摘要:
Antibody formulations are described comprising a mixture of a non-reducing sugar, an anti-α4β7 antibody and at least one amino acid. The disclosed formulations have improved stability, reduced aggregate formation, and may retard degradation of the anti-α4β7 antibody therein or exhibit any combinations thereof. The present invention further provides a safe dosing regimen of these antibody formulations that is easy to follow, and which results in a therapeutically effective amount of the anti-α4β7 anti body in vivo.
摘要:
Antibody formulations are described comprising a mixture of a non-reducing sugar, an anti-α4β7 antibody and at least one amino acid. The disclosed formulations have improved stability, reduced aggregate formation, and may retard degradation of the anti-α4β7 antibody therein or exhibit any combinations thereof. The present invention further provides a safe dosing regimen of these antibody formulations that is easy to follow, and which results in a therapeutically effective amount of the anti-α4β7 antibody in vivo.
摘要:
Antibody formulations are described comprising a mixture of an anti-α4β7 antibody, an antioxidant or chelator, and at least one free amino acid. The disclosed formulations may have improved stability, reduced aggregate formation, or both. The present invention further provides a safe dosing regimen of these antibody formulations that is easy to follow, and which results in a therapeutically effective amount of the anti-α4β7 antibody in vivo.
摘要:
Antibody formulations are described comprising a mixture of an anti-α4β7 antibody, an antioxidant or chelator, and at least one free amino acid. The disclosed formulations may have improved stability, reduced aggregate formation, or both. The present invention further provides a safe dosing regimen of these antibody formulations that is easy to follow, and which results in a therapeutically effective amount of the anti-α4β7 antibody in vivo.
摘要:
A composition comprising: a plurality of identical first synthetic nucleotide oligomers; and a plurality of identical second synthetic nucleotide oligomers which are different to the first synthetic nucleotide oligomers, wherein each of the first synthetic nucleotide oligomers comprises a first primer binding sequence of bases, a first identifier sequence of three to seven bases in length, and a second primer binding sequence of bases, the first identifier sequence being disposed between the first and second primer binding sequences, wherein each of the second synthetic nucleotide oligomers comprises a third primer binding sequence of bases, a second identifier sequence of three to seven bases in length, and a fourth primer binding sequence of bases, the second identifier sequence being disposed between the third and fourth primer binding sequences, and wherein the first identifier sequence is different to the second identifier sequence.
摘要:
Circuits, apparatuses, and methods are disclosed for delay models. In one such example circuit, a first delay model circuit is configured to provide a first output signal by modeling a delay of a signal through a path. A second delay model circuit is configured to provide a second output signal by modeling the delay of the signal through the path. A compare circuit is coupled to the first and second delay model circuits. The compare circuit is configured to compare a third signal from the first delay model circuit and a fourth signal from the second delay model circuit, and, in response provide an adjustment signal to adjust the delay of the second delay model circuit.
摘要:
Devices and methods are disclosed by which a smart card or UICC that is removably insertable into a wireless terminal will only allow operation in either a specific terminal or a specific set of terminals. A mechanism to restrict the set of terminals that a UICC will operate with based upon logic embedded in a memory within the UICC. The UICC receives specific information from the wireless terminal when the terminal is turned on. If the information received satisfies a plurality of rules or conditions stored within the UICC, the UICC functions normally and the terminal may be registered with the network. If the UICC is inserted in an unsupported terminal, the UICC will refuse to function normally. This provides a deterrent against UICC theft.
摘要:
Methods, devices, and systems are disclosed, including those for a buffer having pre-driver circuitry that provide voltages to thin-gate dielectric transistors. One such buffer may include a primary pull-up pre-driver operably coupled to a primary pull-up transistor; a secondary pull-up pre-driver operably coupled to a secondary pull-up transistor; a primary pull-down pre-driver operably coupled to a primary pull-down transistor; and a secondary pull-down pre-driver operably coupled to a secondary pull-down transistor. The pre-drivers may provide a sufficiently low voltage to a gate of a transistor operably coupled thereto so as to sustain a gate dielectric integrity of the transistor, wherein at least one of the primary pull-up pre-driver, the secondary pull-up pre-driver, primary pull-down pre-driver, and the secondary pull-down pre-driver is configured to provide a voltage greater than or equal to a ground voltage and less than or equal to a supply voltage.
摘要:
Methods, devices, and systems are disclosed, including those for a buffer having pre-driver circuitry configured to provide voltages to thin-gate dielectric transistors. One such buffer may comprise a plurality of pre-drivers wherein each pre-driver of the plurality of pre-drivers is operably coupled to a transistor of a plurality of transistors. The buffer may further comprise one or more clamping devices, wherein at least one transistor of the plurality of transistors has a gate coupled to at least one clamping device of the one or more clamping devices.
摘要:
Circuits, memories, and methods for latching a write command and later provided write data including write command and write data timing circuits. One such timing circuit includes internal write command latch to latch an internal write command in response to write command latch signal. The internal write command latch releases the latched write command in response to the write command latch signal after a latency delay. The timing circuit further includes a write leveling flip-flop (FF) circuit and a write data register. One such method includes generating and latching an internal write command. The latched internal write command is released after a latency delay responsive to the memory clock signal. The internal write command is propagated over an internal write command path. Write data is captured and internal write command latched in response to a write clock signal. The captured write data is released to be written to memory.