-
公开(公告)号：US12161726B2
公开(公告)日：2024-12-10
申请号：US17932736
申请日：2022-09-16
Inventor： K. Craig Kent , Shaoqin Gong , Lianwang Guo , Bowen Wang , Guojun Chen , Go Urabe
Abstract: The present disclosure relates to unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. The disclosed compositions are useful for treating a subject with a disease or condition, such as a cardiovascular disease. In a further aspect, the cardiovascular disease can be a vascular stenosis or restenosis. Also described herein are methods of making and using the unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
-
公开(公告)号：US20210205473A1
公开(公告)日：2021-07-08
申请号：US17057415
申请日：2019-05-23
Inventor： K. Craig Kent , Shaoqin Gong , Lianwang Guo , Bowen Wang , Guojun Chen , Go Urabe
Abstract: The present disclosure relates to unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. The disclosed compositions are useful for treating a subject with a disease or condition, such as a cardiovascular disease. In a further aspect, the cardiovascular disease can be a vascular stenosis or restenosis. Also described herein are methods of making and using the unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
-
公开(公告)号：US10668017B2
公开(公告)日：2020-06-02
申请号：US15674293
申请日：2017-08-10
Applicant: Wisconsin Alumni Research Foundation
Inventor： K. Craig Kent , Shaoqin Gong , Xudong Shi , Guojun Chen , Lian-Wang Guo
IPC: A61K9/107 , A61K31/436 , A61K47/34 , A61K9/06 , A61K9/51
Abstract: The present technology provide compositions that are drug delivery systems for the sustained release of anti-stenotic drugs for the treatment and prevention of occlusion of blood vessels, particularly after perivascular surgery. The compositions include a hydrogel, unimolecular micelles dispersed within the hydrogel, and an effective amount of anti-stenotic drug dispersed within the unimolecular micelle. The hydrogel may be a di-or tri-block copolymer comprising one block of poly(ethylene glycol) (PEG) and one or two blocks of poly(lactic-co-glycolic acid) (PLGA). The unimolecular micelle may include three domains: a dendritic polymer core, hydrophobic block polymers (e.g., PVL, PVCL, and/or PCL) attached to the core and PEG attached to the hydrophobic block polymers.
-
Patent Agency Ranking
公开(公告)号：US20150011492A1
公开(公告)日：2015-01-08
申请号：US14322630
申请日：2014-07-02
Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
Inventor： F. Michael Hoffmann , K. Craig Kent , Shakti Goel , Lian-Wang Guo , Toshio Takayama
IPC: A61K31/704 , A61F2/82 , A61K31/517 , A61K31/436 , A61K31/047
CPC classification number: A61K31/704 , A61F2/82 , A61F2250/0067 , A61K31/047 , A61K31/05 , A61K31/436 , A61K31/517 , A61K47/10 , A61K47/34 , A61K2300/00
Abstract: The present invention relates generally to the pathology of restenosis. In particular, provided herein are devices comprising a compound that selectively decreasing smooth muscle cell proliferation without a substantial decrease in endothelial cell proliferation. Also provided are methods of using such devices to treat, prevent, or reduce vascular disease or the likelihood of restenosis following angioplasty.
Abstract translation: 本发明一般涉及再狭窄的病理学。 特别地，本文提供了包含选择性地降低平滑肌细胞增殖而不显着降低内皮细胞增殖的化合物的装置。 还提供了使用这种装置治疗，预防或减少血管疾病或血管成形术后再狭窄的可能性的方法。
-
公开(公告)号：US20230346972A1
公开(公告)日：2023-11-02
申请号：US17932736
申请日：2022-09-16
Inventor： K. Craig Kent , Shaoqin Gong , Lianwang Guo , Bowen Wang , Guojun Chen , Go Urabe
CPC classification number: A61K47/6937 , A61K9/5153 , A61K45/06 , B82Y5/00
Abstract: The present disclosure relates to unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. The disclosed compositions are useful for treating a subject with a disease or condition, such as a cardiovascular disease. In a further aspect, the cardiovascular disease can be a vascular stenosis or restenosis. Also described herein are methods of making and using the unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
-
公开(公告)号：US11446392B2
公开(公告)日：2022-09-20
申请号：US17057415
申请日：2019-05-23
Inventor： K. Craig Kent , Shaoqin Gong , Lianwang Guo , Bowen Wang , Guojun Chen , Go Urabe
Abstract: The present disclosure relates to unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. The disclosed compositions are useful for treating a subject with a disease or condition, such as a cardiovascular disease. In a further aspect, the cardiovascular disease can be a vascular stenosis or restenosis. Also described herein are methods of making and using the unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
-
公开(公告)号：US09132171B2
公开(公告)日：2015-09-15
申请号：US13795235
申请日：2013-03-12
Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
Inventor： Shakti Goel , Lian Guo , K. Craig Kent
IPC: A61K38/28 , A61K38/18 , A61K38/00 , A61K38/16 , C07K1/00 , A61K9/00 , A61K31/28 , A61L31/16 , A61L31/14
CPC classification number: A61K38/28 , A61K9/00 , A61K31/28 , A61K38/18 , A61L31/145 , A61L31/16 , A61L2300/414 , A61L2300/43 , A61K2300/00
Abstract: Methods, compositions, and devices for treating restenosis are described. In accord with the invention, a composition containing CTGF and insulin is applied to blood vessels and restenosis is reduced or prevented.
Abstract translation: 描述了用于治疗再狭窄的方法，组合物和装置。 根据本发明，将含有CTGF和胰岛素的组合物应用于血管，减少或预防再狭窄。
-
公开(公告)号：US20130330376A1
公开(公告)日：2013-12-12
申请号：US13795235
申请日：2013-03-12
Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
Inventor： Shakti Goel , Lian Guo , K. Craig Kent
CPC classification number: A61K38/28 , A61K9/00 , A61K31/28 , A61K38/18 , A61L31/145 , A61L31/16 , A61L2300/414 , A61L2300/43 , A61K2300/00
Abstract: Methods, compositions, and devices for treating restenosis are described. In accord with the invention, a composition containing CTGF and insulin is applied to blood vessels and restenosis is reduced or prevented.
Abstract translation: 描述了用于治疗再狭窄的方法，组合物和装置。 根据本发明，将含有CTGF和胰岛素的组合物应用于血管，减少或预防再狭窄。
-
-
-
-
-
-
-
Search Results
8
records
(took 0.014 seconds)
