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公开(公告)号：US20100168021A1
公开(公告)日：2010-07-01
申请号：US12632715
申请日：2009-12-07
申请人： Wylie Walker Vale, JR. , Teresa M. Reyes , Paul E. Sawchenko , Jean E. Rivier , Kathy A. Lewis , John B. Hogenesch , Joan M. Vaughan , Marilyn H. Perrin
发明人： Wylie Walker Vale, JR. , Teresa M. Reyes , Paul E. Sawchenko , Jean E. Rivier , Kathy A. Lewis , John B. Hogenesch , Joan M. Vaughan , Marilyn H. Perrin
CPC分类号： C07K14/57509 , A61K38/00 , A61K39/00
摘要： A human urocortin-related peptide with significant sequence homology to the CRF neuropeptide family was identified. A mouse cDNA was isolated from whole brain poly (A+) RNA that encodes a predicted 38 amino acid peptide protein designated herein as urocortin II. Both human URP and mouse Ucn II are structurally related to the other known mammalian family members, CRF and urocortin (Ucn). These peptides are involved in the regulation of the hypothalamic-pituitary-adrenal axis under basal and stress conditions, suggesting a similar role for URP and Ucn IL Synthesized Ucn-II and URP peptide binds with higher affinity to CRF-R2 than to CRF-R1 Ucn II and human URP appear to be involved in the regulation of body temperature and appetite and may play a role in other stress related phenomenon. These findings identify Ucn II and human URP as a new members of the CRF family of neuropeptides, which are expressed centrally and bind to CRF-R2.
摘要翻译： 鉴定出与CRF神经肽家族具有显着序列同源性的人尿皮质素相关肽。 从编码本文称为尿皮质素II的预测的38个氨基酸的肽蛋白质的全脑poly（A +）RNA中分离出小鼠cDNA。 人URP和小鼠Ucn II都与其他已知的哺乳动物家族成员CRF和尿皮质素（Ucn）结构相关。 这些肽在基底和应激条件下参与下丘脑 - 垂体 - 肾上腺轴的调节，这表明URP和Ucn IL的相似作用合成的Ucn-II和URP肽与CRF-R2的亲和力高于CRF-R1 Ucn II和人类URP似乎参与了体温和食欲的调节，可能在其他压力相关现象中起作用。 这些发现将Ucn II和人类URP鉴定为CRF家族的新成员，它们集中表达并结合CRF-R2。
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公开(公告)号：US08044025B2
公开(公告)日：2011-10-25
申请号：US12632715
申请日：2009-12-07
申请人： Wylie W. Vale, Jr. , Teresa M. Reyes , Paul E. Sawchenko , Jean E. Rivier , Kathy A. Lewis , John B. Hogenesch , Joan M. Vaughan , Marilyn H. Perrin
发明人： Wylie W. Vale, Jr. , Teresa M. Reyes , Paul E. Sawchenko , Jean E. Rivier , Kathy A. Lewis , John B. Hogenesch , Joan M. Vaughan , Marilyn H. Perrin
CPC分类号： C07K14/57509 , A61K38/00 , A61K39/00
摘要： A human urocortin-related peptide with significant sequence homology to the CRF neuropeptide family was identified. A mouse cDNA was isolated from whole brain poly (A+) RNA that encodes a predicted 38 amino acid peptide protein designated herein as urocortin II. Both human URP and mouse Ucn II are structurally related to the other known mammalian family members, CRF and urocortin (Ucn). These peptides are involved in the regulation of the hypothalamic-pituitary-adrenal axis under basal and stress conditions, suggesting a similar role for URP and Ucn IL Synthesized Ucn-II and URP peptide binds with higher affinity to CRF-R2 than to CRF-R1 Ucn II and human URP appear to be involved in the regulation of body temperature and appetite and may play a role in other stress related phenomenon. These findings identify Ucn II and human URP as a new members of the CRF family of neuropeptides, which are expressed centrally and bind to CRF-R2.
摘要翻译： 鉴定出与CRF神经肽家族具有显着序列同源性的人尿皮质素相关肽。 从编码本文称为尿皮质素II的预测的38个氨基酸的肽蛋白质的全脑poly（A +）RNA中分离出小鼠cDNA。 人URP和小鼠Ucn II都与其他已知的哺乳动物家族成员CRF和尿皮质素（Ucn）结构相关。 这些肽在基底和应激条件下参与下丘脑 - 垂体 - 肾上腺轴的调节，这表明URP和Ucn IL的相似作用合成的Ucn-II和URP肽与CRF-R2的亲和力高于CRF-R1 Ucn II和人类URP似乎参与了体温和食欲的调节，可能在其他压力相关现象中起作用。 这些发现将Ucn II和人类URP鉴定为CRF家族的新成员，它们集中表达并结合CRF-R2。
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公开(公告)号：US06838274B2
公开(公告)日：2005-01-04
申请号：US09919473
申请日：2001-07-31
申请人： Wylie W. Vale, Jr. , Teresa M. Reyes , Paul E. Sawchenko , Jean E. Rivier , Kathy A. Lewis , John B. Hogenesch , Joan M. Vaughan , Marilyn H. Perrin
发明人： Wylie W. Vale, Jr. , Teresa M. Reyes , Paul E. Sawchenko , Jean E. Rivier , Kathy A. Lewis , John B. Hogenesch , Joan M. Vaughan , Marilyn H. Perrin
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61K39/00 , A61P3/00 , A61P5/06 , A61P9/04 , A61P9/10 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/26 , A61P25/28 , A61P29/00 , C07K14/435 , C07K14/52 , C07K14/575 , C07K16/24 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/16 , C12P21/08 , C12R1/19 , C12N15/63
CPC分类号： C07K14/57509 , A61K38/00 , A61K39/00
摘要： A human urocortin-related peptide with significant sequence homology to the CRF neuropeptide family was identified. A mouse cDNA was isolated from whole brain poly (A+) RNA that encodes a predicted 38 amino acid peptide protein designated herein as urocortin II. Both human URP and mouse Ucn II are structurally related to the other known mammalian family members, CRF and urocortin (Ucn). These peptides are involved in the regulation of the hypothalamic-pituituary-adrenal axis under basal and stress conditions, suggesting a similar role for URP and Ucn II. Synthesized Ucn-II and URP peptide binds with higher affinity to CRF-R2 than to CRF-R1 Ucn II and human URP appear to be involved in the regulation of body temperature and appetite and may play a role in other stress related phenomenon. These findings identify Ucn II and human URP as a new members of the CRF family of neuropeptides, which are expressed centrally and bind to CRF-R2.
摘要翻译： 鉴定出与CRF神经肽家族具有显着序列同源性的人尿皮质素相关肽。 从编码本文称为尿皮质素II的预测的38个氨基酸的肽蛋白质的全脑poly（A +）RNA中分离出小鼠cDNA。 人URP和小鼠Ucn II都与其他已知的哺乳动物家族成员CRF和尿皮质素（Ucn）结构相关。 这些肽在基础和应激条件下参与下丘脑 - 垂体 - 肾上腺轴的调节，表明URP和Ucn II具有类似的作用。 合成的Ucn-II和URP肽以比CRF-R1 Ucn II更高的亲和力结合，并且人URP似乎参与体温和食欲的调节，并且可能在其他压力相关现象中起作用。 这些发现将Ucn II和人类URP鉴定为CRF家族的新成员，它们集中表达并结合CRF-R2。
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公开(公告)号：US07344833B2
公开(公告)日：2008-03-18
申请号：US10702112
申请日：2003-11-05
IPC分类号： C12Q1/68
CPC分类号： G01N33/5023 , G01N33/574 , G01N33/6875 , G01N2500/00
摘要： This invention provides novel AP-1 modulatory polypeptides. The invention also provides methods for screening modulators of AP-1 transcription factor activities. The methods comprise first screening test agents for modulators of an AP-1-modulatory polypeptide and then further screening the identified modulating agents for modulators of AP-1 transcription factor activities. The invention further provides methods and pharmaceutical compositions for modulating AP-1 transcription factor activities in a cell and for treating diseases and conditions mediated by abnormal cellular proliferation.
摘要翻译： 本发明提供新型AP-1调节多肽。 本发明还提供筛选AP-1转录因子活性调节剂的方法。 所述方法包括首先筛选AP-1调节多肽的调节剂的测试剂，然后进一步筛选鉴定的调节剂用于AP-1转录因子活性的调节剂。 本发明还提供用于调节细胞中AP-1转录因子活性并用于治疗由异常细胞增殖介导的疾病和病症的方法和药物组合物。
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公开(公告)号：US07105647B1
公开(公告)日：2006-09-12
申请号：US09555362
申请日：1998-11-27
IPC分类号： C07H21/02
CPC分类号： C07K14/4702
摘要： The present invention provides isolated nucleic acids and proteins that are new and distinct members of the bHLH-PAS superfamily of transcription regulators. These “MOPs” (members of PAS) are useful in a variety of research, diagnostic and therapeutic applications. Several of the MOPs of the present invention are α-class hypoxia-inducible factors. Several other of the MOPs of the invention are involved in circadian signal transduction.
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6.发明授权cDNAs and proteins involved in hypoxia, circadian and orphan signal transduction pathways, and methods of use 失效涉及缺氧，昼夜节律和孤儿信号转导途径的cDNA和蛋白质，以及使用方法公开(公告)号：US07501489B2
公开(公告)日：2009-03-10
申请号：US11288720
申请日：2005-11-29
CPC分类号： C07K14/4702
摘要： The present invention provides isolated nucleic acids and proteins that are new and distinct members of the bHLH-PAS superfamily of transcription regulators. These “MOPs” (members of PAS) are useful in a variety of research, diagnostic and therapeutic applications. Several of the MOPs of the present invention are α-class hypoxia-inducible factors. Several other of the MOPs of the invention are involved in circadian signal transduction.
摘要翻译： 本发明提供分离的核酸和蛋白质，其是转录调节物的bHLH-PAS超家族的新的和不同的成员。 这些“MOP”（PAS成员）可用于各种研究，诊断和治疗应用。 本发明的几种MOP是α-类缺氧诱导因子。 本发明的其它几种MOP参与昼夜节律信号转导。
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公开(公告)号：US07427489B1
公开(公告)日：2008-09-23
申请号：US10464817
申请日：2003-06-17
IPC分类号： G01N33/53
CPC分类号： G01N33/6872 , G01N33/502 , G01N2500/00
摘要： Screening assays for identifying agents that modulate BK channel activity and further modulate the sleep/wake cycle in a subject, circadian regulated locomotor activity in a subject, or both are provided, as are agents identified using such screening assays. Also provided are methods of modulating the sleep/wake cycle in a subject and methods of modulating circadian regulated locomotor activity in a subject by administering an agent that modulates BK channel activity to the subject, for example, an agent identified by a screening assay as disclosed.
摘要翻译： 提供了用于鉴定调节受试者的BK通道活性并进一步调节受试者的睡眠/唤醒周期的试剂的筛选测定，或者两者的昼夜节律调节的运动活性，或者两者，以及使用这种筛选测定法鉴定的试剂。 还提供了调节受试者的睡眠/觉醒周期的方法以及通过施用调节受试者的BK通道活性的试剂（例如通过如所公开的筛选测定法鉴定的试剂）来调节受试者中昼夜节律调节的运动活性的方法 。
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公开(公告)号：US20090142793A1
公开(公告)日：2009-06-04
申请号：US12236374
申请日：2008-09-23
CPC分类号： G01N33/6872 , G01N33/502 , G01N2500/00
摘要： Screening assays for identifying agents that modulate BK channel activity and further modulate the sleep/wake cycle in a subject, circadian regulated locomotor activity in a subject, or both are provided, as are agents identified using such screening assays. Also provided are methods of modulating the sleep/wake cycle in a subject and methods of modulating circadian regulated locomotor activity in a subject by administering an agent that modulates BK channel activity to the subject, for example, an agent identified by a screening assay as disclosed.
摘要翻译： 提供了用于鉴定调节受试者的BK通道活性并进一步调节受试者的睡眠/唤醒周期的试剂的筛选测定，或者两者的昼夜节律调节的运动活性，或者两者，以及使用这种筛选测定法鉴定的试剂。 还提供了调节受试者的睡眠/觉醒周期的方法以及通过施用调节受试者的BK通道活性的试剂（例如通过如所公开的筛选测定法鉴定的试剂）来调节受试者中昼夜节律调节的运动活性的方法 。
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