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公开(公告)号：US12161726B2
公开(公告)日：2024-12-10
申请号：US17932736
申请日：2022-09-16
Inventor： K. Craig Kent , Shaoqin Gong , Lianwang Guo , Bowen Wang , Guojun Chen , Go Urabe
Abstract: The present disclosure relates to unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. The disclosed compositions are useful for treating a subject with a disease or condition, such as a cardiovascular disease. In a further aspect, the cardiovascular disease can be a vascular stenosis or restenosis. Also described herein are methods of making and using the unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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公开(公告)号：US20210205473A1
公开(公告)日：2021-07-08
申请号：US17057415
申请日：2019-05-23
Inventor： K. Craig Kent , Shaoqin Gong , Lianwang Guo , Bowen Wang , Guojun Chen , Go Urabe
Abstract: The present disclosure relates to unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. The disclosed compositions are useful for treating a subject with a disease or condition, such as a cardiovascular disease. In a further aspect, the cardiovascular disease can be a vascular stenosis or restenosis. Also described herein are methods of making and using the unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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Patent Agency Ranking
公开(公告)号：US11058644B2
公开(公告)日：2021-07-13
申请号：US15819424
申请日：2017-11-21
Applicant: Wisconsin Alumni Research Foundation
Inventor： Shaoqin Gong , Guojun Chen
IPC: C12N15/11 , A61K9/51 , A61K31/713 , A61P35/00
Abstract: Provided are a unimolecular nanoparticle, a composition thereof, and methods of use thereof, and includes 1) a dendritic polymer having a molecular weight of about 500-120,000 Da and terminating in hydroxyl, amino or carboxylic acid groups; 2) cationic polymers attached to at least a majority of the terminating groups of the dendritic polymer via a pH-sensitive linker, wherein each cationic polymer comprises a polymeric backbone attached to cationic functional groups and to weakly basic groups by disulfide bonds, wherein the molar ratio of cationic functional groups to weakly basic groups ranges from 1:1-5:1, and has a molecular weight from about 1,000-5,000 Da; and 3) poly(ethylene glycol) attached to a plurality of cationic polymers and having a terminal group selected from a targeting ligand, OH, O-alkyl, NH2, biotin, or a dye, wherein the terminal group of at least one poly(ethylene glycol) is having a molecular weight of about 1,000-15,000 Da.
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公开(公告)号：US11013695B2
公开(公告)日：2021-05-25
申请号：US16113963
申请日：2018-08-27
Applicant: Wisconsin Alumni Research Foundation
Inventor： Shaoqin Gong , Amr Abdeen , Krishanu Saha , Guojun Chen , Yuyuan Wang , Ruosen Xie
IPC: A61K9/51 , A61K48/00 , A61K47/32 , C12N15/11 , A61K38/46 , C12N15/113 , A61K31/7105 , A61K9/50 , C12N9/22 , C12N15/90
Abstract: Provided herein are nanocapsules comprising a single ribonucleoprotein (RNP) complex as a core and an biodegradable crosslinked polymer shell that encapsulates the core, wherein the RNP complex comprises a Cas9 polypeptide and a guide RNA, and the biodegradable crosslinked polymer shell comprises polymerized monomers of imidazolyl acryloyl monomers, bisacryloyl disulfide monomers (a biodegradable cross-linker), optionally PEG acryloyl monomers, and either cationic acryloyl monomers, anionic acryloyl monomers, or both cationic and anionic acryloyl monomers (optionally in combination with non-ionic acryloyl monomers) as defined herein. Also provided are methods of making the nanocapsules, kits containing the nanocapsules and methods of delivering the encapsulated RNP to cells.
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公开(公告)号：US11446392B2
公开(公告)日：2022-09-20
申请号：US17057415
申请日：2019-05-23
Inventor： K. Craig Kent , Shaoqin Gong , Lianwang Guo , Bowen Wang , Guojun Chen , Go Urabe
Abstract: The present disclosure relates to unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. The disclosed compositions are useful for treating a subject with a disease or condition, such as a cardiovascular disease. In a further aspect, the cardiovascular disease can be a vascular stenosis or restenosis. Also described herein are methods of making and using the unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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公开(公告)号：US10668017B2
公开(公告)日：2020-06-02
申请号：US15674293
申请日：2017-08-10
Applicant: Wisconsin Alumni Research Foundation
Inventor： K. Craig Kent , Shaoqin Gong , Xudong Shi , Guojun Chen , Lian-Wang Guo
IPC: A61K9/107 , A61K31/436 , A61K47/34 , A61K9/06 , A61K9/51
Abstract: The present technology provide compositions that are drug delivery systems for the sustained release of anti-stenotic drugs for the treatment and prevention of occlusion of blood vessels, particularly after perivascular surgery. The compositions include a hydrogel, unimolecular micelles dispersed within the hydrogel, and an effective amount of anti-stenotic drug dispersed within the unimolecular micelle. The hydrogel may be a di-or tri-block copolymer comprising one block of poly(ethylene glycol) (PEG) and one or two blocks of poly(lactic-co-glycolic acid) (PLGA). The unimolecular micelle may include three domains: a dendritic polymer core, hydrophobic block polymers (e.g., PVL, PVCL, and/or PCL) attached to the core and PEG attached to the hydrophobic block polymers.
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公开(公告)号：US20230346972A1
公开(公告)日：2023-11-02
申请号：US17932736
申请日：2022-09-16
Inventor： K. Craig Kent , Shaoqin Gong , Lianwang Guo , Bowen Wang , Guojun Chen , Go Urabe
CPC classification number: A61K47/6937 , A61K9/5153 , A61K45/06 , B82Y5/00
Abstract: The present disclosure relates to unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. The disclosed compositions are useful for treating a subject with a disease or condition, such as a cardiovascular disease. In a further aspect, the cardiovascular disease can be a vascular stenosis or restenosis. Also described herein are methods of making and using the unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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