公开(公告)号：US20060269475A1

公开(公告)日：2006-11-30

申请号：US11402651

申请日：2006-04-11

申请人： WonHyoung Ryu ,  Rainer Fasching ,  Friedrich Prinz ,  Ralph Greco

发明人： WonHyoung Ryu ,  Rainer Fasching ,  Friedrich Prinz ,  Ralph Greco

IPC分类号： A61K51/00 ,  A61K9/14

CPC分类号： A61K9/0097 ,  A61K9/0004 ,  A61K9/0024 ,  A61K9/0051 ,  A61K9/2072 ,  A61K51/1282

摘要： Improved controlled therapy is provided with a polymer multi-layer structure having a predetermined micro-fabricated spatial pattern (e.g., reservoirs and channels). More specifically, all geometrical details of the spatial pattern are substantially predetermined. The increased control of pattern geometry provided by the invention allows for improved control of therapy. In preferred embodiments, the polymer multi-layer structure of the invention is biodegradable, but has an in vivo lifetime that is greater than the duration of the therapy being provided. Thus, the geometrical pattern of the polymer structure that controls delivery of the therapy persists without significant change during therapy, and the structure degrades after completion of therapy. In this manner, possible interference of degradation by-products with therapy is minimized, and delivery of therapy does not depend on details of how degradation proceeds.

摘要翻译： 提供了具有预定的微制造空间图案（例如储存器和通道）的聚合物多层结构的改进的对照治疗。 更具体地，空间图案的所有几何细节基本上是预先确定的。 由本发明提供的图案几何形状的增加的控制允许改善治疗的控制。 在优选的实施方案中，本发明的聚合物多层结构是可生物降解的，但是具有比所提供的治疗持续时间更长的体内寿命。 因此，控制治疗递送的聚合物结构的几何图案在治疗期间持续而没有显着变化，并且结构在治疗完成后降解。 以这种方式，降解副产物与治疗的可能干扰被最小化，并且治疗的递送不依赖于如何降解进行的细节。

公开(公告)号：US20050206048A1

公开(公告)日：2005-09-22

申请号：US11078907

申请日：2005-03-11

申请人： WonHyoung Ryu ,  Seoung Bai ,  Kyle Hammerick ,  Robert Smith ,  Ralph Greco ,  Friedrich Prinz ,  Rainer Fasching

发明人： WonHyoung Ryu ,  Seoung Bai ,  Kyle Hammerick ,  Robert Smith ,  Ralph Greco ,  Friedrich Prinz ,  Rainer Fasching

IPC分类号： B01L3/00 ,  B28B1/00 ,  B29B7/00 ,  B29C33/00 ,  B29C43/02 ,  B29C45/00 ,  B29C59/02 ,  B29C59/04

CPC分类号： B29C43/021 ,  B01L3/5027 ,  B01L3/5085 ,  B29C33/0033 ,  B29C33/424 ,  B29C43/003 ,  B29C59/02 ,  B29C59/022 ,  B29C59/04 ,  B29C2043/025 ,  B29C2043/463 ,  B29C2043/5883 ,  B29C2059/023 ,  B29L2031/7532

摘要： Methods for compression molding through holes in polymer layers are provided, as are the resulting patterned polymer layers. Two key aspects of the invention are provision of a mold and substrate having different mechanical hardness, and provision of room for local flow of material. These aspects of the invention facilitate formation of through holes by compression molding that are not blocked or partially blocked by undesirable material. These polymer layers can be formed into three dimensional patterned structures by bonding patterned layers together. Since the layers include through holes, a three-dimensional polymer pattern can be formed. These patterned polymer layers and three dimensionally patterned polymer constructs have a wide variety of applications. For example, these constructs can be used for fabrication of micro-fluidic devices, and/or can be used for various medical and biological applications including drug delivery devices and tissue engineering devices.

摘要翻译： 提供了聚合物层中的孔的压缩模塑方法，以及所形成的图案化聚合物层。 本发明的两个关键方面是提供具有不同机械硬度的模具和基材，并提供用于局部流动材料的空间。 本发明的这些方面有助于通过压缩成型形成未被不期望的材料阻挡或部分阻挡的通孔。 这些聚合物层可以通过将图案化层结合在一起而形成三维图案化结构。 由于层包括通孔，因此可以形成三维聚合物图案。 这些图案化的聚合物层和三维图案化的聚合物构造物具有广泛的应用。 例如，这些构建体可用于制造微流体装置，和/或可用于各种医疗和生物应用，包括药物递送装置和组织工程装置。

公开(公告)号：US20060213259A1

公开(公告)日：2006-09-28

申请号：US11233677

申请日：2005-09-22

申请人： Friedrich Prinz ,  Ye Tao ,  Rainer Fasching ,  Ralph Greco ,  Kyle Hammerick ,  Robert Smith

发明人： Friedrich Prinz ,  Ye Tao ,  Rainer Fasching ,  Ralph Greco ,  Kyle Hammerick ,  Robert Smith

IPC分类号： B23Q17/09 ,  G01N19/02

CPC分类号： G01Q60/02 ,  G01Q60/38 ,  G01Q60/60 ,  Y10S977/86 ,  Y10S977/869 ,  Y10S977/875

摘要： Sensors and systems for electrical, electrochemical, or topographical analysis, as well as methods of fabricating these sensors are provided. The sensors include a cantilever and one or more probes, each of which has an electrode at its tip. The tips of the probes are sharp, with a radius of curvature of less than about 50 nm. In addition, the probes have a high aspect ratio of more than about 19:1. The sensors are suitable for both Atomic Force Microscopy and Scanning Electrochemical Microscopy.

摘要翻译： 提供了用于电气，电化学或地形分析的传感器和系统，以及制造这些传感器的方法。 传感器包括悬臂和一个或多个探针，每个探针在其尖端具有电极。 探针的尖端是锋利的，其曲率半径小于约50nm。 此外，探针的高纵横比大于约19：1。 传感器适用于原子力显微镜和扫描电化学显微镜。

公开(公告)号：US5578073A

公开(公告)日：1996-11-26

申请号：US37335

申请日：1994-09-16

申请人： Beatrice Haimovich ,  Amihay Freeman ,  Ralph Greco

发明人： Beatrice Haimovich ,  Amihay Freeman ,  Ralph Greco

IPC分类号： A61F2/06 ,  A61L33/06 ,  C09D105/08 ,  A61F2/16 ,  C08L5/08

CPC分类号： C09D105/08 ,  A61F2/06 ,  A61L33/062

摘要： A biomaterial with a thromboresistant surface and a method for forming same are provided. The thromboresistant surface is comprised of a distinct coating layer of a chitosan-based membrane and a biologically active material. The biologically active material is capable of converting the chitosan membrane coating from a highly thrombogenic to an essentially non-thrombogenic one. The biologically active material can be a polymeric substance, such as polyvinyl alcohol, forming a polymeric blend with the chitosan, or, can be a biological substance, such as serum albumin, embedded in or attached to the chitosan membrane which has been activated with a treatment of glutardialdehyde. The thromboresistant biomaterial is suitable for use in vascular grafts having an inside diameter of less than 6 millimeters.

摘要翻译： 提供具有抗血栓表面的生物材料及其形成方法。 抗血栓表面由基于壳聚糖的膜和生物活性物质的不同的涂层组成。 生物活性物质能够将壳聚糖膜涂层从高度血栓形成转变为基本上非致血性的。 生物活性材料可以是聚合物质，例如聚乙烯醇，与壳聚糖形成聚合物共混物，或者可以是嵌入或连接到壳聚糖膜上的生物物质，例如血清白蛋白，其已经用 治疗戊二醛。 抗血栓生物材料适用于内径小于6毫米的血管移植物。