Retard systems for the sustained release of medicinal and/or biological
valuable materials from a depot carrier material
    1.
    发明授权
    Retard systems for the sustained release of medicinal and/or biological valuable materials from a depot carrier material 失效
    阻止用于从贮库载体材料持续释放药物和/或生物有价物质的系统

    公开(公告)号:US5538738A

    公开(公告)日:1996-07-23

    申请号:US133205

    申请日:1993-10-18

    摘要: The invention relates to the use of free radical-reactive cross-linker components based on olefinically unsaturated esters of lower hydroxycarboxylic acids and/or oligomers thereof for modifying depot materials, and especially retard systems, which contain medicinal and/or biological valuable materials in admixture with a carrier material in a sustained release form. The cross-linkers are present as polymer compounds in the application form of the retard system and may be provided in the retard system or depot material to be applied in a largely homogeneous as well as in a non-uniform distribution. The invention also relates to retard systems which contain medicinal and/or biological valuable materials and have been based on oligomer and/or polymer compounds of lower hydroxycarboxylic acids as carrier materials providing a sustained release of the active substance. The retard systems and/or depot materials are modified with polymer compounds prepared from olefinically unsaturated esters of lower hydroxycarboxylic acids and/or oligomers thereof.

    摘要翻译: PCT No.PCT / EP92 / 00825 Sec。 371日期:1993年10月18日 102(e)日期1993年10月18日PCT提交1992年4月11日PCT公布。 WO92 / 18108 PCT出版物 日期:1992年10月29日本发明涉及使用基于低级羟基羧酸和/或其低聚物的烯属不饱和酯的自由基 - 反应性交联剂组分来改性储存材料,特别是延迟体系,其包含药物和/或 生物有价值的材料与持续释放形式的载体材料混合。 交联剂以延迟体系的应用形式作为聚合物化合物存在,并且可以在延迟体系或储库材料中提供以在很大程度上均匀和非均匀分布中施用。 本发明还涉及包含药物和/或生物有价值物质并且基于低级羟基羧酸的低聚物和/或聚合物化合物作为提供活性物质的持续释放的载体材料的延迟系统。 延迟系统和/或贮库材料用由低级羟基羧酸和/或其低聚物的烯属不饱和酯制备的聚合物改性。