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公开(公告)号：US07223808B2
公开(公告)日：2007-05-29
申请号：US10480917
申请日：2002-06-14
CPC分类号： A61L27/46 , A61K6/0023 , A61K6/0273 , A61K6/033 , A61L24/0084 , A61L24/0089 , A61L24/06 , A61L27/446 , C08L33/12 , C08L33/00
摘要： The invention relates to a method for the production of an adhesive and an adhesive kit for joining similar or different metal surfaces or ceramics, especially in the field of biomedicine. The objective of the invention is to avoid polymerization-linked by-products and disadvantageous effects, in addition to enabling a temporary biocompatible bond between metal and metal or metal and ceramics. The inventive method consist in using a monomer-free polymethylmethacrylate which is mixed with a suitable, non-toxic solvent and a bioactive vitreous-crystalline material with a particle size ranging from 0.05–20μ, consisting of 15–45 wt. % CaO, 40–45 wt. % P2O5, 10–40 wt. % ZrO2 and 0.7–3.5 wt. % fluoride, having apatite and calcium zircon phosphate as main crystal phases and a glass phase as an auxiliary component until a flowable mixture is obtained. The invention also relates to an adhesive kit consisting of said components. Sufficient amounts of resistance are obtained for a temporary bond, enabling the bond to be neutralized when desired.
摘要翻译： 本发明涉及生产用于连接类似或不同金属表面或陶瓷的粘合剂和粘合剂试剂盒的方法，特别是在生物医学领域。 本发明的目的是除了能够在金属和金属或金属和陶瓷之间实现临时的生物相容性结合之外，避免聚合相互作用的副产物和不利影响。 本发明的方法包括使用无单体的聚甲基丙烯酸甲酯，其与合适的无毒溶剂和粒度范围为0.05-20mu的生物活性玻璃结晶材料混合，其由15-45wt。 ％CaO，40-45wt。 ％P 2 O 5，10-40重量％ ％ZrO 2和0.7-3.5wt。 具有磷灰石和磷酸钙锆作为主要结晶相的氟化物，玻璃相作为辅助成分，直到得到可流动的混合物。 本发明还涉及由所述组分组成的粘合试剂盒。 获得足够量的电阻用于临时键，使得当需要时可以中和该键。
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公开(公告)号：US07109254B2
公开(公告)日：2006-09-19
申请号：US10480886
申请日：2002-06-14
申请人： Wolf-Dieter Müller , Emil Nagel , Georg Berger
发明人： Wolf-Dieter Müller , Emil Nagel , Georg Berger
CPC分类号： A61L24/0084 , A61L24/0089 , A61L27/446 , A61L27/46 , A61L2430/02 , C08L33/12
摘要： A method for producing a bioactive bone cement and a bone cement kit for anchoring artificial joints and for filling out bone defects. The method avoids polymerization-linked by-products and disadvantageous effects, while at the same time providing the bone cement with long-term stability. The inventive method uses a monomer-free polymethylmethacrylate, which is mixed with a suitable non-toxic solvent, and a bioactive, vitreous-crystalline material with a particle size ranging from >20 to 200 μm, having 15–45 wt. % CaO, 40–45 wt. % P2O5, 10–40 wt. % ZrO2 and 0.7–3.5 wt. % fluoride, having apatite and calcium zircon phosphate as main crystal phases and a glass phase as an auxiliary component until a flowable mixture is obtained. The invention also relates to a bone cement kit having said components.
摘要翻译： 生物活性骨水泥的制造方法和用于锚定人造关节并填充骨缺损的骨水泥试剂盒。 该方法避免了与聚合有关的副产物和不利影响，同时为骨水泥提供长期的稳定性。 本发明的方法使用与合适的无毒溶剂混合的无单体聚甲基丙烯酸甲酯和粒度范围> 20至200μm的生物活性玻璃态结晶材料，其具有15-45wt。 ％CaO，40-45wt。 ％P 2 O 5，10-40重量％ ％ZrO 2和0.7-3.5wt。 具有磷灰石和磷酸钙锆作为主要结晶相的氟化物，玻璃相作为辅助成分，直到得到可流动的混合物。 本发明还涉及具有所述组分的骨水泥试剂盒。
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公开(公告)号：US07377943B2
公开(公告)日：2008-05-27
申请号：US10480918
申请日：2002-06-14
申请人： Wolf-Dieter Müller , Georg Berger
发明人： Wolf-Dieter Müller , Georg Berger
CPC分类号： C03C4/0021 , A61L27/306 , A61L27/32 , A61L27/425 , B24C1/06 , B24C11/00 , C03C4/0007 , C03C10/16
摘要： The invention relates to a metallic implant, which has vitreous-crystalline bioactive material on the surface thereof. According to the invention, a metallic implant base body arranged on the surface of the particles has a bioactive, vitreous-crystalline material consisting of 15-45 wt. % CaO, 40-45 wt. % P2O5, 10-40 wt. % ZrO2 and 0.7-3.5 wt. % fluoride, having apatite and calcium zirconium phosphate as main crystalline and a glass phase as an auxiliary component. Said vitreous crystalline material contains at least 35 wt. % main crystal phases and at least 5-15 wt. % auxiliary compounds. All of the percentage data is expressed in relation to the total weight of the vitreous crystalline material and the particle size of the vitreous crystalline material is between 60-350 μm.
摘要翻译： 本发明涉及一种在其表面上具有玻璃态生物活性物质的金属植入物。 根据本发明，布置在颗粒表面上的金属植入物基体具有生物活性的玻璃状结晶材料，其由15-45wt。 ％CaO，40-45wt。 ％P 2 O 5，10-40重量％ ％ZrO 2和0.7-3.5wt。 ％氟化物，磷灰石和磷酸钙锆为主晶，玻璃相为辅助成分。 所述玻璃态结晶材料含有至少35wt。 ％主晶相和至少5-15wt。 ％辅助化合物。 所有百分比数据都以玻璃态结晶材料的总重量表示，玻璃状结晶材料的粒径在60-350μm之间。
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公开(公告)号：USD536452S1
公开(公告)日：2007-02-06
申请号：US29236051
申请日：2005-08-10
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公开(公告)号：US07086116B2
公开(公告)日：2006-08-08
申请号：US10149803
申请日：2000-11-30
IPC分类号： A46B9/04
CPC分类号： A46B5/007 , A46B5/0062 , A46B2200/1066 , B29L2031/425
摘要： A dental cleaning implement such as a toothbrush, having longitudinally disposed first and second parts flexibly joined together. Between the first and second parts is a rotatable member such that when the implement bends the first parts adjacent to the member bear upon the member. The rotatable member has circumferentially disposed relatively softer and harder regions, so that as the member is rotated the parts can be caused to bear compressibly upon selected softer or harder regions.
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6.发明授权Graminae pollen allergen mutants for specific immunotherapy, and production and use of the same 有权Graminae花粉过敏原突变体进行特异性免疫治疗，并进行生产和使用公开(公告)号：US06919086B1
公开(公告)日：2005-07-19
申请号：US09381903
申请日：1998-03-16
申请人： Helga Kahlert , Hans-Thomas Stüwe , Helmut Fiebig , Oliver Cromwell , Wolf-Meinhard Becker , Albrecht Bufe , Gabriele Schramm , Lothar Jäger , Wolf-Dieter Müller
发明人： Helga Kahlert , Hans-Thomas Stüwe , Helmut Fiebig , Oliver Cromwell , Wolf-Meinhard Becker , Albrecht Bufe , Gabriele Schramm , Lothar Jäger , Wolf-Dieter Müller
IPC分类号： C12N15/09 , A61K36/899 , A61K38/00 , A61K39/00 , A61P37/08 , C07K14/415 , C12Q1/68 , A61K39/36
CPC分类号： C07K14/415 , A61K38/00
摘要： The invention relates to modified recombinant allergen mutants which can be obtained from recombinant allergens which are derived from allergens which can be obtained by extraction from natural raw materials such as pollen of the species Phleum pratense. While these modified recombinant allergens stimulate lymphocytes from patients who are allergic to pollent to proliferate and synthesize cytokines, they exhibit a markedly diminished ability to bind to the IgE antibodies which are present in the serum of the T lymphocyte donors and to grass pollen allergen-specific IgEs and can therefore be used for a specific, made-to-release allergy therapy.
摘要翻译： 本发明涉及可从源自变应原的重组变应原获得的修饰的重组变应原突变体，其可以通过从诸如Phleum pratense种的花粉等天然原料中提取而获得。 虽然这些修饰的重组变应原刺激对花粉过敏的患者的淋巴细胞增殖和合成细胞因子，但是它们显示出与T淋巴细胞供体的血清中存在的IgE抗体和草花粉过敏原特异性结合的显着降低的能力 IgE，因此可用于特定的，即时释放的过敏疗法。
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公开(公告)号：USD483184S1
公开(公告)日：2003-12-09
申请号：US29171390
申请日：2002-11-21
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公开(公告)号：US11589961B2
公开(公告)日：2023-02-28
申请号：US16336400
申请日：2017-11-14
摘要： A customizable implant made of plastic including a thermoplastic which is reinforced with long fibers arranged multidirectionally in a targeted manner and has a modulus of elasticity E of 10-70 GPa is provided. A system for producing a customizable implant including a device for collecting patient data regarding the environment into which an implant is to be inserted, a computer program for creating a model for a customized implant based on the patient data collected, and a device for producing the customized implant based on the calculated model by means of 3D printing and/or laser sintering is also provided.
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公开(公告)号：USD543702S1
公开(公告)日：2007-06-05
申请号：US29256688
申请日：2006-03-23
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公开(公告)号：US06990706B2
公开(公告)日：2006-01-31
申请号：US10149796
申请日：2000-11-30
IPC分类号： A46B9/04
CPC分类号： A46B5/0062 , A46B5/0066 , A46B2200/1066 , B29L2031/425
摘要： A toothbrush having a head which carries a dental cleaning tool, and a grip handle, the head and handle being disposed along a longitudinal head-handle axis, the toothbrush having a resiliently flexible structure which can resiliently bend under the action of toothbrushing pressure and having adjustment means comprising a longitudinally moveable stiffening member which can be moved longitudinally into greater or lesser engagement with the resiliently flexible structure.
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