组合物，同时加入激活腺苷酸环化酶的天然植物物质以避免 衰减并防止药理学耐受。 本发明描述了旨在改善认知功能，诱导睡眠，改善副交感神经功能，改善自主神经平衡，增加一氧化氮产生，降低血压，增加血流量和治疗病毒感染的医用食品的组合物。 组合物包括氨基酸如胆碱，草本银杏和其他食物如古柯。 本发明还描述了诸如24小时ECG监测的生理测试的使用以产生适当的组合并评估有用的比例。

    Composition and method to augment and sustain neurotransmitter production
    3.
    发明申请
    Composition and method to augment and sustain neurotransmitter production 有权
    增加和维持神经递质生成的组成和方法

    公开(公告)号：US20070160690A1

    公开(公告)日：2007-07-12

    申请号：US11713907

    申请日：2007-03-05

    Applicant: William Shell ,  Elizabeth Charuvastra

    Inventor： William Shell ,  Elizabeth Charuvastra

    IPC: A61K36/254 ,  A61K36/38 ,  A61K36/54 ,  A61K36/16 ,  A61K36/73 ,  A61K31/522 ,  A61K31/405

    CPC classification number: A61K31/522 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/16 ,  A61K36/185 ,  A61K36/258 ,  A61K36/28 ,  A61K36/38 ,  A61K36/54 ,  A61K36/734 ,  A61K45/06 ,  A61K2300/00 ,  A23V2250/2108 ,  A23V2250/0624 ,  A23V2250/0652 ,  A23V2250/2122 ,  A23V2250/304 ,  A23V2250/0618 ,  A23V2250/2106

    Abstract: This invention describes a method and composition to enhance the synthesis and release of the neurotransmitters by the oral administration of neurotransmitter precursors, along with natural plant substances that stimulate uptake of the neurotransmitters precursors, while adding natural plant substances that activate adenylate cyclase in order to avoid attenuation and prevent pharmacologic tolerance. The invention describes compositions for a medical foods that are designed to improve cognitive function, induced sleep, a improve Parasympathetic function, improve autonomic balance, increase nitric oxide production, reduce blood pressure, increase blood flow, and treat virus infections. The compositions include amino acids such as choline, herbs such ginkgo biloba, and other foods such as coca. The invention also describes the use of physiologic tests such as 24 hour ECG monitoring to create the appropriate combinations and assess the useful proportions.

    Abstract translation: 本发明描述了通过口服神经递质前体以及刺激神经递质前体摄取的天然植物物质来增强神经递质的合成和释放的方法和组合物，同时加入激活腺苷酸环化酶的天然植物物质以避免 衰减并防止药理学耐受。 本发明描述了旨在改善认知功能，诱导睡眠，改善副交感神经功能，改善自主神经平衡，增加一氧化氮产生，降低血压，增加血流量和治疗病毒感染的医用食品的组合物。 组合物包括氨基酸如胆碱，草本银杏和其他食物如古柯。 本发明还描述了诸如24小时ECG监测的生理测试的使用以产生适当的组合并评估有用的比例。

    Process for measuring QT intervals and constructing composite histograms to compare groups
    9.
    发明申请
    Process for measuring QT intervals and constructing composite histograms to compare groups 审中-公开
    测量QT间隔和构建复合直方图以比较组的过程

    公开(公告)号：US20050010123A1

    公开(公告)日：2005-01-13

    申请号：US10617159

    申请日：2003-07-09

    Applicant: Elizabeth Charuvastra ,  William Shell ,  Joan Horvath

    Inventor： Elizabeth Charuvastra ,  William Shell ,  Joan Horvath

    IPC: A61B5/0402 ,  A61B5/0452

    CPC classification number: A61B5/0452

    Abstract: A quantitative method for measuring a cardiac function interval is described as well as its application to differentiating among populations of patients. Once such populations are characterized, said method can be used as a diagnostic test for individual patients when their measured data is compared against the composite data collected by the methods herein. Beat-to-beat electrocardiographic interval data is collected over an extended period of time, such beat-to-beat data being obtained from more than one subject, the beat-to-beat interval data from each subject is then used to create a composite histogram. A series of bins representing a histogram, each of which has a value range, is defined for each subject. The collected data are organized into the bins in accordance with the value of the data and the value range of the bin, thereby creating a set of bins of each interval for each subject. A composite histogram from the set of patients is constructed by summing the data from each bin. Two composite histograms, representing two sets of observations, can then be compared using measures of central tendency, variance and outliers. This method is then applied to distinguish among populations with particular characteristics, including normal subjects persons with congenital abnormalities, and persons affected by the exposure to a pharmaceutical, toxic chemical, or other ingested or inhaled substance.

    Abstract translation: 描述了用于测量心脏功能间隔的定量方法以及其在区分患者群体中的应用。 一旦这样的群体被表征，当将其测量数据与通过本文的方法收集的复合数据进行比较时，所述方法可以用作个体患者的诊断测试。 在延长的时间段内收集节拍心电图间隔数据，从多于一个受试者获得这种节拍数据，然后使用来自每个受试者的节拍间隔数据来创建复合物 直方图。 为每个对象定义一系列表示每个具有值范围的直方图的条形图。 所收集的数据根据​​数据的值和存储体的数值范围被组织到存储箱中，从而为每个对象创建每个区间的一组区块。 通过对来自每个仓的数据求和来构建来自患者组的复合直方图。 然后可以使用中心趋势，方差和异常值的度量来比较两个表示两组观察值的复合直方图。 然后应用该方法来区分具有特殊特征的群体，包括正常受试者先天性异常者，以及受到药物，有毒化学物质或其他摄入或吸入物质暴露影响的人群。

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